• Investigative Magnetic Resonance Imaging
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• 제22권1호
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• pp.37-49
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• 2018

Purpose: The effect of global inhomogeneity on quantitative susceptibility mapping (QSM) was investigated. A technique referred to as Simultaneous Unwrapping Phase with Error Recovery from inhomogeneity (SUPER) is suggested as a preprocessing to QSM to remove global field inhomogeneity-induced phase by polynomial fitting. Materials and Methods: The effect of global inhomogeneity on QSM was investigated by numerical simulations. Three types of global inhomogeneity were added to the tissue susceptibility phase, and the root mean square error (RMSE) in the susceptibility map was evaluated. In-vivo QSM imaging with volunteers was carried out for 3.0T and 7.0T MRI systems to demonstrate the efficacy of the proposed method. Results: The SUPER technique removed harmonic and non-harmonic global phases. Previously only the harmonic phase was removed by the background phase removal method. The global phase contained a non-harmonic phase due to various experimental and physiological causes, which degraded a susceptibility map. The RMSE in the susceptibility map increased under the influence of global inhomogeneity; while the error was consistent, irrespective of the global inhomogeneity, if the inhomogeneity was corrected by the SUPER technique. In-vivo QSM imaging with volunteers at 3.0T and 7.0T MRI systems showed better definition in small vascular structures and reduced fluctuation and non-uniformity in the frontal lobes, where field inhomogeneity was more severe. Conclusion: Correcting global inhomogeneity using the SUPER technique is an effective way to obtain an accurate susceptibility map on QSM method. Since the susceptibility variations are small quantities in the brain tissue, correction of the inhomogeneity is an essential element for obtaining an accurate QSM.

• 인지과학
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• 제14권3호
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• pp.13-21
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• 2003

이 연구에서는 기존의 지능형 교수기계와 또래 튜터링의 단점을 보완하여 '가르치기를 통한 학습'을 위한 교수가능 에이전트(Teachable Agent, 이하 TA) 의 이론적 배경 및 설계방안을 제시하고자 한다. TA는 학습자가 컴퓨터 에이전트를 가르치는 과정을 통해 학습하는 시스템으로 교수 Module, 묻고 답하기 Module, 테스트 Module, 학습자료 Module 등의 4 가지 Module로 구성된다. 교수 Module에서는 개념도(concept map)의 구성을 통해 튜터 역할을 하는 학습자가 TA 의 심성모형 (mental model)을 수정하고 update하게 되며, 묻고 답하기 Module에서는 인터렉티브 창을 통해 튜터와 TA가 제한된 방식으로 학습내용에 관한 질문과 응답을 함으로써 개념도를 수정보완하게 된다. 테스트 Module에서는 튜터가 가르친 TA가 미리 정해놓은 학습목표에 도달하였는지를 평가하게 된다. 테스트 결과 TA가 일정 수준에 도달하지 못한 경우에는 개념도의 재수정 과정을 통해 계속적인 학습이 이루어지도록 한다. 학습자료 Module은 튜터가 참고할 자료를 제공해 주는 Module이다. 이러한 TA는 튜터의 역할을 담당하는 학습자에게 깊이 있는 인지적 처리와 능동적인 학습동기를 경험하도록 함으로써 실제 교육현장에서의 유용한 교수/학습도구로 활용될 수 있을 것으로 기대된다.

• 한국통신학회논문지
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• 제37A권11호
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• pp.918-926
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• 2012

3차원 비디오 전송에 있어서, 렌더링에 사용되는 깊이 맵은 압축 효율을 위하여 일반적으로 낮은 해상도로 다운샘플링 되어 전송된다. 이때, 다운샘플링 과정에서 발생하는 오류는 디코딩 후의 적절한 업샘플링 기법을 통하여 효과적으로 복구할 수 있다. 하지만 기존의 연구들은 이러한 오류를 줄이기 위하여 여러 업샘플링 기법에 대해서만 초점이 맞춰져 있었다. 본 논문에서는 사람의 인지적인 화질을 보다 제고시키기 위하여 동적인 객체와 정적인 배경에 서로 다른 다운샘플링 비율을 적용시키는 새로운 하이브리드 깊이 맵 다운샘플링 기법을 제안한다. 실험적인 결과는 제안하는 방법이 시각적인 품질과 PSNR 측면에서의 이득이 있음을 보여준다. 또한 제안하는 방법은 여러 업샘플링 기법들과 호환이 가능하다.

• IMMUNE NETWORK
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• 제10권5호
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• pp.145-152
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• 2010

Background: The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for the treatment of inflammatory diseases. In the present study, we investigated the anti-inflammatory properties of Inulae Flos Extract (IFE). Methods: The anti-inflammatory effects of IFE against nitric oxide (NO), $PGE_2$, TNF-${\alpha}$, and IL-6 release, as well as NF-${\kappa}B$ and MAP kinase activation were evaluated in RAW 264.7 cells. Results: IFE inhibited the production of NO and the expression of inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW264.7 cells. In addition, IFE reduced the release of pro-inflammatory cytokines, such as TNF-${\alpha}$ and IL-6. Furthermore, IFE inhibited the NF-${\kappa}B$ activation induced by LPS, which was associated with the abrogation of $I{\kappa}B-{\alpha}$ degradation and subsequent decreases in nuclear p65 and p50 levels. Moreover, the phosphorylation of ERK, JNK, and p38 MAP kinases in LPS-stimulated RAW 264.7 cells was suppressed by IFE in a dose-dependent manner. Conclusion: These results suggest that the anti-inflammation activities of IFE might be attributed to the inhibition of NO, iNOS and cytokine expression through the down-regulation of NF-${\kappa}B$ activation via suppression of $I{\kappa}B{\alpha}$ and MAP kinase phosphorylation in macrophages.

• 방송공학회논문지
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• 제16권1호
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• pp.44-53
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• 2011

본 논문에서는 depth layer partition을 이용한 2D 동영상의 자동 3D 변환 기법을 제안한다. 제안하는 기법에서는 먼저 2D 동영상의 장면 전환점을 검출하여 각각의 프레임 그룹을 설정하여 움직임 연산 과정에서의 오류 확산을 방지하여 깊이맵(depth map) 생성과 정에서 오차를 줄여준다. 깊이정보는 두 가지 방법으로 생성되는데 하나는 영역 분할과 움직임 정보를 이용하여 깊이맵을 추출하는 것이고 다른 하나는 에지 방향성 히스토그램(edge directional histogram)을 이용하는 방법이다. 제안하는 기법에서는 객체와 배경을 분리하는 depth layer partition 과정을 수행한 후 생성된 두 개의 깊이맵을 원 영상에 최적이 되도록 병합하게 된다. 제안된 기법으로 신뢰도 높은 깊이맵과 결과 영상을 생성할 수 있다는 것을 다양한 실험 결과를 통해 알 수 있다.

• 건축역사연구
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• 제9권1호
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• pp.27-46
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• 2000

This study aims at examining the background and development process of Masan city after Koryo Dynasty, making a reconstructive map of Original Masan using the first registration maps made in 1912 and analyzing the urban structure of the Original Masan area. The origin of Masan city went back to Koryo dynasty. Around 1040 Koryo government placed an official shipping facility in Masan to transport the taxed grain to the capital city. After that Masan became an important port covering the southern part of KyungSang-Do. And the urbanization of the Original Masan began to bud after a shipping facility was again established by the Chosun Dynasty in 1760 and strengthened in the 19th century after the social standing system was broken and many peasants moved to cities as daily workers. In 1899 Masan was forced to be opened to foreign powers and they placed an international settlement distanced from the area(Original Masan). After this many Japanese advanced to the international settlement and further to the area. The advancement of Japanese brought a critical change in the urban structure of the area. Land was owned by Japanese and many modern sysytems were introduced such as modern buildings, new roads, railroad and modern factories. According to the reconstructive map of the area, 80.5% of land lots are less than $200m^2$ showing the size of each land lot is comparatively small. And Japanese occupied 31.5% of the land in the area. Their land was located on the stratigic points near the port and the center of commerce. The ratio of the road area to the whole land was around 14%, not so low for urban areas in that time. The reconstructive map reveals the exact coastline of the year 1912 erased now due to filling the sea and extending the land, Present Masan city has been developed having the Original Masan as its nucleus. The area has been always the center of urban activities for Masan city. Making an exact reconstructive map for the area and analyzing the urban structure of the area in 1912 is a very important work to understand Masan city wholy.

• 대한지리학회지
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• 제49권4호
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• pp.585-600
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• 2014

이 연구의 목적은 프랑스 왕실 과학원이 18세기의 유럽의 중국지도 제작에 미친 영향을 살펴보는 것이다. 이를 위해 먼저 1685년 루이 14세가 예수회 선교사를 왕실수학자로 임명하여 중국에 파견한 역사적 배경을 살펴보았는데, 세계 지도 제작을 위한 지리좌표 측정이 선교사 파견 원인임을 확인하였다. 둘째, 카시니는 선교사들에게 경도측량법을 전수하였고, 선교사들은 과학원의 통신회원으로 활동하며, 과학원에 탐사결과를 보고하였다. 셋째, 선교사들의 초반 관측 기록은 중국의 전반적인 지도를 수정할 정도로는 충분하지 않았다. 그렇지만 1700년 이후의 지도에서는 프톨레마이오스의 전통에서 벗어나서 베이징의 좌표를 이전에 비해 약 $20^{\circ}$ 정도 서쪽으로 이동시켜 지도상에서 중국의 너비의 폭을 축소하였다. 넷째, 파견된 선교사들이 참여하여 제작한 "황여전람도"는 프랑스로 전달되었으며, 당빌에 의해 "신중국지도첩"으로 제작되었다. 그리고 이 지도는 이후 100년이 넘게 유럽의 중국 표준지도로 사용되었다.

• Tuberculosis and Respiratory Diseases
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• 제78권2호
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• pp.85-91
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• 2015

Background: In sepsis patients, target mean arterial pressures (MAPs) greater than 65 mm Hg are recommended. However, there is no such recommendation for patients receiving mechanical ventilation. We aimed to evaluate the influence of MAP over the first 24 hours after intensive care unit (ICU) admission on the mortality rate at 60 days post-admission in patients showing acute hypoxemic respiratory failure under mechanical ventilation. Methods: This prospective, multicenter study included 22 ICUs and compared the mortality and clinical outcomes in patients showing acute hypoxemic respiratory failure with high (75-90 mm Hg) and low (65-74.9 mm Hg) MAPs over the first 24 hours of admission to the ICU. Results: Of the 844 patients with acute hypoxemic respiratory failure, 338 had a sustained MAP of 65-90 mm Hg over the first 24 hours of admission to the ICU. At 60 days, the mortality rates in the low (26.2%) and high (24.5%) MAP groups were not significantly different. The ICU days, hospital days, and 60-day mortality rate did not differ between the groups. Conclusion: In the first 24 hours of ICU admission, MAP range between 65 and 90 mm Hg in patients with acute hypoxemic respiratory failure under mechanical ventilation may not cause significantly differences in 60-day mortality.

• Journal of Dental Anesthesia and Pain Medicine
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• 제18권3호
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• pp.143-149
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• 2018

Background: We evaluated the changes in mean arterial pressure (MAP) and heart rate (HR), and the anesthetic and hemostatic effects, after injection of 2% lidocaine containing various concentrations of epinephrine in rats and mice to determine the appropriate concentration of epinephrine in various anesthetic mixtures. Methods: Rats and mice were randomly allocated to experimental groups: 2% lidocaine without epinephrine (L0), 2% lidocaine with epinephrine 1:200,000 (L200), 1:100,000 (L100), and 1:80,000 (L80). Changes in MAP and HR after administration of the anesthetic mixture were evaluated using a physiological recording system in rats. Onset and duration of local anesthesia was evaluated by pricking the hind paw of mice. A spectrophotometric hemoglobin assay was used to quantify the hemostatic effect. Results: MAP increased in response to epinephrine in a dose-dependent manner; it was significantly higher in the L80 group than in the L0 group at 5 min post-administration. The HR was relatively lower in the L0 group than in the L80 group. The time required for onset of action was < 1 min in all evaluation groups. The duration of action and hemostatic effect of the local anesthetic were significantly better in the L200, L100, and L80 groups than in the L0 group. Conclusion: L200 demonstrated relatively stable MAP and HR values with satisfactory efficacy and hemostatic effect. L200 might be a better local anesthetic for dental patients in terms of anesthetic efficacy and safety.

• 한국환경농학회지
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• 제34권3호
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• pp.168-177
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• 2015

BACKGROUND: In recent year, there has been great concern regarding agricultural land uses and their importance for the conservation of biodiversity. Rice fields are managed unique wetland for wildlife, especially waterbirds. A comprehensive monitoring of the waterbird assemblage to understand patterning changes was attempted for rice ecosystem in South Korea. This rice ecosystem has been recognized as one of the most important for waterbirds conservation. METHODS AND RESULTS: Biweekly monitoring was implemented for the 4 years from April 2009 to March 2010, from April 2011 to March 2014. 32 species of waterbirds were observed. Self-organizing map (SOM) and random forest were applied to the waterbirds dataset to identify the characteristics in waterbirds distribution. SOM and random forest analysis clearly classified into four clusters and extract ecological information from waterbird dataset. Waterbird assemblages represented strong seasonality and habitat use according to waterbird group such as shorebirds, herons and waterfowl. CONCLUSION: Our results showed that the combination of SOM and random forest analysis could be useful for ecosystem assessment and management. Furthermore, we strongly suggested that a strict management strategy for the rice fields to conserve the waterbirds. The strategy could be seasonally and species specific.