• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3455-3460
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• 2012

Objectives: To report the prevalence of atypical squamous cells of undetermined significance and atypical squamous cells-cannot exclude high squamous intraepithelial lesions and to determine the possible association of Pap test results with high-risk human papillomavirus and high squamous intraepithelial lesions in women from Duhok, Iraq. Design: A prospective, observational study was conducted between January 2005 and December 2011. Overall, 596 women with a cervicovaginal Pap test showing atypical squamous cells of undetermined significance and 93 atypical squamous cells-cannot exclude high squamous intraepithelial lesion for whom pathologic follow-up was available were studied. Follow-up consisted of repeat cytology, colposcopy and histology. High risk human papillomavirus DNA testing was performed on exfoliated cervical cells from 106 women, using conventional PCR after at least 36 months from the initial Pap smear. Results: Significantly high proportions of both atypical squamous cells of undetermined significance (87.9%) and atypical squamous cells-cannot exclude high squamous intraepithelial lesion (62.4%) demonstrated no significant lesion on subsequent follow up. Low squamous intraepithelial lesions were observed in 1.7% of cases of atypical squamous cells of undetermined significance and in 5.4% of atypical squamous cells-cannot exclude high squamous intraepithelial lesion. High squamous intraepithelial lesion was demonstrated in 0.8% and 16.1% respectively. In the latter there was also one case of invasive carcinoma. High-risk HPV DNA was demonstrated in 40% of atypical squamous cells of undetermined significance and 57.1% of atypical squamous cells-cannot exclude high squamous intraepithelial lesions. Conclusions: Since both atypical squamous cells of undetermined significance and atypical squamous cells-cannot exclude high squamous intraepithelial lesion identify patients who are at an increased risk for the development of high squamous intraepithelial lesions and a considerable percentage harbor high risk-HPV, both should be retained as diagnostic categories and patients warrant a diligent follow up and testing for high risk-HPV DNA. Colposcopic evaluation and biopsy, when indicated, are a must.

• 셀메드
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• 제14권1호
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• pp.65.1-65.3
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• 2024

Objective: Report on the improvement of gastritis accompanied by atypical regenerative cells through Ortho-Cellular Nutrition Therapy. Methods: A Korean male in his 50s suffering from gastritis accompanied by atypical regenerative cells. Results: Improvement observed in gastritis accompanied by atypical regenerative cells after the implementation of the nutrition therapy. Conclusion: Nutrition therapy can be beneficial in alleviating symptoms of gastritis accompanied by atypical regenerative cells.

• 한국임상수의학회지
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• 제41권1호
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• pp.65-70
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• 2024

Ten cutaneous masses from Djungarina hamsters (Phodopus sungorus) were diagnosed as nine atypical fibromas and one fibrosarcoma derived from cutaneous ganglion cell-like cells. Among these patients, nine were male and one was female. Histologically, these abnormal masses were composed of spindle-shaped or polygonal neoplastic 'ganglion cell-like' cells with abundant amphophilic vacuolated cytoplasm. Immunohistochemically, these neoplastic cells were stained for vimentin, S100, and neuron-specific enolase. Out of 9 males, 3 showed positive reactions to the androgen receptor. This report provides a detailed histologic and immunohistochemical characterization of atypical fibroma, fibrosarcoma, and the tumorigenesis of ganglion cell-like cells in Djungarian hamsters.

• 대한세포병리학회지
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• 제15권1호
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• pp.28-32
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• 2004

It was reported that the main cause of intraepithelial neoplasm and squamous cell carcinoma of the uterine cervix is human papilloma virus infection, and that the expression of p16 is increased in cells infected by human papilloma virus. We performed an immunocytochemical staining for protein p16 in 17 cases of cervocovaginal smears initially diagnosed as atypical squamous cells of undetermined significance, to know whether the staining could help the differentiation of neoplastic cells from reactive atypical cells. Of 17 smears, 6 were diagnosed finally as high grade intraepithelial neoplasm or invasive squamous cell carcinoma by follow-up biopsy and smear, and 5 of the 6 were positive for p16. Three were diagnosed as koilocytosis, and one of them was weakly positive for p16. Eight were diagnosed as reactive atypical cells, and all of them were negative for p16. We thought that immunocytochemical staining of p16 in cervocovaginal smears could help the differentiation of neoplastic cells from reactive atypical cells.

• 대한세포병리학회지
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• 제14권2호
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• pp.60-65
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• 2003

Objective: The sensitivity of the AutoPap Primary Screening System with Location-Guided Screening (AutoPap LGS) for Identifying atypical cells in cervicovaginal smears was evaluated. Methods: Two hundred forty one slides with atypical cervical cytology randomly sampled were rescreened both manually and by the AutoPap LGS. The AutoPap LGS localized the atypical cells as 15 fields of view(FOVs), which were reexamined by manual review. The sensitivity was also evaluated in accordance with the cellularity of the smears. Results: The AutoPap LGS successfully processed 232 out of 241 slides. The sensitivity of the AutoPap LGS identifying the atypical cells in successfully processed slides was 97.4%(226/232). The false negative rate was 2.6%(6/232). There was no false negative case on high grade squamous intraepithelial lesion (HSIL) or squamous cell carcinoma(SCC) smears in the AutoPap LGS. The FOVs localized the diagnostic-atypical cells in 97.8%(221/226). The number of diagnostic-atypical FOVs was increased in higher-degree of atypical cytology. The AutoPap LGS localized the atypical cells in 100% of adequately cellular smears and in 92.5% even in low cellular smears. Conclusion: The AutoPap LGS showed relatively good sensitivity to detect atypical cells. It can be a valuable system to localize atypical cells, especially in HSIL or cancer slides, even in smears with low cellularity.

• 대한세포병리학회지
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• 제9권1호
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• pp.29-35
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• 1998

In 1988, The Bethesda System for reporting cervical and vaginal cytologic diagnoses was introduced and this was revised in 1991. The new diagnostic category "atypical squamous cells of undetermined significance(ASCUS)" introduced by The Bethesda System is an area of controversy about the diagnostic category, clinical significance and appropriate treatment. A retrospective 2 years and 9 months study(April, 1994-December, 1996) was performed to evaluate the significance of reporting ASCUS on cervical smears. Sixtyseven(1.17%) of 5,730 smears were diagnosed as ASCUS and 21 cases were followed by cervical biopsies and/or endocervical curettages in 4 cases(19%), and repeat cervical smears in 17 cases(81%). Tissue diagnoses were benign in 2 cases and squamous cell carcinoma in situ in 2 cases. Cytologic diagnosis of follow up smear were negative in 14 cases(82.4%) and persistent ASCUS in 3 cases(17.6%).

• 대한세포병리학회지
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• 제8권1호
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• pp.76-82
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• 1997

Two cases of pulmonary atypical carcinoid tumor were diagnosed by fine needle aspiration cytology. Although the cytologic features of atypical carcinoid tumor have been relatively well described, it is easy to confuse atypical carcinoid tumor with typical carcinoid tumor, small cell carcinoma and adenocarcinoma of the lung. Atypical carcinoid tumor has been recognized as a distinct variant of pulmonary neuroendocrine carcinoma, with characteristic histopathologic and clinical features that separate it from both carcinoid and small cell carelnoma. The distinction of atypical carcinoid tumor from small cell carcinoma has important prognostic and therapeutic implications. The cytologic characteristics of atypical carcinoid tumor included polygonal to fusiform cells with a variable amount of lacy cytoplasm, oval nuclei with coarsely dispersed chromatin and frequent nucleoli, and mild pleomorphism. The malignant cells were arranged either in acinus-like clusterg or in epithelial sheets.

• 대한세포병리학회지
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• 제5권1호
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• pp.52-56
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• 1994

We experienced a case of fine-needle aspiration (FNA) cytology of breast which showed atypical proliferative lesion. It was very difficult to differentiate this case from malignancy, because of hypercellular smear and many clusters composed of large, atypical ductal cells. However, it showed other features favoring benignancy, such as tendency of cellular cohesiveness, only slightly increased nucleus/cytoplasm ratio and most importantly presence of myoepithelial cells. It's histologic diagnosis was intraductal hyperplasia with atypia. This case indicates that all atypical breast FNA specimen should lead to the suggestion of surgical biopsy for avoiding over- or under-diagnosis.

• 한국패류학회지
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• 제31권1호
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• pp.9-19
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• 2015

피뿔고둥, Rapana venosa의 정소소엽 내에서 정자형성과정 중에 생성되는 정상적인 생식세포의 발달과 함께 섞이어 일정 시기에만 출현하는 비정형세포들을 미세구조적으로 관찰하였고, 또한 정소 발달단계에 따른 저정낭 내층 상피세포들의 주기적 변화를 조직학적 관찰에 의해 조사하였다. 생식세포의 발달단계는 정원세포기, 정모세포기, 정세포기, 정자기로 나누어지며, 정모세포기는 다시 제1 정모세포기와 제2 정모세포기로 세분할 수 있어, 총 5 단계로 구분할 수 있었다. 정상적인 웅성생식세포들의 분화와 발달과정은 다른 복족류 종들과 유사하였다. 정자는 길이가 대략 $50{\mu}m$ 정도이었다. 정자의 미부 편모의 악소님 (axoneme) 은 주변에 9쌍의 미세소관들과 중앙에 1쌍의 미세소관들로 구성되어 있다. 즉, 9+2 구조를 이루고 있다. 특히, 대형 복족류 중 뿔소라과 피뿔고둥의 경우는 예외적으로 다른 이매패류나 두족류 등과 달리 정소소엽 내에서 정자형성과정 중에 정상적인 생식세포들 사이에서 총 4종 (Type IA, IB, Type IIA, IIB) 의 비정형세포들 (atypical cells) 이 함께 출현하는 특징을 보이고 있는데, 이러한 현상은 대형 복족류의 단지 소수의 종들에 한하여 출현하는 예외적인 특이한 현상이라 할 수 있다. 그러나 비정형세포들은 저정낭의 여러 단계 중 내층 상피세포들 내에서는 발견되지 않았다. 추측컨대 몇 가지 비정형세포들은 리소좀-모양의 공포들이나 리소좀-모양의 소체들을 가지는데, 이들은 정소소엽 내에서 붕괴나 그 자신들의 흡수에 관여하는 것으로 추정된다. 상당량의 정자들이 정소소엽 내에서 형성되어, 그들의 일부는 7월 말까지 정소에서 저정낭으로 이동된다. 교미 성기는 6-7 월 사이이었다. 피뿔고둥 저정낭 발달단계의 주기적 변화는 (1) S-1 단계 (휴지단계), (2) S-II 단계 (축적단계), 그리고 S-III 단계 (배정단계) 의 3 단계로 구분되었다.

• 대한세포병리학회지
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• 제4권2호
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• pp.81-86
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• 1993

The recently proposed Bethesda system for cervical/vaginal cytology has made a standardization related to "atypia". In cellular changes due to inflammation or repair, the word "benign cellular change" has been suggested as a substitute for atypia. Terminology related to atypical cells may become standardized, but the cytologic criteria has not been well defined yet. We evaluated 160 cases of atypical squamous cells of undetermined significance(ASCUS) by the Bethesda Sys4em(TBS). Among 30,428 cases screened, a cytologic diagnosis of ASCUS was made in 498 cases(1.6%) and 160 cases were histologically verified ASCUS was diagnosed based on nuclear enlargement and nonclassical signs of condyloma. The results are as follows: One hundred and twenty three cases(76.9%) revealed chronic cervicitis. Thirty seven cases(23.1%) demonstrated squamous intraepithelial lesion. Among intraepithelial lesions, condyloma and mild dysplasia were 28 cases(75.7%). Moderate and severe dysplasia were 5 cases(13.5%) and 4 cases(10.8%), respectively. it is concluded that patients with ASCUS should be colposcopically examined.