• The Korean Journal of Mycology
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• v.1 no.1
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• pp.29-33
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• 1973

The discovery of ideal therapeutics of fungal infections are remain a major problems of several mycoses. The antifungal activities of a new antifungal antibiotic named Siccanin and Azalomycin-F studies in vitro against some various species of fungi especially dermatophytes. The antifungal activity tests were performed according to the tube-dilution method and all subcultures were incubated at room temperature for 14 days. Results were obtained as follows: 1. All of the Candida spp. were grow on the various concentration of Siccanin tested but Azalomycin-F were growth inhibited at 7mcg-10mcg per ml. 2. Trichophyton spp. and Microsporum spp. were inhibited for growth at 2mcg-6mcg per ml. and 3mcg-5mcg per ml. concentration of Siccanin and 1mcg-4mcg per ml. of Azalomycin-F. 3. Deep mycoses and some saprophytes were grow on the all tested concentration of Siccania and Azalomycin-F.

• Applied Biological Chemistry
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• v.42 no.4
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• pp.271-276
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• 1999

Several Streptomyces strains were tested for potent antifungal agents active against phytopathogenic fungi. Among the tested, S. hygroscopicus MJM1004 showed a potent antifungal activity when assayed using Candida albicans as indicator organism. With the strain of MJM1004, fermentation medium for the production of an antifungal agent was developed with varying carbon sources, nitrogen sources, and mineral elements, which resulted in the highest productivity in the medium containing 2% soybean meal, 1% glucose, 2% starch, 0.3% $CaCO_3$, 0.05% $MgSO_4{\cdot}7H_2O$, 0.05% $K_2HPO_4$. The active compound showed a broad spectrum of antifungal activity against several plant pathogenic fungi. The antifungal compound was purified and showed the physicochemical characteristics similar to azalomycin F complex in NMR and MS analysis.