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Multiple Genes Related to Muscle Identified through a Joint Analysis of a Two-stage Genome-wide Association Study for Racing Performance of 1,156 Thoroughbreds

  • Shin, Dong-Hyun;Lee, Jin Woo;Park, Jong-Eun;Choi, Ik-Young;Oh, Hee-Seok;Kim, Hyeon Jeong;Kim, Heebal
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.6
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    • pp.771-781
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    • 2015
  • Thoroughbred, a relatively recent horse breed, is best known for its use in horse racing. Although myostatin (MSTN) variants have been reported to be highly associated with horse racing performance, the trait is more likely to be polygenic in nature. The purpose of this study was to identify genetic variants strongly associated with racing performance by using estimated breeding value (EBV) for race time as a phenotype. We conducted a two-stage genome-wide association study to search for genetic variants associated with the EBV. In the first stage of genome-wide association study, a relatively large number of markers (~54,000 single-nucleotide polymorphisms, SNPs) were evaluated in a small number of samples (240 horses). In the second stage, a relatively small number of markers identified to have large effects (170 SNPs) were evaluated in a much larger number of samples (1,156 horses). We also validated the SNPs related to MSTN known to have large effects on racing performance and found significant associations in the stage two analysis, but not in stage one. We identified 28 significant SNPs related to 17 genes. Among these, six genes have a function related to myogenesis and five genes are involved in muscle maintenance. To our knowledge, these genes are newly reported for the genetic association with racing performance of Thoroughbreds. It complements a recent horse genome-wide association studies of racing performance that identified other SNPs and genes as the most significant variants. These results will help to expand our knowledge of the polygenic nature of racing performance in Thoroughbreds.

Fast Intra-Mode Decision for H.264/AVC using Inverse Tree-Structure (H.264/AVC 표준에서 역트리 구조를 이용하여 고속으로 화면내 모드를 결정하는 방법)

  • Ko, Hyun-Suk;Yoo, Ki-Won;Seo, Jung-Dong;Sohn, Kwang-Hoon
    • Journal of Broadcast Engineering
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    • v.13 no.3
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    • pp.310-318
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    • 2008
  • The H.264/AVC standard achieves higher coding efficiency than previous video coding standards with the rate-distortion optimization (RDO) technique which selects the best coding mode and reference frame for each macroblock. As a result, the complexity of the encoder have been significantly increased. In this paper, a fast intra-mode decision algorithm is proposed to reduce the computational load of intra-mode search, which is based on the inverse tree-structure edge prediction algorithm. First, we obtained the dominant edge for each $4{\times}4$ block from local edge information, then the RDO process is only performed by the mode which corresponds to dominant edge direction. Then, for the $8{\times}8$ (or $16{\times}16$) block stage, the dominant edge is calculated from its four $4{\times}4$ (or $16{\times}16$) blocks' dominant edges without additional calculation and the RDO process is also performed by the mode which is related to dominant edge direction. Experimental results show that proposed scheme can significantly improve the speed of the intra prediction with a negligible loss in the peak signal to noise ratio (PSNR) and a little increase of bits.

Development of Red Pepper Dryer -Simulation and Optimization- (고추 건조기(乾燥機)의 개발(開發)에 관한 연구(硏究) -시뮬레이션 및 최적화-)

  • Keum, D.H.;Choi, C.H.;Kim, S.Y.
    • Journal of Biosystems Engineering
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    • v.16 no.3
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    • pp.248-262
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    • 1991
  • Simulation model was developed to analyze drying process for tray type red pepper dryer and validated by experiments. This model could predict satisfactorily temperatures and moisture contents of red pepper and temperatures of drying air during drying. Optimize algorithm was developed to search control valiables (drying air temperature, air recycle ratio and air flow rate) of red pepper dryer based on a criterion of minimizing energy consumption under the constraint conditions that statisfied carotenoid retension of at least 210mg per 100g dry matter, the moisture content of bottom layer of 15% (d.b) and drying time of less than 35 hours. Step changes in drying air temperature and air recycle ratio were considered in the optimization. In single step in control variables, the difference of the moisture content between top layer and bottom layer was great and more fan power was required. As the drying trays were exchanged when the moisture content of bottom layer reached to 100% (d.b), fifty percent of energy was saved and the difference of moisture content was little. In double step changes in control variables, optimal conditions were found by changing the step when the moisture content of bottom layer reached to 100% (d.b) (about 19.8 hours from starting drying). Optimum air flow rate was $18.1cmm/m^2$. Optimum drying air temperature and air recycle ratio in the first step was $55.8^{\circ}C$ and 0.80, and in the second step $65.6^{\circ}C$ and 0.88, respectively. In triple step changes in control variables, the optimal conditions were found by changing the steps when the moisture content of bottom layer reached to 250% (d.b) and 150% (d.b). Optimal air temperatures were $66.2^{\circ}C$, $58.4^{\circ}C$ and $66.9^{\circ}C$, and optimal air recycle ratios were 0.778, 0.785, 0.862 at each step, respectively. Optimal air flow rate was $18.9cmm/m^2$. The best operating mode was triple step mode considering energy consumption, drying time, fan power, and quality of dried red pepper. When the triple step mode was used to dry the red pepper, the energy consumption was about 16.5%~57.2% less than that of the single step mode and the drying time was 6.6 hours shorter than that of the double step mode.

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Partial Dimensional Clustering based on Projection Filtering in High Dimensional Data Space (대용량의 고차원 데이터 공간에서 프로젝션 필터링 기반의 부분차원 클러스터링 기법)

  • 이혜명;정종진
    • The Journal of Society for e-Business Studies
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    • v.8 no.4
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    • pp.69-88
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    • 2003
  • In high dimensional data, most of clustering algorithms tend to degrade the performance rapidly because of nature of sparsity and amount of noise. Recently, partial dimensional clustering algorithms have been studied, which have good performance in clustering. These algorithms select the dimensional data closely related to clustering but discard the dimensional data which are not directly related to clustering in entire dimensional data. However, the traditional algorithms have some problems. At first, the algorithms employ grid based techniques but the large amount of grids make worse the performance of algorithm in terms of computational time and memory space. Secondly, the algorithms explore dimensions related to clustering using k-medoid but it is very difficult to determine the best quality of k-medoids in large amount of high dimensional data. In this paper, we propose an efficient partial dimensional clustering algorithm which is called CLIP. CLIP explores dense regions for cluster on a certain dimension. Then, the algorithm probes dense regions on a next dimension. dependent on the dense regions of the explored dimension using incremental projection. CLIP repeats these probing work in all dimensions. Clustering by Incremental projection can prune the search space largely and reduce the computational time considerably. We evaluate the performance(efficiency, effectiveness and accuracy, etc.) of the proposed algorithm compared with other algorithms using common synthetic data.

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Locating Microseismic Events using a Single Vertical Well Data (단일 수직 관측정 자료를 이용한 미소진동 위치결정)

  • Kim, Dowan;Kim, Myungsun;Byun, Joongmoo;Seol, Soon Jee
    • Geophysics and Geophysical Exploration
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    • v.18 no.2
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    • pp.64-73
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    • 2015
  • Recently, hydraulic fracturing is used in various fields and microseismic monitoring is one of the best methods for judging where hydraulic fractures exist and how they are developing. When locating microseismic events using single vertical well data, distances from the vertical array and depths from the surface are generally decided using time differences between compressional (P) wave and shear (S) wave arrivals and azimuths are calculated using P wave hodogram analysis. However, in field data, it is sometimes hard to acquire P wave data which has smaller amplitude than S wave because microseismic data often have very low signal to noise (S/N) ratio. To overcome this problem, in this study, we developed a grid search algorithm which can find event location using all combinations of arrival times recorded at receivers. In addition, we introduced and analyzed the method which calculates azimuths using S wave. The tests of synthetic data show the inversion method using all combinations of arrival times and receivers can locate events without considering the origin time even using only single phase. In addition, the method can locate events with higher accuracy and has lower sensitivity on first arrival picking errors than conventional method. The method which calculates azimuths using S wave can provide reliable results when the dip between event and receiver is relatively small. However, this method shows the limitation when dip is greater than about $20^{\circ}$ in our model test.

A Network Analysis of Ballistic Helmet Technology Keyword (방탄헬멧 기술분야 키워드에 대한 네트워크 분석)

  • Kang, Jinwoo;Park, Jaewoo;Kim, Jihoon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.4
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    • pp.311-316
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    • 2017
  • The network analysis method has emerged as a new methodology for various disciplines, due to its ability to provide a representative knowledge network of references, co-authors and keywords. Bulletproof technology is an interdisciplinary field involving various disciplines, such as material mechanics, structural mechanics, and ballistics, so it is essential to keep up with the recent trends in technological research. In this research, the recent R&D trends in the field of bulletproof materials were analyzed using keyword based network analysis. From the results, the core keywords were identified as 'Composite', 'Model' and 'Head' using the scholar search engine, google scholar. The centrality analysis for the core keywords showed that bulletproof technology has developed in 3 different areas, viz. material, structure and effects. To the best of our knowledge, this is the first application of (network analysis?) to bulletproof technology. Moreover, we are also convinced that the results of this study will be useful for defense technology planning and determining the direction of R&D in the field of bulletproof technology.

Exploring the Effective Herbal Prescription for Cognitive Disorder Treatment among Licensed Herbal Medicines in Korea - A Preliminary Study for Clinical Trial of Cognitive Disorders (기허가 한약제제를 대상으로 한 인지장애 치료 유효 약물 탐색 - 인지장애 임상연구를 위한 예비연구)

  • Seo, Young Kyung;Lee, Ji yoon;Oh, You Chang;Lee, Jung Jin;Li, Wei;Jeong, Yun Hee;Lee, Sun Joo;Go, Young Hoon;Jung, In Chul
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.33 no.4
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    • pp.207-218
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    • 2019
  • It is necessary to investigate the efficacy of commercial Korean herbal medicine for cognitive disorder. The purpose of this study is to select candidates among licensed herbal medicines that are expected to be effective in the treatment of cognitive disorders and can be used in future clinical trial. From laboratory experiments, we first found individual single herbal drugs that could be effective for cognitive disorder, and then through experts recommendation, selected five priorities of single herbal drug and obtained the information of the best herb as a combination of each herbal drug. To derive the final herbal prescriptions, we searched the KFDA drug information system for licensed herbal medicines containing each drug and its combination. As a result of laboratory experiments and experts recommendation, we found that the five effective single herbal drugs for cognitive disorders. They are Ginseng Radix, Acori Graminei Rhizoma, Cyperi Rhizoma, Coptidis Rhizoma, Pinelliae Rhizoma, Hoelen cum Pini Radix, and Rehmanniae Radix Preparata(Pinelliae Rhizoma, Hoelen cum Pini Radix, and Rehmanniae Radix Preparata were tied for $5^{th}$). And licensed herbal prescriptions derived from the planned search are Palbohoichoon-tang, Taehwa-hwan, Bosim-hwan, and so on. Among these, in consideration of the feasibility of research and possibility of success in development, Yukgunja-tang, Samhwangjichul-hwan can be selected as future study subjects. Through experimental studies and expert recommendations, we have derived herbal prescriptions that can be effective in treating cognitive disorders from licensed herbal medicines.

Analyzing Perceptions of Unused Facilities in Rural Areas Using Big Data Techniques - Focusing on the Utilization of Closed Schools as a Youth Start-up Space - (빅데이터 분석 기법을 활용한 농촌지역 유휴공간 인식 분석 - 청년창업 공간으로써 폐교 활용성을 중심으로 -)

  • Jee Yoon Do;Suyeon Kim
    • Journal of Environmental Impact Assessment
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    • v.32 no.6
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    • pp.556-576
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    • 2023
  • This study attempted to find a way to utilize idle spaces in rural areas as a way to respond to rural extinction. Based on the keywords "startup," "youth start-up," and "youth start-up+rural," start-up+rural," the study sought to identify the perception of idle facilities in rural areas through the keywords "Idle facilities" and "closed schools." The study presented basic data for policy direction and plan search by reviewing frequency analysis, major keyword analysis, network analysis, emotional analysis, and domestic and foreign cases. As a result of the analysis, first, it was found that idle facilities and school closures are acting importantly as factors for regional regeneration. Second, in the case of youth startups in rural areas, it was found that not only education on agriculture but also problems for residence should be solved together. Third, in the case of young people, it was confirmed that it was necessary to establish digital utilization for agriculture by actively starting a business using digital. Finally, in order to attract young people and revitalize the region through best practices at home and abroad, policy measures that can serve as various platforms such as culture and education as well as startups should be presented in connection with local residents. These results are significant in that they presented implications for youth start-ups in rural areas by reviewing start-up recognition for the influx of young people as one of the alternatives for the use of idle facilities and regional regeneration, and if additional solutions are presented through field surveys, they can be used to set policy goals that fit the reality.

Digital Archives of Cultural Archetype Contents: Its Problems and Direction (디지털 아카이브즈의 문제점과 방향 - 문화원형 콘텐츠를 중심으로 -)

  • Hahm, Han-Hee;Park, Soon-Cheol
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.17 no.2
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    • pp.23-42
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    • 2006
  • This is a study of the digital archives of Culturecontent.com where 'Cultural Archetype Contents' are currently in service. One of the major purposes of our study is to point out problems in the current system and eventually propose improvements to the digital archives. The government launched a four-year project for developing the cultural archetype content sources and establishing its related business with the hope of enhancing the nation's competitiveness. More specifically, the project focuses on the production of source materials of cultural archetype contents in the subjects of Korea's history. tradition, everyday life. arts and general geographical books. In addition, through this project, the government also intends to establish a proper distribution system of digitalized culture contents and to control copyright issues. This paper analyzes the digital archives system that stores the culture content data that have been produced from 2002 to 2005 and evaluates the current system's weaknesses and strengths. The summary of our findings is as follows. First. the digital archives system does not contain a semantic search engine and therefore its full function is 1agged. Second, similar data is not classified into the same categories but into the different ones, thereby confusing and inconveniencing users. Users who want to find source materials could be disappointed by the current distributive system. Our paper suggests a better system of digital archives with text mining technology which consists of five significant intelligent process-keyword searches, summarization, clustering, classification and topic tracking. Our paper endeavors to develop the best technical environment for preserving and using culture contents data. With the new digitalized upgraded settings, users of culture contents data will discover a world of new knowledge. The technology we introduce in this paper will lead to the highest achievable digital intelligence through a new framework.

The Effect of Data Size on the k-NN Predictability: Application to Samsung Electronics Stock Market Prediction (데이터 크기에 따른 k-NN의 예측력 연구: 삼성전자주가를 사례로)

  • Chun, Se-Hak
    • Journal of Intelligence and Information Systems
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    • v.25 no.3
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    • pp.239-251
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    • 2019
  • Statistical methods such as moving averages, Kalman filtering, exponential smoothing, regression analysis, and ARIMA (autoregressive integrated moving average) have been used for stock market predictions. However, these statistical methods have not produced superior performances. In recent years, machine learning techniques have been widely used in stock market predictions, including artificial neural network, SVM, and genetic algorithm. In particular, a case-based reasoning method, known as k-nearest neighbor is also widely used for stock price prediction. Case based reasoning retrieves several similar cases from previous cases when a new problem occurs, and combines the class labels of similar cases to create a classification for the new problem. However, case based reasoning has some problems. First, case based reasoning has a tendency to search for a fixed number of neighbors in the observation space and always selects the same number of neighbors rather than the best similar neighbors for the target case. So, case based reasoning may have to take into account more cases even when there are fewer cases applicable depending on the subject. Second, case based reasoning may select neighbors that are far away from the target case. Thus, case based reasoning does not guarantee an optimal pseudo-neighborhood for various target cases, and the predictability can be degraded due to a deviation from the desired similar neighbor. This paper examines how the size of learning data affects stock price predictability through k-nearest neighbor and compares the predictability of k-nearest neighbor with the random walk model according to the size of the learning data and the number of neighbors. In this study, Samsung electronics stock prices were predicted by dividing the learning dataset into two types. For the prediction of next day's closing price, we used four variables: opening value, daily high, daily low, and daily close. In the first experiment, data from January 1, 2000 to December 31, 2017 were used for the learning process. In the second experiment, data from January 1, 2015 to December 31, 2017 were used for the learning process. The test data is from January 1, 2018 to August 31, 2018 for both experiments. We compared the performance of k-NN with the random walk model using the two learning dataset. The mean absolute percentage error (MAPE) was 1.3497 for the random walk model and 1.3570 for the k-NN for the first experiment when the learning data was small. However, the mean absolute percentage error (MAPE) for the random walk model was 1.3497 and the k-NN was 1.2928 for the second experiment when the learning data was large. These results show that the prediction power when more learning data are used is higher than when less learning data are used. Also, this paper shows that k-NN generally produces a better predictive power than random walk model for larger learning datasets and does not when the learning dataset is relatively small. Future studies need to consider macroeconomic variables related to stock price forecasting including opening price, low price, high price, and closing price. Also, to produce better results, it is recommended that the k-nearest neighbor needs to find nearest neighbors using the second step filtering method considering fundamental economic variables as well as a sufficient amount of learning data.