• Archives of Pharmacal Research
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• 제23권4호
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• pp.360-366
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• 2000

The in vivo binding of dopamine (DA) radioligands to $D_2$receptors can be affected by competition with endogenous dopamine. In the present study, we used a brain slice preparation that provides more controlled conditions than in vivo preparations in order to examine the relationship between synaptic DA and the binding of [$^3H$] raclopride to $D_2$receptors. We also estimated the synaptic DA concentration in rat striatal slices by determining the changes in [$^3H$] raclopride binding. To correlate the changes in [$^3$H]raclopride binding with the concentration of synaptic DA, the kinetic parameters were determined. [$^3H$] Raclopride reached equilibrium binding conditions within two hours. The K value for DA in inhibiting [$^3$H]raclopride binding was about 2.2 nM. The increase in synaptic DA evoked by electrical stimulation decreased the striatal binding of [$^3H$] raclopride in a frequency-dependent manner. Increases in the DA concentration evoked by amphetamine (AMPH) or cocaine decreased [$^3H$] raclopride binding by 74% or 20%, respectively, corresponding to increases in the synaptic DA concentrations of 1.6 nM or 0.6 nM, respectively. Pargyline also decreased [$^3H$] raclopride binding by 36%corresponding at a concentration of 1.2 nM. In contrast, the depletion of synaptic DA by $\alpha$-methyl-p-tyrosine ($\alpha$-MpT) increased the specific binding of [$^3H$] raclopride by 43%when the DA concentration was decreased to 0.7 nM. The changes in the DA concentration at the synapse were responsible for the changes in the striatal binding of [$^3H$] raclopride. The values calculated in this study may therefore approximate the changes in the synaptic DA concentration in rat striatal slices following manipulation.

• 한국인터넷방송통신학회논문지
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• 제12권1호
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• pp.65-74
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• 2012

이중 트리 이산 웨이브렛 변환은 이산 웨이브렛 변환 보다 우수하며, 이동 변이(shift variance)의 웨이브렛 보다 적은 계산량을 가진다. 이러한 특성들은 잡음 제거, 텍스쳐 분할 등에서 효율적으로 사용된다. 이중 트리 이산 웨이브렛 변환을 수행하는 과정에 Quincunx 표본화를 적용하였다. 이 방법은 이중 트리 이산 웨이브렛 변환의 주된 특징인 이동 불변성의 성질과 다양한 방향성의 특징 그리고 비분리 영상처리 효과를 증가시킬 수 있다. 본 논문에서는 제안된 방법에 대한 성능을 평가하고 실험결과를 제시하였다. 따라서 비분리 처리특성으로 인위적인 패턴을 갖는 디지털 영상에 대해서 웨이브렛 변환의 특징을 얻을 수 있어 효율적인 영상처리가 가능하다.

• 전자공학회논문지S
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• 제36S권10호
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• pp.51-57
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• 1999

본 논문에서는 웨이브렛 신경회로망을 사용하여 알려지지 않은 비선형 시스템을 안정하게 제어하는 문제를 다룬다. 비선형 시스템의 정확한 제어는 함수를 근사화하는 데 사용되는 함수 근사화기의 정확성과 효율성에 의존한다. 그러므로 기준 함수의 선택이 자유롭고 함수 근사화 능력이 뛰어난 웨이브렛 신경회로망을 비선형 시스템 제어에 이용한다. 초기 웨이브렛 신경회로망 제어기를 설정하기 위해서 먼저 제어기 입력의 시-주파수 특성을 분석해서 웨이브렛 신경회로망 변수인 신축과 이동 값을 구한다. 다음에 Lyapunov 안정성 이론에 기초한 적응 법칙을 사용하여 연결강도를 조절한다. 이 직접 적응 웨이브렛 신경회로망 제어기를 비선형 시스템인 역 진자 시스템을 제어하는데 적용한다.

• Smart Structures and Systems
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• 제20권6호
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• pp.709-728
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• 2017

This disquisition proposes a nonlocal strain gradient beam theory for thermo-mechanical dynamic characteristics of embedded smart shear deformable curved piezoelectric nanobeams made of porous electro-elastic functionally graded materials by using an analytical method. Electro-elastic properties of embedded curved porous FG nanobeam are assumed to be temperature-dependent and vary through the thickness direction of beam according to the power-law which is modified to approximate material properties for even distributions of porosities. It is perceived that during manufacturing of functionally graded materials (FGMs) porosities and micro-voids can be occurred inside the material. Since variation of pores along the thickness direction influences the mechanical and physical properties, so in this study thermo-mechanical vibration analysis of curve FG piezoelectric nanobeam by considering the effect of these imperfections is performed. Nonlocal strain gradient elasticity theory is utilized to consider the size effects in which the stress for not only the nonlocal stress field but also the strain gradients stress field. The governing equations and related boundary condition of embedded smart curved porous FG nanobeam subjected to thermal and electric field are derived via the energy method based on Timoshenko beam theory. An analytical Navier solution procedure is utilized to achieve the natural frequencies of porous FG curved piezoelectric nanobeam resting on Winkler and Pasternak foundation. The results for simpler states are confirmed with known data in the literature. The effects of various parameters such as nonlocality parameter, electric voltage, coefficient of porosity, elastic foundation parameters, thermal effect, gradient index, strain gradient, elastic opening angle and slenderness ratio on the natural frequency of embedded curved FG porous piezoelectric nanobeam are successfully discussed. It is concluded that these parameters play important roles on the dynamic behavior of porous FG curved nanobeam. Presented numerical results can serve as benchmarks for future analyses of curve FG nanobeam with porosity phases.

• 대한미생물학회지
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• 제22권3호
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• pp.251-258
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• 1987

A total of 58 strains of Enterobacter species isolated from clinical specimens at Kyungpook National University Hospital in Taegu and Yonsei University Hospital in Seoul were tested for the molecular characterization to investigate the nosocomial infection through the study of R plasmids which might spread among Gram negative organisms regardless of their originated strains. All strains resistant to ampicillin, cefoxitin and cephalothin but susceptible to moxalactam were subjected to the further test for the determination of in detail MIC value against 23 drugs of common use including beta-lactam antibiotics and R plasmid profile analysis. The reistance frequency of strains against carbenicillin (53.4%) was similar to those against chloramphenicol, tobramycin, and sulfisomidine. Though the MIC values of resistance criteria against ceftazidime, aztreonam, imipenem, and norfloxacine in NCCLS manual were not available but MIC ranges of strains tested were very low. There were differences in patterns and frequencies of resistance between the strains isolated in Seoul and Taegu isolates. Seoul isolates showed a tendency of higher multiplicity of resistance than those of Taegu isolates. The resistances against cefoxitin, cephalothin, cefoperazone, cefotaxime, nalidixic acid, and rifampin were not conferred to the conjugally transferable R plasmid. The approximate molecular size of conjugally transferable R plasmids ranged 30 to 151 megadalton, and one or 2 to 3 R plasmids were identified in each transconjugants.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2017년도 학술발표회
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• pp.329-329
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• 2017

In this study attempted to evaluate the stability of the protection methods by examining hydraulic characteristics of the area around the point in which marine cable protector is installed such as surf zone occurrence point of shore-end submarine cables suitable for coastal marine environmental conditions, flow rate t the tope of the protector and maximum wave height, and to provide basic data for the selection of the optimal protection method. In performing hydraulic model experiments, the topography of submarine cable installation location was reproduced in 2-D sectional channel, and models appropriate for experimental scale and similitude law were produced and installed for each condition of submarine cables and protectors. Since the topography and submarine cable protectors were reproduced and installed in 2-D sectional channel, the exact reproduction of surf and transformation in shallow water zone was possible, and thus the physical properties could be clearly analyzed. For stability review, an experiment to examine the stability was conducted using a wave maker with 50-year frequency design waves as target, and wave height and cycles were applied based on the approximate lowest low water level(Approx. L.L.W), which is the most dangerous in submarine cable protection methods. As for experimental time, typhoon passing time in summer (about 3 hours) was applied, and wave patterns and deviation ratio of the submarine cable protector were investigated after making irregular waves corresponding to design waves. In addition, current meter and wave height meter were installed at the installation location of the submarine cable protector, and the flow rates and wave height at the top of the protector were measured and analyzed to review hydraulic properties.

• Smart Structures and Systems
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• 제23권3호
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• pp.263-278
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• 2019

Moving train load parameters, including train speed, axle spacing, gross train weight and axle weights, are identified based on strain-monitoring data. In this paper, according to influence line theory, the classic moving force identification method is enhanced to handle time-varying velocity of the train. First, the moments that the axles move through a set of fixed points are identified from a series of pulses extracted from the second derivative of the structural strain response. Subsequently, the train speed and axle spacing are identified. In addition, based on the fact that the integral area of the structural strain response is a constant under a unit force at a unit speed, the gross train weight can be obtained from the integral area of the measured strain response. Meanwhile, the corrected second derivative peak values, in which the effect of time-varying velocity is eliminated, are selected to distribute the gross train weight. Hence the axle weights could be identified. Afterwards, numerical simulations are employed to verify the proposed method and investigate the effect of the sampling frequency on the identification accuracy. Eventually, the method is verified using the real-time strain data of a continuous steel truss railway bridge. Results show that train speed, axle spacing and gross train weight can be accurately identified in the time domain. However, only the approximate values of the axle weights could be obtained with the updated method. The identified results can provide reliable reference for determining fatigue deterioration and predicting the remaining service life of railway bridges.

• 대한의용생체공학회:의공학회지
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• 제30권1호
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• pp.49-55
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• 2009

Purpose : The aim of this study is to evaluate a possibility of clinical application for the effects of low intensity ultrasound stimulation (LIUS) in morphological characteristics (i.e., structure, bone mineral density) of bone on osteoporotic fracturesprevention. Materials and Methods : Eight virgin 14-week-old ICR mice (approximate weight 25g) were used and ovariectomized (OVX) to induce osteoporosis. Right tibia (US) for each mouse served as the LIUS (1.5MHz frequency, 1.0 kHz pulse repetition on frequency, $30mW/cm^2$ intensity, $200{\mu}s$ pulse length, and stimulation for 20 minutes a day and 5 days a week over a 6-week period). Left tibia (CON) for each mouse served as the non-stimulated controls. Structural parameters and bone mineral density ($g/cm^3$) on trabecular bone of tibiae were calculated and measured from images derived in-vivo micro computed tomography (micro-CT) at 0 week and after 6weeks. Results : The BV/TV and Tb.N in US group were significantly bigger than those in CON group. The Tb.Pf in US group, moreover, was significantly smaller than that in CON group (p<0.05).For the others structural parameters and BMD, however, there were no significant difference between US group and CON group (p>0.05). Conclusion : The LIUS might prevent bone loss and keep bone connectivity in osteoporotic bones. Therefore, the LIUS might prevent effectively the osteoporotic fractures in clinics.

• 환경영향평가
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• 제26권1호
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• pp.11-26
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• 2017

철도 소음의 환경영향평가 업무에 있어서 소음도에 대한 정확한 예측이 중요하지만, 국내에서는 overall 소음도의 거리별 측정을 통한 경험식이 근사적으로 이용되고 있다. 본 논문에서는 소음원과 소음전파의 주파수 특성을 고려하여 철도 소음의 예측 정확도를 향상할 수 있는 예측 모델을 제안하였다. 먼저 철도 소음원을 궤도(레일 및 침목), 차륜, 동력, 공력 성분으로 구분하여 각각의 옥타브 밴드 주파수별 음향파워와 속도계수를 정의하고 음향 조도와 궤도/교량 특성을 반영할 수 있는 보정항을 도입하였다. 소음원에서 수음점까지의 전파 특성은 ISO 9613-2를 적용하여 기하학적 확산, 대기 흡음, 지면 효과, 장애물의 회절에 따른 감쇠 및 지향특성을 반영하여 계산하였다. 소음원 음향파워와 지향인자를 추정하기 위하여 전동 소음원 해석 모델 및 수치해석 결과와 통과 소음도 측정값을 이용하였다. 본 철도 소음 예측 모델을 이용하여 여러 철도 차량과 궤도 유형에 따라서 예측한 소음도를 측정값과 비교하여 정확도를 검증하였으며 기존 예측 모델보다 비교적 정확한 예측이 가능하였다. 따라서 본 결과는 철도 환경 소음의 정확한 영향 예측과 효율적인 소음 저감 대책 수립에 활용될 수 있을 것이다.

• 한국융합학회논문지
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• 제9권6호
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• pp.175-182
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• 2018

본 연구에서는 초음파 진동에너지가 융합된 커팅기용 공구 혼 제작에 대한 기초 연구 자료를 제작하고자 이론적방법과 유한요소해석을 병행하여 설계하였다. 고 성능의 초음파 절단을 진행하기 위해서는 횡진동이 아닌 종진동으로만 진동해야 하며, 기계적 진동에너지를 효율적으로 전달하기 위해 출력부에 최대진폭이 발생해야 한다. 따라서 공구 혼은 발진기의 가진 주파수와 공구 혼의 고유주파수가 동일하게 설계되어야만 한다. 공구 혼을 공진설계하기 위해서는 1차원 파동방정식을 이용한 이론적 접근법과, 유한요소 해석결과를 설계모델에 반영하는 방법이 있는데, 본 연구에서는 최초에 공구 혼의 대략적인 치수를 1차원 파동방정식을 통해 결정하고, 유한요소 해석 결과를 바탕으로 최적 모델을 선정하여 공구 혼의 최종 형상에 반영하였다. 이와 같은 내용을 실제 커팅용 공구 혼의 기초자료로 활용하고자 하며, 추후 제작 및 실험 데이터를 본 연구내용과 비교할 예정이다.