• Title/Summary/Keyword: best dominant

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Association between a Genetic Variant of CACNA1C and the Risk of Schizophrenia and Bipolar I Disorder Across Diagnostic Boundaries (조현병과 제1형 양극성장애의 진단 경계를 넘어선 공통적 후보유전자로서의 CACNA1C에 대한 단일염기다형성 연합 연구)

  • Lee, Bora;Baek, Ji Hyun;Cho, Eun Young;Yang, So-Yung;Choi, Yoo Jin;Lee, Yu-Sang;Ha, Kyooseob;Hong, Kyung Sue
    • Korean Journal of Schizophrenia Research
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    • v.21 no.2
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    • pp.43-50
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    • 2018
  • Objectives : Genome-wide association studies (GWASs) and meta-analyses indicate that single-nucleotide polymorphisms (SNPs) in the a-1C subunit of the L-type voltage-dependent calcium channel (CACNA1C) gene increase the risk for schizophrenia and bipolar disorders (BDs). We investigated the association between the genetic variants on CACNA1C and schizophrenia and/or BDs in the Korean population. Methods : A total of 582 patients with schizophrenia, 336 patients with BDs consisting of 179 bipolar I disorder (BD-I) and 157 bipolar II disorder (BD-II), and 502 healthy controls were recruited. Based on previous results from other populations, three SNPs (rs10848635, rs1006737, and rs4765905) were selected and genotype-wise association was evaluated using logistic regression analysis under additive, dominant and recessive genetic models. Results : rs10848635 showed a significant association with schizophrenia (p=0.010), the combined schizophrenia and BD group (p=0.018), and the combined schizophrenia and BD-I group (p=0.011). The best fit model was dominant model for all of these phenotypes. The association remained significant after correction for multiple testing in schizophrenia and the combined schizophrenia and BD-I group. Conclusion : We identified a possible role of CACNA1C in the common susceptibility of schizophrenia and BD-I. However no association trend was observed for BD-II. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.

Appication of A Single Linear Reservoir Model for Flood Runoff Computation of Small Watersheds (소유역량의 홍수유출계산을 위한 단일선형 저수지 모형의 적용)

  • 김재형;윤용남
    • Water for future
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    • v.19 no.1
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    • pp.65-74
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    • 1986
  • The purpose of this study was to investigate the applicability of Single Linear Reservoir (SLR) model for runoff computations of small river basins in Korea. In the existing watershed flood routing methods the storage coefficient(K), which is the dominant parameter in the model, has been proposed to be computed in terms of the wqtershed characteristics. However, in the prsent study, the rainfall characteristics in addition to the watershed characteristics were taken into account in the multiple regression analysis for more accurate estimation of storage coefficient. The parameters finally adopted for the regressions were the drainge are, mean stream slope of the watershed, and the duration and total dffective amount of rainfalls. To verify the applicability of SLR model the computed results by SLR model with K determined by the regression equation were compared with the observed gydrographs, and also with those by other runoff computation methods; namely, the Clark method, nakayasu's synthetic unit hydrograph method and Nash model. The results showed that the present zSLR model gave the best results among these methods in the case of small river basins, but for the whatersheds with significant draingage area the Clark method gave the best results. However, it was speculated that the SLR model could also be accurately applied for flood compuatation in large wagersheds provided that the regression for storage coefficients were made with the actual data obtained in the large river basins.

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Identification of Bacteria Occurred Dominantly and Screening of Best VFAs Producing Bacteria in Food Waste Fermentation Process (음식물쓰레기 산발효공정에서 우점하는 세균의 동정 및 효율적인 VFA 생산을 유도하는 세균의 선별)

  • Kim, Tae-Ho;Cho, Hee-Kyung;Song, Young-Hoon;Ahn, Seoung-Koo
    • Journal of Korean Society of Environmental Engineers
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    • v.27 no.9
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    • pp.1016-1021
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    • 2005
  • We studied on screening and isolation of dominant bacteria in the food waste fermentation process and on effective production of VFAs by isolated bacteria. In the result of study, bacteria of twelve species were isolated by anaerobic medium. Among the 12 isolated species including Escherichia coli, Clostridium formicoaceticum, C. butyricum, C. acetobutyricum. E. coli and Clostridium spp. were occurred dominantly in the fermentation process and regarded as best VFAs producing bacteria. Acetic acid are produced 287 mg/gTS(8,176 mg/L) by E. coli in concentration of $6{\times}10^8\;cells/gTS$, 551 mg/gTS(15,715 mg/L) by Clostridium formicoaceticum in concentration of $5{\times}10^4\;cells/gTS$. Three times as much acetic acid were produced as blank. Butyric acid are produced 214 mg/gTS(6,106 mg/L) by C. butyricum in concentration of $2.5{\times}10^5\;cells/gTS$ and produced 254 mg/gTS(7,261 mg/L) by C. acetobutyricum of concentration of $1.5{\times}10^5\;cells/gTS$. Two times as much butyric acid were produced as blank.

A Study on the Influence of Multinational R&D Labs' Expansion Motives on Business Performance in China - Centered on a Mediating Effect of Control Levels - (중국내 다국적 기업 R&D 랩의 진출동기가 경영성과에 미치는 영향 - 통제수준의 매개효과를 중심으로 -)

  • JIN, XING;Cho, Dae-Woo
    • International Area Studies Review
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    • v.22 no.1
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    • pp.101-121
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    • 2018
  • This paper studies the influence of multinational R&D Labs' expansion motives on their business performance and the mediating effect of the level of control on this motive-performance relationship. Through an in-depth study of the relevant literature, the expansion motives can be divided into four general types. The first is called a market factor in the sense that the purpose of their expansion is to secure potential markets and customers in China. The second is called a resource factor; their purpose is to obtain excellent technology and a workforce from the country. The third is called an institution factor. An example is the case of R&D Labs advancing into China to make the best of its institutional advantages such as the government's benefits, related policies, and incentive articles. The last is called a strategic factor and indicates the case where they go into China for the purpose of competing in the market, considering it as a major strategic place. The companies' control level on their R&D Labs was measured for each item. According to the empirical analysis on the relevance of their control level and expansion motives, it turns out that giving a free hand to the Labs which pursue market, institutional, and strategic factors is more desirable than highly controlling them. This is because they should be familiar with the local business environment in consideration of those companies' objectives. In light of the mediating effects of the control level on expansion motives and business performance, the R&D Labs pursuing resource factors seem to need their headquarters' control to make the best use of the high-end technology obtained in the country. The companies pursuing strategic factors seem to hold a dominant position and perform more competitively when their headquarters control the Labs more tightly.

What makes Consumers to Prolong their Consumption on Perishable Food beyond Its Expiration Date?

  • Suh, Hyunsuk;Ju, Hyoungjun
    • Asia Marketing Journal
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    • v.15 no.2
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    • pp.133-173
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    • 2013
  • Consumers empty perfectly safe to intake perishable foods everyday if they are older than what prints on expiration date. The variation in expiration dating is freshness labeling represented in various terms such as sell by, package, best before, and so on. Regardless of the terms used and meanings are attached, consumers tend to conceive of freshness labeling on food as end of its shelf-life. Consequently, the food waste becomes a big issue for businesses in food sector. In an effort to demonstrate flexibility on this, KFDA(Korea Food & Drug Administration) introduced "best before" date in domestic market place to reduce food waste, based on the food safety test conducted by KCA(Korea Consumer Agency 2009). The results indicated freshness labeling on food should not be considered as the end of its life. Current study examined the underlying mechanisms(i.e. risk perception, self-construals, and indecisiveness) that influence consumers' intention on prolonged consumption of food beyond its stamped date when the KCA test results are shown to them. In addition, the moderating effect of regulatory focus is tested in the causal relationships between underlying mechanisms and different groups of prolonged consumption intention. Study participants are divided into three groups of prolonged consumption intention: no-change, moderate-change, and wide-change. The group with moderate-change in intention being as our point of reference, logistic regression analyses are conducted on 276 sample population. The results indicated that consumers with high source credibility risk are likely to show wide-change in intention on prolonged consumption while physical risk did not show significance. The consumers with independent self-construal are likely to show no-change in intention on prolonged consumption while interdependent self-construal did not show significance. Indecisiveness showed association a group with wide-change in intention on prolonged consumption. The moderating effect of regulatory focus showed valid results in most situations; the promotion-focused consumers showed wide-change in intention, while prevention-focused consumers showed no-change in intention. Furthermore, the moderating effect of promotion-focus showed a dominant position over the causal effect of indecisiveness in which decisive consumers(i.e. no-change in intention); if they are promotion-focused they tend show for the wide-change in intention instead. It is important to note that for those promotion-focused consumers(or situations), promotion-related arguments are more effective, while for those prevention-focused consumers(or situations) prevention- related arguments are more effective means of persuasion.

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Data Babe Development for Blue Jeans Marketing Strategy(Part ll) - Focused on Young Adult's Brand Awareness, Brand Image and Consumer's Seeking Image in Fall 1997- (진의류 마케팅 전략을 위한 데이타 베이스 구축에 관한 연구(제2보) -1997년 추계 신세대 진바지 소비자의 상표 인지도, 상표 이미지와 소비자의 추구이미지를 중심으로-)

  • 김칠순;이훈자
    • Journal of the Korean Society of Clothing and Textiles
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    • v.22 no.4
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    • pp.503-514
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    • 1998
  • The purpose of this study was to develop a large representative data base for jeans marketing strategy This study was to survey brand features(launching year, launching company, design concept, sales volume, and price zone) in the current market, and was to examine brand awareness and it's relationship to segmented distribution regions, demo- graphic variables(sex, age, monthly household income, and seasonal clothing expenditure). This study was also to analyze brand image and consumer's seeking image. The 660 questionnaires were distributed and 618 reliable ones were used for statistical analysis. A SAS statistical package including frequency table, Chi-square test, factor analysis, analysis of variance(ANOVA), Duncan's multiple range test and paired-t test was used. The results are as follows: 1. Brand awareness involves "brand recall" based on asking a person to name the brand recalled first, and "brand recognition" based on asking to identify brand name from 30 given brands. The result of recall brand test indicated that Levi's was dominant brand. People recognized about 70.8% of brands on the average. Brand recognition was influenced by segmented distribution region and demographic variables. 2. There was significantly positive relationship between brand recognition and purchasing behavior. 3. National brands were more recognized than Licensed brands. 4. The result showed that "Nix" was best represented for sophisticated brand image, "Strom" for characteristic, "Jambangee" for resonable price, and "Levi's" for classic '||'&'||' comfortable brand image. 5. As a result of factor analysis on consumer's seeking image, six factors(characteristic, young, intelligent/sexy, comfortable, exotic and popular) were found. Several factors had a relationship with preferred design, demographic variables, fashion interest, and brand recognition. variables, fashion interest, and brand recognition.

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Silicon wire array fabrication for energy device (실리콘 와이어 어레이 및 에너지 소자 응용)

  • Kim, Jae-Hyun;Baek, Seung-Ho;Kim, Kang-Pil;Woo, Sung-Ho;Lyu, Hong-Kun
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2009.06a
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    • pp.440-440
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    • 2009
  • Semiconductor nanowires offer exciting possibilities as components of solar cells and have already found applications as active elements in organic, dye-sensitized, quantum-dot sensitized, liquid-junction, and inorganic solid-state devices. Among many semiconductors, silicon is by far the dominant material used for worldwide photovoltaic energy conversion and solar cell manufacture. For silicon wire to be used for solar device, well aligned wire arrays need to be fabricated vertically or horizontally. Macroscopic silicon wire arrays suitable for photovoltaic applications have been commonly grown by the vapor-liquid-solid (VLS) process using metal catalysts such as Au, Ni, Pt, Cu. In the case, the impurity issues inside wire originated from metal catalyst are inevitable, leading to lowering the efficiency of solar cell. To escape from the problem, the wires of purity of wafer are the best for high efficiency of photovoltaic device. The fabrication of wire arrays by the electrochemical etching of silicon wafer with photolithography can solve the contamination of metal catalyst. In this presentation, we introduce silicon wire arrays by electrochemical etching method and then fabrication methods of radial p-n junction wire array solar cell and the various merits compared with conventional silicon solar cells.

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Steatocystoma multiplex: A case report of a rare entity

  • Shin, Nan-Young;Kang, Ju Hee;Kim, Jo-Eun;Symkhampa, Khantaly;Huh, Kyung-Hoe;Yi, Won-Jin;Heo, Min-Suk;Lee, Sam-Sun;Choi, Soon-Chul
    • Imaging Science in Dentistry
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    • v.49 no.4
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    • pp.317-321
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    • 2019
  • Steatocystoma multiplex is an uncommon benign skin disease, which typically manifests as numerous intradermal cysts that can be scattered anywhere on the body. Although usually asymptomatic, it can be significantly disfiguring. One type of steatocystoma multiplex is known to be associated with the autosomal dominant inheritance of a mutation in the gene coding for keratin 17 (KRT17). In such cases, it is often concurrent with other developmental abnormalities of the ectoderm-derived tissues, such as the nails, hair, and teeth. To the best of our knowledge, few cases have been reported of steatocystoma multiplex of the oral and maxillofacial region. This report describes a case of steatocystoma multiplex of both sides of the neck and multiple dental anomalies, with a focus on its clinical, radiological, and histopathological characteristics, as well as the possibility that the patient exhibited the familial type of this condition.

MODELING OF THE ZODIACAL LIGHT FOR THE AKARI MID-IR ALL-SKY DIFFUSE MAPS

  • Kondo, Toru;Ishihara, Daisuke;Kaneda, Hidehiro;Oyabu, Shinki;Amatsutsu, Tomoya;Nakamichi, Keichiro;Sano, Hidetoshi;Ootsubo, Takafumi;Onaka, Takashi
    • Publications of The Korean Astronomical Society
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    • v.32 no.1
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    • pp.59-61
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    • 2017
  • The AKARI 9 and 18 µm diffuse maps reveal the all-sky distribution of the interstellar medium with relatively high spatial resolution of ~6". The zodiacal light is a dominant foreground component in the mid-infrared. Thus, removal of the zodiacal light is a critical issue to study low surface brightness Galactic diffuse emission. We carried out modeling of the zodiacal light based on the Kelsall model which is constructed from the COBE data. In the previous study, only a time-varying component of the zodiacal light brightness was used for determination of the model parameters. However, there remains a residual component of the zodiacal light around the ecliptic plane even after removal with the model. Therefore, instead of using a time-varying component, we use the absolute brightness of the zodiacal light and we find that the new model can better remove the residual component. As a result, the best-fit model parameters are changed from those in the previous study. We discuss the properties of the zodiacal light based on our new result.

Comparative Analysis of Customer Feedback Metrics for Improving Predictability of Customer Loyalty (고객 충성도 예측력 제고를 위한 측정방법(CFM) 비교연구)

  • Kim, Joung-rae;Chung, Byoung-gyu
    • Journal of Venture Innovation
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    • v.1 no.2
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    • pp.61-73
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    • 2018
  • Many studies have focused on improving the predictability of influential variables in the area of customer services. For a long time, customer satisfaction index(CSI) were the best matrics of customer loyalty. In 2003, net promoter score(NPS) was introduced and in many cases this matrics was more predictive than CSI. In 2010, customer effort score(CES) was introduced and in the service areas this matrics was more predictive than CSI and NPS. This study compared with 3 matrics based on the criteria which composed of basic assumptions, time perspective, measuring items, objectives of matrics, application areas, and limitations of application. The dominant matric which was applied in all functions and industries was not exited. For the purpose of improving predictability, single or compound matrics are useful according to industries and usage.