• 한국산학기술학회논문지
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• 제16권2호
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• pp.970-977
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• 2015

본 연구의 목적은 보아의 넘버원 댄스 핵심동작의 생체역학적 3차원분석이며 보아의 전문 안무가가 실험에 참가하였다. 핵심동작의 관절 동작범위는 견관절과 주관절의 전후회전, 분절 동작범위는 몸통과 골반의 좌우회전이 가장 크며 몸통이 골반보다 더 크다. 무게중심이동 속도는 상하방향이 가장 빠르고 좌우, 전후방향 순이다. 최대각속도는 상지관절의 견관절과 주관절 및 하지관절의 고관절과 슬관절의 전후회전에서 가장 크게 나타났으나 족관절의 동작범위와 각속도는 거의 생성되지 않았다. 그리고 최대 회전파워는 상지 견관절과 하지 슬관절을 중심으로 원위분절로 갈수록 작게 나타나고 회전력은 고관절 외전모멘트가 가장 크고 슬관절은 신전모멘트가 크게 나타났다.

• 한국산업보건학회지
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• 제19권2호
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• pp.88-95
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• 2009

There are many assessment techniques used for occupational risk factors of MSDs in the workplaces. However, because all ergonomic assesment techniques or tools are based on theoretical background derived from workphysiology, biomechanics, psychophysics, industrial hygiene, work system, and etc, it is impossible to compare the assessment techniques. This study was conducted to compare the excess rates of risk factors among ergonomic assessment techniques and to make alternative methods. Site-visits to 6 automobile products and parts company provided data for process repeated work where the produced data was examined for evaluating the relationship between workplace lay-out and work posture by using ergonomic assessment techniques. We evaluated 157 jobs for simple repeated work and 37 jobs for manual materials handling (MMH). In simple repeated work, the exceeded rates of AC were 36.3% in OWAS method and 93.0% in RULA method. The exceeded rate for RULA method was significantly higher than those for OWAS method (p<0.05). In MMH, the exceeded rates of AC were 80.0% in NLE method and 76.5% in WAC method. Statistically significant differences were not identified in the exceeded rates for NLE and MAC methods (p<0.05). The analyzed results among ergonomic assessment techniques (OWAS, RULA, NLE/WAC) were applied to the same work places performing simple repeated work and manual materials handling simultaneously. The applied results showed statistically significant differences (p<0.05) among ergonomic assessment techniques (OWAS, RULA, NLE/WAC). Exceeded rates of four ergonomic assessment techniques in decreasing order was "RULA>NLE>WAC>OWAS". The RULA method was the strongest assessment technique for automobile products and parts company. We discovered that the results could easily be overestimated or underestimated when the ergonomic assessment techniques were not applied correctly during the evaluation process. Therefore, we recommend using at least 2 methods when evaluating and analysing the results.

• Journal of Korean Neurosurgical Society
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• 제53권6호
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• pp.331-336
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• 2013

Objective : The offset connector can allow medial and lateral variability and facilitate intralaminar screw incorporation into the construct. The aim of this study was to compare the biomechanical characteristics of C7 intralaminar screw constructs with and without offset connector using a three dimensional finite element model of a C6-7 cervical spine segment. Methods : Finite element models representing C7 intralaminar screw constructs with and without the offset connector were developed. Range of motion (ROM) and maximum von Mises stresses in the vertebra for the two techniques were compared under pure moments in flexion, extension, lateral bending and axial rotation. Results : ROM for intralaminar screw construct with offset connector was less than the construct without the offset connector in the three principal directions. The maximum von Misses stress was observed in the C7 vertebra around the pedicle in both constructs. Maximum von Mises stress in the construct without offset connector was found to be 12-30% higher than the corresponding stresses in the construct with offset connector in the three principal directions. Conclusion : This study demonstrated that the intralaminar screw fixation with offset connector is better than the construct without offset connector in terms of biomechanical stability. Construct with the offset connector reduces the ROM of C6-7 segment more significantly compared to the construct without the offset connector and causes lower stresses around the C7 pedicle-vertebral body complex.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권3호
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• pp.127-141
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• 2015

Silver-based systems activated by low intensity direct current continue to be investigated as an alternative antimicrobial for infection prophylaxis and treatment. However there has been limited research on the quantitative characterization of the antimicrobial efficacy of such systems. The objective of this study was to develop a semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model providing the quantitative relationship between the critical system parameters and the degree of antimicrobial efficacy. First, time-kill curves were experimentally established for a strain of Staphylococcus aureus in a nutrientrich fluid environment over 48 hours. Based on these curves, a modified PK/PD model was developed with two components: a growing silver-susceptible bacterial population and a depreciating bactericidal process. The test of goodness-of-fit showed that the model was robust and had good predictability ($R^2>0.7$). The model demonstrated that the current intensity was positively correlated to the initial killing rate and the bactericidal fatigue rate of the system while the anode surface area was negatively correlated to the fatigue rate. The model also allowed the determination of the effective range of these two parameters within which the system has significant antimicrobial efficacy. In conclusion, the modified PK/PD model successfully described bacterial growth and killing kinetics when the bacteria were exposed to the electrically activated silver-titanium implant system. This modeling approach as well as the model itself can also potentially contribute to the development of optimal design strategies for other similar antimicrobial systems.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권2호
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• pp.97-109
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• 2015

A series of amphiphilic graft copolymers were synthesized by varying the number of graft chains and graft chain lengths. The polarity of the hydrophobic graft chain on the copolymers was varied their solution properties. The glass transition temperature of the copolymers was in the low-temperature region, because of the amorphous nature of poly (trimethylene carbonate) (PTMC). The surface morphology of the lyophilized colloid gel had a bundle structure, which was derived from the combination of poly(N-hydroxyethylacrylamide)( poly(HEAA)) and PTMC. The solution properties were evaluated using dynamic light scattering and fluorescence measurements. The particle size of the graft copolymers was about 30-300 nm. The graft copolymers with a higher number of repeating units attributed to the TMC (trimethylene carbonate) component and with a lower macromonomer ratio showed high thermal stability. The critical association concentration was estimated to be between $2.2{\times}10^{-3}$ and $8.9{\times}10^{-2}mg/mL$, using the pyrene-based fluorescence probe technique. These results showed that the hydrophobic chain of the graft copolymer having a long PTMC segment had a low polarity, dependent on the number of repeating units of TMC and the macromonomer composition ratio. These results demonstrated that a higher number of repeating units of TMC, with a lower macromonomer composition, was preferable for molecular encapsulation.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권2호
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• pp.111-125
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• 2015

For engineers, generating a mesh in porous media (PMs) sometimes represents a smaller computational load than generating realistic stent geometries with computer fluid dynamics (CFD). For this reason, PMs have recently become attractive to mimic flow-diverter stents (FDs), which are used to treat intracranial aneurysms. PMs function by introducing a hydraulic resistance using Darcy's law; therefore, the pressure drop may be computed by test sections parallel and perpendicular to the main flow direction. However, in previous studies, the pressure drop parallel to the flow may have depended on the width of the gap between the stent and the wall of the test section. Furthermore, the influence of parameters such as the test section geometry and the distance over which the pressure drops was not clear. Given these problems, computing the pressure drop parallel to the flow becomes extremely difficult. The aim of the present study is to resolve this lack of information for stent modeling using PM and to compute the pressure drop using several methods to estimate the influence of the relevant parameters. To determine the pressure drop as a function of distance, an FD was placed parallel and perpendicular to the flow in test sections with rectangular geometries. The inclined angle method was employed to extrapolate the flow patterns in the parallel direction. A similar approach was applied with a cylindrical geometry to estimate loss due to pipe friction. Additionally, the pressure drops were computed by using CFD. To determine if the balance of pressure drops (parallel vs perpendicular) affects flow patterns, we calculated the flow patterns for an ideal aneurysm using PMs with various ratios of parallel pressure drop to perpendicular pressure drop. The results show that pressure drop in the parallel direction depends on test section. The PM thickness and the ratio of parallel permeability to perpendicular permeability affect the flow pattern in an ideal aneurysm. Based on the permeability ratio and the flow patterns, the pressure drop in the parallel direction can be determined.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권3호
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• pp.159-172
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• 2015

Treatment of polymicrobial infected musculoskeletal defects continues to be a challenge in orthopaedics. This research investigated single and dual-delivery of two antibiotics, vancomycin and amikacin, targeting different classes of microorganism from a biodegradable calcium sulfate-chitosan-nHA microsphere composite scaffold. The addition of chitosan-nHA was included to provide additional structure for cellular attachment and as a secondary drug-loading device. All scaffolds exhibited an initial burst of antibiotics, but groups containing chitosan reduced the burst for amikacin at 1hr by 50%, and vancomycin by 14-25% over the first 2 days. Extended elution was present in groups containing chitosan; amikacin was above MIC ($2-4{\mu}g/mL$, Pseudomonas aeruginosa) for 7-42 days and vancomycin was above MIC ($0.5-1{\mu}g/mL$ Staphylococcus aureus) for 42 days. The antibiotic activity of the eluates was tested against S. aureus and P. aeruginosa. The elution from the dual-loaded scaffold was most effective against S. aureus (bacteriostatic 34 days and bactericidal 27 days), compared to vancomycin-loaded scaffolds (bacteriostatic and bactericidal 14 days). The dual- and amikacin-loaded scaffolds were effective against P. aeruginosa, but eluates exhibited very short antibacterial properties; only 24 hours bacteriostatic and 1-5 hours bactericidal activity. For all groups, vancomycin recovery was near 100% whereas the amikacin recovery was 41%. In conclusion, in the presence of chitosan-nHA microspheres, the dual-antibiotic loaded scaffold was able to sustain an extended vancomycin elution longer than individually loaded scaffolds. The composite scaffold shows promise as a dual-drug delivery system for infected orthopaedic wounds and overcomes some deficits of other dual-delivery systems by extending the antibiotic release.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권3호
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• pp.143-157
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• 2015

Successful integration of cementless femoral stems using porous surfaces relies on effective periimplant bone healing to secure the bone-implant interface. The initial stages of the healing process involve protein adsorption, fibrin clot formation and cell osteoconduction onto the implant surface. Modelling this process in vitro, the current work considered the effect of fibrin deposition on the responses of human mesenchymal stromal cells cultured on ferritic fibre networks intended for magneto-mechanical actuation of in-growing bone tissue. The underlying hypothesis for the study was that fibrin deposition would support early stromal cell attachment and physiological functions within the optimal regions for strain transmission to the cells in the fibre networks. Highly porous fibre networks composed of 444 ferritic stainless steel were selected due to their ability to support human osteoblasts and mesenchymal stromal cells without inducing untoward inflammatory responses in vitro. Cell attachment, proliferation, metabolic activity, differentiation and penetration into the ferritic fibre networks were examined for one week. For all fibrin-containing samples, cells were observed on and between the metal fibres, supported by the deposited fibrin, while cells on fibrin-free fibre networks (control surface) attached only onto fibre surfaces and junctions. Initial cell attachment, measured by analysis of deoxyribonucleic acid, increased significantly with increasing fibrinogen concentration within the physiological range. Despite higher cell numbers on fibrin-containing samples, similar metabolic activities to control surfaces were observed, which significantly increased for all samples over the duration of the study. It is concluded that fibrin deposition can support the early attachment of viable mesenchymal stromal cells within the inter-fibre spaces of fibre networks intended for magneto-mechanical strain transduction to in-growing cells.

• Advances in biomechanics and applications
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• 제1권1호
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• pp.41-55
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• 2014

Acellular intra-myocardial biomaterial injections have been shown to be therapeutically beneficial in inhibiting ventricular remodelling of myocardial infarction (MI). Based on a biventricular canine cardiac geometry, various finite element models were developed that comprised an ischemic (II) or scarred infarct (SDI) in left ventricular (LV) antero-apical region, without and with intra-myocardial biomaterial injectate in layered (L) and bulk (B) distribution. Changes in myocardial properties and LV geometry were implemented corresponding to infarct stage (tissue softening vs. stiffening, infarct thinning, and cavity dilation) and injectate (infarct thickening). The layered and bulk injectate increased ejection fraction of the infarcted LV by 77% (II+L) and 25% (II+B) at the ischemic stage and by 61% (SDI+L) and 63% (SDI+B) at the remodelling stage. The injectates decreased the mean end-systolic myofibre stress in the infarct by 99% (II+L), 97% (II+B), 70% (SDI+L) and 36% (SDI+B). The bulk injectate was slightly more effective in improving LV function at the remodelling stage whereas the layered injectate was superior in functional improvement at ischemic stage and in reduction of wall stress at ischemic and remodelling stage. These findings may stimulate and guide further research towards tailoring acellular biomaterial injectate therapies for MI.

• PNF and Movement
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• 제19권3호
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• pp.391-399
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• 2021

Purpose: As laptop use increases throughout the COVID-19 pandemic and its use outside of traditional workstations proliferates, it is imperative to expand the limited research available regarding ergonomic exposure. This study aimed to identify the effects of a laptop supporter on biomechanical characteristics in the wrist joint muscles of healthy young adults. Methods: This was a cross-sectional observational study design with thirty-four healthy young adults as participants. They conducted a typing exercise performed under two different conditions, which were with and without a notebook computer supporter. This study measured the biomechanical characteristics of the muscles of the wrist joints including the flexor carpi ulnaris (FCU), the flexor carpi radialis (FCR), the extensor carpi radialis longus (ECRL), and the extensor carpi ulnaris (ECU). Measurements were taken three times: before typing, immediately after typing for 30 minutes with a supporter, and immediately after typing for 30 minutes without a supporter. The statistical method to compare the three different measurement conditions was the repeated measures ANOVA. Results: The participants showed significantly different levels of dynamic stiffness in both the FCU before typing and immediately after 30 minutes of typing with a supporter, and showed significantly different levels of dynamic stiffness in the FCR before typing and immediately after 30 minutes of typing with a supporter. The dynamic stiffness level immediately after 30 minutes of typing without a supporter was significantly different than that immediately after 30 minutes of typing with a supporter. However, the muscle tone was not significantly different among the three different conditions. Conclusion: The results of this study revealed that a laptop supporter used to correct the eye level of the electronic screen increases the dynamic stiffness of the wrist joint flexors, so it is necessary to consider the neutral position of the wrist joint during typing.