• Title/Summary/Keyword: antilipoperoxidation

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Antilipoperoxidatant Effects of Leaves of Phyllostachys bambusoides S. et Z. (왕대잎(Phyllostachys bambusoides S. et Z.)의 지질과산화억제활성)

  • Kim, Nam-Jae;Lee, Suk-Joo;Kwon, Chang-Ho;Hong, Nam-Doo
    • Korean Journal of Pharmacognosy
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    • v.26 no.4
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    • pp.368-376
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    • 1995
  • The leaf of Phyllostachys bambusoides S. et Z. (Gramineae) has been used in traditional herbal medicine as a antipyretics, antitussives and antidiuretcs, etc, in Korea, China and Japan. In order to investigate the effects on antilipoperoxidation and liver protective effect, the leaf of Phyllostachys bambusoides S. et Z. was extracted by water and then fractionated with butanol. The water extract and BuOH soluble fraction strongly exhibited antilipoperoxidatant effect in rat liver homogenate intoxicated with $CCl_4$. The BuOH fraction significantly suppressed the increases of s-GOT, s-GPT and s-LDH activities in injuried rats induced by $CCl_4$. And the BuOH fraction inhibited significantly the decrease of the body weight and showed the antilipoperoxidatant effect in liver and kidney in $CCl_4$ intoxicated rats.

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Studies on the Processing of Crude Drugs (V) - On the Constituents and Biological Activities of Glycyrrhizae Raidx by Processing - (한약수치에 관한 연구(제5보) - 수치에 의한 감초의 성분변화 및 생리활성 -)

  • Hong, Nam-Doo;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
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    • v.27 no.3
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    • pp.196-206
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    • 1996
  • In order to characterize the chemical change, of the constituents and pharmacological transformation of Glycyrrhizae Radix(GR) which may occur during its processing, processed GR has been investigated in comparison with unprocessed GR. It was found that glycyrrhizin(GL) and other several constituents contained in GR were remarkably changed by processing, and the decrease of contents of GL was identified by making use of thin layer chromatography-chromatoscanner. And also, it was found that glycyrrhetic acid (GA) was identified from processed GR. We recognized that commonly processed GR showed less hemolytic effect than unprocessed GR and processed GR at $190{\circ}c$. It was also found that commonly processed GR showed more effective analgesic effect and prolonged the duration of hypnosis induced by pentobarbital-Na in mice as compared with corresponding unprocessed GR and processed GR at $190{\circ}c$. And then, commonly processed GR significantly suppressed the increases of s-GOT, s-GPT and s-LDH activities in injured mice induced by $CCl_4$.

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