• 대한수의학회지
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• 제40권4호
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• pp.729-739
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• 2000

Echocardiography, vital signs, microfilaremia, and blood chemistry of 12 Jindo dogs naturally infected with canine heartworms (Dirofilaria immitis) were analysed and compared with those of 5 uninfected control Jindo dogs. Nine of the twelve infected dogs contained microfiaria in the peripheral blood, whereas the presence of adult heartworms in the pulmonary arteries and/or in the heart was detected from four dogs by echocardiography. Among the four echocardiography-positive dogs, two dogs also displayed evidence of heartworms in the right ventricle by echocardiography. Upon necropsy, a total of 547 adult worms was collected from the 12 infected dogs (av = 45.6, range = 9-166). Dogs with positive echocardiograpic images of heartworms contained 48, 74, 104 and 166 adult worms in the heart, pulmonary arteries and/or in the caudal vena cava (av. 98.0), whereas 9 to 39 worms (av. 19.4) were collected from those organs of dogs with negative echocardiography. Most heartworms were found in the right ventricle (438, 80%) at necropsy, whereas relatively fewer worms were found in the pulmonary arteries (96, 17.6%), and in the caudal vena cava (13, 2.4%). The necropsy findings on the location of adult worms significantly differed from the results of echocardiographic analysis in which the right ventricle of most dogs did not show the presence of heartworms. These results indicated that the adult heartworms had been located in the terminal branches of the pulmonary arteries when the host was alive, but the worms moved toward the right ventricle shortly after the heart of the infected dogs stopped beating. Microfilaremia in the peripheral blood was the highest in the blood samples collected at 10 pm. However, the correlation between the number of microfilaria and of adult worms was not observed. Clinical and vital signs of infected dogs did not show any significant difference before and after a 30 minute-exercise at 5 km/hr compared to those of uninfected control dogs.

• 한국통신학회논문지
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• 제35권2A호
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• pp.202-208
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• 2010

WDM/SCM-PON에서 상향 전송을 할 때 다수의 ONU가 단일 광 채널을 공유하여 다수의 신호를 전송할 경우에 수신부에서 잡음으로 작용하는 OBI가 발생하게 되어 전체 시스템의 성능을 악화시키기 때문에 OBI에 대한 문제 해결이 필수적인 과제이다. 본 논문은 SCM-PON에서 상향 전송을 할 때 발생하는 OBI를 헤테로다인 검출 방식으로 극복하는 새로운 방안을 제시하였다. 제안된 방식은 수신 광검출기 앞부분에 별도의 LD를 사용하여 heterodyne detection을 가능케 함으로써, OBI 성분을 검출신호와 구분되도록 하여 OBI로 인한 문제를 해결하는데 근거를 두고 있다. 또한, 가입자단에서 R-SOA를 사용함으로써 경제적인 저가형 ONU 구현을 가능케 하는 장점을 갖는다.

• 한국광학회지
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• 제18권1호
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• pp.56-65
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• 2007

이득 분산이 두 개의 복소 결합 DFB 영역과 위상조정 영역으로 구성되는 다중 영역 복소 결합 DFB 레이저에서 발진하는 두 모드의 비팅에 의한 self-pulsation (SP) 주파수와 출력 파워의 변조지수에 미치는 영향에 대하여 살펴보았다. 능동 영역의 이득이 최대가 되는 파장을 두 DFB 영역의 발진 모드의 파장 중심 또는 브래그 파장 중심에 위치시킨 경우가 특정 DFB 영역의 발진 모드의 파장 또는 브래그 파장에 위치시킨 경우에 비하여 두 DFB 영역의 브래그 파장 차이, ${\Dalta}{\lambda}_{B}$, 증가에 따른 두 발진 모드가 받는 이득 차이가 적게 발생하여 최대 SP 주파수가 크고, 변조지수 특성도 좋음을 볼 수 있었다. 또한 능동 영역의 이득이 최대가 되는 파장을 두 DFB 영역의 브래그 파장 중심에 위치시키는 경우가 발진 모드의 파장 중심에 위치시키는 경우에 비하여 더 큰 최대 SP 주파수를 얻을 수 있었고 변조지수 특성도 더 우수함을 볼 수 있었다.

• 보존과학연구
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• 통권24호
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• pp.187-213
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• 2003

Sungseonsa Temple site in Chungju city in Chungcheongbuk-doProvince is written in "Goryeosa" as a building for Queen Sinmyeongsunseong, the mother of Gwangjong in AD 954 in Goryeo Dynasty. The museum in Chungcheong University takes charge of the excavation for 3 times from 2000 to 2002 and identified that its construction was carried out till Joseon Dynasty. Among the iron artifacts from the first excavation such as a weeding hoe, a hand knife, a lock, two nails and a plow which had conservation treatments, the sample was collected. Its micro-structure and method of manufacture were investigated. Excavation report for those artifacts has not published yet, therefore, the date of each artifacts is not clearly confirmed. The samples were collected from each part of the objects and then embedded in epoxy resin and etched with nitric acid. The examination of its microstructure is carried out under the microscope and the hardness values were measured by Vickers hardness tester. From the results, some artifacts show different manufacture method sin the each parts. The forming processes of the iron weeding hoe and the iron sickle are similar but the blade of iron weeding hoe was strengthened by carbonization whereas the blade of the iron sickle was done by quenching. The hand knife and the nails were produced through almost same methods and shows similar microstructures. The hand knife seems to be made by repeated beating and folding in low temperature resulting in fine crystallization, but the nail shows large crystallization due to processes in high temperature. Lock is made of white cast iron, that does not show any heat treatment.

• 한국임상수의학회지
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• 제23권1호
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• pp.22-30
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• 2006

말의 근골격계 질환의 진단과 치유 경과 평가를 위한 체열촬영술의 유용성을 검토코자 실험적으로 유발한 감염성 관절염의 치료 과정을 조사하였다. 실험적으로 완관절에 감염성 관절염을 유발하여 항생제와 봉독으로 처치한 후, 치료 과정별로 임상검사, 실험실 검사, 방사선 검사와 병행하여 실시한 체열촬영술은 전반적으로 모든 진단 결과와 유사하게 나타났으며, 진단 시 조직에 대한 비접촉성, 비침습성 및 무통성 특성과 함께 치유경과를 시각화, 객관화하므로 효과적인 것으로 판단되었다. 따라서 말의 근골격계 질환의 체열학적 평가는 기존의 검사나 진단 영상 장치와 더불어 말의 근골격계 질환의 진단 및 치유경과 평가에 있어서 유용할 것으로 사료된다.

• 대한수의학회지
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• 제32권1호
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• pp.41-49
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• 1992

Higenamine is an Aconiti tuber derived compound whose chemical structure is 1-(4'-hydroxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline containing catechol ring and tetrahydroisoquinoline nucleus in its own structure, both of which are well known to have agonistic effects on adrenergic receptors. Using guinea-pig atria(rich in ${\beta}_1$-receptor) and treachea(rich in ${\beta}_2$-receptor), we studied pharmacological actions of higenamine on these organs with special interest of its relevancy of ${\beta}$-receptor selectivity. In order to further clarify its pharmacological characteristics, the influncences of pretreatment of reserpine or cocaine were also investigated. The results were summarized as follows : 1. Higenamine had remarkable chronotropic, inotropic and bronchodilator effects in guinea-pig spontaneously beating right atria, left atria and trachea, in dose-dependent manners. 2. All of above actions were blocked competitively by propranolol, which shows nonselectivity of higenamine on ${\beta}$-receptor. $pA_2$ values of propranolol against higenamine were 7.93, 7.76 and 8.46 in guinea-pig right atria, left atria and treachea, respectively. 3. Reserpine pretreatment(5mg/kg, ip, 24h) did not show my decrease in pharmacological actions of higenamine, which suggests higenamine has direct action on ${\beta}$-receptor not via catecholamine release. 4. Cocaine pretreatment$(1{\mu}M)$ had no influence on pharmacological actions of higenamine in contrast with nor epinephrine, which suggests there is no neuronal uptake mechanism of higenamine in the studied organ preparations.

• The Korean Journal of Physiology and Pharmacology
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• 제21권6호
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• pp.667-674
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• 2017

Angiotensin II (Ang II) is metabolized from N-terminal by aminopeptidases and from C-terminal by Ang converting enzyme (ACE) to generate several truncated angiotensin peptides (Angs). The truncated Angs have different biological effects but it remains unknown whether Ang-(4-8) is an active peptide. The present study was to investigate the effects of Ang-(4-8) on hemodynamics and atrial natriuretic peptide (ANP) secretion using isolated beating rat atria. Atrial stretch caused increases in atrial contractility by 60% and in ANP secretion by 70%. Ang-(4-8) (0.01, 0.1, and $1{\mu}M$) suppressed high stretch-induced ANP secretion in a dose-dependent manner. Ang-(4-8) ($0.1{\mu}M$)-induced suppression of ANP secretion was attenuated by the pretreatment with an antagonist of Ang type 1 receptor ($AT_1R$) but not by an antagonist of $AT_2R$ or $AT_4R$. Ang-(4-8)-induced suppression of ANP secretion was attenuated by the pretreatment with inhibitor of phospholipase (PLC), inositol triphosphate ($IP_3$) receptor, or nonspecific protein kinase C (PKC). The potency of Ang-(4-8) to inhibit ANP secretion was similar to Ang II. However, Ang-(4-8) $10{\mu}M$ caused an increased mean arterial pressure which was similar to that by 1 nM Ang II. Therefore, we suggest that Ang-(4-8) suppresses high stretch-induced ANP secretion through the $AT_1R$ and $PLC/IP_3/PKC$ pathway. Ang-(4-8) is a biologically active peptide which functions as an inhibition mechanism of ANP secretion and an increment of blood pressure.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.38-38
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• 2003

The electrical properties of neurons are produced by the coordinated activity of ion channels (Hille, 1992). $K^{+}$ channels play a key role in shaping action potentials and in determining neural firing patterns. Small conductance $Ca^{2+}$-activated $K^{+}$ (S $K_{Ca}$ ) channels are involved in modulating the slow component of afterhyperpolarization (AHP) (Kohler et al., 1996). Here we examine whether rat type 2 S $K_{Ca}$ (rSK2) channels can affect the shape of the action potential and the neural firing pattern, by overexpressing rat SK2 channels in Aplysia neuron R15. Our results show that rSK2 overexpression decreased the intraburst frequency and changed the regular bursting activity of neurons to an irregular bursting or beating pattern in R15, Furthermore, the overexpression of rSK2 channels increased AHP and reduced the duration of the action potential. Thus, our results suggest that ectopic S $K_{Ca}$ channels play an important role in regulating the filing pattern and the shape of the action potential.ntial.

• Tuberculosis and Respiratory Diseases
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• 제41권6호
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• pp.663-669
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• 1994

저자들은 Kartagener 증후군의 전형적인 특징인 내장 좌우역전증, 기관지 확장증 및 부비동염과 함께, 각각 폐암, 성인 호흡장애 증후군등을 동반한 2예를 포함한 4예를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다.

• 한국음향학회지
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• 제36권3호
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• pp.194-201
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• 2017

신라대종은 성덕대왕신종을 재현하려는 목적으로 제작 되었으며, 동일한 구조와 문양을 갖도록 복원되었다. 가장 어려운 문제는 성덕대왕신종의 소리에 걸 맞는 웅장하고 조화로운 타격음과 끊어질 듯 이어지는 여음의 맥놀이를 재현하는 것이었다. 특히 맥놀이는 주조과정에서 발생하는 제어 불가능한 미세 비대칭성에 기인하므로, 주조 전에는 그 특성을 예측하거나 제어할 수 없다. 본 연구에서는 주조 후 맥놀이의 조절 작업을 통하여 신라대종의 맥놀이가 강하고 적절한 주기를 갖도록 만드는 방법과 과정을 소개한다. 강한 맥놀이를 만드는 모드 쌍과 당좌의 배치 조건을 구하였고, 적절한 주기를 갖도록 종 내부의 두께를 국부적으로 감소시켰다. 이 작업은 등가 종을 이용한 시뮬레이션 결과에 따라 수행되었다. 그 결과 약하고 매우 길었던 초기의 맥놀이는 강하고 적절한 주기의 맥놀이로 만들어졌다.