• Title/Summary/Keyword: bio-medical

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EXPERIMENTS FOR VALIDATING NUMERICAL ANALYSIS USING ADVANCED FLOW VISUALIZATION TECHNOLOGIES (첨단 유동가시화 기술을 이용한 수치해석 검증용 실험)

  • Lee, S.J.
    • 한국전산유체공학회:학술대회논문집
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    • 2008.10a
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    • pp.14-17
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    • 2008
  • Recently, several advanced flow visualization techniques such as Particle Image Velocimetry (PIV) including stereo PIV, holographic PIV, and dynamic PIV have been developed. These advanced techniques have strong potential as the experimental technology which can be used for verifying numerical simulation. In addition, there would be indispensable in solving complicated thermo-fluid flow problems not only in the industrial fields such as automotive, space, electronics, aero- and hydro-dynamics, steel, and information engineering, but also in the basic research fields of medical science, bio-medical engineering, environmental and energy engineering etc. Especially, NT (Nano Technology) and BT (Bio Technology) strongly demand these advanced measurement techniques, because it is difficult for conventional methods to observe most complicated nano- and bio-fluidic phenomena. In this paper, the basic principle of these advanced visualization techniques and their practical applications which cannot be resolved by conventional methods, such as flow in automotive HVAC system, ship and propeller wake, three-dimensional flow measurement in micro-conduits, and flow around a circulating cylinder will be introduced.

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Contralateral Breast Cancer: a Clinico-pathological Study of Second Primaries in Opposite Breasts after Treatment of Breast Malignancy

  • Shankar, Abhishek;Roy, Shubham;Malik, Abhidha;Kamal, Vineet Kumar;Bhandari, Ruchir;Kishor, Kunal;Mahajan, M.K.;Sachdev, Jaineet;Jeyaraj, Pamela;Rath, G.K.
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.3
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    • pp.1207-1211
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    • 2015
  • Background: Breast cancer is by far the most frequent cancer of women (23 % of all cancers), ranking second overall when both sexes are considered together. Contralateral breast cancer (CBC) is becoming an important public health issue because of the increased incidence of primary breast cancer and improved survival. The present communication concerns a study to evaluate the role of various clinico-pathological factors on the occurrence of contralateral breast cancer. Materials and Methods: A detailed analysis was carried out with respect to age, menopausal status, family history, disease stage, surgery performed, histopathology, hormone receptor status, and use of chemotherapy or hormonal therapy. The diagnosis of CBC was confirmed on histopathology report. Relative risk with 95%CI was calculated for different risk factors of contralateral breast cancer development. Results: CBC was found in 24 (4.5%) out of 532 patients. Mean age of presentation was 43.2 years. Family history of breast cancer was found in 37.5% of the patients. There was statistically significant higher rate (83.3%) of CBC in patients in age group of 20-40 years with RR=11.3 (95% CI: 1.4, 89.4, p=0.006) seen in 20-30 years and RR=10.8 (95% CI:1.5-79.6, p=0.002) in 30-40 years as compared to older age of 60-70 years. Risk of development was higher in premenopausal women (RR=8.6, 95% CI: 3.5-21.3, $p{\leq}0.001$). Women with family history of breast cancer had highest rate (20.9%) of CBC (RR=5.4, 95% CI: 2.5-11.6, $p{\leq}0.001$). Use of hormonal therapy in hormone receptor positive patients was protective factor in occurrence of CBC but not significant (RR=0.7, 95% CI: 0.3-1.5, p=0.333). Conclusions: Younger age, premenopausal status, and presence of family history were found to be significant risk factors for the development of CBC. Use of hormonal therapy in hormone receptor positive patients might be protective against occurrence of CBC but did not reach significance.

Analysis of Pupil Size Variability for Effectiveness Verification of Activation Level of Autonomic Nerve System by Electromagnetic Acupuncture System (자화침 시스템의 자율신경계 활성화 효과 검증을 위한 동공크기변이 분석)

  • Liu, Wenxue;Lee, Na-Ra;Choi, Woo-Hyuk;Kim, Soo-Byeong;Lee, Young-Heum;Shin, Tae-Min
    • Korean Journal of Acupuncture
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    • v.29 no.4
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    • pp.554-562
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    • 2012
  • Objectives : The purpose of this research is to verify the effects of the Electromagnetic acupuncture(EMA) on BL15 by Pupil size variability(PSV) which is directly related to the activation of the Autonomic Nervous System. Methods : Thirty male subjects participated in this study and were divided into three groups(non-stimulated, manual acupuncture and EMA group). The size of pupil was measured in the cube place of $60{\times}60{\times}60$ cm in order to avoid the effect of the surrounding circumstances. All subjects were measured the size of left pupil about 200sec in the constant illumination. Results : We observed the decrease in PSV of manual acupuncture group compared to non-stimulation group, but it was not significant statistically(p>0.05). The decrease in PSV of EMA group was observed in comparison to two groups, and we confirmed the result of significant difference statistically(p<0.05). Conclusions : We concluded that EMA treatment method is enough to activate in the parasympathetic nerve system by inducing the biotransformation.

Answer Snippet Retrieval for Question Answering of Medical Documents (의학문서 질의응답을 위한 정답 스닛핏 검색)

  • Lee, Hyeon-gu;Kim, Minkyoung;Kim, Harksoo
    • Journal of KIISE
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    • v.43 no.8
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    • pp.927-932
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    • 2016
  • With the explosive increase in the number of online medical documents, the demand for question-answering systems is increasing. Recently, question-answering models based on machine learning have shown high performances in various domains. However, many question-answering models within the medical domain are still based on information retrieval techniques because of sparseness of training data. Based on various information retrieval techniques, we propose an answer snippet retrieval model for question-answering systems of medical documents. The proposed model first searches candidate answer sentences from medical documents using a cluster-based retrieval technique. Then, it generates reliable answer snippets using a re-ranking model of the candidate answer sentences based on various sentence retrieval techniques. In the experiments with BioASQ 4b, the proposed model showed better performances (MAP of 0.0604) than the previous models.

Cardiac Moniter Using Wirless Communication Network (무선 통신망을 이용한 Cardiac Moniter)

  • Shin, J.H.;Lee, D.H.;Kang, D.J.
    • Proceedings of the KOSOMBE Conference
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    • v.1996 no.11
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    • pp.175-177
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    • 1996
  • 본 논문에서는 일반 심전도 모니터링 장비가 갖는 이동성 및 상시성의 제한을 극복하여 공중무선망을 이용한 심전도 모니터링 장치에 관한것으로서 특히, 활동중인 사람의 심전도 데이터를 공중 무선 통신망에서 제공하는 망써비스를 이용하여 원거리 모니터링 센터에서 모니터링 및 응급조치를 하는 시스템에 관한 것이다.

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Sensitive Determination of Felodipine in Human Plasma by LC-MS/MS

  • Kim, Ho-Hyun;Roh, Hyeon-Jin;Lee, He-Joo;Han, Sang-Beom
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.283.2-283.2
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    • 2003
  • This study established a highly sensitive novel quantification method for detecting felodipine in human plasma using LC-MS/MS. The mobile phase used after degassing was composed of 1 mM ammonium acetate and acetonitrile (20:80, pH 6.0), with flow rate of 200 uL/min. One mL plasma were pipetted into glass tubes and spiked with 0.1 mL of internal standard solution. (omitted)

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Determination of Glimepiride in Human Plasma by LC-MS/MS

  • Kim, Ho-Hyun;Roh, Hyeong-Jin;Lee, Hee-Joo;Han, Sang-Beom
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.282.1-282.1
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    • 2003
  • This study established a sensitive novel Quantification method for detecting glimepiride in human plasma using LC-MS/MS for pharmacokinetic studies. The mobile phase used after degassing was composed of 10 mM ammonium acetate and acetonitrile (20:80, pH 3.0), with flow rate of 200uL/min. One mL plasma were pipetted into glass tubes and spiked with 0.1 mL of internal standard solution. (omitted)

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Dose Distribution of Gamma Irradiators

  • Park, Seung-Woo;Shin, Sang-Hun;Son, Ki-Hong;Lee, Chang-Yeol;Kim, Kum-Bae;Jung, Hai-Jo;Ji, Young-Hoon
    • 대한방사선방어학회:학술대회논문집
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    • 2010.04a
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    • pp.62-63
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    • 2010
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Preparation and Texture Characterization of Surimi Gel Using a Unmarketable Rearing Olive Flounder (저상품성 양식 넙치를 이용한 연제품 제조 및 텍스튜어 특성)

  • Cha, Seon-Heui;Jo, Mi-Ran;Lee, Jung-Suck;Lee, Ji-Hyeok;Ko, Joo-Young;Jeon, You-Jin
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.42 no.2
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    • pp.109-115
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    • 2009
  • The properties of surimi gel from Olive flounder Paralichthys olivaceus were evaluated with addition of various food additives and by heating under different conditions. The optimum heating conditions for get good textured surimi gel from Olive flounder was 40 minutes at $85^{\circ}C$. Optimum texture characteristics such as hardness, cohesiveness, chewiness, gumminess and gel strength of olive flounder fish paste can be acquired by washing the paste 2 times and by adding sodium chloride (2.5%), sodium polyphosphate (0.3%) and starch (4%), respectively. Furthermore, we compared gel texture characteristics and strength of manufactured Olive flounder fish surimi with commercial Alaska pollack to determine their commercial applicability. Texture characteristics and gel strength of Olive flounder surimi were higher than those of the commercial Alaska pollack surimi. In addition, both lightness and whiteness were higher in surimi gel from Olive flounder than from the commercial Alaska pollack.

Development of Controllable Cannular Catheter using Bio Shape Memory Alloy (SMA) during Percutaneous Minimally Invasive Spine Surgery (경피적 최소침습 척추시술 중 디스크 내에서 방향제어가 가능한 Bio-SMA 캐뉼라 카테터의 개발)

  • Kim, Cheol-Woong
    • Proceedings of the KSME Conference
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    • 2007.05a
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    • pp.378-383
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    • 2007
  • As the Minimally Invasive Surgery (MIS) is developed, an interventional procedure becomes the major of the spine surgery in the world. Despite of the use of the expensive medical equipments, the success chance of the nucleoplasty is about 30%. The reason is that the shape of the cannular needle is similar to that of the conventional injector and looks like the straight. Because the tip of these straight needles is not able to reach in the vicinity of the disc bulging or the protrusion, which are the cause of the low back pain and because the far indirect plasma discharge results in the decompression, the nucleoplasty has the limit. Many incurable diseases has not been solved due to the unexistence of the advanced technique for the MIS human body cannula device. If 3-D direction controllable cannular catheter (whose direction is accurately controlled after inserting into the bodies to cure the lesion) is developed, it is expected that new devised cannular catheter can cure many incurable diseases simultaneously. Therefore, the aims of this research are to develop the new devised cannular catheter of SMA direction controller for the medical situation, which has been produced through many previous trial-error procedures, and to produce the commercial medical device.

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