• 제목/요약/키워드: biological

검색결과 33,639건 처리시간 0.053초

Phylogeny of SINE-R Retroposons in Asian Apes

  • Lee, Ji-Won;Yi, Joo-Mi;Jeon, Seung-Heui;Shin, Kyung-Mi;Kim, Myung-Sook;Park, Jin;Jung, A-Ram;Hong, Kyung-Won;Huh, Jae-Won
    • 한국동물학회:학술대회논문집
    • /
    • 한국동물학회 2001년도 한국생물과학협회 학술발표대회
    • /
    • pp.115.3-116
    • /
    • 2001
  • No Abstract, See Full Text

  • PDF

Conformational change of organic cofactor PLP is essential for catalysis in PLP-dependent enzymes

  • Ngo, Ho-Phuong-Thuy;Nguyen, Diem Quynh;Park, Hyunjae;Park, Yoon Sik;Kwak, Kiwoong;Kim, Taejoon;Lee, Jang Ho;Cho, Kyoung Sang;Kang, Lin-Woo
    • BMB Reports
    • /
    • 제55권9호
    • /
    • pp.439-446
    • /
    • 2022
  • Pyridoxal 5'-phosphate (PLP)-dependent enzymes are ubiquitous, catalyzing various biochemical reactions of approximately 4% of all classified enzymatic activities. They transform amines and amino acids into important metabolites or signaling molecules and are important drug targets in many diseases. In the crystal structures of PLP-dependent enzymes, organic cofactor PLP showed diverse conformations depending on the catalytic step. The conformational change of PLP is essential in the catalytic mechanism. In the study, we review the sophisticated catalytic mechanism of PLP, especially in transaldimination reactions. Most drugs targeting PLP-dependent enzymes make a covalent bond to PLP with the transaldimination reaction. A detailed understanding of organic cofactor PLP will help develop a new drug against PLP-dependent enzymes.

Importance of taxonomic research for biodiversity of Korea

  • Hur, Wee-Haeng;Park, Chan-Ho;Min, Gi-Sik;Hyun, Chang-Woo;Bae, Eun Hee;Lee, Jeong Hyun;Jung, Eun-Hee;Yoo, Jung-Sun;Suh, Min Hwan
    • Journal of Species Research
    • /
    • 제5권3호
    • /
    • pp.261-263
    • /
    • 2016
  • In 2012, the NIBR started publishing the Journal of Species Research (JSR) as an international specialized journal of biological taxonomy focusing on taxonomic research. JSR Volume 5 Number 3, to be published in October 2016, has been planned as a 'Special Edition on New and Unrecorded Species of Invertebrates in Korea', and so it consists of the reports of 149 new and unrecorded invertebrate species (including protozoa) discovered in Korea. In future, the JSR should further accelerate the use of such methods to generate valid data for new species and effectively support the compilation of 'National List of Species of Korea'. In this way, it will contribute significantly to enrich for biodiversity in Korea.

Biosafety and Biosecurity Programme: Its Implementation, Requirements and Continuous Development at the Nanyang Technological University in Singapore

  • Tun, Tin;Preiser, Peter Rainer
    • 대한임상검사과학회지
    • /
    • 제50권2호
    • /
    • pp.77-84
    • /
    • 2018
  • In Singapore, biosafety and biosecurity measures are controlled by the Biological Agents and Toxins Act (BATA) and other requirements by regulatory agencies. The law prohibits and otherwise regulates the possession, use, import, transhipment, transfer, and transportation of biological agents, inactivated biological agents, and toxins that are of public health concern. The law also defines the facility requirements for high risk biological agents and toxins. The containment facility (BSL 3) is a minimum requirement to handle biological agents that falls under Schedule 1 (Risk Group 3). The Nanyang Technological University School of Biological Sciences Biosafety Level 3 Facility (NTU-SBS BSL 3) was designed specifically for research involving potential hazardous biological materials. The facility requires yearly re-certification by an approved facility certifier to meet the local requirements and international biosafety standards for a containment facility in many instances. On the other hand, most NTU researchers conduct biological projects involving biological agents with low or moderate risk groups (Risk Groups 1 and 2 or biological agents described in schedule 3 and 4 of BATA) and GMOs, which need only a BSL 2 laboratory. BSL 2 laboratories are yet to be legally certified or registered in Singapore. Institutional Biosafety Committee (IBC) identifies the requirements; defines a minimum standard in the safe control of biological risks and registers all BSL 2 laboratories in the NTU. Therefore, under the guidance of the IBC, the University Biosafety and Biosecurity Programme includes the audit and certification program as a unique and an internal exercise to bring NTU biosafety to a higher level.