• Title/Summary/Keyword: bio technology

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Melanin-concentrating Hormone-1 Receptor (MCH-1) Antagonism of the Leaves Extract from Morus alba

  • Oh, Byung-Koo;Oh, Kwang-Seok;Lee, Sung-Hou;Seo, Ho-Won;Choi, Yeon-Hee;Choi, Jae-Seok;Kim, Young-Sup;Lee, Byung-Ho;Kwon, Kwang-Il;Ryu, Shi-Yong
    • Natural Product Sciences
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    • v.15 no.1
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    • pp.27-31
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    • 2009

  • The present study was performed to investigate the binding affinity of the ethanol extract from the leaves of Morus alba (EMA) and some EMA related plant materials (EMA-D, EMA-DM) for melanin-concentrating hormone-1 receptor (MCH-1) and also to examine the antagonistic effect of them for the recombinant MCH-1 receptor expressed in CHO cells. EMA, dichloromethane fraction (EMA-D) and EMA-DM exhibited high affinity for mammalian MCH receptor in receptor binding assays ($IC_{50}$ value: 2.3, 1.6 and $1.0{\mu}g/ml$, respectively). Other plant materials (MMA-D, MMA-DM) obtained from methanol extracts from the leaves of Morus alba (MMA) also exhibited high affinity for mammalian MCH receptor, even though the $IC_{50}$ values of them were lower than those of EMA-D and EMA-DM. In Chinese hamster ovary (CHO) cells expressing human MCH-1, EMA-DM and EMA-D significantly inhibited MCH-induced intracellular $Ca^{2+}$ increase ($IC_{50}$ values: 16.5 and $22.7{\mu}g/ml$, respectively). These results clearly indicate that the ethanol extract from the leaves of Morus alba (EMA) and some EMA related plant materials (EMA-D, EMA-DM) are novel selective MCH-1 receptor antagonist, respectively.

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Synthesis and Herbicidal Activities of Tetrahydroindazole Derivatives Possessing Hydroxyalkyl Subgroup (하이드록시알킬 치환체를 갖는 테트라하이드로인다졸계 화합물의 합성과 제초활성 연구)

  • Ko, Young-Kwan;Chung, Kun-Hoe;Ryu, Jae-Wook;Woo, Jae-Chun;Koo, Dong-Wan;Choi, Jung-Sup;Kim, Jun-Young;Kim, Su-Ho;Kim, Tae-Joon;Choi, In-Young;Seok, Mee-Young;Choi, Jun-Hyuk;Chung, Bong-Jin
    • The Korean Journal of Pesticide Science
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    • v.12 no.2
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    • pp.201-205
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    • 2008

  • As an ongoing research program for the development of environmental friendly new soil-surface treatment herbicide, several tetrahydroindazole derivatives 6a - 6h possessing hydroxyalkyl subgroup were synthesized and shown to have interesting herbicidal activities exhibiting sumptoms as protoporphyrinogen IX oxidase inhibitor under pre-emergence upland greenhouse screening. Among derivatives tested, compound 6f showed superior herbicidal activity against problem weeds.

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