• Title/Summary/Keyword: biomaterials

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Chemotaxonomic Significance of Taxifolin-3-O-Arabinopyranoside in Rhododendron Species Native to Korea

  • Kim, TaeHee;Kwon, Ye Eun;Park, Sun Min;Kim, Min Seok;Jeong, Young Hwan;Park, Se Yeong;Bae, Young-Soo;Cheong, Eun Ju;He, Yi-Chang;Gong, Chun;Gao, Wei;Kim, Hee Kyu;Ham, Yeon Ho;Kim, Jin-Kyu;Choi, Sun Eun
    • Journal of Forest and Environmental Science
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    • v.38 no.3
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    • pp.159-173
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    • 2022
  • Genus of Rhododendron has been used in traditional medicine since ancient times and is known to be effective in immune function, inflammation, and cold symptoms. And the reason for this activity is the flavanonol type among flavonoids in the genus of Rhododendron. Among the flavanonol types, Taxifolin-3-O-arabinopyranoside was isolated from the root of native R. mucronulatum in Korea, and the structure was finally identified through HPLC, LC-MS/MS, 1H-NMR, and 13C-NMR. Taxifolin-3-O-arabinopyranoside is a compound mainly found in R. mucronulatum, a representative species of the genus of Rhododendron, and exhibits antioxidant, anti-inflammatory, and anti-atopic activities. In this study, Taxifolin-3-O-arabinopyranoside was chemotaxonomic significant in 5 species of the genus Rhododendron native to Korea (R. mucronulatum, R. mucronulatum var. ciliatum, R. schlippenbachii, R. yedoense var. Poukhanense, R. japonicum for. Flavum). Compared with the existing literature, Taxifolin-3-O-arabinopyranoside was identified for the first time in 4 species of Rhododendron except for the R. mucronulatum.

Identification and Characterization of the Vibrio vulnificus rtxA Essential for Cytotoxicity in vitro and Virulence in Mice

  • Lee, Jeong-Hyun;Kim, Myung-Won;Kim, Byoung-Sik;Kim, Seung-Min;Lee, Byung-Cheol;Kim, Tae-Sung;Choi, Sang-Ho
    • Journal of Microbiology
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    • v.45 no.2
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    • pp.146-152
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    • 2007
  • A mutant exhibiting decreased cytotoxic activity toward INT-407 intestinal epithelial cells and carrying a mutation in the rtx gene cluster that consists of rtxCA and rtxBDE operons was screened from a library of V. vulnificus mutants. The functions of the rtxA gene, assessed by constructing an isogenic mutant and evaluating its phenotypic changes, demonstrated that RtxA is essential for the virulence of V. vulnificus in mice as well as in tissue cultures.