• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2004년도 춘계학술발표회
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• pp.380-387
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• 2004

Recently the geosynthetics reinforced retaining wall has been widely used instead of the steel reinforced retaining wall. The geosynthetics reinforced retaining wall is a very dangerous structure if the geosynthetics lose their strength about tension or if it lose their pullout resistence, but it was known that the geosynthetics reinforced wall had a great resistence and was a very safe structure against a earthquake or a dynamic load. It can be said that most important factors in the stability of the geosynthetics reinforced wall are the horizontal length of reinforcement and the vertical distance between two reinforcements. That is to say, as the length of reinforcement is longer, the structure is more stable and as the vertical distance between two reinforcements is shorter, it is more stable. In this study, in order to get the critical condition with a safety rate of 1, various kinds of model tests about geosynthetics reinforced wall has been performed. Photos by B-shutter method has been taken during tests and from photos, which show us the failure state, the critical condition about failure has been conformed. Accordingly the equation, which says the limit of stability in geosynthetics reinforced wall., has been proposed.

• Archives of Pharmacal Research
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• 제29권12호
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• pp.1164-1170
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• 2006

A triptolide-lysozyme (TP-LZM) conjugate was synthesized to achieve renal specific delivery and to reduce the side effects of triptolide. Triptolide was coupled to lysozyme through succinic via an ester bond with an average coupling degree of 1 mol triptolide per 1 mol lysozyme. The lysozyme can specifically accumulate in the proximal tubular cells of the kidney, making it a potential carrier for targeting drugs to the kidney. The structure of triptolide succinate (TPS) was confirmed by IR, $^{1}H-NMR$, MS and UV. The concentrations of triptolide in various samples were determined by reversed-phase high-performance liquid chromatography (HPLC). In this study, the physicochemical and stability profiles of TP-LZM under various conditions were investgated the stability and releasing profiles of triptolide-lysozyme (TP-LZM) under various conditions. In vitro release trails showed triptolide-lysozyme was relatively stable in plasma (less than 30% of free triptolide released) and could release triptolide quickly in lysosome (more than 80% of free triptolide released) at $37^{\circ}C$ for 24 h. In addition, the biological activities of the conjugate on normal rat kidney proximal tubular cells (NRK52E) were also tested. The conjugate can effectively reduce NO production in the medium of NRK52E induced by lipopolysaccharide (LPS) but with much lower toxicity. These studies suggest the possibility to promote curative effect and reduce its extra-renal toxicity of triptolide by TP-LZM conjugate.

• 한국도로학회논문집
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• 제6권3호
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• pp.47-54
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• 2004

도로-포장시스템의 성능은 구성재료 및 기계적 물리화학적 하중에 대한 재료의 민감도에 매우 관련이 깊다 그러나 지금까지 오염원 침투에 따른 도로-포장시스템의 물리적 화학적인 영향에 대한 연구가 깊이 있게 다루어지지 않았다. 이에 대한 연구를 위해 본 논문에서는 도로-포장시스템과 오염원 및 주변환경적 요인과의 상호작용에 대한 고찰이 선행적으로 다루어졌다 도로-포장시스템으로 오염원은 1) 포장표면으로 직접 침투하거나, 2) 도로 경계 면으로 침투하거나 3) 물리적-화학적-생물학적 변화에 의한 흙 사이로의 간접 침투로 이루어진다. 오염원침투가능성은 재료종류. 입자크기. 기후 및 지질학적 특성에 관련이 깊다 도로-포장시스템의 안정성 및 성능 또한 오염원 침투에 의해 영향을 받는다 이와 같은 특성들을 고려 할 때 도로 설계 시공 및 유지보수와 관련된 일을 하는 공학자들은 이 문제를 심각하게 고려하여야 할 것이다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.484-488
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• 1997

Three-dimensional finite element analyses were used to compare the stress distribution and the stability of the fixation among seven different tibial components and to investigate the effect due to implant materials in total knee arthroplasty. The components included an intact tibia(Type I), Cemented Cobalt-Chromium tibial tray implanted with a PMMA cemented Co-Cr stem(Type II), Cemented Co-Cr tibial tray with a uncemented Co-Cr stem(Type III), Cemented Ultra High Molecular Weight Polyethylene (UHMWPE) tibial tray with a cemented UHMWPE stem (Type IV), Cemented UHMWPE tray with a uncemented UHMWPE stem(Type V), Cemented Co-Cr tray without a stem(Type VI), and Cemented UHMWPE tray without a stem(Type VII). Uncemented components were assumed to have complete bony in growth and a rigid state of fixation between component and bone. The interface between bone/cement/component of cemented components was also assumed to be fully bonded. Bi-condylar forces were applied. The results indicated that Uncemented stem components provided lower bone stress shielding and stress concentration. The UHMWPE tray and stem component showed better agreement with the intact tibia than the Co-Cr Alloy tray and stem components. If the implant tray can be fixed firmed without a stem, Cemented PE tray without a stem(Type VII) may be recommended to give the best characteristics in the sense of stress distribution and stability.

• 생약학회지
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• 제49권2호
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• pp.172-181
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• 2018

This study was designed to investigate the stability for chemical contents and biological activities of Mahwang-tang (MT) depending on the preservation temperature and periods. MT decoction pouches were preserved for 3 months at room temperature (RT, $23{\pm}1^{\circ}C$) and refrigeration ($4^{\circ}C$). To evaluate the stability of MT decoction, pH and sugar content were estimated. High-performance liquid chromatography analysis were performed to quantify the contents of marker compounds in MT. Anti-inflammatory effects of MT were evaluated to suppress the generation of nitric oxide, prostaglandin $E_2$ and cytokines (tumor necrosis $factor-{\alpha}$ and interleukin-6) in the RAW 264.7 cells stimulated with lipopolysaccharide. Total antioxidant capacity of MT was determined by ABTS radical scavenging activity. The pH of storage method and period showed a tendency to decrease gradually with time. There were no changes in sugar content depending on the preservation temperature and periods of MT decoction. Among the major components of MT, cinnamaldehyde was reduced time-dependently for 3 months of storage at RT. The inflammatory effect and antioxidant capacity of MT were reduced time-dependently at both RT and $4^{\circ}C$. Our results suggest that the preservation period of MT decoction is recommended in refrigeration within 3 months or less rather than at RT.

• 자원환경지질
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• 제37권2호
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• pp.225-234
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• 2004

춘궁동 오층석탑(보물 제12호)의 암석학적 풍화와 훼손도를 진단하였다. 이 석탑의 정면은 N30$^{\circ}$W를 향하고 있으며, 구성암석은 안구상 편마암과 흑운모 화강암이다. 석탑을 이루는 암석은 박리와 변색이 심하고, 조암광물은 화학적 및 광물학적 풍화에 의하여 점토광물로 변질되어 있다. 석탑의 표면과 부재사이에는 지의류와 이끼류의 모근 및 포자류가 기생하고 있으며, 하단부는 이미 고등식물이 천이하고 있다. 따라서 석탑의 표면에 피복된 지의류와 불연속면에 서식하고 있는 잡초를 제거하기 위한 생화학적 처리가 요구된다. 이 석탑의 구조적 안정을 위해서는 부재사이에 틈이 없도록 재조립을 해야 하며, 삽입한 철편도 제거한 후에 석조문화재 보강용 충전제를 이용한 보존처리가 필요하다. 또한 석탑에 미치는 지면의 습도를 저감하기 위한 차수층의 설치도 고려되어야 할 것이다.

• Macromolecular Research
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• 제17권2호
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• pp.128-132
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• 2009

Fucoidan, a sulfated polysaccharide derived from brown seaweed, is an important material valued for its various biological functions, including anti-coagulation, anti-aging, and immune system support. In this study, we examined the potential of fucoidan as a novel emulsifying agent in BSA (bovine serum albumin)-stabilized emulsion at a neutral pH. We measured the dispersed oil-droplet size, surface zeta-potential and creaming formation of 0.5 wt% BSA emulsion (20 wt% oil traction) in the absence and presence of fucoidan. The average particle size and zeta-potential value were 625.4 nm and -30.91 mV in only BSA-stabilized emulsion and 745.2 nm and -44.2 mV in 1.0 wt% fucoidan-added BSA emulsion, respectively. This result suggested that some positive charges of the BSA molecules interacted with the negative charges of fucoidan to inhibit the flocculation among the oil droplets. The creaming rate calculated from the backscattering data measured by Turbiscan dramatically decreased in 1.0 wt% fucoidan-added BSA emulsion during storage. Accordingly, the repulsion forces induced among the oil particles coated with 1.0 wt% fucoidan in emulsion solution resulted in significantly increased emulsion stability. The turbidity of the BSA-stabilized emulsion at 500 nm decreased during five days of storage. However, the fucoidan-added BSA emulsion exhibited a higher value of turbidity than the BSA-stabilized emulsion did. In conclusion, an anionic sulfated fucoidan lowered the surface zeta-potential of BSA-coated oil droplets via the electrostatic interaction, and subsequently inhibited the flocculation among the oil droplets, thereby clearly minimizing the creaming and phase separation of the emulsion.

• Molecules and Cells
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• 제43권8호
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• pp.739-748
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• 2020

Stringent regulation of the chondrocyte cell cycle is required for endochondral bone formation. During the longitudinal growth of long bones, mesenchymal stem cells condense and differentiate into chondrocytes. Epiphyseal chondrocytes sequentially differentiate to form growth-plate cartilage, which is subsequently replaced with bone. Although the importance of nuclear factor 1C (Nfic) in hard tissue formation has been extensively studied, knowledge regarding its biological roles and molecular mechanisms in this process remains insufficient. Herein, we demonstrated that Nfic deficiency affects femoral growth-plate formation. Chondrocyte proliferation was downregulated and the number of apoptotic cell was increased in the growth plates of Nfic^-/- mice. Further, the expression of the cell cycle inhibitor p21 was upregulated in the primary chondrocytes of Nfic^-/- mice, whereas that of cyclin D1 was downregulated. Our findings suggest that Nfic may contribute to postnatal chondrocyte proliferation by inhibiting p21 expression and by increasing the stability of cyclin D1 protein.

• 한국축산식품학회지
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• 제32권2호
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• pp.174-183
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• 2012

The effects of dietary fiber extracted from pumpkin (pumpkin fiber) on physicochemical properties, textural properties, and sensory characteristics of chicken frankfurters were investigated. Chicken frankfurter was supplemented with pumpkin fiber at levels of 0, 1, 2, 3, and 4%. Adding different levels of pumpkin fiber affected the proximate composition of the chicken frankfurters (p<0.05), except for protein content. In addition of different levels of pumpkin fiber influenced the physicochemical and textural properties of the chicken frankfurters (p<0.05). The yellowness, viscosity, and hardness were higher in chicken frankfurters samples containing pumpkin fiber than those in the control (p<0.05). The results showed that chicken frankfurter samples with higher pumpkin fiber levels had lower lightness values (p<0.05), as well as less cooking loss, emulsion stability, and lower color scores (p<0.05) compared to those control without pumpkin fiber treatment. The chicken frankfurters with 2% and 3% pumpkin fiber had higher overall acceptability than that of the control (p<0.05). The results show that adding pumpkin fiber produced acceptable chicken frankfurters and improved their quality characteristics.

• 대한의용생체공학회:의공학회지
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• 제17권1호
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• pp.61-70
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• 1996

In cementless total hip arthroplasty(THA), an initial stability of the femoral component is mandatory to achieve bony inyowth and secondary long term fixation. Primary stability of the femoral component can be obtained by minimizing the magnitude of relative micromotions at bone stem interface. An accurate evaluation of interf'ace micromotion and stress/strain fields in the bone-implant system may be relevant for better understanding of clinical situations and improving THA design. Recently finite element method(FEM) was introduced in'orthopaedic research field due to its unique capacity to evaluate stress in structure of complex shape, loading and material behavior. The authors developed the 3-dimensional finite element model of proximal femur with $Multilock^{TM}$ stem of 1179 blick elements to analyse the micromotions and mechanical behaviors at the bone-stem inteface in early post-operative period for the load simulating single leg stance. The results indicates that the values of relative motion for this well fit stem were $150{\mu}m$ in maximum $82{\mu}m$ in minimum and the largest relative motion was developed in medial region of Proximal femur and in anterior-posterior direction. The motion in the proximal bone was much greater than in the distal bone and the stress pattern showed high stress concentration on the cortex near the tip of the stem. These findings indicate that the loading on the hip joint in the early postoperative situation before achieving bony ingrowth could produce large micromotion of $150{\mu}m$ and clinicaly non-cemented THA patient should not be allowed weight bearing strictly early in the postoperative period.