• Archives of Pharmacal Research
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• v.23 no.4
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• pp.360-366
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• 2000

The in vivo binding of dopamine (DA) radioligands to $D_2$receptors can be affected by competition with endogenous dopamine. In the present study, we used a brain slice preparation that provides more controlled conditions than in vivo preparations in order to examine the relationship between synaptic DA and the binding of [$^3H$] raclopride to $D_2$receptors. We also estimated the synaptic DA concentration in rat striatal slices by determining the changes in [$^3H$] raclopride binding. To correlate the changes in [$^3$H]raclopride binding with the concentration of synaptic DA, the kinetic parameters were determined. [$^3H$] Raclopride reached equilibrium binding conditions within two hours. The K value for DA in inhibiting [$^3$H]raclopride binding was about 2.2 nM. The increase in synaptic DA evoked by electrical stimulation decreased the striatal binding of [$^3H$] raclopride in a frequency-dependent manner. Increases in the DA concentration evoked by amphetamine (AMPH) or cocaine decreased [$^3H$] raclopride binding by 74% or 20%, respectively, corresponding to increases in the synaptic DA concentrations of 1.6 nM or 0.6 nM, respectively. Pargyline also decreased [$^3H$] raclopride binding by 36%corresponding at a concentration of 1.2 nM. In contrast, the depletion of synaptic DA by $\alpha$-methyl-p-tyrosine ($\alpha$-MpT) increased the specific binding of [$^3H$] raclopride by 43%when the DA concentration was decreased to 0.7 nM. The changes in the DA concentration at the synapse were responsible for the changes in the striatal binding of [$^3H$] raclopride. The values calculated in this study may therefore approximate the changes in the synaptic DA concentration in rat striatal slices following manipulation.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.1
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• pp.65-74
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• 2012

In this paper, we explore the application of 2-D dual-tree discrete wavelet transform (DDWT), which is a directional and redundant transform, for image coding. DDWT introduces limited redundancy and allows the transform to provide approximate shift invariance and directionally selective filters while preserving the usual properties of perfect reconstruction and computational efficiency with good well-balanced frequency responses. Also, quincunx lattice yields a non separable 2D-wavelet transform, which is also symmetric in both horizontal and vertical direction. And non-separable wavelet transformation can generate sub-images of multiple degrees rotated versions. The proposed 2-D non-separable DDWT can provide efficient approximation for directional features of images schemes, such as edges and contours in images that are not aligned with the horizontal or vertical direction. Finally, non-separable image processing using DDWT services good performance.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.10
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• pp.51-57
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• 1999

In this paper, we deal with the problem of controlling an unknown nonlinear dynamical system, using wavelet network. Accurate control of the nonlinear systems depends critically on the accuracy and efficiency of the function approximator used to approximate the function. Thus, we use wavelet network which shows high capability of approximating the functions and includes the free-selection of basis functions for the control of the nonlinear system. We find the dilation and translation that are wavelet network parameters by analyzing the time-frequency characteristics of the controller's input to construct an initial adaptive wavelet network controller. Then, weights is adjusted by the adaptive law based on the Lyapunov stability theory. We apply this direct adaptive wavelet network controller to control the inverted pendulum system which is an nonlinear system.

• Smart Structures and Systems
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• v.20 no.6
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• pp.709-728
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• 2017

This disquisition proposes a nonlocal strain gradient beam theory for thermo-mechanical dynamic characteristics of embedded smart shear deformable curved piezoelectric nanobeams made of porous electro-elastic functionally graded materials by using an analytical method. Electro-elastic properties of embedded curved porous FG nanobeam are assumed to be temperature-dependent and vary through the thickness direction of beam according to the power-law which is modified to approximate material properties for even distributions of porosities. It is perceived that during manufacturing of functionally graded materials (FGMs) porosities and micro-voids can be occurred inside the material. Since variation of pores along the thickness direction influences the mechanical and physical properties, so in this study thermo-mechanical vibration analysis of curve FG piezoelectric nanobeam by considering the effect of these imperfections is performed. Nonlocal strain gradient elasticity theory is utilized to consider the size effects in which the stress for not only the nonlocal stress field but also the strain gradients stress field. The governing equations and related boundary condition of embedded smart curved porous FG nanobeam subjected to thermal and electric field are derived via the energy method based on Timoshenko beam theory. An analytical Navier solution procedure is utilized to achieve the natural frequencies of porous FG curved piezoelectric nanobeam resting on Winkler and Pasternak foundation. The results for simpler states are confirmed with known data in the literature. The effects of various parameters such as nonlocality parameter, electric voltage, coefficient of porosity, elastic foundation parameters, thermal effect, gradient index, strain gradient, elastic opening angle and slenderness ratio on the natural frequency of embedded curved FG porous piezoelectric nanobeam are successfully discussed. It is concluded that these parameters play important roles on the dynamic behavior of porous FG curved nanobeam. Presented numerical results can serve as benchmarks for future analyses of curve FG nanobeam with porosity phases.

• The Journal of the Korean Society for Microbiology
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• v.22 no.3
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• pp.251-258
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• 1987

A total of 58 strains of Enterobacter species isolated from clinical specimens at Kyungpook National University Hospital in Taegu and Yonsei University Hospital in Seoul were tested for the molecular characterization to investigate the nosocomial infection through the study of R plasmids which might spread among Gram negative organisms regardless of their originated strains. All strains resistant to ampicillin, cefoxitin and cephalothin but susceptible to moxalactam were subjected to the further test for the determination of in detail MIC value against 23 drugs of common use including beta-lactam antibiotics and R plasmid profile analysis. The reistance frequency of strains against carbenicillin (53.4%) was similar to those against chloramphenicol, tobramycin, and sulfisomidine. Though the MIC values of resistance criteria against ceftazidime, aztreonam, imipenem, and norfloxacine in NCCLS manual were not available but MIC ranges of strains tested were very low. There were differences in patterns and frequencies of resistance between the strains isolated in Seoul and Taegu isolates. Seoul isolates showed a tendency of higher multiplicity of resistance than those of Taegu isolates. The resistances against cefoxitin, cephalothin, cefoperazone, cefotaxime, nalidixic acid, and rifampin were not conferred to the conjugally transferable R plasmid. The approximate molecular size of conjugally transferable R plasmids ranged 30 to 151 megadalton, and one or 2 to 3 R plasmids were identified in each transconjugants.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.329-329
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• 2017

In this study attempted to evaluate the stability of the protection methods by examining hydraulic characteristics of the area around the point in which marine cable protector is installed such as surf zone occurrence point of shore-end submarine cables suitable for coastal marine environmental conditions, flow rate t the tope of the protector and maximum wave height, and to provide basic data for the selection of the optimal protection method. In performing hydraulic model experiments, the topography of submarine cable installation location was reproduced in 2-D sectional channel, and models appropriate for experimental scale and similitude law were produced and installed for each condition of submarine cables and protectors. Since the topography and submarine cable protectors were reproduced and installed in 2-D sectional channel, the exact reproduction of surf and transformation in shallow water zone was possible, and thus the physical properties could be clearly analyzed. For stability review, an experiment to examine the stability was conducted using a wave maker with 50-year frequency design waves as target, and wave height and cycles were applied based on the approximate lowest low water level(Approx. L.L.W), which is the most dangerous in submarine cable protection methods. As for experimental time, typhoon passing time in summer (about 3 hours) was applied, and wave patterns and deviation ratio of the submarine cable protector were investigated after making irregular waves corresponding to design waves. In addition, current meter and wave height meter were installed at the installation location of the submarine cable protector, and the flow rates and wave height at the top of the protector were measured and analyzed to review hydraulic properties.

• Smart Structures and Systems
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• v.23 no.3
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• pp.263-278
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• 2019

Moving train load parameters, including train speed, axle spacing, gross train weight and axle weights, are identified based on strain-monitoring data. In this paper, according to influence line theory, the classic moving force identification method is enhanced to handle time-varying velocity of the train. First, the moments that the axles move through a set of fixed points are identified from a series of pulses extracted from the second derivative of the structural strain response. Subsequently, the train speed and axle spacing are identified. In addition, based on the fact that the integral area of the structural strain response is a constant under a unit force at a unit speed, the gross train weight can be obtained from the integral area of the measured strain response. Meanwhile, the corrected second derivative peak values, in which the effect of time-varying velocity is eliminated, are selected to distribute the gross train weight. Hence the axle weights could be identified. Afterwards, numerical simulations are employed to verify the proposed method and investigate the effect of the sampling frequency on the identification accuracy. Eventually, the method is verified using the real-time strain data of a continuous steel truss railway bridge. Results show that train speed, axle spacing and gross train weight can be accurately identified in the time domain. However, only the approximate values of the axle weights could be obtained with the updated method. The identified results can provide reliable reference for determining fatigue deterioration and predicting the remaining service life of railway bridges.

• Journal of Biomedical Engineering Research
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• v.30 no.1
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• pp.49-55
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• 2009

Purpose : The aim of this study is to evaluate a possibility of clinical application for the effects of low intensity ultrasound stimulation (LIUS) in morphological characteristics (i.e., structure, bone mineral density) of bone on osteoporotic fracturesprevention. Materials and Methods : Eight virgin 14-week-old ICR mice (approximate weight 25g) were used and ovariectomized (OVX) to induce osteoporosis. Right tibia (US) for each mouse served as the LIUS (1.5MHz frequency, 1.0 kHz pulse repetition on frequency, $30mW/cm^2$ intensity, $200{\mu}s$ pulse length, and stimulation for 20 minutes a day and 5 days a week over a 6-week period). Left tibia (CON) for each mouse served as the non-stimulated controls. Structural parameters and bone mineral density ($g/cm^3$) on trabecular bone of tibiae were calculated and measured from images derived in-vivo micro computed tomography (micro-CT) at 0 week and after 6weeks. Results : The BV/TV and Tb.N in US group were significantly bigger than those in CON group. The Tb.Pf in US group, moreover, was significantly smaller than that in CON group (p<0.05).For the others structural parameters and BMD, however, there were no significant difference between US group and CON group (p>0.05). Conclusion : The LIUS might prevent bone loss and keep bone connectivity in osteoporotic bones. Therefore, the LIUS might prevent effectively the osteoporotic fractures in clinics.

• Journal of Environmental Impact Assessment
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• v.26 no.1
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• pp.11-26
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• 2017

Approximate empirical equations obtained by measuring overall noise levels at different distances have been used to evaluate environmental influence of the railway noise though the accurate prediction of noise levels is important. In this paper, a noise prediction model considering the frequency characteristics of noise sources and propagation was suggested to improve the accuracy of noise prediction. The railway noise source was assorted into track, wheel, traction and aerodynamic components and they were characterized with the source strength and speed coefficient at each octave-band frequency. Correction terms for the acoustic roughness and the track/bridge condition were introduced. The sound attenuation from a source to a receiver was calculated taking account of the geometrical divergence, atmospheric absorption, ground effect, diffraction at obstacles and directivity of source by applying ISO 9613-2. For obtaining the source strength and speed coefficients, the results of rolling noise model, numerical analysis and measurements of pass-by noise were analyzed. We compared the predicted and measured noise levels in various vehicles and tracks, and verified the accuracy of the present model. It is found that the present model gives less error than the conventional one, so that it can be applied to make the accurate prediction of railway noise effect and establish its countermeasures efficiently.

• Journal of the Korea Convergence Society
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• v.9 no.6
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• pp.175-182
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• 2018

In this study, the theoretical method and the finite element analysis were designed in parallel to fabricate basic research data on the production of tool horn for cutting machine with ultrasonic vibration energy. In order to perform high-performance ultrasonic cutting, it is necessary to vibrate only with longitudinal vibration instead of transverse vibration. In order to efficiently transmit the mechanical vibration energy, the maximum amplitude should be generated at the output portion. Therefore, the tool horn must be designed so that the excitation frequency of the oscillator and the natural frequency of the tool horn are the same. In order to design the resonance of the tool horn, there are a theoretical approach using the one-dimensional wave equation and a method of reflecting the finite element analysis result to the design model. In this study, the approximate dimensions of the tool horn are first determined through the one- Based on the results of the finite element analysis, the optimal model was selected and reflected in the final shape of the tool horn. We will use this information as the basic data of actual tool horn for cutting, and will compare the production and experimental data with the contents of this research.