• Journal of Biomedical Engineering Research
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• v.28 no.4
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• pp.449-454
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• 2007

An electrohydraulic (EH) pump-driven closed-loop blood pressure regulatory system was developed based on flow-mediated vascular occlusion using the vascular occlusive cuff technique. It is very useful for investigating blood pressure-dependant physiological variability, in particular, that could identify the principal mediators of renal autoregulation, such as tubuloglomerular feedback (TGF) and myogenic (MYO), during blood pressure regulation. To address this issue, renal perfusion pressure (RPP) should be well regulated under various experimental conditions. In this paper, we designed a new EH pump-driven RPP regulatory system capable of implementing precise and rapid RPP regulation. A closed-loop servo-controlwas developed with an optimal proportional plus integral (PI) compensation using the dynamic feedback RPP signal from animals. An in vivo performance was evaluated in terms of flow-mediated RPP occlusion, maintenance, and release responses. Step change to 80 mmHg reference from normal RPP revealed steady state error of ${\pm}3%$ during the RPP regulatory period after PI action. We obtained rapid RPP release time of approximately 300 ms. It is concluded that the proposed EH RPP regulatory system could be utilized in in vivo performance to study various pressure-flow relationships in diverse fields of physiology, and in particular, in renal autoregulation mechanisms.

• Journal of Biomedical Engineering Research
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• v.18 no.3
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• pp.223-231
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• 1997

In this paper, an interframe coding method for volumetric medical images is proposed. By treating interslice variations as the motion of bones or tissues, we use the motion compensation (MC) technique to predict the current frame from the previous frame. Instead of a block matching algorithm (BMA), which is the most common motion estimation (ME) algorithm in video coding, image warping with biolinear transformation has been suggested to predict complex interslice object variation in medical images. When an object disappears between slices, however, warping prediction has poor performance. In order to overcome this drawback, an overlapped block motion compensation (OBMC) technique is combined with carping prediction. Motion compensated residual images are then encoded by using an embedded zerotree wavelet (EZW) coder with small modification for consistent quality of reconstructed images. The experimental results show that the interframe coding suing warping prediction provides better performance compared with interframe coding, and the OBMC scheme gives some additional improvement over the warping-only MC method.

• Korean Journal of Biological Psychiatry
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• v.20 no.3
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• pp.66-73
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• 2013

Sexual behavior is crucial in life, yet comparatively little is known about the mechanisms in the sexual response in humans. A lot of theories and models have been developed to explain about the process of the sexual response in humans. The first model of sexual function was described by Masters and Johnson, defined the four-phase model (phases of excitation, plateau, orgasm and resolution). Helen Kaplan proposed a slightly different model of human sexual response by adding the conception of the desire phase. Some years later, a new model of circular sexual response pattern was described by Whipple and Brash-McGreer, who acknowledged the cyclic nature of women's sexual response. Basson presented an alternative model of women's normative sexual function, which featured a responsive form of desire in women's sexual response. Bancroft developed a new theoretical model, the Dual Control Model, which postulates sexual response and arousal is ultimately determined by the balance between the sexual activation or excitation system and the sexual inhibition system. The Sexual Tipping Point is a model created by Perelman, suggesting that a sexual response is determined by a balance between excitatory or inhibitory factors that may be psychological, organic, psychosocial, or cultural. A comprehensive understanding of sexual response and function is of paramount importance for the psychiatrist to study sex, offer counseling to the patient on sex, and practice sex therapy. In this literature, models of sexual response would be reviewed to understand the knowledge of the sexual functioning in humans.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.355-361
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• 2015

Background: Deletion types of genetic variants of glutathione S-transferase (GST) M1 and T1, the GSTM1 null and GSTT1 null which are risk factors for certain cancers, have been ubiquitously found in human populations but their worldwide distribution pattern is unclear. Materials and Methods: To perform a meta-analysis, a systematic search for the literature on GSTM1 and GSTT1 null genotypes was done to identify 63 reports for 81 human populations. Relationships between the GSTM1 and GSTT1 null genotype frequencies and the absolute latitude of 81 populations were tested by Spearman's rank correlation coefficient. Results: A significant positive correlation was detected between the GSTM1 null genotype frequency and the absolute latitude (r=0.28, p-value <0.05), whereas the GSTT1 null genotype frequency and absolute latitude showed a significant negative correlation (r= -0.41 p-value <0.01). There was no correlation between the frequencies of GSTM1 and GSTT1 null genotype in each population (r= -0.029, p-value=0.80). Conclusions: Latitudinal clines of the distribution of the GSTM1 and GSTT1 null genotypes may be attributed to the result of gene-environmental adaptation. No functional compensation between GSTM1 and GSTT1 was suggested by the lack of correlation between the null frequencies for GSTM1 and GSTT1.

• Journal of Biomedical Engineering Research
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• v.19 no.6
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• pp.595-602
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• 1998

Among the apex locators, the frequency dependent type is more accurate and convenient to use than others, But the accuracy of the apex locator is still influenced by the presence of various electrolytes used in root canal treatments. In this study, we have developed a frequency dependent electronic apex locator minimizing the influence of the electrolytes on the measurement of root canal lengths. It was also confirmed that two frequencies of 500Hz and 100kHz are optimal for the measuring impedance compare with commercial product used(400Hz and 8kHz)a and there were no differences in accuracy among the three different types of the waveforms; sinusoidal, triangular, and rectangular waves(p>0.05). Impedance ratio of the two different frequencies represents the position of the file in root canal, and the voltage difference of two signals represents the status of the fluid in the root canal. As a result of compensation using the voltage differences, the errors were decreased on the average from +0.54mm to +0.18mm in $H_2O_2$ solution (p<0.01), and from -0.33mm to -0.01mm in NaOCl solution(p<0.01). The accuracies based on ${\pm}$0.5mm, in $H_2O_2$ and NaOCl solutions were improved with the automatic compensation from 71.1% and 91.1% to 82.2% and 100% respectively.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.2
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• pp.251-258
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• 2019

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Inflammation and oxidative stress are associated with COPD. The aim of this study was to evaluate the relationship among inflammation, oxidative stress, and airflow limitation severity in retired miners with COPD. Methods: The levels of serum high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation, degree of reactive oxygen metabolites(dROMs) and biological antioxidants potential(BAP) in plasma as biomarkers for oxidative stress were measured in 211 male subjects with COPD. Degree of airflow limitation severity as determined by spirometry was divided into three grades grouped according to the classification of the Global Initiatives for Obstructive Lung Disease(GOLD)(1, mild; 2, moderate; $3{\leq}$, severe or more) using a fixed ratio, post- bronchodilator $FEV_1/FVC$ < 0.7. Results: Mean levels of dROMs significantly increased in relation to airflow limitation severity(GOLD 1, 317.8 U.CARR vs. GOLD 2, 320.3 U.CARR vs. GOLD $3{\leq}$, 350.9 U.CARR, p=0.047) and dROMs levels were correlated with serum hsCRP levels(r=0.514, p<0.001). Mean levels of hsCRP were higher in current smokers(non-smoker, 1.47 mg/L vs. smoker, 2.34 mg/L, p=0.006), and tended to increase with degree of airflow limitation severity(p=0.071). Mean levels of BAP were lower in current smokers(non-smoker, $1873{\mu}mol/L$ vs. smoker, $1754{\mu}mol/L$, p=0.006). Conclusions: These results suggest that inflammation and oxidative stress are related to airflow limitation severity in retired miners with COPD, and there was a correlation between inflammation and oxidative stress.

• Journal of Biomedical Engineering Research
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• v.13 no.1
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• pp.47-54
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• 1992

We studied the characteristics of the compound electrode and found that the compound electrode provides the four-electrode method in a compact form. We developed a new method of measuring the skin impedance using simple electrodes at low frequencies. At high frequencies where the effect of internal tissue impedance is not negligible, we used the compensation method using compound electrodes since they measure the voltage right under the skin. At 50 kHz, we measured the real part of the skin impedance of less than $80{\Omega}$ on the thorax. We propose a simple instrument which can measure accurate skin impedance at various frequencies.

• Proceedings of the KOSOMBE Conference
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• v.1990 no.05
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• pp.51-55
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• 1990

In this study, a peripheral auditory model used as a frequency feature extractor and a recurrent network which has recurrent links on input nodes is constructed in order to show the reliability of the recurrent network as a recognizer by executing recognition tests for 4 Korean placenames and syllables. As a result of this study, a refined weight compensation method is proposed and, using this method, it is possible to improve the system operation. The recurrent network in this study reflects well time information of temporal speech signal.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.11
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• pp.121-123
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• 1995

This paper presents a new method which compensates loss of loudness for digital hearing aids. Loudness grows more rapidly in frequency domain with substantial shifts of hearing threshold, so that loud sounds reach the uncomfortable sound level (UCL) at about the same physical stimulus level as with normal hearing. The result is a compression of the available dynamic range of hearing. Many techniques have been developed to compensate for hearing losses. In this paper, we propose a digital hearing aid which uses a single digital filter for reducing distortion and the fuzzy function to calculate gain factors. This function describes how much gain is needed for every frequency to restore loudness perception of a normal ear.

• Journal of Biomedical Engineering Research
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• v.11 no.1
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• pp.157-162
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• 1990

In this study, a peripheral auditory model is used as a frequency feature extractor and a recurrent network which has recurrent links on input nodes is constructed in order to show the reliability of the recurrent network as a recognizer by executing recognition tests for 4 Korean place names and syllables. In the case of using the general learning rule, it is found that the weights are diverged for a long sequence because of the characteristics of the node function in the hidden and output layers. So, a refined weight compensation method is proposed and, using this method, it is possible to improve the system operation and to use long data. The recognition results are considerably good, even if time worping and endpoint detection are omitted and learning patterns and test patterns are made of average length of data. The recurrent network used in this study reflects well time information of temporal speech signal.