• Tuberculosis and Respiratory Diseases
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• 제41권2호
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• pp.73-86
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• 1994

In addition to classic cholinergic and adrenergic pathways, the existence of a third division of autonomic control in the human airways has been proved. It is called a nonadrenergic noncholinergic(NANC) nervous system, and difficult to study in the absence of specific blockers. Neuropeptides are certainly suggested to be transmitters of this NANC nervous system. It is very frustrating to understand the pathophysiologic role of these peptides in the absence of any specific antagonists. However, further studies of neuropeptides might eventually lead to novel forms of treatment for bronchial asthma. Another study of the interaction between different components of the autonomic nervous system, either in ganglionic neurotransmission or by presynaptic modulation of neurotransmitters at the end-organ will elute neural control in airway disease, particularly in asthma. Studies of how autonomic control may be disordered in airway disease should lead to improvements in clinical management. Epithelial damage due to airway inflammation in asthma may induce bronchial hyperresponsiveness. Axon reflex mechanism is one of possible mechanisms in bronchial hyperresponsiveness. Epithelial damage may expose sensory nerve terminals and C-fiber nrve endings are stimulated by inflammatory mediators. Bi-directional communication between the nerves and mast cells may have important roles in allergic process. The psychological factors and conditioning of allergic reactions is suggested that mast cell activation might be partly regulated by the central nervous system via the peripheral nerves. Studies in animal models, in huamn airways in vitro and in patients with airway disease will uncover the interaction between allergic disease processes and psychologic factors or neural mechainsms.

• Physical Therapy Rehabilitation Science
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• 제9권4호
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• pp.252-260
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• 2020

Objective: Disorder of the autonomic nervous system is considered to be the cause of primary dysmenorrhea. The spine has a close relationship with the autonomic nervous system, and the sacrum is mechanically and neurologically connected to the uterus through ligaments. Therefore, this study was conducted to check the effect on the autonomic nervous system through measurement of heart rate variability by applying manual therapy to the sacroiliac joints of subjects with primary dysmenorrhea and to suggest an effective treatment method for dysmenorrhea. Design: Randomized controlled trial. Methods: Thirty females with dysmenorrhea were assigned to either the manual therapy group and sham treatment group according to the random treatment method. The manual therapy was applied to the sacroiliac joints, and the sham treatment was only treated with the hands placed in the same position of the intervention. Heart rate variability and the Visual Analogue Scale (VAS) were measured on the day when menstruation began ±2. Interventions were performed between the groups, followed by a 5-minute break and then re-measurements were made. Results: There were significant differences in autonomic balance and VAS scores in the manual therapy group before and after the intervention between groups (p<0.05). In the sham treatment group, there were significant differences in low frequency, autonomic balance, and VAS scores (p<0.05). There were significant differences in autonomic balance between groups (p<0.05). Conclusions: In females with primary dysmenorrhea, manual therapy applied to the sacroiliac joint was found to be effective for a short time on autonomic activity.

• Annals of Clinical Neurophysiology
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• 제23권2호
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• pp.117-120
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• 2021

Tetanus is an infectious disease of the nervous system caused by Clostridium tetani, and is characterized by tonic muscle contractions, painful spasms, and autonomic dysfunction. Severe autonomic dysfunction associated with tetanus can be life-threatening. We present a 62-year-old female who experienced lockjaw after an ankle fracture. The patient was diagnosed with tetanus and received tetanus immunoglobulin and a vaccination. The patient subsequently experienced labile hypertension. This case highlights the challenge and importance of managing cardiovascular instability.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2012년도 춘계학술대회 논문집
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• pp.1195-1196
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• 2012

• 한방비만학회지
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• 제8권1호
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• pp.63-70
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• 2008

Objectives Obesity is the major risk factor of the heart disease and the metabolic disease. The autonomic nervous system is a key contributor in the regulation of energy balance, so the blunted activity may contribute to the maintenance of the obese state. So we evaluated the function of the autonomic nervous system in young overweight and obese women with heart rate variability. Methods The subjects were 26 overweight and obese young women(BMI〉$23kg/m^2$) and 25 lean women who visited Kangnam Kyunghee hospital for obesity management from March 2006 to April 2008. Bioimpedance Analysis (BIA), short-term spectral analysis of heart rate variability (HRV) were performed. Results HRV of obese young group was lower than the lean young group, but there is no statistical significance. BMI had significantly a negative correlation with Low Frequency(LF) of HRV. LF power is mediated by sympathetic nervous system activity. These results indicate a decrease of sympathetic modulation in overweight and obese young women. Conclusions Overweight and obese young women have decreased sympathetic nervous system activity. In clinical practice, an assessement of HRV would be noninvasive and sensitive methods for sympathetic nervous system of young overweight and obese women.

• Journal of Electrical Engineering and Technology
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• 제3권4호
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• pp.576-583
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• 2008

In this study, we attempt to design a real-time autonomic nervous system(ANS) evaluation system usable during exercise using heart instantaneous frequency(HIF). Although heart rate variability(HRV) is considered to be a representative signal widely used ANS evaluation system, the R-peak detection process must be included to obtain an HRV signal, which involves a high sampling frequency and interpolation process. In particular, it cannot accurately evaluate the ANS using HRV signals during exercise because it is difficult to detect the R-peak of electrocardiogram(ECG) signals with exposure to many noises during exercise. Therefore, in this study, we develop the ground for a system that can analyze an ANS in real-time by using the HIF signal circumventing the problem of the HRV signal during exercise. First, we compare the HRV and HIF signals in order to prove that the HIF signal is more efficient for ANS analysis than HRV signals during exercise. Further, we performed real-time ANS analysis using HIF and confirmed that the exerciser's ANS variation experiences massive surges at points of acceleration and deceleration of the treadmill(similar to HRV).

• 전기학회논문지
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• 제64권8호
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• pp.1246-1250
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• 2015

The purpose of this paper is to investigate the autonomic nervous system activity in various ambient temperature situation. To evaluate autonomic function, we use the time domain analysis of heart rate variability. Electrocardiogram was recorded to derive heart rate variability in 3 different temperature room which temperature is controlled in 18℃(low), 25℃ (mid) and 38℃(high), respectively. Totally 22 subjects were participated in the experiment. The result shows that the time-domain variables such as AVNN, SDNN, SDSD, RMSSD, NN50, pNN50, NN20 and pNN20 show the significant difference between low and high temperature (p<0.01). However, these variables has no significance (p>0.05) between mid and high except on AVNN, RMSSD and pNN20. AVNN, RMSSD shows the highest significance (p<0.001) according to the various temperature environment.

• Journal of Korean Biological Nursing Science
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• 제6권2호
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• pp.5-17
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• 2004

Purpose: The purpose of this study is to determine effects of aromatherapy on the activity and balance of autonomic nervous system and on physical resistance to stress. Methods: This research is a primitive experimental design which attempts to analyze aromatherapy EKG monitoring on real-time basis. Lavender & Chamomile, each 30 drops, were blended with 100ml Sweet Almond oil. Subjects was laid relaxed, and had insides of his wrists and ankles attached with electrodes for EKG. Right after applied with essential oil onto his philtrum and parotid, started on EKG monitoring. Results: The activities of parasympathetic and sympathetic nerve were changed as time elapsed, with significant differences(p=.000). In multiple comparison, the value was significantly different(p<.05).The balance of autonomic nerve was changed, becoming close to the normal level in accord with applicable international standards(1.5)(p=.011). In multiple comparison, the value showed a significant difference(p<.05). Physical resistance to stress increased with the passage of time, but not statistically significant. Conclusions: This suggests that aromatherapy can be used as a nursing intervention which aims at alleviating symptoms related to the imbalance of autonomic nerve system such as headache, hot flashes, irregular heartbeat, nervousness, depression and anxiety.

• 한국정보통신학회논문지
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• 제14권9호
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• pp.2099-2104
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• 2010

본 연구에서는 마취 중 리턴맵 분석 방법을 적용하여 ECG 신호에서 R-R 간격의 변화로 표시될 수 있는 HRV 신호를 분석하였다. HRV신호는 자율신경계(autonomic nervous system : ANS)의 상태변이에 따른 심혈관계(cardio vascular system : CVS)의 변화 양상에 대한 객관적인 정보를 구할 수 있으므로 수술중 자율신경계의 변화를 관찰하여 마취심도를 평가할 수 있다. 리턴맵 분석 방법은 일련의 시계열 HRV 신호를 위상공간으로 사상하기 위해 지연시간과 매립차원을 구한 후 2차원의 위상공간에 신호를 재구성하였다. 위상공간에 재구성된 신호 분포를 타원형으로 근사화 한 후 장축과 단축의 길이를 구하여 마취심도를 구별하는데 이용하였다. 마취 단계별 마취심도를 평가하기 위하여 마취 단계를 7단계로 구분하여 분석하였다. 외부자극이 아주 강한 마취유도단계에서 장축과 단축 모두 통계적으로 유의하게 큰값을 나타내었으며, 외부 자극이 가해지지 않은 수술중 단계에서는 장축과 단축의 길이 모두 작은 값을 나타내었다. 따라서 2차원의 위상공간에 매립된 수술중의 HRV 신호를 이용하여 자율신경계의 영향을 판단하여 마취심도를 구분 할 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제44권1호
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• pp.33-40
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• 2023

Transcutaneous auricular vagus nerve stimulation (taVNS) is known to be effective in improving symptoms of numerous diseases such as depression and epilepsy by increasing vagus nerve activity through electrical stimulation. The purpose of this study is to investigate the effect of vagus nerve stimulation on the activity of autonomic nervous system and the changes in postprandial blood glucose levels. Seven healthy adults participated in a non-invasive transcutaneous auricular vagus nerve stimulation experiment. taVNS (25 Hz, 200 ㎲, biphasic pulse) was applied to the cymba concha (taVNS group) or the earlobe (Sham-taVNS group) of the left ear. As autonomic nervous system signals, skin conductance level, skin temperature, and heart rate were recorded during the application of taVNS. Postprandial blood glucose changes due to food intake were recorded at 5 min intervals for 25 minutes after taVNS or sham-taVNS. The taVNS showed a significantly lower skin conductance level than the shamtaVNS (p < 0.05). The increase rate of postprandial blood glucose was significantly lower in the taVNS than in the sham-taVNS (p < 0.05). These results showed that taVNS reduced the activity of the sympathetic nerve system and alleviated early rise in postprandial blood glucose. Although further studies in diabetic patients are needed, this study suggest that taVNS has a potential for clinical use to improve postprandial blood glucose.