• 제목/요약/키워드: biomaterials

검색결과 1,975건 처리시간 0.331초

유산균 발효시 초고압 공정을 통한 산삼배양근으로부터 진세노사이드 Rg3 및 Rh2의 선택적인 함량 증진 (Selective Enhancement of Rg3 and Rh2 Contents from Wild Ginseng Cultured Roots by Lactic Acid Fermentation Associated with Ultra High Pressure Process)

  • 최운용;이춘근;서용창;김지선;송치호;이현용;윤창순;임혜원
    • 한국약용작물학회:학술대회논문집
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    • 한국약용작물학회 2012년도 심포지엄 및 춘계학술발표회
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    • pp.271-272
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    • 2012
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Overexpression of Arabidopsis Homogentisate Phytyltransferase or Tocopherol Cyclase Elevates Vitamin E Content by Increasing γ-tocopherol Level in Lettuce (Lactuca sativa L.)

  • Lee, Koeun;Lee, Sa Mi;Park, Sang-Ryoung;Jung, Jinwook;Moon, Joon-Kwan;Cheong, Jong-Joo;Kim, Minkyun
    • Molecules and Cells
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    • 제24권2호
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    • pp.301-306
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    • 2007
  • Tocopherols, essential components of the human diet, are synthesized exclusively by photosynthetic organisms. To increase tocopherol content by increasing total flux to the tocopherol biosynthetic pathway, genes encoding Arabidopsis homogentisate phytyltransferase (HPT/V-TE2) and tocopherol cyclase (TC/VTE1) were constitutively overexpressed in lettuce (Lactuca sativa L.). Total tocopherol content of the transgenic plants overexpressing either of the genes was increased by more than 2-fold mainly due to an increase in ${\gamma}$-tocopherol. However, chlorophyll content in the HPT/VTE2 and TC/VTE1 transgenic lines decreased by up to 20% and increased by up to 35%, respectively (P < 0.01). These results demonstrate that manipulation of the tocopherol biosynthetic pathway can increase or decrease chlorophyll content depending on the gene introduced.

Construction of Novel Bifunctional Chimeric Proteins Possessing Antitumor and Thrombolytic Activities

  • Hui, Jing;Dai, Youjin;Bian, Yuanyuan;Li, Hui;Cui, Xiaojin;Yu, Xiaojie;You, Song;Hu, Fengqing
    • Journal of Microbiology and Biotechnology
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    • 제22권7호
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    • pp.894-901
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    • 2012
  • Based on their respective antitumor and thrombolytic activities, the superantigen staphylococcal enterotoxin C2 (SEC2) and staphylokinase (Sak) were chosen for the construction of the novel chimeric proteins Sak-linker-SEC2 and SEC2-linker-Sak using a linker composed of nine Ala residues. Both chimeric proteins possessed nearly the same PBMC proliferation stimulating activity and antitumor activity as SEC2 and thrombolytic activity as Sak. Neither the SEC2 or Sak component of each chimeric protein affected the activity of the other component. The results presented in this study provide a possible strategy to prevent and cure tumor thrombus.

엉겅퀴 뿌리 및 꽃 추출물의 간 성상세포 활성 억제 효과 (Inhibitory Effect of Cirsium japonicum Root or Flower Extract on Hepatic Stellate Cells Activation)

  • 김상준;김선영;김지애;박인선;유강열;정창호;심재석;장선일;정승일
    • 생약학회지
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    • 제43권1호
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    • pp.27-31
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    • 2012
  • This study was designed to elucidate the effects of Cirsium japonicum (CJ) extracts on hepatic stellate cells (HSCs, LX-2 cells) proliferation, which is induced by platelet-derived growth factor (PDGF) or transforming growth factor-${\beta}$ (TGF-${\beta}$). The content of total phenol, flavonoid, and silymarin derivatives was more higher in CJ-flower than in CJ-root. Consistent with these results, the LX-2 cells growth inhibition was more effective in CJ-flower extract than in CJ-root extract, the complete growth inhibition concentration was $1{\mu}g/mL$ and $50{\mu}g/mL$, respectively. These results suggest that extracts from CJ-flower can be potentially used as therapeutic substances for the regulatioin of HSCs activation.

Chromium(VI) Adsorption Behavior of Silk Sericin Beads

  • Kwak, Hyo Won;Yang, Ye Sol;Kim, Moo Kon;Lee, Jeong Yun;Yun, Haesung;Kim, Min Hwa;Lee, Ki Hoon
    • International Journal of Industrial Entomology
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    • 제26권1호
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    • pp.47-53
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    • 2013
  • Silk sericin (SS) has been fabricated into beads using a 1 M LiCl/DMSO solvent and utilized as a heavy metal adsorbent. Among the various heavy metals, we targeted Cr(VI) for adsorption using SS beads and found that its adsorption depended on the coagulant used for the fabrication of the SS beads. When methanol was used as a coagulant, the beads had a better adsorption capacity than when ethanol was used except at pH 1. The adsorption behavior of Cr(VI) on the SS beads followed the BET isotherm. The maximum adsorption capacity was 33.76 mg/g at pH 2. The adsorption of Cr(VI) was confirmed by FT-IR and EDS analyses. Finally, the desorption was carried out using NaOH solution, and it was found that 73.19% of the adsorbed Cr(VI) could be detached.

Recent updates for biomaterials used in total hip arthroplasty

  • Hu, Chang Yong;Yoon, Taek-Rim
    • 생체재료학회지
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    • 제22권4호
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    • pp.259-270
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    • 2018
  • Background: Total hip arthroplasty (THA) is probably one of the most successful surgical interventions performed in medicine. Through the revolution of hip arthroplasty by principles of low friction arthroplasty was introduced by Sir John Charnley in 1960s. Thereafter, new bearing materials, fixation methods, and new designs has been improved. The main concern regarding failure of THA has been the biological response to particulate polyethylene debris generated by conventional metal on polyethylene bearing surfaces leading to osteolysis and aseptic loosening of the prosthesis. To resolve these problems, the materials of the modern THA were developed since then. Methods: A literature search strategy was conducted using various search terms in PUBMED. The highest quality articles that met the inclusion criteria and best answered the topics of focus of this review were selected. Key search terms included 'total hip arthroplasty', 'biomaterials', 'stainless steel', 'cobalt-chromium', 'titanium', 'polyethylene', and 'ceramic'. Results: The initial search retrieved 6921 articles. Thirty-two articles were selected and used in the review. Conclusion: This article introduces biomaterials used in THA and discusses various bearing materials in currentclinical use in THA as well as the newer biomaterials which may even further decrease wear and improve THA survivorship.

생체내 미소의료기기에 대한 Biotribology 기초연구 (Fundamental Biotribological Characteristics between Biomaterials and Small Intestine)

  • 김영태;권은영;정효일;김대은
    • 한국정밀공학회:학술대회논문집
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    • 한국정밀공학회 2004년도 추계학술대회 논문집
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    • pp.1361-1364
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    • 2004
  • There is a need for fundamental understanding of biotribological characteristics of various biomaterials sliding against biological materials in order to develop a moving mechanism of medical microsystems having high energy efficiency. A special experimental equipment was designed and built to study the frictional behavior of various biomaterials sliding against a small intestine specimen of a pig. Friction experiments for six biomaterials were performed. Particularly, the effects of load and speed on frictional behavior were investigated. The results of this work will aid in the development of the actuator for a self-propelling micro-endoscope.

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