• Toxicological Research
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• v.11 no.2
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• pp.223-227
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• 1995

This study was conducted to investigate the metallothionein (MT) induction by Lonicerae rios in cadmium chloride intoxication. The results were as follows: Generally, detoxication effects by Lonicerae fios extract increased to the increase of extract concentrations. When 90 mg/kg dosage of Lonicerae fios extract was administered, it showed the highest antitoxic effects in metallothionein induction. From the above results, Lonicerae rios extract increased metallothionein concentration and decreased the toxicity of cadmium in liver.

• Toxicological Research
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• v.11 no.2
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• pp.235-239
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• 1995

This study was conducted to investigate the metallothionein (MT) induction by Panax ginseng C. A. Meyer in cadmium chloride intoxication. The results were as follows: Generally, detoxicatlon effects by Panax ginseng C. A. Meyer extract increased proportionally to the increase of cadmium concentrations. When a 8 mg/g dosage of cadmium was administered, formation of the cadmium and EDTA complex showed the highest antitoxic effect. Also, when a 4 mg/g dosage of cadmium was administered, Panax ginseng C. A. Meyer extract showed the highest antitoxic effect in metallothionein induction. According to the above results, Panax ginseng C. A. Meyer extract administered with cadmium increased metallothionein concentration and decreased the toxicity of cadmium in liver.

• The Korean Journal of Food And Nutrition
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• v.15 no.1
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• pp.36-41
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• 2002

The aim of this study was to assess the antitoxic compounds, flavanones(Leachianone A=LA and Sophoraflavanone G=SFG), from Sophora flavescens(S. flavescens). We investigated the possibility of antitoxicity of LA and SFG against NIH 3T3 fibroblasts cell lines using calorimetric MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl -2H-tetra-azolium bromide] assay. The results were as follows : After cadmium was treated against NIH 3T3 cell lines, we determined IC$\_$50/. Accordingly we have examined the detoxification effects of S. flavescens, LA and SFG under cadmium IC$\_$50/=12.5$\mu$M and was carried out to observe morphological changes by the light microscopic study In NIH 3T3 cells, Sophora flavescens, LA, SFG and LA + SFG showed inhibitory effects on the cytotoxicity of cadmium and these detoxication effects increased in proportion to the concentration of these drugs. These results suggest that LA and SFG from S. flavescens retain a potential antitoxic activity.

• Journal of Society of Preventive Korean Medicine
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• v.4 no.1
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• pp.81-90
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• 2000

This study was conducted to investigate the antitoxic component in methanol extract of Houttuynia cordata $T_{HUNB}$. The results were as follows: Generally, detoxication effects by Houttuynia cordata $T_{HUNB}$ methanol extract increased in proportion to the methanol extract concentrations. When 40 mg/kg dosage of Houttuynia cordata $T_{HUNB}$ methanol extract was administrated, it showed the highest antitoxic effects in metallothionein induction. After the methanol extract treatment. Body weights increased in proportion to methanol extract concentrations. However, after 3 weeks, the body weight decreased insignificantly. From the above results, these results suggest that the methanol extract of Houttuynia cordata $T_{HUNB}$ increased metallothionein concentration and decreased the toxicity of cadmium in rats.

• YAKHAK HOEJI
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• v.53 no.1
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• pp.12-18
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• 2009

The aim of this study was to develop antitoxic compound for cadmium-induced cytotoxic Vero cells. These cells were divided into five groups; control group (medium only), cadmium group (cadmium only), and two experimental groups. SRB (sulphorodamine B) assay was performed to evaluate the cytotoxicity of cell organelles. After cadmium was treated on Vero cells, we determined IC50 values to examine the detoxification effects of Houttuynia cordata methanol extract and quercetin under cadmium-induced cytotoxicity. Furthermore, morphological changes were observed by the light microscope. In Vero cells, methanol extract of Houttuynia cordata, and quercetin showed inhibitory effects on cadmium-induced cytotoxicity and these detoxification effects were increased in a concentration-dependent manner. These results suggest that methanol extract and quercetin from Houttuynia cordata retain a potential antitoxic activity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1163-1167
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• 2008

In this study, cytotoxicity of cadmium on NIH 3T fibroblasts was utilized in order to discover antitoxic compound in methanol extract of Sophora fIavascens Ait. There were treatment groups; control (medium only), $MTT_{50}$ group and five experimental groups. MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H- tetrazoliumbromide} assay was performed to evaluate the cytotoxicity of cell organelles and $IC_{50}$ was also measured. Accordingly we have examined the detoxification effects of methanol extract of S. flavescens Ait. and leachianone A (LA) on cadmium-treated NIH 3T3 fibroblasts ($IC_{50}=\;12.5{\mu}M$) to observe morphological changes by the light microscopy. Both S. flavescens Ait. methanol extract and LA showed inhibitory effects on cadmium-induced cytotoxicity. Furthermore, LA showed dose-dependency in detoxication. From these results, it is conceivable to suggest that LA from S. flavescens Ait. methanol extract is a potential antitoxic agent.

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.149.1-149.1
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• 2001

• Journal of Society of Preventive Korean Medicine
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• v.2 no.1
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• pp.175-192
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• 1998

A study on the antitoxic effects of Semen Mungo extracts against Cadmium Chloride Toxicity in Rats This study was performed to find out the effect of Semen mungo against Cadmium toxicity. The experimental rats were divided into 5 groups such as control group, Cadmium alone treatment group, three simultaneous treatment groups of semen mungo and cadmium. Rats were given pellets administration with three dosage of semen mungo glabrae such as 4mg/kg body weight for four weeks. The results were summarized as follows on: ' 1. The simultaneously administration of semen mungo and cadmium significantly more decreased cadmium concentration in liver and kidney tissues compared to the administration of cadmium alone.(p<0.05) 2. The simultaneously administration of semen mungo and cadmium significantly more decreased metallothionein concentration in liver and kidney tissues compared to administration of cadmium alone(p<0.05) 3. When liver and kidney tissues were observed with optical microscope obvious changes were visible in those tissues.1

• Journal of Society of Preventive Korean Medicine
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• v.1 no.1
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• pp.76-84
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• 1997

A study on the antitoxic effects of Herba Taraxaci extracts against Cadmium Chloride Toxicity in Rats. This study was performed to find out the effect of taraxacum platy carpum against Cadmium toxicity. The experimental rats were divided into 5 groups such as control group, Cadmium alone treatment group, three simultaneous treatment groups of taraxacum platy carpum and cadmium. Rat were given pellets administration with three dosage of taraxacum platy carpum such as 4 mg/kg body weight for four weeks. The results were summarized as follows on: 1. The simultaneously administration of taraxacum platy carpum and cadmium significantly more decreased cadmium concentration in liver and kidney tissues compared to the administration of cadmium alone. (p<0.05) 2. The simultaneously administration of taraxacum platy carpum and cadmium significantly more increased metallothionein concentration in liver and kidney tissues compared to administration alone. (p<0.05) 3. When liver and kidney tissues were observed with optical microscope obvious changes were visible in those tissue.

• Journal of Society of Preventive Korean Medicine
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• v.3 no.2
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• pp.79-89
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• 1999

This study was conducted to investigate the antitoxic component in aqueous extract of Houttuynia cordata $T_{HUNB}$. The results were as follows: Generally, detoxication effects by Houttuynia cordata $T_{HUNB}$ extract increased in proportion to the extract concentrations. When 40mg/kg dosage of Houttuynia cordata $T_{HUNB}$ extract was administered, it showed the highest antitoxic effects in metallothionein induction. After the extract treatment, body weights increased in proportion to the extract concentration. However, after 3 weeks, the body weight decreased insignificantly. From the above results, Houttuynia cordata $T_{HUNB}$ extract increased metallothionein concentration and decreased the toxicity of cadmium in rats.