• Biotechnology and Bioprocess Engineering:BBE
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• 제9권2호
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• pp.127-131
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• 2004

A low-cost, simple strip reader system using a linear movement mechanism of CD-ROM deck has been developed to characterize a lateral flow membrane-based immunochromatographic assay. The test strip reader was assembled by a CD-ROM deck and home-made optical head especially designed for immunoassays. The optical head for detecting reflected light from the test strip surface consists of green light-emitting diode, large area silicon photodiode, and anodized aluminum mounting block providing a slit structure for cutting light from the LED. The stepping motor of the deck was operated in the full step mode, whose distance of each reading point is about 0.15mm. The performance of the strip reader was tested by analysis of HBV(hepatitis B virus) antigen test kit. This strip reader can be useful for inexpensive, disposable, and membrane-based assays that provide visual evidence of the presence of an analyte in a liquid sample.

• 한국염색가공학회지
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• 제22권1호
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• pp.37-42
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• 2010

ABS/MWNT nanocomposites were prepared by using MWNT wrapped with SAN through melt compounding. Effect of wrapping of MWNT by SAN on the morphology, mechanical and electrical properties of ABS/MWNT were analyzed. It was found that SAN could wrap MWNT effectively indicated by the increased thickness after wrapping, which is presumably due to helical structure of polyacrylonitrile component in a block copolymer of SAN. MWNT was observed to be dispersed more evenly in ABS matrix by SAN wrapping, which resulted in improved tensile properties of the composites. On the other hand, there was little effect on the impact strength and electrical properties of ABS having inherently high impact strength.

• International journal of advanced smart convergence
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• 제8권1호
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• pp.18-23
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• 2019

The image projected onto the screen of the floating hologram is no more than a two-dimensional image. Although it creates an illusion that an object appears to float in space as it moves around while showing its different parts. This paper has proposed a novel method of floating 3D hologram display to view stereoscopic three-dimensional images without putting on glasses. The system is comprised of a sharkstooth scrim screen, projector, polarizing filter for the projector, and a polarizing film to block the image projected from the sham screen. As part of the polarization characteristics, the background image and the front object have completely been separated from each other with the stereoscopic 3D effect successfully implemented by the binocular disparity caused by the distance between the two screens.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권5호
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• pp.415-420
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• 2011

Purpose: Calcium phosphate cement (CPC) is one of many useful materials for restoring tooth defects, periodontium and maxillofacial area. Chitosan is a biodegradable material that has been shown to promote the growth and differentiation of osteoblasts in culture. This study examined the interaction between odontoblasts and bio-calcium phosphate cement reinforced with chitosan. Materials and Methods: $5{\times}10^3$ odontoblastic cells were seeded into each well. Various concentrations of bio-calcium phosphate cement reinforced with chitosan (10, 20, 50, 100, 200, 500 ${\mu}g$/ml, 1, 2, 4 mg/ml) were diluted and added to the wells. The well was incubated for 24 h, 48 h and 72 h. After incubation, the number of cells was assessed to determine the cell viability. A cytokinesis-block micronucleus assay and chromosomal aberration test were carried out to estimate the extent of chromosomal abnormalities. Microscopic photographs and RT-PCR were performed to examine the adhesion potential of bio-calcium phosphate cement reinforced with chitosan. Results: Bio-CPC-reinforced chitosan did not show significant cytotoxicity. The number of damaged chromosomes in the cells treated with Bio-CPC-reinforced chitosan was similar to that in the control cells. There was no significant increase in the number of chromosomal aberrations in the Bio-CPC reinforced chitosan exposed cells. Microscopic photographs and RT-PCR confirmed the adhesive potential of bio-CPC reinforced chitosan to odontoblasts. Conclusion: Bio-CPC-reinforced chitosan did not affect the odontoblastic cell viability, and had no significant cytotoxic effect. Bio-CPC-reinforced chitosan showed adhesive potential to odontoblasts. These results are expected form the basis of future studies on the effectiveness of dental restorative materials in Bio-CPC reinforced with chitosan.

• BMB Reports
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• 제56권11호
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• pp.594-599
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• 2023

A number of therapeutic drugs have been developed from functional chemicals found in plants. Knowledge of plants used for medicinal purposes has historically been transmitted by word of mouth or through literature. The aim of the present study is to provide a systemic platform for the development of lead compounds against breast cancer based on a traditional medical text. To verify our systematic approach, integrating processes consisted of text mining of traditional medical texts, 3-D virtual docking screening, and in vitro and in vivo experimental validations were demonstrated. Our text analysis system identified rutin as a specific phytochemical traditionally used for cancer treatment. 3-D virtual screening predicted that rutin could block EGFR signaling. Thus, we validated significant anti-cancer effects of rutin against breast cancer cells through blockade of EGFR signaling pathway in vitro. We also demonstrated in vivo anti-cancer effects of rutin using the breast cancer recurrence in vivo models. In summary, our innovative approach might be proper for discovering new phytochemical lead compounds designing for blockade of malignant neoplasm including breast cancer.

• 한국인터넷방송통신학회논문지
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• 제16권3호
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• pp.203-211
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• 2016

유전자 코드는 바이오 정보 처리에 키 포인트로 인체의 유기적인 조직체이다. 현대 과학에서는 유전자 코드 분자구조의 신비스러운 특성을 체계적으로 설명하고 이해하는데 연구가 집중되고 있다. 본 논문에서는 유전자 시스템을 대칭적으로 해석하는데 중점을 두었고, Jacket 행렬로 무잡음 RNA 유전자 코드를 가장 단순하게 해석했다. 이유는 Jacket 행렬과 RNA는 그 역행렬이 Element (Block)-wise Inverse로 그 역(Inverse)도 자신이란 점과 대칭적 성질, 그리고 Kronecker곱을 갖기 때문이다. 제안된 방법이 유전자 RNA 코돈(Codon : 괘(卦))의 견지에서 Jacket 행렬의 분해를 통해 간단하고 명료함을 보인다.

• 한국융합학회논문지
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• 제11권12호
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• pp.15-22
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• 2020

본 논문은 채널 강조(Channel Attentin)와 공간 강조(Spatial Attention) 방법을 결합한 딥 러닝 기반의 초해상도 방법을 제안하였다. 초해상도 과정에서 질감, 특징과 같은 주변 픽셀의 변화량이 큰 고주파 성분의 복원이 중요하다. 채널 강조와 공간 강조를 결합한 특징 강조를 이용한 초해상도 방법을 제안하였다. 기존의 CNN(Convolutional Neural Network) 기반의 초해상도 방법은 깊은 네트워크의 학습이 어려우며, 고주파 성분의 강조가 부족하여 윤곽선이 흐려지거나 왜곡이 발생한다. 문제를 해결하기 위해 스킵-커넥션(Skip Connection)을 적용한 채널 강조와 공간 강조를 결합한 강조 블록과 잔차 블록(Residual Block)을 사용하였다. 방법으로 추출한 강조된 특징 맵을 부-픽셀 컨볼루션(Sub-pixel Convolution)을 통해 특징맵을 확장하여 초해상도를 진행하였다. 이를 통해 기존의 SRCNN과 비교하여 약 PSNR는 5%, SSIM은 3% 향상되었으며 VDSR과 비교를 통해 약 PSNR는 2%, SSIM은 1% 향상된 결과를 보였다.

• 한국식품영양학회지
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• 제33권4호
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• pp.363-371
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• 2020

This study was designed to evaluate the improvement in exercise endurance by Hovenia dulcis fruit hot water extract (HDWE) for the potential application as a functional food material. The effect was based on the evaluation of the forced-swimming capacity and changes in biochemical parameters in mice. Six-week-old mice were classified into four groups based on a randomized block design: the negative control group, the HDWE 50 mg/kg body weight group, the HDWE 200 mg/kg body weight group, and the 1-octacosanol 50 mg/kg body weight group (n=8 mice per group). The swimming exercise time in the HDWE-50 group was increased at 545±43 sec compared to the control group at 263±28 sec. The HDWE-200 fatigue indicators, lactate acid and ammonia content, decreased to 4.99±0.33 mg/mL and 0.63±0.05 mg/mL, respectively. In addition, the content of glycogen in the liver and muscle tended to increase in the group administered HDWE but was not significant. Likewise, the LDH and glucose contents were increased compared to the control group. The muscle damage indicators ALT (52.7±2.6 U/L) and AST (42.5±5.2 U/L) tended to decrease compared to the control group (76.4±10.2 U/L).

• 대한수의학회지
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• 제41권1호
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• pp.37-42
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• 2001

This research was conducted to investigate the effects of far infrared radiological materials on growth performance, immune response and changes of microbial flora in feces for growing pigs. Twelve growing pigs($Duroc{\times}Yorkshire{\times}Landrace$, average initial body weight of $15.6{\pm}0.5kg$) were used in a 40 day growth assay. Treatments were control(saline injection with diet: S); saline injection with Bio-Plus in diet(SBP); and vaccination with Bio-Plus in diet(VBP) in a randomized complete block design with initial BW as the blocking criterion. Serum concentrations of IgG of SBP and VBP were higher than those of S at day 10(p<0.05), 20(p<0.05), 30(p<0.05) and 40(p<0.05). Pigs fed with treatment diets had increased lymphocyte level compared to S at day 20(p<0.05) and 40(p<0.05). Cortisol was lower in treatments than in S at day 30(p<0.05). At day 20, there was no significant difference in E. coli among the treatments. However, it was observed that E, coli of the treatments was decreased compared to S at day 40(p<0.01). Lactobacillus of SBP was significantly higher(p<0.05) than that of S at day 40. In conclusion, the results of the experiment suggest that far infrared radiological materials could be a very beneficial immune response for growing pigs in health aspects.

• Journal of Biosystems Engineering
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• 제38권1호
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• pp.33-40
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• 2013

Purpose: The goal of this study was to build an accurate digital factory that evaluates the performance of a factory using computer simulation. To achieve this goal, we evaluated the effect of worker-related variables on production in a simulation model using comparative analysis of two cases. Methods: The overall work process and worker-related variables were determined and used to build a simulation model. Siemens PLM Software's Plant Simulation was used to build a simulation model. Also, two simulation models were built, where the only difference was the use of the worker-related variable, and the total daily production analyzed and compared in terms of the individual process. Additionally, worker efficiency was evaluated based on worker analysis. Results: When the daily production of the two models were compared, a 0.16% error rate was observed for the model where the worker-related variables were applied and error rate was approximately 5.35% for the model where the worker-related variables were not applied. In addition, the production in the individual processes showed lower error rate in the model that included the worker-related variables than the model where the worker-related variables were not used. Also, among the total of 22 workers, only three workers satisfied the IFRS (International Financial Reporting Standards) suggested worker capacity rate (90%). Conclusions: In the daily total production and individual process production, the model that included the worker-related variables produced results that were closer to the real production values. This result indicates the importance of worker elements as input variables, in regards to building accurate simulation models. Also, as suggested in this study, the model that included the worker-related variables can be utilized to analyze in more detail actual production. The results from this study are expected to be utilized to improve the work process and worker efficiency.