• Tunnel and Underground Space
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• v.27 no.6
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• pp.343-350
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• 2017

Amid increasingly saturated ground space, development of underground space has been booming throughout the world and excavation has been underway near the structure above or under the ground level. But the ground subsidence caused by improper or poor construction technologies, underground water leakage, sudden changes of stratum and the problem with earth retaining system component has been emerged as hot social issue. To deal with such problems nationwide, establishment of preventive and proactive disaster management and rapid restoration system has been pushed now. In this study, collection of the data on technology development trend to secure the underground safety was made, taking into account of internal change elements (changing groundwater level, damage to underground utilities, etc) and external change elements (vehicle load, earthquake and ground excavation, etc) during excavation. Amid the growing need of ground behavior analysis, ground subsidence evaluation technology, safe excavation to prevent ground subsidence and reinforcement technology, improvement of rapid restoration technology in preparation for ground subsidence and development of independent capability, this study is intended to introduce the technology development in a bid to prevent the ground subsidence during excavation. It's categorized into prediction/evaluation technology, complex detect technology, waterproof reinforcement technology, rapid restoration technology and excavation technology which, in part, has been in process now.

• Fire Science and Engineering
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• v.31 no.6
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• pp.33-39
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• 2017

Composite panel refers to the particular plywood produced in a way of stacking the different kinds of material in sandwich form and adhering them using adhesives and is widely used as building material for its constructability and cost efficiency. But as the surface is finished with steel plate, fire extinguishing agent cannot reach to the core material because of such steel plate on surface which causes the difficulties in suppressing the fire as well as in fire-fighting activities due to collapse. This study, to deal with such problem, is intended to set the fire pipe in core material to prevent the fire from spreading and in a bid to achieve this using minimized fire water, water supply test device was fabricated to estimate the required water flow of fire extinguisher and consequently, optimal water flow (0.5 L/min) was determined through a full-scale fire test.

• The Journal of Internal Korean Medicine
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• v.28 no.3
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• pp.473-491
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• 2007

Objectives : This study was designed to investigate the antiproliferative activity of the water extract of Samgibopae-tang (SGBPT) in NCI-H460 and A549 non-small-cell lung cancer cell lines Methods : In this study, we measured the subsistence, form of NCI-H460 and A549 non-small-cell lung cancer cell by hemocytometer and DAPI staining. In each cell, we analyzed DNA fragmentation. reverse transcription-polymerase chain reaction and measured activity of caspase-3, caspase-8 and caspase-9. Results and Conclusions : We found that exposure of A549 cells to SGBPT resulted in growth inhibition in a dose-dependent manner. butSGBPT did not affect the growth of NCI-H460 cells. The antiproliferative effect by SGBPT treatment in A549 cells was associated with morphological changes. SGBPT treatment partially induced the expression of DR5 cells and the expression of Faswas markedly increased in both transcriptional and translational levels in A549 cells. SGBPT treatment partially induced the expression of Bcl-2, Bcl-XL and the expression of Bid was markedly decreased in translational levels in A549 cells. However, SGBPT treatment did not affect the expression of IAP family in A549 orNCI-H460 cells. SGBPT treatment partially induced the expression of caspase-3, caspase-8, caspase-9 activity which markedly increased in a dose-dependent manners in A549 cells. The fragmental development of PARP and ${\beta}$-catenin protein was observed in A549 cells by SGBPT treatment. SGBPT treatment induced the expression of PLC-${\gamma}1$ protein which decreased in A549 cells. SGBPT treatment partially induced the expression of DFF45/ICAD which markedly increased in a dose-dependent manner in A549 cells. Taken together. these findings suggested that SGBPT-induced inhibition of human lung carcinoma did not affect NCI-H460 cell growth. However, SGBPT-induced inhibition of human lung carcinoma A549 cell growth was associated with the induction of death receptor and mitochondrial pathway. The results provided important new insights into the possible molecular mechanisms of the anti-cancer activity of SGBPT.

• Biomolecules & Therapeutics
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• v.22 no.3
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• pp.184-192
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• 2014

${\beta}$-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in a variety of human cancer cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated. In this study, we investigated the effects of ${\beta}$-lapachone on the induction of apoptosis in human gastric carcinoma AGS cells. ${\beta}$-lapachone significantly inhibited cellular proliferation, and some typical apoptotic characteristics such as chromatin condensation and an increase in the population of sub-G1 hypodiploid cells were observed in ${\beta}$-lapachone-treated AGS cells. Treatment with ${\beta}$-lapachone caused mitochondrial transmembrane potential dissipation, stimulated the mitochondria-mediated intrinsic apoptotic pathway, as indicated by caspase-9 activation, cytochrome c release, Bcl-2 downregulation and Bax upregulation, as well as death receptor-mediated extrinsic apoptotic pathway, as indicated by activation of caspase-8 and truncation of Bid. This process was accompanied by activation of caspase-3 and concomitant with cleavage of poly(ADP-ribose) polymerase. The general caspase inhibitor, z-VAD-fmk, significantly abolished ${\beta}$-lapachone-induced cell death and inhibited growth. Further analysis demonstrated that the induction of apoptosis by ${\beta}$-lapachone was accompanied by inactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. The PI3K inhibitor LY29004 significantly increased ${\beta}$-lapachone-induced apoptosis and growth inhibition. Taken together, these findings indicate that the apoptotic activity of ${\beta}$-lapachone is probably regulated by a caspase-dependent cascade through activation of both intrinsic and extrinsic signaling pathways, and that inhibition of the PI3K/Akt signaling may contribute to ${\beta}$-lapachone-mediated AGS cell growth inhibition and apoptosis induction.

• Journal of Korean society of Dental Hygiene
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• v.10 no.5
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• pp.819-829
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• 2010

Objectives : The purpose of this study was to examine factors affecting the effective demand of workers for dental treatment in a bid to provide some information on the improvement of oral health. Methods : The subjects in this study were 255 workers who were engaged in the pharmaceutical industry. A self-administered survey was conducted, and the collected data were analyzed by a spss(statistical package for the social science) win 12.0 program to find out their demographic characteristics, oral health awareness, oral health behavior and factors for the choice of a dental institution. Results : 1. Concerning the level of oral health awareness, 47.0 percent were at a low level(0 to three scores), and 35.2 percent were at an intermediate level(four to six scores). 2. As to oral health behavior involving a daily mean toothbrushing frequency, they brushed their teeth 2.65 times per day on the average. The most widely utilized oral hygiene supply was mouth rinse. Regarding oral health status, 53.7 percent weren't in good dental health, and just 23.0 percent got a dental checkup on a regular basis. 45.8 percent of those who didn't get a dental checkup cited time constraints as the reason. 26.0 percent received oral health education, and 91.4 percent were aware of the necessity of a corporate incremental dental care system. 3. Marital status, age and the reliability of dental institutions made differences to their choice of a dental institution. 4. As for the relationship between oral health awareness and the factors for the choice of a dental institution, oral health awareness had a statistically significant positive correlation to the reliability of dental institutions. Conclusions : The above-mentioned findings suggest that oral health education enables workers to have a correct knowledge on oral health, to change their own oral health behavior and to make the right choice of a dental institution in consideration of their oral characteristics. They should be urged to get a regular dental checkup not to develop chronic oral diseases so that they couldn't have to receive first-aid dental treatment. To promote the oral health of workers, oral health care personnels available should be utilized, and the incremental dental care system should be more vitalized to cut down on their effective demand for dental treatment.

• Journal of Korean society of Dental Hygiene
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• v.10 no.5
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• pp.935-945
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• 2010

Objectives : The purpose of this study was to examine the knowledge of dental hygienists on infection control in dental office and their attitude toward that in a bid to provide some information on ways of enhancing the level of infection control in dental office. Methods : The subjects in this study were 220 dental hygienists who worked in dental hospitals and clinics in Busan and South Gyeongsang Province. A survey was conducted from May 17 to June 17, 2010, and the answer sheets from 183 respondents were analyzed with a SPSS WIN 12.0 program. Statistical data on frequency, percentage and mean were obtained, and t-test, Pearson correlation coefficient and one-way ANOVA were utilized. Results : They got a mean of $4.59{\pm}.68$ in six categories of infection control knowledge. They had the best knowledge on dental waste disposal, followed by hand washing, post-sterilization management, instrument disinfection and sterilization, surface management of dental equipment and wearing personal protective equipment. They got a mean of $3.99{\pm}.54$ in attitude, and they scored lowest in practice of surface management of dental equipment. Overall, they scored higher in every aspect of knowledge than in attitude(t=11.410, p=.0.000). There was the greatest gap between their knowledge and practice in surface management of dental equipment (t=13.885, p=0.000), and there was the smallest gap between their knowledge and practice in hand washing(t=5.460, p=0.000). And a positive correlation was found between knowledge and attitude, as better knowledge of infection control led to better attitude toward that(p<.001). Finally, concerning infection control knowledge and attitude by general characteristics, the presence or absence of infection control guidelines made differences to infection control knowledge, and infection control attitude was statistically significantly different according to infection control education experiences(t=6.501, p=.012) and the presence or absence of infection control guidelines(t=22.836, p=.000). Conclusions : In order to bolster infection control in dental office, the related system should be improved to legally require dental personnels to implement infection control. Every dental office must be furnished with infection control guidelines, and sustained education should be provided for dental hygienists to carry out infection control.

• Journal of Elementary Mathematics Education in Korea
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• v.12 no.2
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• pp.149-163
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• 2008

The purpose of this study was to investigate research trends of the articles in Math-Educational journals between 1998 and 2006 in a bid to discuss whether the articles evenly dealt with different fields and whether studies on elementary mathematics education were in line with the 7th national curricula. It's basically meant to determine some of the right directions for future research on elementary mathematics education. The articles included in Math-Educational journals during the selected period were analyzed to find out the theme, area, method and subjects of the studies and when the studies were conducted. After checking National Assembly Digital Library by inputting a keyword 'elementary mathematics', 235 articles were found, and a content analysis was carried out, and statistical data on percentage were obtained. The results of this study were as follows: First, there had been steady research efforts about elementary mathematics education, as 20 or 30 studies had been conducted on a yearly basis. Second, as for theme of research, the most common themes were instructional design and method(25.5%), and an analysis of curricula and textbook(15.3%) was the second most dominant theme. Third, regarding the area of study, the most widely investigated area was number and operation (30.0%), followed by character/expression(27.8%), figure (23.9%), regularity/function (8.9%), probability/statistics(5.6%), and measurement (3.9%). Fourth, concerning the method of research, didactical analysis(43.8%) was most prevalent, followed by quantitative research(29.8%), qualitative research(16.6%) and a combination of qualitative and quantitative approaches(9.8%). Fifth, as to subjects, many of the studies(21.7%) investigated upper graders. In conclusion, it has to be accomplished the impartial researches for the whole area in order to develop elementary mathematics education and attain the objects of the 7th national curricula.

• Journal of Internet Computing and Services
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• v.8 no.4
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• pp.105-117
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• 2007

In order to succeed in a bid or development, the project manager should estimate its cost and schedule more accurately in the early stage of the project. Usually, the nominal schedule of most projects can be derived from rule of thumb, first-order estimation practice, or ball-park schedule estimation table. But the rule-of-thumb models for the nominal schedule estimation are so various, and the first-order estimation practice does not provide sufficient information. So they do not help much to decide on the proper development effort and schedule for a particular size of project. This paper presents a statistical regression model for deciding the development effort and schedule of a project using the ball-park schedule estimation table. First, we have redefined such words suggested in the ballpark schedule estimation table as shortest possible schedule, efficient schedule and nominal schedule, Next, we have investigated the relationship between the development effort and the schedule. Finally, we have suggested a model for estimating the development effort and the more accurate schedule of such particular sizes of software as are not presented in the ball-park schedule estimation table. The experimental results show that our proposed regression analysis model decreases the mean magnitude of relative error by 2% at maximum. Also this model can estimated the development effort and schedule for a particular size of software.

• Korean Journal of Construction Engineering and Management
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• v.14 no.4
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• pp.24-34
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• 2013

Since 2004, the government decided to gradually introduce Actual Cost Data into cost estimate for improving problems of below-cost tendering and to reflect fair market price through competition and carry contract efficiently. However, there are many concerns that Actual Cost Data has not reflected real market price, even that has contributed to reduce the government's budget. General construction firm's burden for labor cost is imputed to specialty contractors and eventually it becomes construction worker's burden. Therefore, realization of Actual Cost Data is very important factor to settle this system. To understand realization level and make short term forecast, this paper drew construction group of which labor cost constitutes more than 95% of direct cost, and compares their Actual Cost Data with relevant skilled workers's unit wage and predicts using time series analysis. The bid price which is not be reflected market price accelerates work environment changes and leads to directly affect such as late disbursement of wages, bankruptcy to workers. Therefore this paper is expected to be used to the preliminary data for solving the problem and establishing improvement of Actual Cost Data.

• Journal of the Korean Geographical Society
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• v.31 no.4
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• pp.648-661
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• 1996

The traditional von Thunen model has various shortcomings. Perhaps the greatest dificiency is the model's sole emphasis on the production side of the economy;that is, the agricultural markets are rarely closed for demand. In thes paoer a closed model for a three-activity, two-dimensional economy is developed. Equillibrium solutions are generated for prices, land areas, and outputs. Comparative static analysis then follows. Attention is next given to a maximum expected-return model under environmental uncertainty. Land uses for the traditional model and the closed model are then compared.