• Fisheries and Aquatic Sciences
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• 제24권1호
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• pp.1-9
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• 2021

Human prostate cancer is the second most frequently diagnosed cancer worldwide, and its incidence rate continues to increase. Advanced prostate cancer is more difficult to treat than early forms due to its chemotherapy resistance. There is need for more effective agents that can inhibit the progression of advanced prostate cancer. Demethoxyfumitremorgin C (DMFTC) was isolated from the fermentation extract of the marine fungus Aspergillus fumigatus. Antiproliferative activity of DMFTC against human prostate cancer PC3 cells was examined through cell cycle analysis by flow cytometry, the fluorescent nuclear imaging analysis with propidium iodide (PI), and proteins expression related to cell cycle arrest and apoptosis were investigated via Western blotting. DMFTC inhibited PC3 cells growth through G1 phase cell cycle arrest and apoptosis induction. It activated the tumor suppressor p53 and the Cdk inhibitor p21, which regulate the cell progression into the G1 phase. Additionally, PI-positive late apoptotic non-viable cells were increased and the expression levels of the G1-positive downstream regulators cyclin D, cyclin E, Cdk2, and Cdk4 were decreased by DMFTC treatment. These results suggest that DMFTC induces G1 arrest and apoptosis induction through regulation of p53/p21-dependent cyclin-Cdk complexes, and it may be a useful therapeutic agent for the treatment of human advanced prostate cancer.

• 디지털융복합연구
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• 제15권1호
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• pp.227-238
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• 2017

급성 심정지는 갑작스러운 심장 기능의 상실로 인하여 수 분 안에 뇌를 비롯하여 온 몸에 혈액 공급이 되지 않아 사망으로 이어지는 대표적인 중증응급질환이다. 특히 병원 밖에서 발생하는 병원외 심정지 환자는 생존율이 매우 낮다. 그 이유는 갑작스런 발병으로 인해 주변사람들이 심정지 환자라는 것을 인식하지 못할 뿐만 아니라 인식한다 하더라도 전문 의료지식이 없어 정확한 응급조치를 취하는 것이 어렵기 때문이다. 기존의 심정지 관련 연구는 대부분 심정지 발생 후의 치료법 방안에 집중되어 있었으나, 이는 근본적인 문제해결이 어려워 생존율을 높이는데 한계가 있었다. 이러한 문제를 해결하기 위해 본 논문에서는 널리 보급된 스마트폰을 활용하여 급성 심정지 환자를 위한 알림, 사전예방, 응급조치 등의 기능을 갖춘 솔루션을 개발하였다. 이 솔루션을 활용하면 급성 심정지를 사전에 예방할 수 있고, 설사 발병한다고 하더라도 주변사람에게 신속하게 알려 최대한 골든타임(4분)을 지킬 수 있으며, 1차 발견자가 신속하고 정확한 심폐소생술을 실시할 수 있어 생존율을 한층 더 높일 것으로 기대한다.

• 디지털융복합연구
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• 제13권1호
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• pp.353-366
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• 2015

본 연구의 목적은 심정지 발생의 지역별 변이요인을 규명하는 것이다. 분석을 위하여 244개 행정구역별로 건강상태 및 심정지발생에 관한 지표를 수집하여 분석용 데이터 셋을 구축하였다. 지표 선정을 위해 질병관리본부의 2010년 심정지 조사자료와 지역사회 건강조사자료를 이용하였다. 자료 분석은 다중회귀분석, 지리적 가중회귀분석, 의사결정나무분석 기법을 이용하였다. 의사결정나무를 이용하여 심정지 발생의 지역별 변이를 설명하는 최종 모형을 설정하였다. 최종 모형인 의사결정나무에 근거한 지역별 변이요인은 인구밀도, 고혈압 평생의사 경험진단율, 스트레스 인지율, 고지혈증 평생의사 경험진단율, 우울증 경험률, 건강검진 수검율, 고위험음주율, 현재 흡연율로 나타났다. 심정지 발생을 감소시키기 위한 지역별 보건정책의 수립은 지역의 건강상태, 건강행위 및 사회경제적 요인 등에 근거하여 이루어질 필요가 있다.

• 한국해양공학회지
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• 제6권1호
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• pp.131-139
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• 1992

The understanding and appllication of fatigue crack propagation mechanism in variable amplitude loading is very important for life prediction of the air travel structures. Particularly, the retardation and arrest behavior of fatigue crack propagation by single tension overloading is essential to the understanding and appllication of fatigue crack propagation mechanism in variable amplitude loading. Numerous studies of the retardation behavior have been performed, however investigations of the arrest behavior have not been enough yet. As for the arrest behavior, Willenborg had reported that the overload shut-off ratio $[R_{so}=(K_{OL})/K_{max})_{crack arrest}]$ had been the material constant, but recently several investigators have reported that the overload shut-off ratio depends upon the stress ratio. In this study, authors have investigated the effect of stress ratio on the threshold overload shut-off ratio to generate arrest of fatigue crack growth in high tensile aluminum alloy 7075-T735 which have used in material for air travel structures, It has been $-0.4\leqqR\leqq0.4$ till now, the region of stress ratio investigated. The threshold overload shut-off ratio has decreased as stress ratio has increased in overall region of -$-0.4\leqqR\leqq0.4$ and the linearity has been seen in this material. Moreover, the experimental equation between $R_{so}$ and R has been made; The relation has been $R_{so}=-R+2.6$.

• Journal of Chest Surgery
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• 제48권5호
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• pp.318-327
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• 2015

Background: With improvements in cardiopulmonary resuscitation (CPR) techniques, the quality and the effectiveness of CPR have been established; nevertheless, the survival rate after cardiac arrest still remains poor. Recently, many reports have shown good outcomes in cases where extracorporeal membrane oxygenation (ECMO) was used during prolonged CPR. Accordingly, we attempted to evaluate the impact of extracorporeal cardiopulmonary resuscitation (ECPR) on the survival of patients who experienced a prolonged cardiac arrest and compared it with that of conventional CPR (CCPR). Methods: Between March 2009 and April 2014, CPR, including both in-hospital and out-of-hospital CPR, was carried out in 955 patients. The ECPR group, counted from the start of the ECPR program in March 2010, included 81 patients in total, and the CCPR group consisted of 874 patients. All data were retrospectively collected from the patients' medical records. Results: The return of spontaneous circulation (ROSC) rate was 2.24 times better in CPR of in-hospital cardiac arrest (IHCA) patients than in CPR of out-of-hospital CA (OHCA) patients (p=0.0012). For every 1-minute increase in the CPR duration, the ROSC rate decreased by 1% (p=0.0228). Further, for every 10-year decrease in the age, the rate of survival discharge increased by 31%. The CPR of IHCA patients showed a 2.49 times higher survival discharge rate than the CPR of OHCA patients (p=0.03). For every 1-minute increase in the CPR duration, the rate of survival discharge was decreased by 4%. ECPR showed superiority in terms of the survival discharge in the univariate analysis, although with no statistical significance in the multivariate analysis. Conclusion: The survival discharge rate of the ECPR group was comparable to that of the CCPR group. As the CPR duration increased, the survival discharge and the ROSC rate decreased. Therefore, a continuous effort to reduce the time for the decision of ECMO initiation and ECMO team activation is necessary, particularly during the CPR of relatively young patients and IHCA patients.

• 한국응급구조학회지
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• 제16권3호
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• pp.9-18
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• 2012

Purpose : The purpose of this study was to determine the changes that occur due to the real-time monitoring of paddle pressures which has an important influence on the defibrillation success rate in defibrillation treatment known as the only treatment for cardiac arrest patients with VF. Methods : 40 people participated in the cardiac arrest simulation training and played the role of the defibrillation operator. Investigators measured the pressure of paddle while defibrillating by using instrument which was developed by the investigator. Results : Through real-time monitoring of the paddle pressures of defibrillator by indicator, the front sternum paddle showed a 77.5% success rate and the apex paddle showed a 40% success rate. While the values without monitoring the paddle pressures, the front sternum paddle showed a 51% success rate and the apex paddle showed a 20% success rate. These experiment revealed statistically significant(p <.001) low success rate. Conclusion : The method of monitoring the paddle pressures during defibrillation showed that the paddle can be precisely gripped. The success rate of paddle pressures is significantly correlated with height, weight and grip strength.

• Journal of Trauma and Injury
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• 제33권1호
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• pp.23-30
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• 2020

Purpose: Hemorrhagic shock is the leading cause of death in trauma patients worldwide. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a technique used to improve the hemodynamic stability of patients with traumatic shock and to temporarily control arterial hemorrhage. However, further research is required to determine whether REBOA with cardiopulmonary resuscitation (CPR) in near-arrest or arrest trauma patients can help resuscitation. We analyzed trauma patients who underwent REBOA according to their CPR status and evaluated the effects of REBOA in arrest situations. Methods: This study was a retrospective single-regional trauma center study conducted at a tertiary medical institution from February 2017 to November 2019. We evaluated the mortality of severely injured patients who underwent REBOA and analyzed the factors that influenced the outcome. Patients were divided into CPR and non-CPR groups. Results: We reviewed 1,596 trauma patients with shock, of whom 23 patients underwent REBOA (1.4%). Two patients were excluded due to failure and a repeated attempt of REBOA. The Glasgow Coma Scale score was lower in the CPR group than in the non-CPR group (p=0.009). Blood pressure readings at the emergency room were lower in the CPR group than in the non-CPR group, including systolic blood pressure (p=0.012), diastolic blood pressure (p=0.002), and mean arterial pressure (p=0.008). In addition, the mortality rate was higher in the CPR group (100%) than in the non-CPR group (50%) (p=0.012). The overall mortality rate was 76.2%. Conclusions: Our study suggests that if REBOA is deemed necessary in a timely manner, it is better to perform REBOA before an arrest occurs. Therefore, appropriate protocols, including pre-hospital REBOA, should be constructed to demonstrate the effectiveness of REBOA in reducing mortality in arrest or impending arrest patients.

• International Journal of Advanced Culture Technology
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• 제10권4호
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• pp.434-443
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• 2022

CPR in High-rise building is one of the challenging tasks to 119 paramedics, evacuating patient from the narrow and vertical area. This study was built to compare the method of mechanical CPR and manual CPR is to maximizing on-scene treatment time, and minimizing the hand-off time in cardiac arrest, transporting patient as fast as possible. The electronic data research (Science, Pubmed, Medline, Medline and 55 academic DB interworking) was conducted, and five articles were included by reviewing and excluding through the Covidence program and Review Manager version 5.4(Cochrane Collaboration). OHCA occurring on the higher floor indicates lower in survival. A total studies uniformly reported mechanical CPR is more effective during the high-rise building evacuation, than manual CPR in rate, depth, and hands-on time of chest compression. Use of mechanical CPR device is more suitable in case of High-rise building OHCA to improve the survival rate which is affected by high-quality CPR.

• 한국응급구조학회지
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• 제8권1호
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• pp.149-160
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• 2004

Background : To save out-of-hospital cardiac arrest cases is a major concern for Korea. Cardiac arrest is a very common problem, with > 18,000 cases dying each year in Korea. Overall, survival to hospital discharge remains poor. Resuscitation has become an important multidisciplinary branch of medicine, demanding a spectrum of skills and attracting a plethora of specialities and organizations. Since the "Utstein Style" was advocated in 1991, many reports about out-of-hospital cardiac arrest have been published based on this guideline. These differences prevent valid inter-hospital and international comparisons. However, we do not know the true effectiveness of resuscitation. There are no guideline for reviewing, reporting, conducting research on resuscitation in Korea. This study evaluated the out-of-hospital factor associated with survival discharge of out-of-hospital cardiac arrest, was especially to provide basic data for the unified reporting guideline of resuscitation in Korea. Methods : From January 1990 to July 2004, we collected data about out-of-hospital cardiac arrest at Wonju Christian Hospital(WCH-CAD), Ewha Women University Mokdong Hospital(Ewha-CAD), I used same record form based on the "Utstein Style". The "Utstein Style" is internationally recommended guidelines for reporting outcome data from resuscitation events. Results : Resuscitation was performed in 1443 out-of-hospital cardiac arrest patients at 2 hospitals. Five hundred eighty(40.25%) patients recovered the spontaneous circulation at least once and One hundred sixty eight(11.66%) patients discharged alive. Initial EKG showed Ventricular Tachycardia/Ventricular Fibrillation in One hundred thirty five(9.33%) patients, asystole in one thousand nine(69.73%) patients and other rhythms in one hundred thirty nine(20.94%) patients. Among one hundred two cardiogenic cardiac arrest patients, two(2.0%) patients was discharged alive. Conclusion : Overall survival rate of out-of-hospital cardiac arrest patients was 11.66% which was poorer than that of the western country. The proportion of the cardiogenic cause was 33.38% which was only half of the western country. VT/VF is relatively not common ac a initial EKG rhythm. These differences might be to due difference in the prevalence pattern of out-of-hospital cardiac arrest as well as prematurity of the EMSS. It is needed that the best survival can be achieved if all following links have been optimized : rapid access, early CPR, early defibrillation, early ACLS.

• 한국인공지능학회지
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• 제10권1호
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• pp.21-25
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• 2022

Korea has relatively less crime than other countries. However, the crime rate is steadily increasing. Many people think the crime rate is decreasing, but the crime arrest rate has increased. The goal is to check the relationship between CCTV and the crime rate as a way to lower the crime rate, and to identify the correlation between areas without CCTV and areas without CCTV. If you see a crime that can happen at any time, I think you should use a random forest algorithm. We also plan to use machine learning random forest algorithms to reduce the risk of overfitting, reduce the required training time, and verify high-level accuracy. The goal is to identify the relationship between CCTV and crime occurrence by creating a crime prevention algorithm using machine learning random forest techniques. Assuming that no crime occurs without CCTV, it compares the crime rate between the areas where the most crimes occur and the areas where there are no crimes, and predicts areas where there are many crimes. The impact of CCTV on crime prevention and arrest can be interpreted as a comprehensive effect in part, and the purpose isto identify areas and frequency of frequent crimes by comparing the time and time without CCTV.