• 농업과학연구
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• 제10권2호
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• pp.193-199
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• 1983

대전근교(大田近郊)의 목장(牧場)에서 자유중인 유우(乳牛)를 대상(對象)으로 CMT법(法)에 의하여 유방염(乳房炎)으로 판정(判定)된 양성우(陽性牛)의 유즙(乳汁)으로부터 분리(分離)한 Staphylococcus aureus를 공시(供試)하여 유방염치료(乳房淡治療)에 있어 보다 개선(改善)된 방법(方法)을 모색(模索)하기 위하여 시판(市販)되고 있는 복합처방(複合處方)된 항균제(抗菌劑)를 선택(選擇)하여 내성시험법(耐性試驗法)을 개발(開發)할 목적(目的)으로 실시(實施)한 결과(結果)를 다음과 같이 요약(要約)한다. 1. 치료용(治療用) 항균제(抗菌劑)를 계속(繼續) 반복(反復)하여 사용(使用)하게되면 차등(差等)있는 내성(耐性)을 나타내었다. 2. Rifamastene, Neo-cillin은 다같이 4회(回)까지 Abimasten-100, Neo-Masti, Special formula, Mastalone은 6회(回)까지 약(弱)한 내성(耐性)을 나타내었다. 3. Tardomyocel-L는 6회(回)까지 내성(耐性)이 거의 나타나지 않았다. 4. 내성시험(耐性試驗)을 거처 선택(選擇)된 약제(藥齊)를 3일간격(日間隔)으로 교체사용(交替使用)할 것을 권장한다.

• 한국응용곤충학회지
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• 제62권2호
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• pp.95-102
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• 2023

최근 들어 반려동물을 키우는 가구 수가 증가하고 있다. 그로인해 진드기와 냄새에 대한 관심 또한 증가하고 있다. 본 연구는 제충국 추출물(Tanacetum cinerariifolium), 수용성 피톤치드(water-soluble phytoncide)가 진드기 퇴치제로서 효과와 탈취 및 항균 효과가 있는지 알아보기 위하여 연구를 진행하였다. 틱 클라이밍 테스트(Tick climbing test)에서 제충국 추출물(Tanacetum cinerariifolium) 23.33점, 수용성 피톤치드 22.00점으로 높은 기피효과를 보였다. 복합추출물로서의 진드기 기피 효과를 확인하기 위해 위 실험에서 기피 효과가 확인된 제충국 추출물, 수용성 피톤치드를 포함한 복합추출물(Sample이라 함.), 타사 제품(Control이라 함.)로 틱 클라이밍 테스트(Tick climbing test)를 진행하였다. 결과 Sample 13.00점, Control 26.67점으로 Sample이 높은 기피 효과를 나타내었다. 참진드기 실내 기피제 효력 시험법에서도 Sample이 88%, Control이 12%로 우수한 진드기 기피효과를 보인다는 것을 확인하였다. Sample을 가지고 탈취 시험을 진행한 결과 암모니아에서 98.3%, 트리메틸아민에서 99.5%의 탈취 효과를 보여주었으며, 항균시험에서 대장균, 황색포도상구균, 폐렴균 모두 99.9%의 항균 효과를 보여주었다. 본 연구결과를 종합해 볼 때 위 소재를 포함한 복합추출물은 추후 진드기 기피제와 탈취 및 항균에도 효과가 있는 소재로서의 활용 가치가 높다고 판단된다.

• 복식
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• 제53권2호
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• pp.119-125
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• 2003

This study shows the dyeability and antibacterial activity about cotton and silk fabrics dyed with Chrysanthem indicum L. In the case of dyeability, in the first, K/S value was shown comparatively high numerical value. The value of all test sample was over 20. In the next, in the case of colorfastness, the light colorfastness showed the lowest grade, the other colorfastness was relatively good. However there are some differences according to fabrics and mordants. In the case of antibacterial activity to Klebsielia pneumoniae, the cotton fabrics had the most antibacterial effect at the dyed fabrics that had been mordanted $CuSO_4$.$5H_2O$, and the silk fabrics had the most antibacterial effect at the dyed fabrics that had been mordanted $CuSO_4$.$5H_2O$.$Al_2$ and $(SO_4)_3$.

• 한국응용과학기술학회지
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• 제18권3호
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• pp.180-185
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• 2001

Antibiotics polymer prepared by chemical bonding and simple blending of antibacterial into polymers have attracted much interest because of their long-lasting and antibacterial activity. Antibiotics polymer can significantly reduce losses associated with dissolution, photolytic decomposition and volatillization. Further more, increased efficiency safety and selectivity are additional benefits which may be realized. In this study, Antibiotics polymer was synthesized by chemical reaction of polyacrylic acid with sulfamethazine by N,N'-dicyclohexylcarbodiimide(DCC) method. Antibacterial susceptibility was determined against Streptococcus pyrogenes[gram(+)] and Esherichia coli.[gram(-)] using a standardized disc test. As a result, the synthetic antibiotics polymer exhibited the broad susceptibilty against Streptococcus pyrogenes and Esherichia coli. Especially, the antibiotic effect of antibacterial polymer against Gram negative(Esherichia coli) was much stronger than that against Gram positive(Streptococcus pyrogenes).

• 대한의생명과학회지
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• 제15권1호
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• pp.73-80
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• 2009

Bloodstream infections (BSI) are caused by planktonic microorganisms, sometimes leading to serious infections such as bacteremia and sepsis. BSI occurs more frequently to the patients wearing the central venous catheter (CVC). The ciprofloxacin-incorporated CVC (CFX-CVC) has been reported previously to possess antimicrobial activity. In this study, the antibacterial activity of CFX-CVC and its mechanism against planktonic BSI cells were explored by using the shake flask test and by examining the release rate of 260 nm-absorbing substances from the bacterial cells indicative of the membrane damage of the bacterial cells. CFX-CVC reduced more than 99.9% of the viable planktonic BSI cells demonstrating its potent antibacterial activity. It provoked bacteriolysis causing leakage of a large amount of 260 nm-absorbing materials from the planktonic bacterial cells like S. aureus and E. coli. These results provide evidence that the antibacterial activity of CFX-CVC came from the inhibition of the stability of the planktonic bacterial cells.

• Natural Product Sciences
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• 제4권3호
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• pp.130-135
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• 1998

The water extracts of 83 oriental herbal medicines (Hanbang) which have been clinically used to treat bacterial infections in Korea were screened for in vitro antibacterial activity by the paper disc assay method. Two Gram positive bacteria, Staphylococcus aureus SG 511, Bacillus subtilis ATCC 6633, and two Gram negative bacteria, Escherichia coli 055, Pseudomonas aeruginosa 9027 were used as test organisms. Among the extracts tested, MeOH extract of Baenongtang showed remarkably potent antibacterial activity. Activity-guided chromatographic fractionations of the $CH_2Cl_2$ extract of Baenongtang afforded seven antibacterial compounds.

• 한국의류산업학회지
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• 제8권6호
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• pp.702-708
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• 2006

The purpose of this study was to investigate the dyeing-property and antibacterial activity on nylon fabric dyed with cochineal at variable dyeing conditions. Al, Cr, Fe, Cu and Sn were used as mordants and adsorption was compared with different mordanting methods. The maximum UV-visible absorption band of cochineal extract was 495 nm. The dyeability on nylon fabric was good because of having a amine group. The optimum dyeing conditions of nylon fabrics are dyeing concentration 1.5%(o.w.s), dyeing temperature $60^{\circ}C$, pH 3 and dyeing time 30 minutes. The pre-mordanting method is preferred for Al and Cr, and the post-mordanting one is preferred for Cu, Sn and Fe to achieve better dyeing. The optimum mordanting conditions of wool fabrics dyed with cochineal are mordanting concentration of 0.5%(o.w.s), mordanting temperature $60^{\circ}C$, and dyeing time 30 minutes. Nylon fabrics dyed with cochineal show a little antibacterial activity, but it was increased by Sn mordanting. MIC test results in antibacterial activities revealed that the antibacterial activity of Cu was the highest among mordants, but Sn mordant was the most effective in antibacterial activities after mordanting treatment of nylon fabric. The fastness properties of dyed nylon fabric showd a little worse or a similar level and there was no significant difference between a mordanted and non-mordanted fabric.

• 한국수산과학회지
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• 제48권1호
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• pp.51-57
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• 2015

With continuing demand for the development of new, effective and safe therapies, an investigation was carried out to test the efficacy of an antibacterial agent derived from marine edible seaweed. The methanolic extract of Ecklonia cava from marine edible seaweed evinced potential antibacterial activity against Enterococcus faecalis. Among five solvent-soluble fractions of E. cava methanolic extract, the ethyl acetate soluble extract (EtOAc) exhibited the strongest antibacterial activity, with a MIC value of $128{\mu}g/mL $ against E. faecalis strains. Furthermore, a synergistic antibacterial effect between an antibiotic and the EtOAc fraction was assessed using fractional inhibitory concentration (FIC) indices. A combination of ciprofloxacin and the EtOAc fraction resulted in a ${\sum}FIC_{min}$ range of 0.188 and ${\sum}FIC_{max}$ of 0.508 to 563, suggesting that the ciprofloxacin-EtOAc fraction of E. cava combination resulted in an antibacterial synergy effect against E. faecalis.

• Genomics & Informatics
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• 제16권3호
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• pp.44-51
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• 2018

Fluoroquinolone (FQ) antibiotics are an important class of synthetic antibacterial agents. These are the most extensively used drugs for treating bacterial infections in the field of both human and veterinary medicine. Herein, the antibacterial and pharmacological properties of four fluoroquinolones: lomefloxacin, norfloxacin, ciprofloxacin, and ofloxacin have been studied. The objective of this study was to analyze the antibacterial characteristics of the different fluoroquinolones. Also, the pharmacological properties of the compounds including the Lipinski rule of five, absorption, distribution, metabolism, and excretion, LD50, drug likeliness, and toxicity were evaluated. We found that among all four FQ molecules, ofloxacin showed the highest antibacterial activity through in silico assays with a strong interaction (-38.52 kJ/mol) with the antibacterial target protein (topoisomerase-II DNA gyrase enzyme). The pharmacological and pharmacokinetic analysis also showed that the compounds ciprofloxacin, ofloxacin, lomefloxacin and norfloxacin have good pharmacological properties. Notably, ofloxacin was found to possess an IGC50 (concentration needed to inhibit 50% growth) value of $0.286{\mu}g/L$ against the Tetrahymena pyriformis protozoa. It also tested negative for the Ames toxicity test, showing its non-carcinogenic character.

• 미생물학회지
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• 제12권2호
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• pp.85-93
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• 1974

Four stereoisomers of inositol p-aminosalicylate, that is hexaris-O-(p-aminosalicylyl)-myo-inositol, hexaris-O-(p-aminosalicylyl)-muco-inositol were synthesized by p-aminosalicylyl chloride with myo-, epi-, scyllo-, and muco-inositol respectively. Their antibacterial activity was tested against human type tubercle bacilli $H_{37}$/Rv, in contrast to 1.25.gamma./ml of p-aminosalicylic acid used as control. Hexaris-O-(p-aminoslicylyl)-muco-inositol showed the strongest antibacterial action at 0.625.gamma./ml, the other compounds more or less active than p-aminosalicylic acid.