• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8235-8238
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• 2016

Background: Lung cancer is one of the most common types of cancer causing high morbidity and mortality worldwide. An increasing incidence of lung cancer has been observed in India. Objectives:To evaluate the clinicpathological profile and haematological abnormalities associated with lung cancer in Bangalore, India. Materials and Methods: This prospective study was carried out over a period of 2 years. A total of 96 newly diagnosed and histopathologically confirmed cases of lung cancer were included in the study. Results: Our lung cancer cases had a male to female ratio of 3:1. Distribution of age varied from 40 to 90 years, with a major contribution in the age group between 61 and 80 years (55.2%). Smoking was the commonest risk factor found in 69.7% of patients. The most frequent symptom was cough (86.4%) followed by loss of weight and appetite (65.6%) and dyspnea (64.5%). The most common radiological presentation was a mass lesion (55%). The most common histopathological type was squamous cell carcinoma (47.9%), followed by adenocarcinoma (28.1%) and small cell carcinoma (12.5%). Distant metastasis at presentation was seen in 53.1% patients. Among the haematological abnormalities, anaemia was seen in 61.4% of patients, leucocytosis in 36.4%, thrombocytosis in 14.5% and eosinophilia in 19.7% of patients. Haematological abnormalities were more commonly seen in non small cell lung cancer. Conclusions: Squamous cell carcinoma was found to be the most common histopathological type and smoking still remains the major risk factor for lung cancer. Haematological abnormalities are frequently observed in lung cancer patients, anaemia being the commonest of all.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6095-6098
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• 2014

Background:Cervical cancer is potentially the most preventable and treatable cancer. Despite the known efficacy of cervical screening, a significant number of women do not avail themselves of the procedure due to lack of awareness. Objectives: This study was conducted to elicit information on the knowledge, attitude and practice (KAP) regarding screening (Pap test) and vaccination for carcinoma cervix among female doctors and nurses in a tertiary care hospital in Bangalore and to assess barriers to acceptance of the Pap test. Materials and Methods: A cross-sectional, descriptive study was conducted with semi-structured, self-administered questionnaire among female health professionals. The study subjects were interviewed for KAP regarding risk factors for cancer cervix, Pap test and HPV vaccination for protection against carcinoma cervix. Results: Higher proportion of doctors 45 (78.9%) had very good knowledge as compared to only 13 (13.3%) of the nurses, about risk factors for cancer cervix and Pap test (p=0.001). As many as 138(89.6%) of the study subjects had favorable attitude towards Pap test and vaccination, but 114 (73.6%) of the study subjects never had a Pap test and the most common reason 35 (31%) for not practicing was absence of disease symptoms. Conclusions: In spite of good knowledge and attitudes towards cancer cervix and Pap test being good, practice remained low among the study subjects and most common reasons for not undergoing Pap test was absence of disease symptoms. The independent predictors of ever having a Pap test done was found to be the occupation and duration of married life above 9yrs. Hence there is a strong need to improve uptake of Pap test by health professionals by demystifying the barriers.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1891-1898
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• 2016

Imperata cylindrica, a tall tufted grass which has multiple pharmacological applications is one of the key ingredients in various traditional medicinal formula used in India. Previous reports have shown that I. cylindrica plant extract inhibited cell proliferation and induced apoptosis in various cancer cell lines. To our knowledge, no studies have been published on the effect of I. cylindrica leaf extract on human oral cancers. The present study was undertaken in order to evaluate the anticancer properties of the leaf extract of I. cylindrica using an oral squamous cell carcinoma cell line SCC-9 as an in vitro model system. A methanol extract from dried leaves of I. cylindrica (ICL) was prepared by standard procedures. Effects of the ICL extract on the morphology of SCC-9 cells was visualized by microscopy. Cytotoxicity was determined by MTT assay. Effects of the ICL extract on colony forming ability of SCC-9 cells was evaluated using clonogenic assay. Cell cycle analysis was performed by flow cytometry and induction of apoptosis was determined by DNA fragmentation assay. The ICL extract treatment caused cytotoxicity and induced cell death in vitro in SCC-9 cells in a dose-dependent manner. This treatment also significantly reduced the clonogenic potential and inhibited cell proliferation by arresting the cell cycle in the G2/M phase. Furthermore, DNA fragmentation assays showed that the observed cell death was caused by apoptosis. This is the first report showing the anticancer activity of the methanol extracts from the leaves of I. cylindrica in human oral cancer cell line. Our data indicates that ICL extract could be considered as one of the lead compounds for the formulation of anticancer therapeutic agents to treat/manage human oral cancers. The natural abundance of I. cylindrica and its wide geographic distribution could render it one of the primary resource materials for preparation of anticancer therapeutic agents.

• International Journal of Aeronautical and Space Sciences
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• v.14 no.1
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• pp.1-10
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• 2013

This is a written version of the keynote speech delivered at the International Symposium on Hypersonic Aerothermodynamics - Recent Advances held in Bangalore, India, from December $6^{th}$ to $10^{th}$, 2012. In this document, what was accomplished in the past, the present status, and what is expected in the future in the field of hypersonic aerothermodynamics are reviewed. Solved problems are categorized into four items; unsolved problems into twelve items, and emerging problems into four items. Removing one degree uncertainty in trim angle of attack, studying the thermochemical phenomena in a hydrogen-helium-methane mixture, and entry flights of meteoroids are cited as the tasks for the future.

• Asian Journal of Innovation and Policy
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• v.3 no.2
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• pp.216-244
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• 2014

This paper empirically establishes the role played by the ecosystem related parameters in the emergence and growth of high technology start-up clusters in India. It is mainly based on secondary data from six major start-up hubs in India during the period 2005-2013. Our results throw up several interesting findings. First of all, we find that traditional infrastructure related factors or robust macroeconomic situation in general are not the most important drivers. What really seem to matter are the specific start-up ecosystem related factors - such as the Internet penetration, volume of deal flow, availability of VC funding and a pre-existing critical mass of relevant high technology businesses and skill-sets. Above all, our study points out that high economic growth alone will not automatically lead to spillovers in the form of a vibrant start-up ecosystem. Rather it has to be a product of conscious and concerted policy efforts at all levels that directly address the main challenges faced by the early-stage start-ups.

• Journal of Korea Technology Innovation Society
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• v.5 no.2
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• pp.167-188
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• 2002

Summary: This paper analyzes Indian software industry in the perspective of innovation cluster. The research shows that the software industry has been following an upstream clustering process, where the major value activity is expanding from low value product/services to high value product/services. The growth of software industry could be successful because there was appropriate initial condition of Bangalore, such as the availability of high qualified human resources, excellent research institutes, small high-tech companies. The role of government was helpful for the late growth of software industry but not a critical factor for the initial development of the S/W cluster. It is suggested that government should consider the initial condition of a concerned location critically to implement a cluster-type innovation policy.

• Journal of Power Electronics
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• v.8 no.4
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• pp.317-324
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• 2008

This paper proposes a Multiband Shunt Hybrid Active Filter (SHAF) with sensorless control. A plant is modeled in the discrete- time domain and a controller is designed using the Pole shifting law in the polynomial domain. This control approach is very useful for filtering the load harmonics with reduced sensor counts where a low cost solution like SHAF is required. Multiple Synchronous Reference Frames (MSRF) and low pass filters are used to measure the $5^{th}$ and $7^{th}$ harmonic components separately from the load and filter currents. Individual current controllers are designed for the $5^{th}$ and $7^{th}$ harmonic currents. Control is realized in the stationary, three-phase (abc) reference frame. Performance of the controller is validated through simulation, using realistic plant and controller models, as well as experimentally on a full-scale distribution system.

• Journal of Information Science Theory and Practice
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• v.1 no.2
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• pp.6-15
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• 2013

Dr. Ranganathan's "Principles for Helpful Sequence" among the set of normative principles play an exclusive role in the arrangement of subject isolates. Each subject in the universe of subjects is regulated by a guiding principle of its own which analogously determines the sequence of Arrays in ordering the subject surrogates or isolates. For example, the "Principle of Later-in-Evolution" is applied for sequencing isolates of Animal and Plant Species; this concept can be applied to one of the tools of KOS viz. Taxonomies. The application of Principles for Helpful Sequence is summarily presented and in the process the paper highlights the inherent elements of knowledge organization in each one of these principles in a manner that might map the future course of research in this area with the potentiality to bring about a relation between principles for helpful sequence and KOS.

• Geomechanics and Engineering
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• v.5 no.4
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• pp.299-312
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• 2013

The horizontal pullout capacity of a group of two vertical strip plate anchors, placed along the same vertical plane, in a fully cohesive soil has been computed by using the lower bound finite element limit analysis. The effect of spacing between the plate anchors on the magnitude of total group failure load ($P_{uT}$) has been evaluated. An increase of soil cohesion with depth has also been incorporated in the analysis. For a weightless medium, the total pullout resistance of the group becomes maximum corresponding to a certain optimum spacing between the anchor plates which has been found to vary generally between 0.5B and B; where B is the width of the anchor plate. As compared to a single plate anchor, the increase in the pullout resistance for a group of two anchors becomes greater at a higher embedment ratio. The effect of soil unit weight has also been analyzed. It is noted that the interference effect on the pullout resistance increases further with an increase in the unit weight of soil mass.

• Journal of Electrical Engineering and Technology
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• v.3 no.2
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• pp.243-253
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• 2008

This paper deals with the analysis, design, and implementation of a single phase AC-DC Zeta converter with high frequency transformer isolation and power factor correction(PFC) in two modes of operation, discontinuous current mode of operation(DCM), and continuous current mode of operation(CCM). A Digital Signal Processor(DSP) based implementation is carried out for validation of the Zeta converter developed design in discontinuous mode of operation. A comparison of both modes of operation is presented for a 1kW power rating from the point of view of steady state and dynamic behavior, power quality, simplicity, control technique, device rating, and converter size. The experimental results of a developed prototype of Zeta converter are presented for validation of the developed design. It is observed that CCM is most suitable for higher power applications where it requires some complex control and sensing of the additional variables.