• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.55-60
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• 2010

Caesalpinia sappan L. (C. sappan) has long been used in traditional medicine as an emmenagogue, hemostatic and anti-inflammatory agent. The present study investigated the effects of water extract of C. sappan in human lymphoma U937 cells. The proliferation of U937 cells was decreased by C. sappan in a dose-dependently manner. Anti-proliferative effect of C. sappan on U937 cells was associated with G2/M phase arrest, which was mediated by regulating the expression of p21 protein. Moreover, phosphorylation of JNK and p38 was increased by C. sappan. Blockade of JNK and p38 was significantly inhibited C. sappan-induced G2/M phase arrest. Taken together, these results suggest that Anti-proliferative effect of C. sappan on U937 is assocated with G2/M phase cell cycle arrest by expression of p21 protein and, JNK and p38 activation.

• Korean Journal of Microbiology
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• v.47 no.2
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• pp.163-166
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• 2011

For reduction of side effects by anti-fungal agents, a less toxic anti-fungal substance or a synergistic substance with a new mechanism is needed. The anti-yeast substance (AYS) originated from Rahnella aquatilis strain AY2000 is like to be a heterogeneous protein. The AYS inhibited the growth of Candida albicans in culture broth, and AYS-treated cells were arrested in each phase during cell cycle. Among AYS-treated cells, the population of the cells belonging to sub-G1 phase was not increased during cell cycle. Therefore, AYS has rather yeaststatic than yeastcidal effect to C. albicans. Moreover, with combination of itraconazole or fluconazole, AYS had a synergistic anti-yeast activity against Saccharomyces cerevisiae based on the analysis of fractional inhibitory concentration index.

• Journal of Power Electronics
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• v.11 no.3
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• pp.360-368
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• 2011

This paper proposes an active frequency with a positive feedback in the d-q frame anti-islanding method suitable for a robust phase-locked loop (PLL) algorithm using the FFT concept. In general, PLL algorithms for grid-connected PV PCS use d-q transformation and controllers to make zero an imaginary part of the transformed voltage vector. In a real grid system, the grid voltage is not ideal. It may be unbalanced, noisy and have many harmonics. For these reasons, the d-q transformed components do not have a pure DC component. The controller tuning of a PLL algorithm is difficult. The proposed PLL algorithm using the FFT concept can use the strong noise cancelation characteristics of a FFT algorithm without a PI controller. Therefore, the proposed PLL algorithm has no gain-tuning of a PI controller, and it is hardly influenced by voltage drops, phase step changes and harmonics. Islanding prediction is a necessary feature of inverter-based photovoltaic (PV) systems in order to meet the stringent standard requirements for interconnection with an electrical grid. Both passive and active anti-islanding methods exist. Typically, active methods modify a given parameter, which also affects the shape and quality of the grid injected current. In this paper, the active anti-islanding algorithm for a grid-connected PV PCS uses positive feedback control in the d-q frame. The proposed PLL and anti-islanding algorithm are implemented for a 250kW PV PCS. This system has four DC/DC converters each with a 25kW power rating. This is only one-third of the total system power. The experimental results show that the proposed PLL, anti-islanding method and topology demonstrate good performance in a 250kW PV PCS.

• The Transactions of the Korean Institute of Power Electronics
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• v.15 no.3
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• pp.179-187
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• 2010

This paper proposes a new anti-islanding method for single-phase grid-connected photovoltaic (PV) systems using Goertzel algorithm. The proposed scheme is based on inducing increases or decreases of frequencies of load voltage and current that is in the form of existences or periodical variations of the reactive power components. The frequency detection is needed to apply this power variation method to the grid-connected power converter. The proposed method is able to get a fast detection for anti-islanding without the effect of harmonics and noises. The simulation and experiment results validate the effectiveness of the proposed method.

• Korean Journal of Optics and Photonics
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• v.16 no.6
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• pp.527-534
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• 2005

We investigate the pulsation characteristics in a multi-section DFB laser which is composed of one DFB section, phase tuning section, and gain section. Multi-section DFB lasers with anti-phase (AP) complex-coupled (CC) DFB structure show wide current ranges of gain and phase tuning sections fer stable pulsations compared to those with in-phase CC DFB structure or index-coupled DFB structure. For multi-section DFB lasers with AP CC DFB structure, the current range of a gain section for stable pulsations increases and the tuning range of the pulsation frequency increases as a coupling strength or a gain coupling coefficient increases Also, the tuning range using the phase variation in a phase tuning section increases. For a fixed coupling strength, the current ranges of gain and phase tuning sections for stable pulsations increase and the tuning range of the pulsation frequency increases as the length of a DFB section increases.

• Journal of Life Science
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• v.16 no.3 s.76
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• pp.387-395
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• 2006

To isolate and purify anti-fungal active substances from immunized housefly (Musca domestica), low dose of Candida albicans was injected into the larvae of the housefly to induce the appearance of potent anti-fungal active substances in the hemolymph. This purification work was performed by the routine isolation and purification processes of protein, namely, solid phase extraction (SPE), SDS-PACE electrophoresis, HPLC purification. Three 4-16 kDa peptides which exhibited antifungal activity against Candida albican and other fungi were isolated from induced hemolymph. Consequently, further anti-fungal activity study showed that these three peptides were different either in molecular weight or in anti-fungal activity. All isolated substances were proved to be active and resistant to high-temperature. It was deduced that these peptides isolated from induced housefly were novel members of the insect defensin family and they were inducible.

• Advances in Traditional Medicine
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• v.7 no.2
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• pp.141-149
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• 2007

Madhuca indica has been used ethnomedically in Indian folks. In the present study we have investigated anti-inflammatory, anti-ulcer and hypoglycaemic effect of ethanolic extract (EE) and crude alkaloid extract of Madhuca indica seed cake on albino rats. The study showed that the EE had a significant, dose dependent anti-edematogenic, anti-ulcerogenic and hypoglycaemic activity, whereas the crude alkaloid extract exhibited a significant only. Both the extracts possess dose dependent inhibitory activity on carrageenan-induced edema, inhibiting prostaglandins or mediators involved in prostaglandin synthesis, the second phase of inflammation. The EE was significantly effective in protecting pylorus-ligation-induced gastric ulcers at a higher dose level. The active principle of EE seems to be a selective inhibitor of the COX II (prostaglandin synthesis) without important effect on COX I since, EE exhibited both anti-edematogenic and anti-ulcerogenic effect. The EE was effective in reducing the plasma glucose level in normal albino rats in a dose dependent manner, producing hypoglycaemic effect by stimulating the release of insulin from the ${\beta}-cells$ and/or increasing the uptake of glucose from the plasma.

• Journal of Acupuncture Research
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• v.26 no.6
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• pp.91-100
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• 2009

Objectives : The objective of this study is to investigate Anti-nociceptive and anti-inflammatory effects of Clematidis Radix (CR) herbal-acupuncture on the test rats with induced acute pain. Methods : The effects of Clematidis Radix (CR)-distillates were investigated in three types of models with three different pain. Highly purified distillate of CR called CR herbal-acupuncture was injected to Zusanli ($ST_{36}$) acupoint. In the tail flick test, the CR herbal-acupuncture treatment did not show a significant effect of relieving acute pain. To investigate the anti-inflammatory effect of CR herbal-acupuncture, the second testing model'pain was induced by injecting formalin to its planter. For the last model, carrageenan was injected into tarsal joint. the medicinal effect of CR herbal-acupuncture was evaluated through the behavioral analyses such as licking time, weight distribution ratio and ankle circumference. Results : In the formalin test, the analgesic effect of CR herbal-acupuncture was more pronounced in the late phase (for 20 min after the early phase) than in the early phase (for the first 10 min post formalin injection). It was proven by weight distribution ratio testing and ankle edema testing that herbal-acupuncture of CR inhibited arthritis caused by the carrageenan. Conclusions : These results revealed that CR herbal-acupuncture was effective to alleviate the inflammatory pain and could be used as an analgesic treatment with an anti-inflammatory effect.

• Biomedical Science Letters
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• v.19 no.1
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• pp.61-69
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• 2013

The aim of this study was to evaluate the effect of exercise-based cardiac rehabilitation on pro- and anti-inflammatory markers in patients with acute coronary syndrome (ACS). ACS patients who underwent percutaneous coronary intervention (PCI) and took medicine during phase II of rehabilitation were recruited for study. Subjects were divided into two groups; exercise group (EX, n=21) and a non-exercise group (non-EX, n=13). Supervised exercise program in hospital consisted of treadmill and bicycle exercise was performed three times per week for 6 weeks. Patients of EX received individual counseling, including knowledge of heart disease, risk factor modification, and physical training. Cardiopulmonary fitness, body composition, and biochemical blood factors were analyzed before and after experiment. There was no significant difference in serum levels of hs-CRP and TGF-${\beta}1$ between groups, and between time intervals. But there was a significant decrease in serum levels of IL-18 (P<.001). And there was a significant increase in ratio of IL-18 to IL-10 (P<.01) and serum levels of IL-10 (P<.001). After cardiac rehabilitation, there was significant increase in exercise duration (P<.001), maximal oxygen uptake ($VO_{2peak}$; P<.001) and decrease in submaximal rate-pressure product (sRPP; P<.05) in EX. In conclusion, exercise-based cardiac rehabilitation during phase II in patients with ACS after PCI decreased serum IL-18 (pro-inflammatory) content and ratio of IL-18 to IL-10 in serum (highly related with disease recurrence), and increased serum IL-10 (anti-inflammatory) content. In addition, it led to improved cardiopulmonary fitness.

• Journal of KIISE:Software and Applications
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• v.36 no.7
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• pp.560-570
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• 2009

RFID, Radio Frequency Identification, is a technology of automated identification replacing bar-code. RFID technology has advantages that it recognizes fast and it is strong to contamination using wireless communication. However, there are difficult problems that should be solved for popularization of RFID. Among of these, tag anti-collision problem is dealed in this paper. It affected the performance of RFID system directly. This paper analyzes conventional algorithms and proposes new algorithms of tag anti-collision. The algorithm proposed was composed of appropriate properties to each phase of distribution and recognition as hybrid between ALOHA-based algorithm and QT-based algorithm. At phase of distribution, the number of tags recognizing at a frame was reduced using ALOHA-based algorithm. It addressed the delay problem because of deep depth of tree. At phase of recognition, it solved ALOHA-based chronic problem that couldn't recognize all the tags sometimes. Moreover, QTR algorithm that recognize by reversed tag IDs was adopted for the performance. The FQTR algorithm proposed in this paper showed brilliant performance as compared with convention algorithms by simulation.