• Journal of Dental Anesthesia and Pain Medicine
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• 제22권1호
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• pp.11-18
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• 2022

Background: The vasoconstrictive effect of epinephrine in local anesthetics affects the heart, which leads to hesitation among dentists in injecting local anesthetics into patients with cardiovascular disease. Due to its vasoconstrictive effects, the present study investigated the effects of vasopressin administration on cardiac function in rats. Methods: Experiment 1 aimed to determine the vasopressin concentration that could affect cardiac function. An arterial catheter was inserted into the male Wistar rats. Next, 0.03, 0.3, and 3.0 U/mL arginine vasopressin (AVP) (0.03V, 0.3V, and 3.0V) was injected into the tongue, and the blood pressure was measured. The control group received normal saline only. In Experiment 2, following anesthesia infiltration, a pressure-volume catheter was placed in the left ventricle. Baseline values of end-systolic elastance, end-diastolic volume, end-systolic pressure, stroke work, stroke volume, and end-systolic elastance were recorded. Next, normal saline and 3.0V AVP were injected into the tongue to measure their effect on hemodynamic and cardiac function. Results: After 3.0V administration, systolic blood pressures at 10 and 15 min were higher than those of the control group; they increased at 10 min compared with those at baseline. The diastolic blood pressures at 5-15 min were higher than those of the control group; they increased at 5 and 10 min compared with those at baseline. The preload decreased at 5 and 10 min compared to that at baseline. However, the afterload increased from 5 to 15 min compared with that of the control group; it increased at 10 min compared with that at baseline. Stroke volume decreased at 10 and 15 min compared with that of the control group; it decreased from 5 to 15 min compared with that at baseline. Stroke work decreased from 5 to 15 min compared with that of the control group; it decreased from 5 to 15 min compared with that at baseline. Conclusion: Our results showed that 3.0 U/mL concentration of vasopressin resulted in increased blood pressure, decreased stroke volume and stoke work, decreased preload and increased afterload, without any effect on myocardial contractility.

• 산업경영시스템학회지
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• 제35권4호
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• pp.55-62
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• 2012

In this study, it was observed through the ability of performing secondary tasks and baseline fetal heart rate how the supply of lavender, peppermint and highly concentrated oxygen (40%) affected distraction due to the performance of secondary tasks in the driving environment. Twelve male university students conducted secondary tasks while driving in the environments (6 in total) mixed and designed with oxygen concentration (21%, 40%) and the condition of odors (Normal, Lavender, Peppermint). The test was proceeded in order of stable state (5mins), driving (5mins), and secondary tasks (1min), and by extracting ECG data from every section by 30secs, the mean value of baseline fetal heart rate was calculated. As a result of analysis, in the ability of performing secondary tasks, a percentage of correct answers showed no difference in oxygen concentration and the condition of odors (p > 0.05). In performance completion time, a percentage of correct answers decreased showing a statistically significant difference in the condition of odors compared with the condition where odors were not provided (p < 0.05). As for baseline fetal heart rate, in the comparison between sections, while performing secondary tasks, it increased showing a significant difference compared with stable state and driving state (p < 0.05). The effect of interaction was observed in oxygen concentration and the condition of odors. When odors were not provided, baseline fetal heart rate decreased in 40% oxygen concentration compared with 21% oxygen concentration (p < 0.05), however, when peppermint was provided, it increased in 40% oxygen concentration compared with 21% oxygen concentration (p < 0.05). In conclusion, the fact that the condition of odors increased the ability of calculation, and when only the highly concentrated oxygen was provided, parasympathetic nerve system was activated, however, when highly concentrated oxygen was provided with peppermint at the same time, sympathetic nervous system (sns) was activated, which had a negative effect on the autonomic nervous system was drawn.

• 한국발생생물학회지:발생과생식
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• 제21권3호
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• pp.249-257
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• 2017

In a 12-week experiment, the rock bream, Oplegnathus fasciatus, and olive flounder, Paralichthys olivaceus, were investigated to determine the effects of starvation on their physiological parameters. The protein and DNA contents of the starved fish were significantly higher than the initial values and those of the fed fish. The RNA contents and RNA/DNA ratios of the fed fish were significantly higher than those of the other groups (P<0.05). The hematocrit, hemoglobin, red blood cells (RBC), and mean corpuscular volume (MCV) of the fed rock bream were significantly higher than at baseline (P<0.05), whereas the mean corpuscular hemoglobin concentration (MCHC) of the fed fish was lower than at baseline (P<0.05). The hematocrit, hemoglobin, RBC, and MCHC of the starved group were significantly lower than the baseline values, whereas the MCV of the starved group was significantly higher than the baseline value (P<0.05). No significant difference in alanine aminotransferase was observed between the fed fish and baseline, whereas the starved fish value was significantly higher than the baseline value (P>0.05). There were no significant differences in cortisol levels. However, the glucose level in the fed group was significantly higher than the baseline level and that in the starved group was significantly lower than the baseline level (P<0.05).

• 지구물리와물리탐사
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• 제18권3호
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• pp.97-104
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• 2015

한국지질자원연구원은 1982년부터 전국토를 대상으로 하는 장기 프로젝트인 항공 방사능 탐사 연구를 통하여 Total, K, U, Th 등의 4가지 방사능도를 지속적으로 작성, 발간하고 있으며, 머지않아 전국토에 대한 방사능 원소 이상도를 작성, 완료할 수 있을 것이다. 그러나 탐사 기간이 너무 길고, 탐사 조건이 일정하지 않아서 자료들이 물리적 의미에서 일관성이 부족하며, 더욱이 방사성 원소 K, U, Th들의 함량이 아니라 기계값인 count/sec로 표현되어 있어 자료들을 하나로 취합할 수 없으며, 국제 표준을 충족하지 못하므로 자료의 신뢰성이 낮고 유용성과 활용성이 제한적이다. 이러한 문제를 해결하기 위하여 인접한 두 도폭인 진천과 음성 지역에서 자료 맞춤(leveling)을 위한 baseline 시험탐사를 하였다. baseline 탐사에 의한 맞춤으로 조정된 방사능 원소 함량도는 절대적 의미를 갖는 단위의 방사능도이며, International Atomic Energy Agency (IAEA)의 국제 표준에 부합하는 자료로 변환되었기 때문에 표준적 자료로서 신뢰성이 높아졌다. 이 연구 과제를 통하여 마련된 자료 맞추기의 방법과 절차는 보유하고 있는 모든 방사능 자료를 표준화하고, 국제 기준에 부합시킴으로써 자료의 질과 신뢰성을 높이고 자료의 유용성과 활용성을 크게 향상시킬 것이며, 한국의 방사능 함량도를 취합, 발간할 수 있을 것이다.

• Asian-Australasian Journal of Animal Sciences
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• 제6권2호
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• pp.211-218
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• 1993

The effect of active immunization against porcine somatostatin (SRIF-14) on somatostation and somatotropin secretion profile in 18 gilts was investigated. Gilts were assigned to the following treatments: control (sham injection, n = 6); bovine serum albumin (BSA) (injection of BSA with bacterial protein adjuvant, n = 6); SRIF (injection of BSA-SRIF-14 conjugate with bacterial protein adjuvant n = 6). Serum SRIF and pST were assayed from the blood samples taken on day 7 after the last immunization injection. Anti-SRIF antibody titres were assayed in weekly samples two weeks after the initial immunization to one week after the last immunization. Results revealed that the immunization protocol used in the present investigation failed to produce antibodies capable of neutralizing endogenous somatostatin. In addition, the porcine somatotropin assay revealed no significant differences in baseline pST concentration, mean peak amplitude and number of peaks during a 24 h secretory period among SRIF, BSA and control treatment. There were also no differences in SRIF baseline concentration, peak amplitude, and number of peaks during a 24 h secretory period among any of the three treatments. Circulating concentrations of pST and pSRIF were highly correlated (r = -0.09). Furthermore, anti-SRIF antibody titre was not detected in the serum of the gilts actively immunized against SRIF. These data, collectively, suggest that the protocol employed in the present investigation for active immunization against SRIF is not an effective method for changing SRIF and pST secretion profiles of the gilt and thus to enhance performance.

• 대한방사선기술학회지:방사선기술과학
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• 제44권4호
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• pp.315-325
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• 2021

The purpose of this study is to investigate the changes in lipid proton (LP) composition according to the induced obese fatty liver and to use it as basic data for treatment and diagnosis of fatty liver in the future. The phantom study was conducted to identify differences between STEAM and PRESS Pulse sequences in LP concentration. A high-fat diet (60%) was administered to eight Sprague-Dawley rats to induce obesity and fatty liver disease. Baseline magnetic resonance imaging /spectroscopy data were obtained prior to the introduction of high-fat diet, and data acquisition experiments were performed after eight weeks using procedures identical to those used for baseline studies. The six lipid proton metabolites were calculated using LCModel software. The correlation between the fat percentage and each LP, revealed that the methylene protons at 1.3 ppm showed the highest positive correlation. The α-methylene protons to carboxyl and diallylic protons showed negative correlation with fat percentage. The methylene proton showed the highest increase in the LP; however, it constituted only 71.86% of the total LP concentration. The methylene proton plays a leading role in fat accumulation in liver parenchyma.

• 한국대기환경학회지
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• 제12권5호
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• pp.541-554
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• 1996

A set of 1994 data was analyzed to investigate the characteristics of background surface SO$_{2}$ concentrations at Kosan, Cheju Island, Korea. The SO$_{2}$ concentrations at Kosan site show a seasonal variation with a minimum(0.46 ppb) in summer, maximum(1.02 ppb) in spring and an annual mean of 0.83 ppb. These values were 4-7 times higher than those measured in other remote areas, such as Bermuda and Oki Island, but they were similar to the baseline concentrations of other sites in the world. The diurnal variation of SO$_{2}$ concentrations was very small and it shows a peak at 10 am in spring and fall, 2 pm in summer, and 1 pm in winter, respectively. Correlations between local meteorological parameters and SO$_{2}$ concentrations were mot significant. This suggests that the variations of the Kosan's SO$_{2}$ comcentrations were relatively independent on local meteorological variables. Backward trajectory analysis results showed that the seasonal variation of the OS$_{2}$ concentration was mainly due to the inflow of air masses from the continent in spring and from the Pacific Ocean im summer. The results also revealed that the air masses with the highest SO$_{2}$ concentration came through China or the Korea peninsula in spring and through Japan during summer. It was found that the SO$_{2}$ concentrations at Kosan were under the influence of passage of air masses arriving at this site.

• 한국농공학회논문집
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• 제52권3호
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• pp.57-64
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• 2010

The impacts of climate change on yield and evapotranspiration of rice have been modeled using AquaCrop model developed by Food and Agriculture Organization (FAO). Climate change scenario downscaled by Mesoscale Model 5 (MM5) regional model from ECHO-G General Circulation Model (GCM) outputs by Korea Meteorological Research Institute (METRI) was used in this study. Monthly average climate data for baseline (1971-2000) and three time periods (2020s, 2050s and 2080s) were used as inputs to the AquaCrop model. The results showed that the evapotranspiration after transplanting was projected to increase by 4 % (2020s), 8 % (2050s) and 14 % (2080s), respectively, from the baseline value of 464 mm. The potential rice yield was 6.4 t/ha and water productivity was 1.4 kg/$m^3$ for the baseline. The potential rice yield was projected to increase by 23 % (2020s), 55 % (2050s), and 98 % (2080s), respectively, by the increased photosynthesis along with the $CO_2$ concentration increases. The water productivity was projected to increase by 19 % (2020s), 44 % (2050s), and 75 % (2080s), respectively.

• Nutritional Sciences
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• 제9권1호
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• pp.42-47
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• 2006

It has been reported that taking a proper amount of calcium and vitamin D helps to increase bone mineral density (BMD) and is effective in decreasing the risk of osteoporosis. This study investigated the supplementary effects of calcium and vitamin D on postmenopausal women who had osteoporosis and used calcium and vitamin D supplements. The study subjects consisted of osteoporotic postmenopausal women who were recruited from the Department of Orthopedics in a university-affiliated hospital. Sixty-seven study subjects were orally administrated 1,000 mg of calcium (calcium carbonate) and 2.5 mg of active vitamin D (1-$\alpha$ hydroxyvitamin D) (cholecalciferol 250 IU) twice a day for a year and a half. BMD and biochemical markers were evaluated and repeated every six months. One year after the intervention test, the bone mineral density of the lumbar spine was significantly increased as compared to the baseline. Six months after supplement administration, the level of serum alkaline phosphatase began to decrease, and afterwards a significant difference was maintained Concentration of 1, 25-dihydroxy-vitamin D at 1.5 years was higher than that of the baseline. In comparison with that of the baseline, the level of urinary hydroxyproline in the study subjects over six months was significantly decreased This study continued that effects such as BMD improvement and changes in biochemical markers appeared at least one year after administration of supplements.

• Journal of Pharmaceutical Investigation
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• 제23권3호
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• pp.165-177
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• 1993

The relationship between the plasma haloperidol (HP) concentration and clinical response, and the effects of its active metabolite, reduced haloperidol (RH) on clinical response of HP were investigated in schizophrenic patients. In clinical study I, with 17 schizophrenic patients (male 8, fermale 9) who were administered with three different fixed doses of HP (15, 30 and 50 mg/day) for 3 weeks, the concentrations of HP and RH in plasma and blood and clinical response had been checked before and every week during the study. The clinical response was evaluated by the method of brief psychiatric rating scale (BPRS), and relative improvement of clinical response based on baseline BPRS (before drug treatment) was calculated. The concentrations of HP and RH in plasma and blood were assayed by HPLC. In clinical study II, the plasma RH/HP concentration ratios were checked in 11 patients who were administered with high doses of HP, over 60 mg a day, because of the poor clinical response at usual doses of HP. Plasma HP concentration and relative improvement of BPRS at 3 week in schizophrenic patients showed a 'curvilinear' relationship, and the clinical response was improved relatively over 50% based on the baseline BPRS in the range of $5{\sim}57\;ng/ml $ of HP in plasma. Also, the plasma RH concentrations were increased nonlinearly as the plasma HP concentration increased, and in high plasma HP concentration, over 30 ng/mI, clinical response gradually decreased, while the plasma RH/HP concentration ratio increased nonlinearly. Blood partition coefficients of HP and RH were not changed according to daily HP dose and duration of drug therapy. From these results, it is noted that the higher plasma RH/HP concentration ratio, resulted from the accumulation of RH as HP concentration increased, might explain the 'curvilinear' decrease of HP clinical response.