• BMB Reports
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• v.56 no.6
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• pp.326-334
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• 2023

Antibiotic resistance (AR) is a silent pandemic that kills millions worldwide. Although the development of new therapeutic agents against antibiotic resistance is in urgent demand, this has presented a great challenge, especially for Gram-negative bacteria that have inherent drug-resistance mediated by impermeable outer membranes and multidrug efflux pumps that actively extrude various drugs from the bacteria. For the last two decades, multidrug efflux pumps, including AcrAB-TolC, the most clinically important efflux pump in Gram-negative bacteria, have drawn great attention as strategic targets for re-sensitizing bacteria to the existing antibiotics. This article aims to provide a concise overview of the AcrAB-TolC operational mechanism, reviewing its architecture and substrate specificity, as well as the recent development of AcrAB-TolC inhibitors.

• Annual Conference on Human and Language Technology
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• 2021.10a
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• pp.490-495
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• 2021

표준어와 방언사이에는 위계가 존재하지 않고 열등하지 않다는 사상을 기반으로 방언을 보존하기 위한 다양한 노력들이 이루어지고있다. 또한 동일한 국가내에서 표준어와 방언간의 의사소통이 잘 이루어져야한다. 본 논문은 방언 연구보존과 의사소통의 중요성을 바탕으로 한국어 방언 기계번역 연구를 진행하였다. 대표적인 방언 중 하나인 제주어와 더불어 강원어, 경상어, 전라어, 충청어 기반의 기계번역 연구를 진행하였다. 공개된 AI Hub 데이터를 바탕으로 Transformer기반 copy mechanism을 적용하여 방언 기계번역의 성능을 높이는 모델링 연구를 진행하였으며 모델배포의 효율성을 위하여 Many-to-one기반 universal한 방언 기계번역기를 개발하였고 이를 one-to-one 모델과의 성능비교를 진행하였다. 실험결과 copy mechanism이 방언 기계번역 모델에 매우 효과적인 요소임을 알 수 있었다.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.37 no.1
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• pp.11-25
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• 2024

Lithium-ion batteries (LIBs) have attracted great attention as the common power source in energy storage fields of large-scale applications such as electrical vehicles (EVs), industries, power plants, and grid-scale energy storage systems (ESSs). Insertion, alloying, and conversion reactions are the main electrochemical energy storage mechanisms in LIBs, which determine their electrochemical properties and performances. The electrochemical reaction mechanisms are determined by several factors including crystal structure, components, and composition of electrode materials. This article reviews a new strategy to compensate for the intrinsic shortcomings of each reaction mechanism by introducing the material systems to form a single compound with different types of reaction mechanisms and to allow the simultaneous hybrid electrochemical reaction of two different mechanisms in a single solid solution phase.

• Computers and Concrete
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• v.32 no.6
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• pp.615-623
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• 2023

Crack detection is an essential method to ensure the safety of dam concrete structures. Low-quality crack images of dam concrete structures limit the application of neural network methods in crack detection. This research proposes a modified attentional mechanism model to reduce the disturbance caused by uneven light, shadow, and water spots in crack images. Also, the focal loss function solves the small ratio of crack information. The dataset collects from the network, laboratory and actual inspection dataset of dam concrete structures. This research proposes a novel method for crack detection of dam concrete structures based on the U-Net neural network, namely AF-UNet. A mutual comparison of OTSU, Canny, region growing, DeepLab V3+, SegFormer, U-Net, and AF-UNet (proposed) verified the detection accuracy. A binocular camera detects cracks in the experimental scene. The smallest measurement width of the system is 0.27 mm. The potential goal is to achieve real-time detection and localization of cracks in dam concrete structures.

• Korean Institute of Interior Design Journal
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• v.27 no.2
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• pp.3-11
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• 2018

This study aims to investigate whether there is intensionally changing eye - gaze on the cafe space images with floor finishing materials. In the Yarbus' experiment, he argued that changing information that an observer is asked to obtain from an image changes pattern of eye movements. Based on the scan path evidence, this research have questions as (1) the difference of visual attention on finishing floor material stimulus, (2) visual attention of initial activity time and type of movement paths on AOIs, and (3) visual relation floor area with another AOIs. Eye movements were recorded with the SMI REDn Scientific, which sampled eye position at 30Hz and lasted 2 minutes(120s). Although viewing was binocular, only the right eye was tracked. Of the 66 observers(mean age 22 years, standard deviation: ${\pm}1.82$) who participated in the experiment done by the four point calibration and validation procedures at the beginning tasks. Analyzing qualitative data from the number of fixation and duration on AOIs divided into four parts (AOI I-Floor, AOI II-Wall, AOI III-Ceiling, and AOI IV-Counter) in the stimulus. The results from this experiment analyzed as follows. First, it was significant in the difference of the average number of AOIs fixation times observed for the spatial image using the wood tile flooring material and the polishing tile. The wood tile flooring of stimulus had higher fixation number on AOI-II, AOI-III, and AOI-IV than the polishing tile. On seeing AOI-I was higher attention in the polishing tile stimulus. Second, the observers examined AOI-II intensively in both stimuli. However, the visual intensity was also followed by on the AOI-IV and AOI-I in the wood tile flooring stimulus, and on AOI-I, AO-IV in the polishing tile. Third, visual attention data on each AOIs have divided into the time range of "5 sec" for both images. In the wood tile stimulus, the horizontal movement path followed by AOI-II, AOI-IV, and AOI-II. In the polished tile stimulus, the movement path followed by moving vertically to AOI-II, AOI-I, and AOI-II. This study approached meaningfully and found out the characteristics of visual attention, according to the different intentions of visual attention, the relationship pathways of visual mechanism appeared and also activated by eye-tracking experiments.

• Anxiety and mood
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• v.15 no.2
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• pp.101-108
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• 2019

Objective : This study aimed to investigate the associations of anxiety symptoms with behavior and attention in elementary school children with attention-deficit/hyperactivity disorder (ADHD). Methods : A total of 195 elementary school children with ADHD participated in the study. The Korean Version of ADHD Rating Scale (K-ARS) and Behavior Assessment System for Children(BASC-2) were used to measure the children's behavior. Anxiety and attention was assessed with State-Trait Anxiety Inventory for Children (STAIC) and ADHD Diagnostic System (ADS), respectively. Children with ADHD were categorized to two groups of ADHD with low anxiety (ADHD-LA) and ADHD with high anxiety (ADHD-HA) according to the total STAIC scores. Scores on K-ARS, BASC-2 and ADS were compared between two groups of ADHD-LA and ADHD-HA. Results : The Scores on K-ARS total and both subscales in ADHD-HA group were significantly higher than ADHD-LA group. Scores on the BASC-2 subscales including hyperactivity, aggression, conduct problem, anxiety, depression, somatization, withdrawal, attention problems were also significantly higher in ADHD-HA group compared to ADHD-LA group. In contrary, scores on ADS subscales were not significantly different between the both groups. Conclusion : Our study identified that the anxiety accompanied with ADHD was associated with the negative behavioral aspect in children with ADHD. However, the performances on attention task were not affected by the anxiety comorbid with ADHD. Future studies to reveal underlying mechanism are needed for further understanding the association with anxiety and ADHD.

• Bulletin of the Korean Space Science Society
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• 2004.04a
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• pp.39-39
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• 2004

It has been known that ring current particles can be lost through dayside MP(magnetopause). However, details of the loss mechanism of this process has not received much attention. In this study, we show that the solar wind dynamic pressure P$\sub$D/ can play a significant role in the dayside loss. In order to show that, we have first conducted superposed epoch analysis using 95 geomagnetic storm events selected from the period 1997 to 2002. (omitted)

• International Journal of Contents
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• v.2 no.1
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• pp.5-8
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• 2006

This paper describes a new mechanism of detecting object of interest from a noisy image, without using any a-priori knowledge about the target. It employs a parallel set of filters inspired upon biological findings of mammalian vision. In our proposed system, several basic features are extracted directly from original input visual stimuli, and these features are integrated based on their local competitive relations and statistical information. Through integration process, unnecessary features for detecting the target are spontaneously decreased, while useful features are enhanced. Experiments have been performed on a set of computer generated and real images corrupted with noise.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2009.05a
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• pp.129-129
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• 2009

Much attention has been recently paid to the trivalent chromium electro-plating for the application of surface finishing, mainly because of the environmental issues. Nevertheless, trivalent chromium plating has several critical issues to be figured out for such applications, including instability of the plating solution, poor property of plates and etc.

• KSBB Journal
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• v.8 no.1
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• pp.1-9
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• 1993

The acetone-butanol fermentation by C. acetobutylicum has gained increasing attention for the following reasons. First, the finite supply of petrochemical resources, combined with increasing concern over global environmental effects and the unstable nature of the price of petroleum has renewed interest in the development of fermentation technology that allows utilzation of biomass wastes for the production of alcohol. Second, it serves as excellent model system for understading the regulation and molecular biology of tightly regulated complex primary metabolism, and for applications of metabolic engineering. In this review various aspects of acetone-butanol fermentation by C. acetobutylicm including strain and fermentation characteristics, enzyme regulation, and solvent formation mechanism, and product recovery and summarized.