• Asia pacific journal of information systems
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• v.33 no.3
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• pp.792-811
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• 2023

Recently, Web 3.0 services such as virtual currency, block chain, and NFT are attracting public attention. Users who depended on platforms are moving away from being dependent on service providers and moving to Web 3.0 services. Representative services of Web 3.0 include P2E (Play to Earn) and M2E (Move to Earn). In the case of P2E, various studies have been conducted as it is widely covered in the press and media, but research on M2E is relatively lacking. This study attempts to identify the intention to use M2E by using the expanded technology acceptance model. External factors were selected based on M2E's own characteristics and personal characteristics, a research model was designed, and the proposed hypotheses were verified through factor analysis and goodness of model fit. As a result of the study, it was confirmed that profitability, innovativeness, and self-expression had a positive effect on perceived characteristics, and that perceived usefulness, perceived enjoyment, and social influence had a positive effect on intention to use. Through the research results, practical implications for efficient service operation that meets the needs of users are presented to M2E platform providers.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.22 no.2
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• pp.164-173
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• 2000

The p16 protein is a cyclin dependent kinase inhibitor that inhibits cell cycle progression from $G_1$ phase to S phase in cell cycle. Many p16 gene mutations have been noted in many cancer-cell lines and in some primary cancers, and alterations of p16 gene function by DNA methylation have been noticed in various kinds of cancer tissues and cell-lines. There have been a large body of literature has accumulated indicating that abnormal patterns of DNA methylation (both hypomethylation and hypermethylation) occur in a wide variety of human neoplasma and that these aberrations of DNA methylation may play an important epigenetic role in the development and progression of neoplasia. DNA methylation is a part of the inheritable epigenetic system that influences expression or silencing of genes necessary for normal differentiation and proliferation. Gene activity may be silenced by methylation of up steream regulatory regions. Reactivation is associated with demethylation. Although evidence or a high incidence of p16 alterations in a variety of cell lines and primary tumors has been reported, that has been contested by other investigators. The precise mechanisms by which abnormal methylation might contribute to carcinogenesis are still not fully elucidated, but conceivably could involve the modulation of oncogene and other important regulatory gene expression, in addition to creating areas of genetic instability, thus predisposing to mutational events causing neoplasia. There have been many variable results of studies of head and neck squamous cell carcinoma(HNSCC). This investigation was studied on 13 primary HNSCC for p16 gene status by protein expression in immunohistochemistry, and DNA genetic/epigenetic analyzed to determine the incidence, the mechanisms, and the potential biological significance of its Inactivation. As methylation detection method of p16 gene, the methylation specific PCR(MSP) is sensitive and specific for methylation of any block of CpG sites in a CpG islands using bisulfite-modified DNA. The genomic DNA is modified by treatment with sodium bisulfate, which converts all unmethylated cytosines to uracil(thymidine). The primers designed for MSP were chosen for regions containing frequent cytosines (to distinguish unmodified from modified DNA), and CpG pairs near the 5' end of the primers (to provide maximal discrimination in the PCR between methylated and unmethylated DNA). The two strands of DNA are no longer complementary after bisulfite treatment, primers can be designed for either modified strand. In this study, 13 paraffin embedded block tissues were used, so the fragment of DNA to be amplified was intentionally small, to allow the assessment of methylation pattern in a limited region and to facilitate the application of this technique to samlples. In this 13 primary HNSCC tissues, there was no methylation of p16 promoter gene (detected by MSP and automatic sequencing). The p16 protein-specific immunohistochemical staining was performed on 13 paraffin embedded primary HNSCC tissue samples. Twelve cases among the 13 showed altered expression of p16 proteins (negative expression). In this study, The author suggested that low expression of p16 protein may play an important role in human HNSCC, and this study suggested that many kinds of genetic mechanisms including DNA methylation may play the role in carcinogenesis.

• Journal of Navigation and Port Research
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• v.31 no.3 s.119
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• pp.165-172
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• 2007

Logistics needs in Asia are surprisingly increasing due to rapid growth of China in Northeast Asia We are endeavoring to make an economic block in opposition to NAFTA and EU by economic revival, political stability, and easing of exclusive parts between countries as increasing of traffic infra such as asian highway, transcontinental railway in the region of Northeast Asia and as considering diversification of transportation mode. Now, Busan is not a final terminal of this business, and it is not a concreted level in considering an undersea tunnel between Korea and Japan as effort to extend to Japan. Therefore, this study performed an effect analysis which be affected to Northeast Asia and Korea in future by analysis and comparison of a cost and time required of marine transportation and railway before and after construction through course analysis and summary of discussed content until now for undersea tunnel between Korea and Japan. This result expects as a accelerative play for study cf undersea tunnel between Korea and Japan in future. In this result, we estimate that it is an effective things in a cost and time required if undersea tunnel between Korea and Japan is constructed, and we simply searched for theirs effects in the aspects of Northeast Asia, national balanced development, regional economic in Busan, and marine logistics.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.5
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• pp.143-150
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• 2018

With the rapid development of RF based high speed wireless communication technology, devices that can be applied to IoT networks based on RF bandwidth are rapidly spreading, nevertheless, the development speed of the RF communication is not possible to keep up with the spread of the RF band for wireless communication. In this situation, OWC technology that uses visible light source as a transmitter is attracting attention as a technology that can overcome the band exhaustion problem of RF based wireless communication technology. Although, due to the distortion of the LED illumination shape by camera exposure time and LED blinking period, the LED illumination detection rate is degraded and the RoI setting is inaccurate. In this paper, we propose an adaptive median filter applied LED illumination detection algorithm for low rate CamCom, it is possible to detect a clear RoI and LED illumination. This research will be able to play a role as a complementary material of RF based wireless communication technology efficiently.

• Korean Journal of Social Welfare
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• v.53
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• pp.179-207
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• 2003

The purpose of this study is to find out the structural characteristics of interorganizational networks for women, and to identify the magnitude of efficient structure for network using 30 organizations for women in Buchon. This study attempted to examine the characteristic of interorganizational networks through searching out the central organization and block modeling. The research sample was 30 organizations, and the data analyzed by UCINET V and KP(Krack Plot) 3.1. The results show that public agencies are central organizations of all dimensions(information exchange, client referral, cooperation, resource exchange) and they also play an important part as intermediary of interorganizational network. A prominent characteristics of network is "ggiri-network" that means network between similar agencies. This finding provides important strategy to build and expand the network. Also this finding can be direction of network structure to meet women's needs and empower women.

• Tunnel and Underground Space
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• v.28 no.6
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• pp.692-705
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• 2018

Ground vibration is one of the remarkable issues in tunnel blasting. In recent studies, to improve the fragmentation with reduction of ground vibration in tunnel blasting, a vibration-controlled blasting method with artificial cutting slot near the center-cut holes has been suggested. This study examines the effect of the different arrangement of artificial cut-slot on the vibration reduction and fragmentation by performing the full-scaled concrete block blast experiments and the numerical simulations with 3D-DFPA. The results show that the existence of artificial slot contributes to the improvement of vibration reduction, blast fragmentation and the efficiency of the cutting slot blast. It can be explained that the artificial slot play a free surface role and should decrease the burden between the cut holes. Crater volumes of the blasted concrete blocks were measured by 3-dimensional digital image analysis and compared with the ideal standard crater volume which can be calculated by theoretical standard blast design method. As a result, the ratio of burden and hole diameter which should achieve the standard crater in the cut-hole blasting were suggested.

• Journal of Music and Human Behavior
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• v.19 no.2
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• pp.81-103
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• 2022

The effects of therapeutic instrumental music performance (TIMP) using a ukulele were examined in adults with central nervous system damage and impaired hand functions. The participants were three adults with neurological damage who participated in 30-min sessions twice a week over 6 weeks. Changes in hand function was measured by the Box and Block Test (BBT), the 9-Hole Peg Test (9-HPT), and the Jebsen-Taylor Hand Function Test (JTHFT). Following the intervention, all three participants showed increases in the BBT and 9-HPT scores, indicating positive changes in fine motor coordination and dexterity. In terms of the JTHFT, all three participants showed increases in the "writing" and "card flipping" subtask scores, indicating that the intervention was effective in improving more coordinated finger movements. All participants reported the satisfaction with the intervention. They also pointed out that they were motivated to play the ukulele and that following the intervention used their affected hand more frequently in daily activities. These findings suggest that TIMP with a ukulele for patients with central nervous system damage can have positive effects on their functional hand movements and motivate these patients to practice their rehabilitation exercises.

• Korean Institute of Interior Design Journal
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• v.26 no.6
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• pp.210-221
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• 2017

First, we can define how our body perceives the external world and embodies its senses through the philosopher Merleau - Ponty. These philosophical orientations of Merleau-Ponty also appear to urban theorists such as Jane Jacobs, Gordon Cullen, and Juhani Pallasmaa. In other words, after the Second World War, people began to pay attention to human emotions and perceptions while opposing human rational thinking. Especially, they reject the abstract space of modernism and explore the everyday city space where the local character of the area lives. This place is a space where the collective memory of the group is shared over several generations. So, in this space, people's active perceptual system works actively. In the sense of this continuity of time, their ideas intersect with the concept of urban. Specifically, Jacobs criticizes massive development and proposes the development of a small block-based city with a commonality of old and new. In addition, we argue that urban space can be a visually interesting object through the continuous visual concept of urban theorist Cullen. In particular, he rediscovers the value of traditional urban space through visual experience between architecture and urban facilities. Finally, the architectural city theorist, Pallasmaa., criticizes the visual centrality of modern cities and thinks about the value of multidisciplinary space that can be experienced in architecture. This study examines the space of reproduction in detail on the perspective of the body philosophy and urban theorists. In other words, the play space inherits the natural city time, so when our body experiences this play space, we can actively sense and perceive the various senses. So we can invoke the active external actions of our bodies. Through the analysis of the size of the reconstruction space of the architectural city, various types of body senses and responses can be. Yoon Dongju Literary Museum, which renovated the old water tank of the city, can recognize the unfamiliar sense of body in everyday life through the traces and smells of water in the past and the restrained visuality. In addition, Seonyudo Park, which regenerates the waste water purification plant, can experience a phenomenal phenomenon through water space, old concrete and traces of steel. Finally, with the most recently played Seoul Road 7017 can experience interesting urban spaces in terms of a variety of plants, a human scale space creating movement, and a continuous visual.

• Journal of the Korea Fashion and Costume Design Association
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• v.16 no.4
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• pp.217-228
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• 2014

The purpose of this study is to grasp inconveniences and improvements by examining wearing condition and satisfaction of protective clothing targeting 114 Korean farmers and to suggest basic data for enhancement of pattern and wearing satisfaction of protective clothing by understanding problems of pesticide-proof clothing through comparative analysis on the size of its commercial products. Most of male subjects were in charge of spraying pesticide, whereas female were most likely to play an assistant role to hold the hose of pesticide applicator. Both of female and male subjects were very aware of the harmful effect of pesticide on human body and tried to take off the clothes immediately after spraying it to reduce possible damage caused by pesticide. As a result of examining wearing condition, the farmers avoided wearing protective clothing because that it feels hot, stuffy, and uncomfortable to move. This hesitant response of wearing the clothing was not shown significantly in case of female subjects who play an assistant role for spraying. Although the farmers wore protective equipments such as mask or gloves in a proper way as compared to protective clothing, they seemed to choose alternative way rather than best way to block pesticide completely. The satisfaction regarding to the fitting of protective clothing which the subjects showed low in all items of upper-lower clothes except waistline. It is necessary to improve the functionality such as relief from heat stress and convenience for movement rather than design or economic in protective clothing development. As a result of comparing the size of five kinds of commercial protective clothing, the farmers got confused to choose the product since designation method of size across companies showed a significant difference in an identical clothing size. In addition, the sizing system developed on a basis of a well-built man has become a hindering factor in wearing satisfaction of female farmers.

• Animal cells and systems
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• v.3 no.3
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• pp.311-317
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• 1999

Prolactin (PRL) was reported to be locally synthesized in many brain areas including the hypothalamus, thalamus (TH) and hippocampus (HIP). In the pituitary lactotrophs, PRL synthesis is dependent upon a pituitary-specific transcription factor, Pit-1. In the present study, we attempted to identify Pit-1 or Pit-1-like protein in brain areas known as the synthetic sites of PRL. Reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot analysis showed the same Pit-1 transcripts in brain areas such as the medial basal hypothalamus (MBH), preoptic area (POA), TH, and HIP with the Pit-1 transcripts in the anterior pituitary (AP). Electrophoretic mobility shift assay (EMSA) was run with nuclear protein extracts from brain tissues using a double strand oligomer probe containing a putative Pit-1 binding domain. Shifted bands were found in EMSA results with nuclear proteins from MBH, POA, TH and HIP. Specific binding of the Pit-1-like protein was further confirmed by competition with an unlabeled cold probe. Antisense Pit-1 oligodeoxynucleotide (Pit-1 ODN), which was designed to bind to the Pit-1 translation initiation site and block Pit-1 biosynthesis, was used to test Pit-1 dependent brain PRL transcription. Two nmol of Pit-1 ODN was introduced into the lateral ventricle of a 60-day old male rat brain. RNA blot hybridization and in situ hybridization indicated a decrease of PRL mRNA signals by the treatment of Pit-1 ODN. Taken together, the present study suggests that Pit-1 may play an important role in the transcriptional regulation of local PRL synthesis in the brain.