• Journal of Veterinary Science
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• 제24권3호
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• pp.44.1-44.17
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• 2023

Background: Antibiotic resistance is a significant public health concern around the globe. Antimicrobial peptides exhibit broad-spectrum and efficient antibacterial activity with an added advantage of low drug resistance. The higher water content and 3D network structure of the hydrogels are beneficial for maintaining antimicrobial peptide activity and help to prevent degradation. The antimicrobial peptide released from hydrogels also hasten the local wound healing by promoting epithelial tissue regeneration and granulation tissue formation. Objective: This study aimed at developing sodium alginate based hydrogel loaded with a novel antimicrobial peptide Chol-37(F34-R) and to investigate the characteristics in vitro and in vivo as an alternative antibacterial wound dressing to treat infectious wounds. Methods: Hydrogels were developed and optimized by varying the concentrations of crosslinkers and subjected to various characterization tests like cross-sectional morphology, swelling index, percent water contents, water retention ratio, drug release and antibacterial activity in vitro, and Pseudomonas aeruginosa infected wound mice model in vivo. Results: The results indicated that the hydrogel C proved superior in terms of cross-sectional morphology having uniformly sized interconnected pores, a good swelling index, with the capacity to retain a higher quantity of water. Furthermore, the optimized hydrogel has been found to exert a significant antimicrobial activity against bacteria and was also found to prevent bacterial infiltration into the wound site due to forming an impermeable barrier between the wound bed and external environment. The optimized hydrogel was found to significantly hasten skin regeneration in animal models when compared to other treatments in addition to strong inhibitory effect on the release of pro-inflammatory cytokines (interleukin-1β and tumor necrosis factor-α). Conclusions: Our results suggest that sodium alginate -based hydrogels loaded with Chol-37(F34-R) hold the potential to be used as an alternative to conventional antibiotics in treating infectious skin wounds.

• 대한화상학회지
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• 제16권2호
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• pp.99-103
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• 2013

Purpose: The biggest problem of wound healing is a possible occurrence of lesion. Especially, in the case of patients who have a skin injury around exposed body parts, if their treatment period drag on for long time, they can suffer from aftereffects and the costs can be passed on to a society. Therefore, in this research, we investigated the need to develop the effective medicine and appliances for the patients by examining which therapy methods are being applying to the skin damage and what is the advantage and limit by evaluating the patient's satisfaction level. Methods: We carried out an online and offline survey targeting medical teams in order to analyze device for wound care. A total of 125 medical teams applied to the research, and investigate the level of customer satisfaction. Results: The moist dressings are the most used method for wound healing. When it comes to the level of customer satisfaction, biological dressing product also has a high satisfaction level. However its high cost tends to limit the use. Conclusion: This research reached a conclusion that it is need to develop a low cost and high efficiency wound care product considering the fact that its high cost and low efficiency induced economic problems. Generally, it is needed to develop a product for skin regeneration based on biological technologies, not a product just for damage cure.

• 한국환경농학회지
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• 제24권3호
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• pp.215-221
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• 2005

납석광산 폐석의 중화제로서 Solvay 공정에서 발생되는 알칼리성 부산물인 부산석회의 활용 가능성을 평가하기 위하여 폐석을 충진한 컬럼 용출시험을 수행한 결과는 다음과 같다. 폐석의 pH 값은 3.67로 매우 낮았으며 화학성분 중 $Al_2O_3$ 함량은 16.44%, $Fe_2O_3$의 함량은 11.62%로 높게 나타났다. 컬럼시험에서는 폐석 단독 처리구의 경우 침출수의 pH가 $3.5{\sim}4.0$으로 매우 낮게 나타났으나 폐석+탄산석회 전층혼합 및 폐석+부산석회 전층혼합 처리에서는 침출수의 pH가 $7.0{\sim}8.0$의 수준으로 유지되어 뚜렷한 중화효과를 나타내었다. 침출수의 EC 값은 폐석+부산석회 전층혼합 처리에서 초기에 높게 나타났는데 이는 부산석회에 Ca을 비롯한 염류물질이 다량 함유되었기 때문인 것으로 판단되었다. 침출수 중 Fe의 농도는 폐석+부산석회 전층혼합 처리예서 1 mg $L^{-1}$ 이하의 수준으로 나타났고, Al의 농도는 초기 용출에서 다소 높게 나타났으나 이후 1 mg $L^{-1}$ 이하의 수준으로 안정화되었다. 이상의 결과를 통해 부산석회는 복토제의 피복 없이도 납석광산 폐석의 오염물질 유출을 차단할 수 있는 중화제로 활용할 수 있을 것으로 판단되었고, 부산석회는 폐석과 혼합하여 처리하는 것이 효율적이었다.

• 대한암한의학회지
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• 제25권1호
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• pp.11-24
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• 2020

Objective : Radiodermatitis is a common sequelae in 95% of patients receiving radiation therapy, which is important to be well managed as it can affect the patient's quality of life as well as the cancer treatment schedule. The aim of this study is to review and summarize the interventions available for the treatment of acute radiodermatitis, including traditional Korean medicine, and to propose treatment algorithms for clinicians. Methods : To collect studies about managements for radiodermatitis, domestic and foreign database were used such as Korean journal of traditional knowledge portal (KTKP), Korean studies information service system (KISS), national discovery or science leaders (NDSL), and oriental medicine advance searching integrated system (OASIS), Pubmed, Google scholar and Scopus. Results : Thirty-two studies were selected. There were nine studies on usual care and dressing, eleven studies on chemical agents, two studies on biological preparations, and ten studies on herbal medicines. Conclusion : Hygienic options and dressings have proved to be useful in the management of radiodermatitis. Chemical agents such as corticosteroid, statin, and topical antibiotic agent have proved to alleviate symptoms and severity, regenerate damaged skin, and prevent secondary infection. In biological preparations, EGF (epidermal growth factor) and GM-CSF (granulocyte-macrophage colony-stimulating factor) could be used to protect skin and prevent radiodermatitis. For herbal medicines, Calendula, catechin, β-sitosterol, and Jaungo (紫雲膏) may be effective for symptoms including pain, itching, and burning sensation induced by radiation therapy. Because of some research with conflicting results, further studies are needed to propose an algorithm for more optimal treatments.

• Applied Biological Chemistry
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• 제25권3호
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• pp.150-154
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• 1982

중질소요소(重窒素尿素)를 사용(使用) 3품종(品種)에 대(對)한 분시시험(分施試驗)을 폿드에서 수행하였다. 2회분시(回分施)는 4회분시(回分施)보다 통일계(統一系)에 월등히 좋았다. 시비효율(Fe), 이용율(利用率) 및 흡수시비질소효율(吸收施肥窒素效率)(Ef)은 4회분시(回分施)보다 2회분시(回分施)에서 월등히 컸다. Fe의 순위는 Ef의 순위와 같았다. 수량(收量)과 중질소과잉율(重素窒過利率)은 통일계(統一系)가 생육초기(生育初期)에 시용질소(施用窒素)를 많이 흡수(吸收)하여 후기(後期)에 상당히 재전류(再轉流)시킴을 나타내었다. 흡수시비질소(吸收施肥窒素)에 대(對)한 토양질소흡수증가량(土壤窒素吸收增加量) $({\Delta}Ns/Nf)$은 시비(施肥)로 인(因)한 토양질소이용율(土壤窒素利用率)의 지표(指標)가 될 수 있다.

• Applied Biological Chemistry
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• 제25권3호
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• pp.142-149
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• 1982

유수형성기추비(幼穗形成期追肥)(30%)한 표식질소(慓識窒素)의 이용율(利用率)은 $23{\sim}61%$(5개포장(個圃場))였으며 품종간차이(品種間差異)가 없었다. 고수답(高收沓)에서 추비질소(追肥窒素)의 이용율(利用率)이 컸으며 식물체내비료(植物體內肥料) 유래질소(由來窒素)의 50% 이상(以上)이 유수형성기이후(幼穗形成期以後)에 흡수(吸收)된 것으로 보였다. 정조(正租)에서 중질소과잉율(重窒素過剩率)이 가장 컸으며 이는 추비(追肥)된 질소(窒素)가 정조(正租)로 쉽게 전류(轉流)됨을 나타낸다. 일반계(一般系)보다 통일계(統一系)에서 정조(正租)와 엽간(葉間)의 중질소과잉율(重窒素過剩率)의 차이(差異)가 커서 통일계(統一系)에서 질소(窒素)의 전류(轉流)가 빠른것을 나타낸다. 지상부추비유래질소(地上部追肥由來窒素)는 $14{\sim}27%$였다. 특별(特別)한 관리(管理)를 한다면 포장조건(圃場條件)에서 중질소이용(重窒素利用)한 시험(試驗)은 처리당(處理當) 2구(區)에 구당(區當) 3주(株)로 충분(充分)할 것 같다.

• 한국의류산업학회지
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• 제1권3호
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• pp.218-230
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• 1999

The purpose of this study is -under the post-modem situation- to emphasize the role of women which has various several logic on feminism, to look forward to division of men's consciousness of women, and to reflect a trend to accept the role of sex which is occurring in the system of sex, that is, 'The Third Gender and Homosexuality'. The category of biological and sociocultural on feminism discussed, meantime expressed the sexual logic under post-modern situation, and probed the sexual logic on feminism which was expressed in modem dress and its ornaments by redefining some characters as follows; Imitation-it was to attain masculinity by imitating the body of the opposite sex. Interaction such situations like...... masculinity in women, feminity in men was demonstrated as transvestism of cross-dressing and the symbolic meaning of homosexuality was demonstrated in the shoes of sociocultural on Feminism. Dispersion appeared as a moderation charm and a resistance against the men-ruling culture. Destruction-expressed the fetishism of punk of porny image and maternal affectional image of biological trend as playful satire. Therefore, It is conceived that Feminism would be created true human-phase come true in the men's world as long as the realization of women themselves make the phase of women higher; and further not only propose new image of women but the system of gender.

• Mycobiology
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• 제30권4호
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• pp.233-239
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• 2002

The main aim of this study is to evaluate the efficiency of two biologically active compounds(Strom and F-760) in control of wheat root rot disease and its causal organisms. Fusarium graminearum, F. oxysporum, F. solani and Bipolaris sorokiniana were used as target organisms. In vitro, the two compounds showed fungicidal effect on all investigated pathogens resulted in suppression of radial growth and mycelial dry weight of them. Under greenhouse conditions, treatment of wheat grains with either Strom or F-760 before cultivation significantly reduced the percent of disease distribution as well as the mean disease rating of plants in both seedling and flowering stages. Fresh and dry weights of plants as well as water maintenance capacity were increased as the result of applying these compounds as seed dressing. Also data showed that the membrane stability of plants was injured as a result of infection with all investigated organisms, while this injury was alleviated when F-760 and Strom were applied. The $K^+$ efflux and the leakage of UV absorbing metabolites was stimulated with fungal infection. However, F-760 and Storm treatment partially retarded the stimulatory effect on leakage of $K^+$ and UV-absorbing metabolites of fungal infected plants. On the other side, the fungal infection had inhibitory effects on pigment fractions(chlorophyll a, b, and carotenoids) biosynthesis in wheat leaves. This retarding effect was partially or completely alleviated as the grains were treated with the applied compounds.

• Journal of Biosystems Engineering
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• 제35권2호
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• pp.132-137
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• 2010

Site-specific N application for corn is one of the precision crop management. To implement the site-specific N application, various nitrogen stress sensing methods, including aerial image, tissue analysis, soil sampling analysis, and SPAD meter readings, have been used. Use of side-dressing, an efficient nitrogen application method than a uniform application in either late fall or early spring, relies mainly on the capability of nitrogen deficiency detection. This paper presents map-based variable rate nitrogen application based using a multi-spectral corn nitrogen deficiency(CND) sensor. This sensor assess the nitrogen stress by means of the estimated SPAD reading calculated from the corn leave reflectance. The estimated SPAD value from the CND sensor system and location information form DGPS of each field block was combined into the field map using a ArcView program. Then this map was converted into a raster file for a map-based variable rate application software. The relative SPAD (RSPAD = SPAD over reference SPAD) was investigated 2 weeks after the treatments. The results showed that the map-based variable rate application system was feasible.

• 대한의용생체공학회:의공학회지
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• 제29권3호
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• pp.173-178
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• 2008

Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and morphological features. A wide range of biopolymers can be electrospun into mats with a specific fiber arrangement and structural integrity. These features of nanofiber mats are morphologically similar to the extracellular matrix of natural tissues, which are characterized by a wide pore diameter distribution, a high porosity, effective mechanical properties, and specific biochemical properties. This has resulted in various kinds of applications for polymer nanofibers in the field of biomedicine and biotechnology. The current emphasis of research is on exploiting these properties and focusing on determining the appropriate conditions for electrospinning various biopolymers for biomedical applications, including scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, and vascular grafts, and for protective shields in specialty fabrics. This paper reviews the research on biomedical applications of electrospun nanofibers.