• Journal of Acupuncture Research
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• v.30 no.5
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• pp.185-192
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• 2013

Objectives : Weight loss and loss of appetite in amyotrophic lateral sclerosis patients are common symptoms, these are associated with survival as well as nutritional condition. The changes in weight and appetite were reported after treatment using Megestrol acetate and Korean medical treatments. Methods : Amyotrophic lateral sclerosis patient with weight loss and loss of appetite were treated by administering megestrol acetate a known anti-malignant tumor agent and Korean medical treatments such as acupuncture, pharmacopuncture and herbal medicine. The changes in weight and appetite were checked using body mass index(BMI) and simplified nutritional appetite questionnaire(SNAQ). Results : There was a more than 17 kg increase in weight. BMI increased from 15.94 $kg/m^2$ to 21.97 $kg/m^2$ and SNAQ score increased from 7 to 16. Owing to several side effects, Megestrol acetate was stopped after which only Korean medical treatments were provided. After which the lasting effects in BMI and appetite could be seen. Conclusion : There are few studies on weight loss and loss of appetite in ALS patients. Using only megestrol acetate can cause several considerable side effects. Which respect to this, the findings in this study could open up new clinical guideline possibilities.

• The Journal of Korean Medicine
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• v.36 no.4
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• pp.145-149
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• 2015

Objectives: We carried out an observational study of the effects of Nei Guan (P6) and Gong Sun (SP4) acupuncture for the treatment of CINV, preparing for further randomized controlled trial study. This is a case series to explore the changes in the incidence of CINV by acupuncture. Methods: Patients reported a Rhodex index indicating the severity of nausea and vomiting and loss of appetite, before acupuncture, after acupuncture and 1-week follow-up examination. Twelve patients with CINV participated in this study. We included patients receiving chemotherapeutic agents that might induce moderate or severe nausea and vomiting. We conducted 5 treatment sessions with P6 and SP4 acupuncture over the course of 5 days. Results: The median Rhodex score were decreased in 5 patients over time, while we observed loss of appetite of 6 patients were improved over time. During the study, the mean of Rhodex of total patients revealed a decrease of Day 1, Day 7, Day 14; 0.74, 0.68, 0.38, respectively, while the mean of loss of appetite showed a decrease of Day 1, Day 7, Day 14; 5.25, 4.08, 4.00, respectively. Conclusions: The study gives a preliminary data that manual acupuncture of P6 and SP4 may reduce the severity of CINV and loss of appetite, and justifies further study.

• Journal of Veterinary Clinics
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• v.20 no.4
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• pp.449-457
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• 2003

To investigate the renal effects of enrofloxacin administration on rats induced with dehydration or hyperoxaluria, male rats were treated with enrofloxacin of 50 mg to 500 mg/kg b.w.. The microscopical observations of kidney and urine sediment were carried out in the experimental groups. The result obtained were as follows; The male rats deprived of water for 72 hours and administered with enrofloxacin. As enrofloxacin administration dose was increased, clinical signs such as loss of appetite, depression, weakness, and loss of urine output became more severe. In the histopathological findings, there were hyperemia and hemorrhage in renal cortex, vacuolation and necrosis of renal tubular epithelia, proteinous casts within renal tubules. The male rats were orally administered with sodium oxalate and injected with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, and weakness became more severe. In the histopathological findings, there are hemorrhage of glomeruli and cortical hyperemia, vacuolation and necrosis of tubular epithelia, proteinous casts in renal tubules. In the microscopical findings of urine sediment, there are calcium oxalate crystal (diamond-like type) and magnesium ammonium phosphate crystals (rhomboid). The male rats were intraperitoneally injected with sodium oxalate and administered with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, weakness were more severe. In the histopathological findings, there were hyperemia and hemorrhage in both glomeruli and renal cortex. Severe necrosis of renal tubular epithelia, bluish materials within renal tubules were also found. In the microscopical findings of urine sediment, there were many calcium oxalate crystals. The present results suggest that enrofloxacin has some injurious effects in rats having dehydration or hyperoxaluria, and clinically, we should consider these renal injury effects when we use enrofloxacin in patients accompanied renal disease, dehydration and hyperoxaluria conditions.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.1943-1948
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• 2014

Purpose: The prevalence of weight loss in esophageal carcinoma patients is high and associated with impairment of physical function, increased psychological distress and low quality of life. It is not known which factors may contribute to weight loss in patients with esophageal carcinoma during radiotherapy in China. The objective of this study was to identify the associated demographic and clinical factors influencing weight loss. Methods: We evaluated 159 esophageal carcinoma patients between August 2010 and August 2013 in a crosssectional, descriptive study. Patient characteristics, tumor and treatment details, psychological status, adverse effects, and dietary intake were evaluated at baseline and during radiotherapy. A multivariate logistic regression analyss was performed to identify the potential factors leading to weight loss. Results: 64 (40.3%) patients had weight loss ${\geq}5%$ during radiotherapy. According to logistic regression analysis, depression, esophagitis, and loss of appetite were adverse factors linked to weight loss. Dietary counseling, early stage disease and total energy intake ${\geq}1441.3$ (kcal/d) were protective factors. Conclusions It was found that dietary counseling, TNM stage, total energy intake, depression, esophagitis, and loss of appetite were the most important factors for weight loss. The results underline the importance of maintaining energy intake and providing dietary advice in EC patients during RT. At the same time, by identifying associated factors, medical staff can provide appropriate medical care to reduce weight loss. Further studies should determine the effect of these factors on weight loss and propose a predictive model.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.2
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• pp.171-177
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• 2013

The aim of the present study was to determine the evidence of post-parturient disorders and backfat loss during lactation in sows raised in tropical areas in relation to their backfat thickness before farrowing and postpartum intravenous supportive treatment. Backfat thickness was measured using A-mode ultrasonography at farrowing and weaning ($25.5{\pm}1.4$ d) in 70 sows. The sows were divided into three groups according to backfat thickness before farrowing, i.e., 15.0 to 20.0 mm (n = 21), 20.5 to 25.0 mm (n = 35), >25.0 mm (n = 14) and were categorized into two groups according to the postpartum supportive treatment, i.e., control (n = 31) and treatment (n = 39). After farrowing, the sows in treatment group received the same medications as in control sows. Furthermore an intravenous supportive treatment with amino acids and vitamins was administered in treatment groups. Rectal temperature and clinical signs of the sows including vaginal discharge, udder problems and appetite were determined at d 0, 1, 2 and 3 of parturition. It was found that, on average, the backfat thickness was $22.4{\pm}3.9$ mm at farrowing and $19.9{\pm}2.9$ mm at weaning. The backfat loss and the relative backfat loss during the lactation period were 2.6 mm and 10.6%, respectively. The sows with a backfat of 15.0 to 20.0 mm before farrowing lost less backfat than those with a backfat of 20.5 to 25.0 mm and >25.0 mm (p<0.05). Sows with a backfat of 15.0 to 20.0 mm had a better appetite on d 1 postpartum than sows with a backfat of 20.5 to 25.0 mm (p = 0.020). The percentage of sows losing backfat >10% during lactation were higher in sows with a backfat of >25.0 mm before farrowing (85.7%) than sows with a backfat of 15.0 to 20.0 mm before farrowing (35.0%) (p = 0.008). The percentage of sows with a reduced appetite on d 1 (90.3% vs 71.8%, p = 0.018) and d 2 (61.3% versus 33.3%, p = 0.005) postpartum in the treatment group was lower than the control group. In conclusion, the backfat thickness of sows at farrowing influenced backfat loss during lactation under hot and humid climates. The intravenous supportive treatment of sows with amino acid and vitamins significantly improved the appetite of postpartum sows.

• Journal of Ginseng Research
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• v.46 no.4
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• pp.609-619
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• 2022

Obesity is a primary factor provoking various chronic disorders, including cardiovascular disease, diabetes, and cancer, and causes the death of 2.8 million individuals each year. Diet, physical activity, medications, and surgery are the main therapies for overweightness and obesity. During weight loss therapy, a decrease in energy stores activates appetite signaling pathways under the regulation of neuropeptides, including anorexigenic [corticotropin-releasing hormone, proopiomelanocortin (POMC), cholecystokinin (CCK), and cocaine- and amphetamine-regulated transcript] and orexigenic [agoutirelated protein (AgRP), neuropeptide Y (NPY), and melanin-concentrating hormone] neuropeptides, which increase food intake and lead to failure in attaining weight loss goals. Ginseng and ginsenosides reverse these signaling pathways by suppressing orexigenic neuropeptides (NPY and AgRP) and provoking anorexigenic neuropeptides (CCK and POMC), which prevent the increase in food intake. Moreover, the results of network pharmacology analysis have revealed that constituents of ginseng radix, including campesterol, beta-elemene, ginsenoside Rb1, biotin, and pantothenic acid, are highly correlated with neuropeptide genes that regulate energy balance and food intake, including ADIPOQ, NAMPT, UBL5, NUCB2, LEP, CCK, GAST, IGF1, RLN1, PENK, PDYN, and POMC. Based on previous studies and network pharmacology analysis data, ginseng and its compounds may be a potent source for obesity treatment by regulating neuropeptides associated with appetite.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5121-5126
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• 2016

Objective: To investigate the impact of chemotherapy on quality of life (QoL) among breast cancer patients and to evaluate the relationship with age, cancer stage and presence of any comorbidity. Methods: A prospective study was conducted among breast cancer patients receiving chemotherapy in Hospital Melaka from 1st January 2014 to 31st July 2014. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) was given to patients to fill in prior chemotherapy (baseline) and after the third cycle of chemotherapy. Socio-demographic and clinical data were collected and analyzed using SPSS version 20. Result: Respondents were 32 female patients [mean age (SD): 49.7(9.93) years]. They reported a significant lower global health status (P < 0.01) and significant higher symptoms of nausea and vomiting (P < 0.01), loss of appetite (P = 0.028) and diarrhea (P = 0.026) after the third cycle of chemotherapy as compared to baseline. Compare to, this study showed significant better emotional functioning (P < 0.01) and social functioning (P < 0.01) than the EORTC QLQ-C30 Reference Values 2008 for breast cancer cases. Under symptom scales higher scores were noted for appetite loss (P = 0.017), nausea and vomiting (P < 0.01). Age, stage and comorbidity had no clear associations with global health status in our patients (P > 0.05). Conclusion: Chemotherapy did reduce the QoL of breast cancer patients. Management of chemotherapy-induced loss of appetite, diarrhea, nausea and vomiting should be improved for a better outcome.

• Journal of the Korean Society of Food Culture
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• v.38 no.4
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• pp.224-238
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• 2023

To develop customized food products for gastric cancer patients, it is crucial to understand their dietary characteristics and changes in their perception of smell and taste due to their condition. This study conducted in-depth interviews and administered olfactory and gustatory tests on 20 patients with gastric cancer. A control group of 20 healthy, gender and age matched individuals, was included for comparison. Patients reported difficulties in sustaining their appetite, particularly during chemotherapy. This could be attributed to gastrointestinal discomfort and an altered perception of smell and taste. The olfactory test revealed that cancer patients were significantly less sensitive than the control group. Also, a smaller number of participants in the cancer group were reported to have a normal taste function, which enabled them to perceive umami, one of the five basic taste compared to those in the control group. These findings demonstrated that gastric cancer patients experience post-surgical digestive issues, chemotherapy-induced changes in smell and taste, and appetite loss. To improve the quality of life of these patients and the efficacy of the treatment, it is necessary to consider not only their nutritional requirements but also other factors such as appetite loss and discomfort when developing meals specifically for them.

• The Journal of Internal Korean Medicine
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• v.25 no.2
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• pp.320-328
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• 2004

Gastrectomy is the most common treatment for gastric cancer, but patients often suffer from post-operative side effects. This study describes the clinical effects of HyangSaPyungWiSan on a pateint who suffered from nausea, vomitting, indigestion, headache, abdomen pain, and loss of appetite after his gastrectomy. The patient undewent a gastrectomy due to gastric cancer, and HyangSaPyungWiSan was used to treat all thses symptoms. This study suggests that treatment with HyangSaPyungWiSan is effectious for such aftereffects of gastrectomy as nausea, vomitting, indigestion, headache, abdomen pain, and loss of appetite.

• Journal of Pharmaceutical Investigation
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• v.9 no.3
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• pp.22-26
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• 1979

This report was carried out toxicity test for the mosquito coil made of Ginseng leaf and the residue after extraction of Ginseng root. This results are as follows: In the first group, was not shown any special difference on the body weight, the motion and dissection. In the second group, was not shown any Special difference on the body weight, considerable difference on the motion and considerable loss of appetite besides very slight loss, but came cack soon again to normal state by change of air after a moment. In the third group, the body weight and appetite was depressed very slightly and the motion was shown very slightly difference, but came back soon again to normal state by chenge of air after a moment too. No one was died, and all the animal were the normal state on the reslt of dessection, Therefore, we have positive evidence that this mosquito coil powder is applied to animals without any toxicity.