• 한국건설관리학회논문집
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• 제13권2호
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• pp.3-10
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• 2012

현행 "건설기술관리법" 시행규칙의 환경보전비 세부산출기준에 따르면 환경보전비는 표준품셈 등을 이용하여 원가계산에 따라 산출하거나 원가계산이 곤란한 경우에는 공종별로 직접비에 요율을 적용하여 산정하도록 규정하고 있다. 그러나 원가 계산으로 산정할 경우, 현행 표준품셈에 환경보전비에 해당하는 항목이 일부 제한된 항목만 명시되어 있어 다양한 환경오염 방지시설의 설치 및 운영에 사용되는 제반비용을 반영하는 데 현실적인 제약이 있다. 아울러 요율을 적용하여 산정하는 경우에도 공종별로 획일적인 요율을 적용하도록 규정되어 공사현장의 입지여건 등에 따른 특성을 제대로 반영하지 못하고 있어 공사현장의 효율적인 환경관리가 어려운 실정이다. 따라서 본 연구에서는 도로공사 건설현장을 대상으로 공사규모, 현장 입지조건, 환경보전비 계상방식 등에 대하여 실태 조사 및 분석을 실시하여 이를 토대로 환경보전비의 적정 계상 방안을 제시하고자 한다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.33-36
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• 2007

The majority of fly ash pipes in thermal power stations use steel pipes. This makes frequent replacement inevitable due to severe abrasion near the hot and curved section of pipes. Recently, there have been efforts to prevent this abrasion with lining techniques using ceramic or basalt on the inner wall of the pipe. This study uses composite and anti-wear material to maximize the anti-abrasion effects on the hot section of the pipe. The thickness of the abrasion layer was determined by the abrasion ratio of material found through the experiment; the thickness of the reinforcement layer was determined by micromechanics. Experiments were conducted on epoxy resins to test for heat and abrasion. Anti-abrasion test using particle impingement was intended to recreate realistic conditions when abrasion occurs within the hot section of an actual pipe. This study analyzes the abrasion ratio obtained from both the specimen experiment and from on-site measurement and provides evidence that a combination of composites and anti-wear agent can be used to create a fly ash pipe that is lower in costs and higher in quality than what is used currently.

• 약학회지
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• 제40권4호
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• pp.422-427
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• 1996

The anti-Ex-A IgG was specifically labeled with stable isotopes, DL-His-2,4-$d_2$, L-Phe-$d_5$, L-Trp-$d_5$, L-Tyr-2,6-$d_2$ and L-[1-$^{13}C$]Trp, by growing hybridoma cell in serum-free medium. By use of NMR spectroscopy with selectively labeled Fab fragment, we applied a paratope mapping on antigen-antibody complex. Assignments of the observed carbonyl carbon resonances have been determined by using $^{13}C$-$^{15}N$ double labeling method in order to assign the Trp resonances. Photo CIDNP was also applied to investigate the antigen-binding site(s) on the surface residues of antibody. We found that Trp 36, which is located at the $V_H$ domain, is an important residue to bind to Ex-A, however, two Tyr on the surface of anti-Ex-A IgG plays no crucial role to bind to antigen. On the basis of these results, we demonstrate that stable isotope-aided NMR strategy can be extended to molecular structural analyses of the complex of an Fab fragment and a protein antigen.

• Journal of Gastric Cancer
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• 제21권3호
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• pp.319-324
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• 2021

The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with brain radiotherapy and anti-programmed death-1 (PD-1) therapy-induced abscopal effect. Although anti-PD-1 therapy alone could not prevent disease progression, the metastatic lesions in the brain and also in the abdominal lymph node showed a drastic response after brain radiotherapy and anti-PD-1 therapy. To our knowledge, this is the first reported case of successful treatment of advanced gastric cancer with multiple brain and abdominal lymph node metastases, possibly through anti-PD-1 therapy combined with brain radiotherapy-induced abscopal effect. We suggest that the combination of brain radiotherapy and anti-PD-1 therapy may be considered as a therapeutic option for advanced gastric cancer, especially when there is brain metastasis.

• 시스템엔지니어링학술지
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• 제17권2호
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• pp.23-36
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• 2021

Recently, the rapid development of drones is increasing as a variety of threats to important facilities of the country. In order to build an anti-drone system that responds to drones with high technical characteristics, standardization is required in terms of operation, system, and technology. By applying the defense architecture framework, it contributes to the establishment of the optimal system by proposing a standardization plan for the operational and system perspectives of the anti-drone system by creating outputs equivalent to the stage of prior research on weapons systems. It is a prerequisite for building a drone system the operational concept of the anti-drone system, the definition of the drone threat, the function of each component, the interface, the definition of data flow, the system performance and effect scale, etc. Management, security officers, and equipment manufacturers of important national and public facilities on site expect that it will be used as an objective standard at the government level for the component technology of the equipment to respond to the drone threat and the performance required in the environment.

• IMMUNE NETWORK
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• 제20권3호
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• pp.21.1-21.10
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• 2020

TLRs are pattern recognition receptors (PRRs) whose cytoplasmic signalling domain is similar to that of IL-1. The extracellular domain of TLRs serve as the binding site of pathogen associated molecular patterns. TLRs are found on both plasma and endosomal membranes and they mainly exert their function by activating genes which lead to production of inflammatory factors. The latest TLR to be discovered, TLR10 is a unique TLR which exhibit anti-inflammatory properties. TLR10 is found on the plasma membrane with other TLRs namely TLR1, TLR2, TLR4, TLR5 and TLR6. Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an "orphan receptor" but much recent studies have identified ligands for TLR10. Currently there is no review article on TLR10 that has been published. In this narrative review, we are going to give an account of TLR10, its functions mainly as an anti-inflammatory PRR and its possible applications as a target in therapeutics.

• 한방안이비인후피부과학회지
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• 제25권4호
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• pp.12-34
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• 2012

Objective : The purpose of this study is to survey the experimental studies for herbal simplexes of Anti-inflammatory Effects by reviewing oriental medicine journals since 2001. Methods : We collected 65 research papers on Oriental herbal simplexes medicines (herbs and Pharmacopunctures) of Anti-inflammatory effects in the internet site OASIS using the keyword 'Anti-inflammation'. Then we analyzed them according to published journals, years, and research methods, etc. Results : 65 papers in relation to Oriental herbal medicines of anti-inflammatory effects have been published in many kinds of journals and shows a tendency to increase recently. There are 60 cases of using herbal simplexes and 5 cases of Pharmacopuncture. Conclusions : This result will provide useful information of field of Oriental herbal medicine for the development and clinical use of anti-inflammatory related herb simplexes. In the future, we have to perform more studies such as clinical trial and research papers on developed design and herb-combined prescription study for anti-inflammatory effects.

• 통합자연과학논문집
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• 제7권3호
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• pp.159-165
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• 2014

Pyrazole, hydroxyimino, aldehyde and isoxazole derivatives exhibit a broad spectrum of biological activities such as antimicrobial, anti-inflammatory and antitumor activities. With growing application on their synthesis and bioactivity, chemists and biologists in recent years have considerable attention on the research of these derivatives. In the view of potential importance of these derivatives, we have crystallized few of the derivatives and its report has been published. The present study focuses on docking studies of these derivatives against Phospholipases $A_2$ enzyme. This enzymes has implicated as potential targets for anti-inflammatory drug design. co-crystal structure (PDB ID: 1POE) of $PLA_2$ deposited in Protein Data Bank has been retrieved for docking analysis. Docking studies using Schrodinger's GLIDE reveals that these derivatives shows better binding energy and score in the defined active site. These results may provide a guiding role to design a lead molecule which may reduce inflamation.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2017년도 춘계 학술논문 발표대회
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• pp.137-138
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• 2017

The Waterproofing and Anti corrosion materials applied to the water supply facility did not consider environment of water supply facility, thus defects occurred consistently on the site. In this study, it suggests safety adhesion test of wet surface and have a test for safety adhesion performance.

• 대한안전경영과학회지
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• 제16권3호
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• pp.55-62
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• 2014

During five years (Year 2009~2013), Total victims of 72 %(81,560 people) and those 50.6 %(1,258 people) of death accident occurs in small scale construction site which operate 2 million USD less construction budget. Especially, falling death accident account for 785 people, in the share of 33.2 %(261 people) death disaster takes due to defect of original cause materials. The major safety issues in small scale work place take place while scaffold installation, disassembling, work-plate improper installation or non-professional skills of workers. Furthermore, labor subcontract systems make small construction site shortage of resources. Those workers regard work-plate as unnecessary and consumables supplies. Because of that most of workers use unsafe workplace in most construction site. Therefore, in order to prevent falling accident occurring in small scale work site, government should organize related regulations such as "Work site safety construction method" and then expands education support, financial aid, and sourcing safety supplies for work plate which offer broad variety experiences. Also, introduce certificate solutions for various work plates to improve safety function such as anchoring type method and anti sliding function.