• Title/Summary/Keyword: blind calibration

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A Compact Optical System using LED and CMOS Image Sensor for Liver Function Analysis (LED와 CMOS 이미지 센서 기반 간 기능 분석용 소형 광학장치)

  • Kim, Chul;Lim, Chang-Jin;Nam, Myung-Hyun;Kim, Dong-Sik;Seo, Sung-Kyu;Pak, Jung-Ho
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.61 no.2
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    • pp.270-275
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    • 2012
  • This paper presents a portable and compact optical device which can conveniently be used to perform a functional analysis of human liver function. The proposed system employed red/green LEDs, as a light source, and CMOS image sensor, which is commonly used in cellular phones. With this system, several blood serum samples have been evaluated for liver functional analysis by measuring light absorption level through the blood serum samples depending on aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin concentration. The light absorption through the blood serum samples containing AST, ALT, or total bilirubin can provide their concentrations. The green light absorption is more sensitive to the concentration of AST or ALT, and the red light absorption is more sensitive to the total bilirubuin concentration. Additional calibration steps were performed by using a MATLAB program in order to eliminate the light scattering effects from the extraneous particles existing in each blood serum sample. From the blind test, three standard light intensity curves through each enzyme have been obtained and the enzyme concentration values have been compared to those obtained from a commercially available biochemistry analyzer (Toshiba 200 FR). The average percent difference in the obtained concentrations from two systems for AST, ALT, and total bilirubin concentration came out to be 7.79%, 7.98%. and 7.56%, respectively, with the adjusted coefficient of determination (R2) higher than 0.98. This system can possibly lead to a low-cost and simple system that can be used as a point-of-care (POC) system in a condition without advanced equipments.

Multi-aperture Photometry Pipeline for DEEP-South Data

  • Chang, Seo-Won;Byun, Yong-Ik;Kim, Myung-Jin;Moon, Hong-Kyu;Yim, Hong-Suh;Shin, Min-Su;Kang, Young-Woon
    • The Bulletin of The Korean Astronomical Society
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    • v.41 no.1
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    • pp.56.2-56.2
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    • 2016
  • We present a multi-aperture photometry pipeline for DEEP-South (Deep Ecliptic Patrol of the Southern Sky) time-series data, written in C. The pipeline is designed to do robust high-precision photometry and calibration of non-crowded fields with a varying point-spread function, allowing for the wholesale search and characterization of both temporal and spatial variabilities. Our time-series photometry method consists of three parts: (i) extracting all point sources with several pixel/blind parameters, (ii) determining the optimized aperture for each source where we consider whether the measured flux within the aperture is contaminated by unwanted artifacts, and (iii) correcting position-dependent variations in the PSF shape across the mosaic CCD. In order to provide faster access to the resultant catalogs, we also utilize an efficient indexing technique using compressed bitmap indices (FastBit). Lastly, we focus on the development and application of catalog-based searches that aid the identification of high-probable single events from the indexed database. This catalog-based approach is still useful to identify new point-sources or moving objects in non-crowded fields. The performance of the pipeline is being tested on various sets of time-series data available in several archives: DEEP-South asteroid survey and HAT-South/MMT exoplanet survey data sets.

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A Research on V2I-based Accident Prevention System for the Prevention of Unexpected Accident of Autonomous Vehicle (자율주행 차량의 돌발사고 방지를 위한 V2I 기반의 사고 방지체계 연구)

  • Han, SangYong;Kim, Myeong-jun;Kang, Dongwan;Baek, Sunwoo;Shin, Hee-seok;Kim, Jungha
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.20 no.3
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    • pp.86-99
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    • 2021
  • This research proposes the Accident Prevention System to prevent collision accident that can occur due to blind spots such as crossway or school zone using V2I communication. Vision sensor and LiDAR sensor located in the infrastructure of crossway somewhere like that recognize objects and warn vehicles at risk of accidents to prevent accidents in advance. Using deep learning-based YOLOv4 to recognize the object entering the intersection and using the Manhattan Distance value with LiDAR sensors to calculate the expected collision time and the weight of braking distance and secure safe distance. V2I communication used ROS (Robot Operating System) communication to prevent accidents in advance by conveying various information to the vehicle, including class, distance, and speed of entry objects, in addition to collision warning.

Quality Assurance Program of Electron Beams Using Thermoluminescence Dosimetry (열형광선량계를 이용한 전자선 품질보증 프로그램에 관한 연구)

  • Rah Jeong-Eun;Kim Gwe-Ya;Jeong Hee-Kyo;Shin Dong-Oh;Suh Tae-Suk
    • Progress in Medical Physics
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    • v.16 no.2
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    • pp.62-69
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    • 2005
  • The purpose of this study has been performed to investigate the possibility of external audit program using thermoluminescence dosimetry for electron beam in korea. The TLD system consists of LiF powder, type TLD-700 read with a PCL 3 reader. In order to determine a calibration coefficient of the TLD system, the reference dosimeters are irradiated to 2 Gy in a $^{60}CO$ beam at the KFDA The irradiation is performed under reference conditions is water phantom using the IAEA standard holder for TLD of electron beam. The energy correction factor is determined for LiF powder irradiated of dose to water 2 Gy in electron beams of 6, 9, 12, 16 and 20 MeV (Varian CL 2100C). The dose is determined according to the IAEA TRS-398 and by measurement with a PTW Roos type plane-parallel chamber. The TLD for each electron energy are positioned in water at reference depth. In this study, to verify of the accuracy of dose determination by the TLD system are performed through a 'blind' TLD irradiation. The results of blind test are $2.98\%,\;3.39\%\;and\;0.01\%(1\sigma)$ at 9, 16, 20 MeV, respectively. The value generally agrees within the acceptance level of $5\%$ for electron beam. The results of this study prove the possibility of the TLD quality assurance program for electron beams. It has contributed to the improvement of clinical electron dosimetry in radiotherapy centers.

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Detection and Absorbed-Dose Estimation of Irradiated Enzyme Powder Using ESR Spectroscopy (ESR Spectroscopy를 이용한 방사선 조사 효소분말의 검지와 흡수선량 예측)

  • Chung, Hyung-Wook;Jeong, Jae-Young;Kwon, Joong-Ho
    • Korean Journal of Food Science and Technology
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    • v.31 no.5
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    • pp.1159-1163
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    • 1999
  • Along with the increasing demands for food irradiation technology in the food industry, a proper detection means for controlling irradiated foods is required. Enzyme powder, which is permitted to be irradiated in Korea, was subjected to a detection trial by ESR spectroscopy. The high correlation coefficients were observed between the absorbed doses ranging from 2.5 to 15.0 kGy and the corresponding ESR signal intensity, such as $R^2$ = 0.9904 in gamma irradiation and $R^2$ = 0.9696 in electron beam. Pre-established threshold values for both non-irradiated control (1.19) and 2.5 kGy-irradiated samples (6.97 in gamma-ray; 7.36 in electron-beam) were successfully applicable to the detection of 30 coded unknown samples of enzyme powder. The calibration curves obtained from the samples irradiated at 2.5 to 15 kGy were expected to be potentially adopted to estimate absorbed doses ranging front 4 to 7 kGy with a quadratic equation.

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A Study on the Measurements of Sub-surface Residual Stress in the Field of Linear Stress Gradient (선형구배 응력장에서 표층의 잔류응력 측정에 관한 연구)

  • 최병길;전상윤;이택순
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.16 no.9
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    • pp.1632-1642
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    • 1992
  • When a blind hole of small diameter is drilled in the field of residual stress, strain relieved around the hole is function of magnitude of stress, patterns of stress distribution and hole geometry of diameter and depth. Relieved strain coefficients can be calculated from FEM analysis of relieved strain and actual stress. These relieved strain coefficients make it possible to measure residual stress which vary along the depth in the subsurface of stressed material. In this study, the calibration tests of residual stress measurement are carried out by drilling a hole incrementally on the cantilever or on the tensile test bar. Residual stresses can be determined from measured strains around a shallow hole by application of power series method. For the sake of reliable measurement of residual stress, much efforts should be done to measure relieved strains and hole depth more accurately comparing with conventional procedures of gage subject to the external load. Otherwise linear equations converting strains into stresses may yield erratic residual stresses because of ill-conditions of linear equations. With accurate measurements of relieved strains, residual stress even if varying along the depth can be measured. It is also possible to measure residual stress in the thin film of material by drilling a shallow hole.

Detection of Irradiation Treatment for Seasoned-Powdered Foods by Thermoluminescence Measurement (Thermoluminescence 측정에 의한 조미분말식품의 방사선 조사유무 확인)

  • Chung, Hyung-Wook;Kwon, Joong-Ho
    • Korean Journal of Food Science and Technology
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    • v.30 no.3
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    • pp.509-516
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    • 1998
  • Thermoluminescence measurements were applied to the detection of seasoned-powered foods such as shellfish extract powder, seasoned marine products, Ramen soup powder and sardine extract powder whether they are irradiated or not. Correlation coefficients $(R^2)$ between irradiation doses and corresponding TL responses were more than 0.5966 in all samples and 0.9500 in Ramen soup powder. TL threshold value was pre-established for the detection of unknown Ramen soup powders by verifying TL responses with a re-irradiation step. Threshold values were maximum 1.37 for the nonirradiated samples and minimum 6.06 for the 2.5 kGy-irradiated samples. The samples showing values between 1.37 and 6.06 were subjected to a re-irradiation step for their detection, which results were reconfirmed by enumerating the total bacterial load of the detected samples. Pre-established threshold values were successfully applicable to the detection of 167 coded unknown samples, both nonirradiated and irradiated with gamma or electron-beam energy. In the assessment of irradiated doses, three calibration curves were pre-established by plotting TL intensity versus applied doses, of which a quadratic equation was obtained for the potential estimation of irradiated doses with some variations from the real doses.

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Quality of Radiomics Research on Brain Metastasis: A Roadmap to Promote Clinical Translation

  • Chae Jung Park;Yae Won Park;Sung Soo Ahn;Dain Kim;Eui Hyun Kim;Seok-Gu Kang;Jong Hee Chang;Se Hoon Kim;Seung-Koo Lee
    • Korean Journal of Radiology
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    • v.23 no.1
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    • pp.77-88
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    • 2022
  • Objective: Our study aimed to evaluate the quality of radiomics studies on brain metastases based on the radiomics quality score (RQS), Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) checklist, and the Image Biomarker Standardization Initiative (IBSI) guidelines. Materials and Methods: PubMed MEDLINE, and EMBASE were searched for articles on radiomics for evaluating brain metastases, published until February 2021. Of the 572 articles, 29 relevant original research articles were included and evaluated according to the RQS, TRIPOD checklist, and IBSI guidelines. Results: External validation was performed in only three studies (10.3%). The median RQS was 3.0 (range, -6 to 12), with a low basic adherence rate of 50.0%. The adherence rate was low in comparison to the "gold standard" (10.3%), stating the potential clinical utility (10.3%), performing the cut-off analysis (3.4%), reporting calibration statistics (6.9%), and providing open science and data (3.4%). None of the studies involved test-retest or phantom studies, prospective studies, or cost-effectiveness analyses. The overall rate of adherence to the TRIPOD checklist was 60.3% and low for reporting title (3.4%), blind assessment of outcome (0%), description of the handling of missing data (0%), and presentation of the full prediction model (0%). The majority of studies lacked pre-processing steps, with bias-field correction, isovoxel resampling, skull stripping, and gray-level discretization performed in only six (20.7%), nine (31.0%), four (3.8%), and four (13.8%) studies, respectively. Conclusion: The overall scientific and reporting quality of radiomics studies on brain metastases published during the study period was insufficient. Radiomics studies should adhere to the RQS, TRIPOD, and IBSI guidelines to facilitate the translation of radiomics into the clinical field.