• Bulletin of the Korean Chemical Society
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• v.28 no.8
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• pp.1335-1340
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• 2007

β-Ketoacyl acyl carrier protein synthase (KAS) III is a particularly attractive target in the type II fatty acid synthetic pathway, since it is central to the initiation of fatty acid synthesis. Enterococcus faecalis, a Grampositive bacterium, is one of the major causes of hospital acquired infections. The rise of multidrug-resistant of most bacteria requires the development of new antibiotics, such as inhibition of the KAS III. In order to block the fatty acid synthesis by inhibition of KAS III, at first, three dimensional structure of Enterococcus faecalis KAS III (efKAS III) was determined by comparative homology modeling using MODELLER based on x-ray structure of Staphylococcus aureus KAS III (saKAS III) which is a gram-positive bacteria and is 36.1% identical in amino acid sequences with efKAS III. Since His-Asn-Cys catalytic triad is conserved in efKAS III and saKAS III, substrate specificity of efKAS III and saKAS III and the size of primer binding pocket of these two proteins are expected to be similar. Ligand docking study of efKAS III with naringenin and apigenin showed that naringenin docked more strongly with efKAS III than apigenin, resulting in the intensive hydrogen bond network between naringenin and efKAS III. Also, only naringenin showed antibacterial activity against E. faecalis at 256 μg/mL. This study may give practical implications of flavonoids for antimicrobial effects against E. faecalis.

• Rapid Communication in Photoscience
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• v.3 no.3
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• pp.59-60
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• 2014

The trans-$A_2B_2$ porphyrin and Ni-porphyrin derivatives were synthesized by Suzuki coupling of bromoporphyrin with arylborate as a key step. The band gaps of those complexes were measured from their absorption, emission and cyclic voltammetric data. All the LUMO energy level of porphyrin derivatives is lower than that of P3HT, and the HOMO energy level is evaluated higher than the HOMO of PCBM.

• Bulletin of the Korean Chemical Society
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• v.31 no.8
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• pp.2375-2378
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• 2010

• Bioinformatics and Biosystems
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• v.2 no.2
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• pp.62-65
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• 2007

We present here the strategy of data integration for inference of genetic regulatory modules. First, we construct all possible combinations of regulators of genes using chromatin-immunoprecipitation(ChIP)-chip data. Second, hierarchical clustering method is employed to analyze mRNA expression profiles. Third, integration method is applied to both of the data. Finally, we construct a genetic regulatory module which is involved in the function of ribosomal protein synthesis.

• Bulletin of the Korean Chemical Society
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• v.33 no.4
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• pp.1349-1352
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• 2012

• Journal of the Korean Chemical Society
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• v.55 no.4
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• pp.719-722
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• 2011

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.330-330
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• 2006

The elaboration of fluorescent submicronic polymer particles exhibiting narrow particle size distribution as well as good photostability is of particular interest in various biomedical applications. In the frame of this work, labeled polystyrene latexes have been synthesized by miniemulsion polymerization using luminescent semiconductor nanoparticles (quantum dots, QD). The influence of incorporation of QDs on the polymerization kinetics as well as on the optical properties of the obtained latexes will be discussed.

• Bulletin of the Korean Chemical Society
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• v.30 no.11
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• pp.2621-2625
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• 2009

To identify a non-acylguanidine NHE-1 inhibitor, an acylguanidne group was replaced with an imidazole group in the potent NHE-1 inhibitors with furan or benzothiphene core template, found from our previous studies. We synthesized and biologically evaluated 4-heteroaryl-2-amino-5-methylimidazole derivatives. All those imidazole compounds (16-18) represented the potent NHE-1 inhibitory activities, similar to the corresponding acylguanidine compounds.

• Analytical Science and Technology
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• v.16 no.1
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• pp.25-31
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• 2003

Chromium(III) picolinate, a highly bioavailable compound, is known to be used for supplementing essential chromium(III) to human beings and animals. Two different methods were used to synthesize chromium(III) picolinate. The synthetic products were characterized by elemental analysis, FTI-IR, high performance liquid chromatography (HPLC) and MALDI-MS.

• Textile Coloration and Finishing
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• v.19 no.3
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• pp.6-11
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• 2007

The indigoid-type dyes based on isatin $\alpha-chloride$ were synthesized and the dyes were discussed with relevance to the "H-chromophore" or "cross-conjugated chromophore". The color-changed properties of the dyes were also investigated by means of visible absorption spectra. The novel dyes from isatin $\alpha-chloride$ are of theoretical interest and such dyes can be used as continuous pH indicators in acid/base titrimetric analyses.