• Journal of Chest Surgery
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• 제3권2호
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• pp.121-126
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• 1970

This is a report on a total of 8 cases of benign mediastinal tumors and cysts in Department of Thoracic Surgery, Chonnam University Hospital during the period from 1961 to 1969. The patients age was distributed between 18 and 38 year old with the highest incidence in the age group of second decade. Sex ratio of male to female was 3: 5. The tumors were classificed as follow; 3 case:, of neurogenic tumors, 2 cases of teratomas, one case of pericardial cyst, one case of cystic hygroma, and one case of brochogenic cyst. The symptomatic patients were 5 cases(62. 6%) and asymptomatic patients were 3 cases(37.5%). The symptomatic patients had the symptoms not referable to their lesion and the mediastinal tumors of asymptomatic patients were incidently found by routine chest X-ray. The Symptoms occurred by compression to adjacent nerve system in 3 cases. by perforation into the lung with infection in one case and by infection of bronchial cyst in one case. The complications were Pancoast's syndrome including Horner's syndrome(2 cases), middle lobe syndrome (one case), bro:1chial infection(one case) and intercostal neuralgia(one case). All tbe tumors were surgicai[y resectable with good recovery postoperatively. In 5 cases of the symptomatic patents, their symptoms were disappeared dramatically after operation.

• Journal of Veterinary Science
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• 제21권5호
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• pp.70.1-70.7
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• 2020

Background: Oral neoplasia has been reported to account for 6-7% of all canine cancer and 3% of all feline cancers. To the authors' knowledge the last epidemiologic analysis of general oral cancer in dogs and cats was published in 1976. Objectives: The goal of this study was to report contemporary demographic information regarding oral tumors in dogs and cats. Methods: Information was collected from cats or dogs diagnosed with oral neoplasia from the Veterinary Medical Data Base. Medical records representing cases that presented to one of 26 veterinary teaching hospitals from January 1, 1996 through December 31, 2017 were included. Results: A total of 1,810 dogs and 443 cats were identified. A total of 962 cases (53.6%) of canine oral tumors were classified as malignant and 455 cases as benign (25.4%). The majority of feline oral tumors were classified as malignant (257 cases, 58.1%) and only a few benign (11 cases, 2.5%). The incidence of oral tumors was calculated to be 4.9 per 1,000 dogs (0.5%) and 4.9 per 1,000 cats (0.5%). Conclusions: This incidence of oral tumors is considerably higher than previously reported in both dogs and cats. These results provide valuable information for generation of hypotheses for future investigations of breed-based and pathology-based oral neoplastic studies.

• 대한두경부종양학회지
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• 제10권1호
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• pp.46-52
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• 1994

This review is based on the 52 cases of salivary gland tumors treated at the department of surgerym Hallym University Kangdong Sacred Heart hospital during the period from March 1987 to May 1992. There were 43 benign and 9 malignant tumors. Twenty eight(54%) of these cases were located in the parotid gland, 14(27%) in the submandibular gland, the rest of 10 cases(19%) in the minor salivary glands. Female outnumbered male by the ratio 1.6:1. Pleomorphic adenoma was the most common tumor followed by carcinoma and adenolymphoma(Warthin's tumor). The most common presenting symptom in both benign and malignant tumors was palpable mass. However, some patients with malignancy presented symptoms such as pain, facial palsy and dysphagia. Among 9 cases with malignancies 3 cases were found to have metastasis in the regional lymphnodes and two cases had distant metastasis. In majority of benign parotid tumors, superficial parotidectomy was carried out. In three cases of carcinoma of parotid gland with lymphnode metastasis, total parotidectomy with radical neck dissection was done. One case out of two cases of carcinoma of submandibular gland was treated with total excision of the gland with radical neck dissection. There were no postoperative mortalies. Two cases each of facial palsies and wound infections were observed as complication.

• Journal of Chest Surgery
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• 제18권4호
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• pp.881-885
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• 1985

This report is an analysis of 183 cases of mediastinal tumors which were experienced in the Department of Thoracic and Cardiovascular Surgery, Yonsei Medical Center from January 1960 to June 1985. In this series, teratoma and neurogenic tumors were found to be the most frequent tumors [24.0%] histopathologically. Male to female sex distribution was 1.2 to 1 with the male predominant. The main clinical symptom was dyspnea, and there was no definitive symptom in 10.9% of all cases. In operating, all of the benign tumors were removed. The most frequent complication was wound infection. [13.7%].

• Maxillofacial Plastic and Reconstructive Surgery
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• 제22권2호
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• pp.217-232
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• 2000

The author studied on the 128 cases of benign odontogenic tumors which had been diagnosed with biopsy during the period of Jan. 1989 to Dec. 1998 at the Kyungpook National University Hospital, Yeungnam University Medical Center, Keimyung University Dongsan Medical Center, and Taegu Catholic Medical Center. This study contained the clinicostatistical analysis of the frequency in relation to sex, age, locations, chief complaints, duration, radiographic findings, recurrence, teeth, and treatment methods. The results were as follow : 1. Of a total of 128 benign odontogenic tumors, ameloblastomas(57 cases; 44.5%) and odontomas (44 cases ; 34.4%) mostly occupied. The other types of lesions were 8 calcifying odontogenic cysts, 7 benign cementoblastomas, 4 myxomas, 3 adenomatoid odontogenic tumors, 2 calcifying epithelial odontogenic tumors, 2 ameloblastic fibro-odontomas, and 1 odontogenic fibroma. 2. In age and sex distribution, benign odontogenic tumors occured slightly more often in males(53.9%) than females(46.1%) and the majority of cases(79.7%) were found during 2nd, 3rd, and 4th decade. 3. There was a predilection for mandibular lesions(mandible-maxilla ratio, 2.6 : 1). 4. The most common chief complaint was swelling(29.7%) and in respect to duration, the cases less than 1 year(50.0%) mainly appeared. 5. There were 7 cases(13.0%) of recurrence on ameloblastoma and there was no recurrence in the others. 6. In Ameloblastoma It commonly occured during 3rd and 4th decade(59.6%) and mean age was 30.2 years. The majority of cases were occurred in mandible(96.5%) , especially mandibular molar and angle area(71.9%). The most common chief complaint was swelling(47.4%) and in respect to duration, the cases less than 1 year(52.6%) mainly appeared. In relation to teeth, there were resorption of root(52.6%), displacement of teeth(31.6%), and in relation to impacted teeth(43.9%). There was higher recurrence rate in the cases by conservative treatment(14.7%) than radical treatment(10.0%). As regards radiographic findings, conservative treatments were prevalent in the cases of unilocular type(85.7%) as compared with multilocular type(48.5%). and there was higherrecurrence rate in the cases of multilocular type(18.2%) than unilocular type(4.8%). As regards the type of treatment in relation to age, conservative treatments were prevalent in patients younger than 20 years of age. 7. In Odontomas It commonly occured during 2nd decade(50.0%) and in maxillary anterior teeth(40.9%). The most common chief complaint was delayed retention and permanent impaction of teeth(72.7%), and most frequently associated with impacted teeth(79.5%).

• 대한영상의학회지
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• 제82권1호
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• pp.152-161
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• 2021

목적 CT나 MRI에서 이하선의 양성종양, 악성종양 및 염증 질환에서 나타나는 활경근 침윤의 빈도와 어떤 상황에서 잘 일어나는지 그 조건을 알아보고자 하였다. 대상과 방법 이하선에서 발생한 양성종양 314명, 악성종양 52명 그리고 염증 22명을 대상으로 하였다. CT나 MRI에서 활경근 침윤의 빈도 및 병변의 위치, 피막침범 유무, 국소성에 따른 활경근 침윤 유무를 후향적으로 알아보았다. 결과 활경근 침윤의 빈도는 양성종양에서 0%, 악성종양에서 19.2% (10/52), 염증 환자에서 50% (11/22)였다. 피막을 침범한 염증 환자 13명 중 10명에서 활경근 침윤을 보였다. 활경근 침윤을 보인 염증 환자 11명 중 10명이 미만성을, 1명은 국소성을 보였다. 활경근 침윤을 보인 악성종양 총 10명 모두에서 피막을 침범하였으며, 그중 미만성 병변이 7명, 국소성이 3명이었다. 결론 이하선 질환에서 활경근 침윤은 악성종양보다 염증 질환에서 더 흔하게 일어났다. 염증 질환에서의 활경근 침윤은 이하선 피막을 침범하거나 미만성 병변일 경우 더 잘 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3479-3482
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• 2013

Background: Proliferation markers widely have been used to diagnose and determine the behaviour and prognosis of benign and malignant tumours. Minichromosome maintenance 3 (MCM3) is a novel proliferation marker. The aim of this study was to evaluate and compare MCM3 with Ki-67 in diagnosis of salivary gland tumours. Materials and Methods: In this retrospective study, immunohistochemical expression of MCM3 and Ki-67 was evaluated in 15 pleomorphic adenomas (PA), 17 mucoepidermoid carcinomas (MEC) and 18 adenoid cystic carcinomas (ADCC). Labeling indices (LIs) for the two markers were calculated and compared. Results: MCM3 and Ki-67 LIs were significantly higher in MEC and ADCC compared to PA. The LI of MCM3 was significantly higher than that of Ki-67 in MEC and PA. There was no significant difference between the two markers in ADCC. A cut-off point of 8% with 74.3% sensitivity and 93.3% specificity for MCM3 was obtained to discern between benign and malignant tumors. Conclusions: These results suggest that MCM3 might be a useful proliferation marker for differential diagnosis and recognition of clinical behavior of salivary gland tumors.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2571-2576
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• 2012

Breast cancer is the first of the most common ten cancers in Iraq. Its etiology is multifactorial, oxidative stress and lipid peroxidation being suggested to play important roles in carcinogenesis. The purpose of this study was to investigate the oxidant-antioxidant status in breast cancer patients, by measuring SOD isoenzyme activities (total SOD, CuZn-SOD, Mn-SOD and EC-SOD) in plasma and breast tumors, and by estimating thiobarbituric reactive substances (TBRS) in tissue homogenates. General increase in total SOD activity was observed in plasma and tissue samples of breast tumors, greater in the malignant when compared to benign group (p<0.05). Mn-SOD showed a significant decrease in tissue malignant samples (p<0.05), and insignificant decrease in plasma malignant samples compared with control and benign samples. Plasma EC-SOD activity in both patient benign and malignant breast tumors demonstrated 3.5% and 22.8% increase, respectively. However, there was a decrease in tissue EC-SOD activity in malignant breast tumors when compared with benign. A similar tendency was noted for TBRS. We suggest that elevated total SOD might reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in the carcinogenesis process. If there is proteolytic removal of the heparin binding domain, EC-SOD will lose its affinity for the extracellular matrix and diffuse out of the tissue. This will result in a decreased EC-SOD activity, thus leading to an increase in the steady-state concentration of $O^{2-}$ in this domain, and increase in EC-SOD activity in the extracellular fluid. This might explain the results recorded here concerning the decrease in tissue EC-SOD activity and increase in plasma of breast cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9071-9075
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• 2014

Background: microRNAs are small non-coding RNA that control gene expression by mRNA degradation or translational inhibition. These molecules are known to play essential roles in many biological and physiological processes. miR-205 may be differentially expressed in head and neck cancers; however, there are conflicting data and localization of expression has yet to be determined. Materials and Methods: miR-205 expression was investigated in 48 cases of inflammatory, benign and malignant tumor tissue array of the neck, oronasopharynx, larynx and salivary glands by Locked Nucleic Acid in situ hybridization (LNA-ISH) technology. Results: miR-205 expression was significantly differentially expressed across all of the inflammatory, benign and malignant tumor tissues of the neck. A significant increase in miR-205 staining intensity (p<0.05) was observed from inflammation to benign and malignant tumors in head and neck tissue array, suggesting that miR-205 could be a biomarker to differentiate between cancer and non-cancer tissues. Conclusions: LNA-ISH revealed that miR-205 exhibited significant differential cytoplasmic and nuclear staining among inflammation, benign and malignant tumors of head and neck. miR-205 was not only exclusively expressed in squamous epithelial malignancy. This study offers information and a basis for a comprehensive study of the role of miR-205 that may be useful as a biomarker and/or therapeutic target in head and neck tumors.

• Nuclear Medicine and Molecular Imaging
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• 제41권6호
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• pp.553-560
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• 2007

목적: F-18 FDG PET은 근골격계 종양에서 양성과 악성병변을 감별하는 유용성에 대하여 다양한 결과가 보고되고 있다. 저자들은 F-18 FDG를 이용한 PET/CT로 근골격계 종양의 maxSUV를 분석하고 비교하여 유용성을 알아보았다. 대상 및 방법: 치료 전 46개 병소(연부 조직 종양 양성/악성 : 11/12, 골종양 양성/악성 9/14)에 대하여 F-18 FDG PET/CT를 시행하였으며, 조직학적 검사로 확진하였다. 악성과 양성을 구분하는 maxSUV 절단값은 연부 조직 종양에서는 4.1, 골종양에서는 3.05로 하였다. 결과: 연부 조직 종양에서 양성(R=11; maxSUV $3.4{\pm}3.2$)과 악성(n=12; maxSUV $14.8{\pm}12.2$) 간에 maxSUV는 통계학적으로 유의하게 (p<0.001) 차이가 있었다. 민감도와 특이도는 각각 83%, 91%였다. 그러나 골종양에서는 양성 종양(n=9; maxSUV $5.4{\pm}4.0$)과 악성 골종양(n=14; maxSUV $7.3{\pm}3.2$) 간에 통계학적으로 유의한 차이를 보이지 않았다. 연부 조직 종양에서는 결절성 근막염이 위양성으로 나타났고(maxSUV=12.4) 골종양에서는 섬유성 골이형성증과 랑게르한스세포 조직구증식증 2예 및 골모세포종이 있었다. 결론: 연부 조직 종양에서 maxSUV는 양성과 악성을 감별하는데 유용하였다. 그러나 골종양의 경우에는 maxSUV가 낮은 경우에는 악성을 배제할 수 있었으나, maxSUV가 높은 경우에는 조직학적으로 조직구나 섬유모세포 등이 포함된 종양의 감별진단을 고려하여야한다.