• Journal of the Korea Institute of Building Construction
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• v.13 no.5
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• pp.434-440
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• 2013

Generally, the envelope of a freeform building is composed of a structure made with rectangular or C-shaped steel pipe, and steel or aluminum panel finishes on the structure. However, these construction methods increase material loss and cost and time. There are also numerous cases of misunderstanding of design and difficulties in construction, which frequently cause construction errors. Such construction errors decrease construction productivity, resulting in poor construction quality and the need for rework, as well as cost and time overruns. To solve the problem, this study proposes a 3D coordinate control technology for freeform structure implemented through a CNC(Computerized Numerical Control) Twisted tube method, and by extension, develops a BIM-based envelope construction method for freeform building.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4519-4525
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• 2014

Oleanolic acid (OA) is a nutritional component widely distributed in various vegetables. Although it has been well recognized for decades that OA exerts certain anti-tumor activity by inducing mitochondria-dependent apoptosis, it is still unclear that what molecular signaling is responsible for this effect. In this study, we employed cancer cell lines, A549, BXPC-3, PANC-1 and U2OS to elucidate the molecular mechanisms underlying OA anti-tumor activity. We found that activation of MAPK pathways, including p-38 MAPK, JNK and ERK, was triggered by OA in both a dose and time-dependent fashion in all the tested cancer cells. Activation was accompanied by cleavage of caspases and PARP as well as cytochrome C release. SB203580 (p38 MAPK inhibitor), but not SP600125 (JNK inhibitor) and U0126 (ERK inhibitor), rescued the pro-apoptotic effect of OA on A549 and BXPC-3 cells. OA induced p38 MAPK activation promoted mitochondrial translocation of Bax and Bim, and inhibited Bcl-2 function by enhancing their phosphorylation. OA can induce reactive oxygen species (ROS)-dependent ASK1 activation, and this event was indispensable for p38 MAPK-dependent apoptosis in cancer cells. In vivo, p38 MAPK knockdown A549 tumors proved resistant to the growth-inhibitory effect of OA. Collectively, we elucidated that activation of ROS/ASK1/p38 MAPK pathways is responsible for the apoptosis stimulated by OA in cancer cells. Our finding can contribute to a better understanding of molecular mechanisms underlying the antitumor activity of nutritional components.

• Journal of the Korean housing association
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• v.23 no.6
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• pp.49-59
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• 2012

This study suggested a new model in consideration of long life and constructability of apartment house suggested in the former part. New model suggested the possibility of cost saving based on the idea that people trend to reject because of the recognition that the new model would cost a lot of expense which work as the barrier for the expansion and distribution at the local market so as to prepare the ground for its activation. The Study was aimed at verifying the possibility of cost saving through comparing it with the existing standard apartment house system centered on the skeleton and cladding system among the new structural design models suggested in the former part. Assuming that these existing standard both models should be changed structural design into new model system, the quantity volume, cost and construction period along with the alteration of finished materials between two models were compared altogether. Simultaneously BIM library was built for easy taking-off bill of quantity and consideration of working methodology for construction working cycle, which was translated into construction cost so as to derive the cost of the two subject systems to be counted. Through the analysis, it was concluded that new model would secure variability in the future and constructability along with shortening the construction period (29%) and achieve cost saving (13%) of construction against the those of existing model.

• Journal of Internet Computing and Services
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• v.17 no.4
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• pp.87-93
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• 2016

Since aging population in Korea is rapidly progressing, the need for improving the life quality of the elderly has been increasing. Accordingly, in order to respond in a residential environment improvement and behavior change for the elderly, architecture design and construction methods have become converted into a modular construction method and various IT systems for the elderly have been proposed. Unlike current residential design techniques for the elderly in which architectural design techniques are performed separately with IT system design, the methodology for converging architectural design techniques with IT has not been discussed and proposed. Therefore, this paper extensively studies about requirements for converging architectural design techniques with IT such as elderly behavior, residential IT Service plan factor analysis, and residential modular construction method including IT services.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.2
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• pp.139-146
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• 2001

L-type $Ca^{2+}$ channels play an important role in regulating cytosolic $Ca^{2+}$ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated the role of some kinase activators and inhibitors in the regulation of the L-type $Ca^{2+}$ channel currents in rat pituitary $GH_3$ cells using the patch-clamp technique. Phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator, and vanadate, a protein tyrosine phosphatase (PTP) inhibitor, increased the $Ba^{2+}$ current through the L-type $Ca^{2+}$ channels. In contrast, bisindolylmaleimide I (BIM I), a PKC inhibitor, and genistein, a protein tyrosine kinase (PTK) inhibitor, suppressed the $Ba^{2+}$ currents. Forskolin, an adenylate cyclase activator, and isobutyl methylxanthine (IBMX), a non-specific phosphodiesterase inhibitor, reduced $Ba^{2+}$ currents. The above results show that the L-type $Ca^{2+}$ channels are activated by PKC and PTK, and inhibited by elevation of cyclic nucleotides such as cAMP. From these results, it is suggested that the regulation of hormone secretion by various kinase activity in $GH_3$ cells may be attributable, at least in part, to their effect on L-type $Ca^{2+}$ channels.

• Korean Journal of Computational Design and Engineering
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• v.12 no.2
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• pp.137-145
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• 2007

This paper concerns about residential environment analysis program implementation for design and analysis on public housing complexes such that view and daylight analysis processes are automated and integrated into existing design routine to achieve better design efficiency. Considering the architectural design trends this paper chooses ArchiCAD as a platform for a CAD system, which contains the concepts such as integrated object-oriented CAD, virtual building and BIM. Residential environment analysis system consists of three components. The first component is the 3D modeling part defining 3D form information for external geographic contour models, site models and interior/exterior of apartment buildings. The second is the parametric library part handling the design parameters for view and daylight analysis. The last is the user interface for the input/output and integration of data for the environment analysis. Daylight analysis shows rendered images as well as results of daylight reports and grades per time and performs the calculations for floor shadow. It separates the site-only analysis from the analysis of site and exterior environmental parameters. View analysis considers horizontal and vertical view angles to produce view image from each unit and uses the bitmap analysis method to determine opening ratio, scenery ratio and void ratio. We could expect better performance and precision from this residential environment analysis system than the existing 2D drawing based view and daylight analysis methods and overcome the existing one-way flow of design information from 3D form to analysis reports so that site design modifications are automatically reflected on analysis results. Each part is developed in a module so that further integration and extension into other related estimation and construction management systems are made possible.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.33 no.4
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• pp.245-253
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• 2020

In this study, natural frequencies are compared using several pile-soil interaction (PSI) models to evaluate the effects of each model on resonance safety checks for a monopile type of wind turbine structure. Base spring, distributed spring, and three-dimensional brick-shell models represented the PSIs in the finite element model. To analyze the effects of the PSI models on a natural frequency, after a stiffness matrix calculation and Winkler-based beam model for base spring and distributed spring models were presented, respectively; natural frequencies from these models were investigated for monopiles with different geometries and soil properties. These results were compared with those from the brick-shell model. The results show that differences in the first natural frequency of the monopiles from each model are small when the small diameter of monopile penetrates hard soil and rock, while the distributed spring model can over-estimate the natural frequency for large monopiles installed in weak soil. Thus, an appropriate PSI model for natural frequency analyses should be adopted by considering soil conditions and structure scale.

• Journal of Digital Contents Society
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• v.18 no.1
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• pp.63-70
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• 2017

Recently, as user feedback such as social reading become active, demand has been increased on e-book contents making which is based on user feedback. However, to reflect the user feedback onto the e-book, direct coding is required, which was difficult to the author who was not good at programming. To resolve this problem, Block assembly style feedback editor system, using Blockly was developed. This editor enables to reflect the user feedback by area allocation, component allocation, block editing, and code generating insertion, contrary to the existing way of programming realization in which direct coding was required for input, processing and output separately. This system was developed by using HTML. Javascript, PHP, and Codeigniter. Block editing is enabled to do provision and assembly of blocks by Blockly. The function of code generation & insertion allows to insert the Library function code. Through this system, the general users who are not capable of coding also can reflect feedback without doing actual coding.

• Smart Structures and Systems
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• v.20 no.2
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• pp.163-173
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• 2017

Structural health monitoring (SHM) of civil infrastructure using fiber Bragg grating sensor networks (FBGSNs) has received significant public attention in recent years. However, there is currently little research on the health-monitoring technology of high-piled wharfs in coastal ports using the fiber Bragg grating (FBG) sensor technique. The benefits of FBG sensors are their small size, light weight, lack of conductivity, resistance corrosion, multiplexing ability and immunity to electromagnetic interference. Based on the properties of high-piled wharfs in coastal ports and servicing seawater environment and the benefits of FBG sensors, the SHM system for a high-piled wharf in the Tianjin Port of China is devised and deployed partly using the FBG sensor technique. In addition, the health-monitoring parameters are proposed. The system can monitor the structural mechanical properties and durability, which provides a state-of-the-art mean to monitor the health conditions of the wharf and display the monitored data with the BIM technique. In total, 289 FBG stain sensors, 87 FBG temperature sensors, 20 FBG obliquity sensors, 16 FBG pressure sensors, 8 FBG acceleration sensors and 4 anode ladders are installed in the components of the back platform and front platform. After the installation of some components in the wharf construction site, the good signal that each sensor measures demonstrates the suitability of the sensor setup methods, and it is proper for the full-scale, continuous, autonomous SHM deployment for the high-piled wharf in the costal port. The South 27# Wharf SHM system constitutes the largest deployment of FBG sensors for wharf structures in costal ports to date. This deployment demonstrates the strong potential of FBGSNs to monitor the health of large-scale coastal wharf structures. This study can provide a reference to the long-term health-monitoring system deployment for high-piled wharf structures in coastal ports.

• Journal of Microbiology and Biotechnology
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• v.22 no.1
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• pp.50-57
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• 2012

Phospholipase C-${\gamma}l$ (PLC-${\gamma}l$) expression is associated with cellular transformation. Notably, PLC-${\gamma}$ is up-regulated in colorectal cancer tissue and breast carcinoma. Because exotoxins released by Clostridium botulinum have been shown to induce apoptosis and promote growth arrest in various cancer cell lines, we examined here the potential of Clostridium difficile toxin A to selectively induce apoptosis in cells transformed by PLC-${\gamma}l$ overexpression. We found that PLC-${\gamma}l$-transformed cells, but not vector-transformed (control) cells, were highly sensitive to C. difficile toxin A-induced apoptosis and mitotic inhibition. Moreover, expression of the proapoptotic Bcl2 family member, Bim, and activation of caspase-3 were significantly up-regulated by toxin A in PLC-${\gamma}l$-transformed cells. Toxin A-induced cell rounding and paxillin dephosphorylation were also significantly higher in PLC-${\gamma}l$-transformed cells than in control cells. These findings suggest that C. difficile toxin A may have potential as an anticancer agent against colorectal cancers and breast carcinomas in which PLC-${\gamma}l$ is highly up-regulated.