• Title/Summary/Keyword: atitumour activity

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Design and Synthesis of (${\pm}$) -3-Deoxygericudranin A as an Antitumour Agent (항암제로서의 (${\pm}$) -3-데옥시제리쿠드라닌 A의 설계 및 합성)

  • Choi, Yoon-Jung;Shim, Pil-Jong;Kim, Hee-Doo
    • YAKHAK HOEJI
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    • v.41 no.1
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    • pp.14-17
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    • 1997

  • (${\pm}$)-3-Deoxygericudranin A was designed and synthesized for the development of novel antitumour agent and for the elucidation of the effect of 3-hydroxyl group in gericudranin A on antitumour activity. 2,4.6-Trihydroxyacetophenone was converted to 3-deoxygericudranin A in 5 steps via sequential protection, aldol condensation, Michael tvpe-cyclization, regioselective, C-benzylation and deprotection.

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