• Journal of Yeungnam Medical Science
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• 제18권1호
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• pp.39-50
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• 2001

본 연구는 여러 가지 질병의 원인을 규명하는데 있어서 자율신경계 역할의 중요성을 인식하여 심전도 및 호흡신호의 변이를 이용하여 자율신경계를 감시할 수 있는 시스템을 개발하였다. 본 연구에서 제작된 증폭기에서는 트랜스를 사용하여 교류전원으로부터 환자를 격리시키고, 30 KHz의 고주파를 이용하여 임피던스법에 의한 호흡신호를 심전도와 동시에 처리할 수 있도록 하였으며, 아울러 서로의 채널에 대한 혼신의 영향을 최소화하도록 회로를 설계하였다. 시뮬레이터에 의한 테스트 결과에서 입력 조건에 따라 증폭기의 출력에 나타나는 시간 간격이 일치하게 나타나는 것을 확인하였다. 또 실제 서로 다른 조건을 가진 세 부류의 임상 환자의 심전도에서 R-R interval 및 호흡신호를 측정하여 추출할 수 있었다. 기존에는 주로 생체 신호 파라미터를 각각 측정하여 그 결과를 추출하였으나 본 연구에서는 R-R interval과 respiration의 파라미터를 통합하여 데이터를 수집, 처리함으로써 환자로부터 얻은 데이터를 임상 응용에 보다 효과적으로 적용할 수 있게 되었다. 따라서 향후 개발된 시스템의 보완을 통해 환자에 직접 적용하여 자율신경계 장애 환자에 대한 감시장치로 활용하고자 한다.

• 대한한방내과학회지
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• 제29권3호
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• pp.778-786
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• 2008

Objectives : This study was to investigate the short time effect of caffeine on heart rate variability(HRV) and the effect of Neiguan(PC6) acupuncture stimulation on HRV. Methods : 27 healthy adult volunteers were randomly allocated to two groups: Neiguan group (N=13) or placebo group (N=14). The study was carried out under a randomized double-blinded placebo-controlled trial method. Each group orally received the same tablets with 200 mg caffeine. After 1 hour, acupuncture was applied to the Neiguan(PC6) points for the Neiguan group, and for the placebo group was applied to a non-acupuncture point. Both groups were estimated with HRV 3 times, before and after caffeine ingestion, 20 minutes after acupuncture stimulation. Results : After taking caffeine, pulse rate, mean-HRV, and pNN50(the proportion derived by dividing NN50 by the total number of NN intervals) decreased, SDNN(standard deviation of all normal-to-normal (NN) intervals), RMSSD (the root square of successive differences), TP log, HF(high frequency), and HRV index was increased. There were significant changes to the autonomic nervous system after taking caffeine. There were no significant differences between the two groups after acupuncture at Neiguan. Conclusion : Caffeine could induce general activation of the autonomic nervous system. Neiguan acupuncture stimulation may not have significant influence on the autonomic nervous system.

• Journal of Acupuncture Research
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• 제29권3호
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• pp.81-88
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• 2012

Objectives : The purpose of this study was to assess the effect of Taegeuk acupuncture on reducing mental stress by analyzing heart rate variability in Soyangin. Methods : Eight Soyangin-diagnosed women participated in this study. They were randomly divided into group A and group B. Each participant went through 3 sessions every week with 1 week of washout period in between each session. HRV was measured three times at every session; at baseline, after administering mentally stressful circumstances and after applying either one of simple rest, Soyangin Taegeuk acupuncture or Soeumin Taegeuk acupuncture. This study was designed as a crossover clinical trial. After same initial simple resting session for both groups at week 1, acupuncture for group A were executed in the order of Soyangin Taegeuk acupuncture and Soeumin Taegeuk acupuncture at week 2 and 3 respectively, with acupuncture for group B conducted in reverse order. Results : Simple rest and Soeumin Taegeuk acupuncture did not show the significant changes in response to LF(norm) and HF(norm) after stress stimuli. Soyangin Taegeuk acupuncture did, however, significantly decrease LF(norm) and increase HF(norm). Soyangin Taegeuk acupuncture, compared to Soeumin Taegeuk acupuncture, significantly stabilized autonomic nervous system. Conclusions : This study suggests that Soyangin Taegeuk acupuncture might be an effective means of stabilizing mental stress-induced imbalance of autonomic nervous system for Soyangin.

• 여성건강간호학회지
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• 제23권1호
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• pp.33-41
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• 2017

Purpose: The purpose of this study was to investigate the effect of aroma inhalation therapy on stress, anxiety, depression, and an autonomic nervous system reaction in high-risk hospitalized pregnant women. Methods: A quasiexperimental study used a non-equivalent control group non-synchronized design. Fifty high-risk hospitalized pregnant women were selected as participants on delivery room and maternity ward at university hospital. Twenty-five were selected for the experimental group while 25 were assigned to a control group. Neroli essential oil was used for aroma therapy and was already identified as not being hazard to pregnant women. It provided emotional stability from previous study. The participants inhaled Neroli 2 minutes, 3 times (9 am to 10 am, 4 pm to 5 pm, just before sleep) a day. A total of 15 sessions were held from the day of the preliminary investigation. Pre and post written survey and measuring an autonomic nervous system reaction were collected from both groups. Results: The data were analyzed by $x^2$ test, t-test, and paired t-test. There was a statistically significant difference in stress (t=-3.98, p<.001) between the experimental group and the control group. Conclusion: These findings indicate that aroma inhalation therapy is effective as a nursing intervention for the stress relief of hospitalized high-risk pregnant women.

• 한국전자통신학회논문지
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• 제8권7호
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• pp.1093-1101
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• 2013

기치유가 자율신경계의 조절 능력에 미치는 영향을 알아보기 위하여 19명을 대상으로 '생활이완 시행'과 '기치유 시술' 전 후의 체감 변화와 심박변이도의 신체저항도, 평균심박수, 주파수 영역분석의 차이를 조사 및 측정하였다. 대상자들은 '생활이완 시행'과 '기치유 시술' 전 후의 체감 변화 설문에서 각각 약 8.5%와 약 23.3%의 스트레스 감소 변화율을 나타내어 '기치유 시술'이 스트레스 완화 및 감소에 긍정적인 영향을 미친 것으로 판단되었다. 심박 변이도의 신체저항도, 평균심박수, 주파수 영역 분석을 조사한 결과에서 '생활이완 시행'은 유의한 차이가 없었으나 '기치유 시술'에서는 6개 항목에서 유의한 차이를 나타내어 '기치유 시술'이 자율신경계의 조절 능력에 영향을 미쳐 스트레스 저항도를 향상시키고 스트레스 감소 및 완화에 조력할 수 있음이 입증되어 보완 대체 요법으로서 가치가 있다고 판단된다.

• 우울조울병
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• 제15권3호
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• pp.117-122
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• 2017

Objectives : Early life stress (ELS) may have impact on functions of the autonomic nervous system. Heart rate variability (HRV) is a reliable psychophysiological marker for functions of the autonomic nervous system. The purpose of this study was to investigate characteristics of HRV associated with ELS in patients with major depressive disorder (MDD). Methods : We compared HRV measures of MDD patients with ELS and without ELS in a 5-minute resting-state electrocardiogram recoding. Forty subjects participated in the study (25 with ELS, 15 without ELS). The Mann-Whitney test was conducted to identify group differences. Results : We found significant group differences in standard deviation of the NN interval (SDNN) and total power (TP). SDNN was lower in the ELS group (M=38.80 ms, SD=13.05 ms) than in the Non-ELS group (M=53.53 ms, SD=19.47 ms). TP was lower in the ELS group ($M=7.07ms^2$, $SD=0.69ms^2$) than in the Non-ELS group ($M=7.72ms^2$, $SD=0.77ms^2$). Conclusion : ELS may have a negative impact on the autonomic nervous system function in patients with MDD. ELS and dysfunction of autonomic nervous system should be considered in treatment for patients with MDD.

• 대한한의학회지
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• 제40권1호
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• pp.99-113
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• 2019

Objectives: This study is designed to identify the responses of autonomic nervous system and gastrointestinal function which are induced by acupuncture at abdominal anterior cutaneous nerve. Methods: This study is one group before and after pilot study. Subjects were treated once, after having been fasting six hours. They had before tests, labeling points for acupuncture, acupuncture, and after tests in order. The points of acupuncture were motor points of rectus abdominis where the abdominal anterior cutaneous nerve came to the skin from abdominal wall. Before and after tests were consisted of three things: Digital Infrared Thermographic Imaging(D.I.T.I.), Heart Rate Variability(HRV), and Recording of bowel sounds. Results: There were significant differences on the skin temperature of upper body and the frequency of bowel sounds(p<0.001, p<0.001). The HRV parameters and volume of bowel sounds had no significant differences(p>0.05, p>0.05). Conclusion: Even though no significant differences in HRV parameters, the significant differences of skin temperature of upper body and frequency of bowel sounds could mean acupuncture at abdominal anterior cutaneous nerve could affect the autonomic nervous system and gastrointestinal function. However, this study had no group to compare with. Future randomized project should address this issue.

• 산업과 과학
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• 제1권2호
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• pp.9-16
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• 2022

본 연구는 이완음악감상이 입원한 정신질환자의 기분상태 및 자율신경계 즉 심박동수에 미치는 영향을 파악하고자 실험군 17명, 대조군 17명을 대상으로 시행한 무작위 대조군 전후설계이다. 수집된 자료는 SPSS V15.0으로 분석하였다. 기분상태와 자율신경계 즉 심박동수는 두 집단 간에 통계적으로 유의한 차이가 있어 이완음악감상의 효과를 객관적으로 검증하였다(<.05). 기분상태의 하위 영역 중 분노(>.39)와 혼돈(>.33)을 제외한 긴장(<.00), 우울(<.00), 활력(<.03), 피로(<.01)에서 유의한 차이가 있는 것으로 나타나 입원한 정신질환자에게 적용할 수 있는 효과적인 중재방법임을 입증하였다. 향후 장기적인 중재 연구개발 및 적용과 개인의 선호음악을 이용하여 기분변화와 자율신경계에 효과연구를 제언하고자 한다.

• Physical Therapy Rehabilitation Science
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• 제11권4호
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• pp.493-501
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• 2022

Objective: The purpose of this study is to present basic data for appropriate therapeutic intervention by confirming changes in the autonomic nervous system and pain by applying high-frequency deep diathermy to the lower abdomen in patients with primary dysmenorrhea. Design: A randomized controlled clinical trial. Methods: Thirty-eight women aged 18-50 years who complained of regular menstrual cycles (24-32 days) and primary dysmenorrhea symptoms were randomly assigned to a high-frequency therapy group (5, 7, or 9 mins) and a superficial heat therapy group (20 min). High frequency treatment group: The subject was in a supine position, and radio frequency was applied to the lower abdomen below the umbilicus. The radio frequency therapy device used in this study uses a 300 kHz capacitive electrode and a 500 kHz resistive electric transfer to deliver deep heat. Superficial heat treatment Group: Subjects applied a hot pack to the lower abdomen for 20 minutes while lying on their back. Evaluations were made of Heart rate variability and Visual Analogue Scale. Results: In subjects with menstrual pain, there was a significant difference in pain between the high-frequency therapy group and the superficial heat therapy group (p=0.026). However, there was no significant difference between the autonomic nervous system and the stress resistance (p>0.05). Conclusions: As a result of this study, high-frequencytreatment using radiofrequency was effective in relieving pain because it can penetrate deeper tissues than conventional hot packs using superficial heat. In particular, it was found that the optimum effect was obtained when high frequency was applied forfive-seven minutes.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1993년도 추계학술대회
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• pp.51-54
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• 1993

The purpose of this research is to investigate the relationship between the blood flow and autonomic nervous system which regulates the circulation system. After the oral glucose tolerance test(GTT) the velocity changes of the blood flow were measured from the normal, hyperglycemia and diabetic neuropathy using the laser doppler. The FFT analyses showed that the spectrums were concentrated around the particular bands(0.02-0.166Hz, 0.8-1.1Hz) for the normal, while almost uniform distribution of the spectrums was observed for the abnormal. The blood glucose affects the compliance of the blood vessels and viscosity and finally causes the resistance problem in the blood vessels. An index PG was introduced, which was determined by the ratio of the change or the integral power spectrum in the range between 0.02 and 0.166Hz to change of the blood glucose before and after GTT. The index shows 1.0. 0.3 and 0.1 for the normal, hyperglycemia and diabetic neuropathy, respectively. As a conclusion, this spectrum analysis shows the potential of checking the progress or the diabetic, also car be used to evaluate the vasomotion which are regulated by the autonomic nervous system.