• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1851-1857
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• 2014

Objective: The main purpose of this work was to investigate the effect of berberine hydrochloride (BH) on the proliferation, apoptosis, migration, and invasion of CNE-1 nasopharyngeal carcinoma cells. Our results shed light on the functional components of traditional Chinese herbs for potential use in modern medicine. Methods: The CNE-1 cell line was treated with different concentrations of BH and effects on cell viability and proliferation were evaluated using the Cell Counting Kit-8 (CCK-8) assay. Anti-migratory and anti-invasive actions of BH were investigated using wound healing assays and the Millicell Hanging cell culture insert system, respectively. Expression of the epithelial-mesenchymal transition (EMT)-related gene twist (Twist) was analyzed by real-time PCR and Western blotting. Apoptosis was estimated with an annexin-V fluorescein (FITC) apoptosis detection kit, as well as with reference to levels of activated caspase-3 of CNE-1 cells before and after treatment with BH utilizing fluorescence spectroscopy. Results: BH was capable of reducing proliferation and viability of CNE-1 cells in a dose- and time-dependent manner, also demonstrating anti-migratory and anti-invasive capacities which correlated with reduction in expression of Twist. Finally, BH was able to induce significant amounts of apoptosis in CNE-1 cells, as demonstrated by an increase in the activity of caspase-3 and in annexin-V staining following treatment. Conclusion: BH extracted from rhizoma coptidis demonstrated an ability to block proliferation, induce apoptosis, and impair the migration and invasion of the CNE-1 cell line Considering these properties, our results suggest that BH could be an important compound for consideration in the treatment of nasopharyngeal carcinoma.

• 대한화학회지
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• 제54권6호
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• pp.707-710
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• 2010

우리나라 서남단의 지리산에는 천연야생에서 자생하는 한방약초의 보고라고 할 수 있다. 현재 약초로 분류되는 식물로는 1200여종이 자생 혹은 재배되고 있다. 최근들어 이들 중 현대인의 피부노화억제와 관련하여 관심을 끌고 있는 약초로 홍화에 관한 연구가 활발히 연구되고 있는데 금번연구에서는 홍화의 주성분인 폴리페놀 화합물(Polyphenol cocktail)이 30 - 40대 중년기의 여성에게 주름생성을 억제시켜 피부노화에 대한 지연효과를 줄 수 있는 천연물질임을 확인하고자 한다. 본 연구에서는 1차적으로 in vitro법으로 DPPH assay로 항산화효과를 확인하고 더불어 인체에 대한 임상시험을 통해 얼굴피부의 주름발생에 대한 억제 혹은 개선효과가 있음을 입증하고자 한다. 또한 홍화추출물을 주성분으로 하는 항노화 마스크팩 시제품의 개발로 진일보하여 기능성화장품 산업의 발전에 기여할 것임을 확신한다.

• 복식
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• 제51권6호
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• pp.5-24
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• 2001

This paper is intended to explore femininity the ideal beauty of body and the features in fashion pursued in the Fashion system and the Anti-Fashion Movement in the Victorian period, on which the modern fashion is based. For the informative facts needed in this paper, books on history, fashion history, feminism, art history of aestheticism and the ideal beauty of body are referred to. On the part Ⅱ of this paper, the femininity and the ideal beauty of body implied in the Aesthetic Movement and Rational Dress Movement as the anti-fashion movement in the Victorian period will be reviewed. Following are the conclusion : First, the works in Aesthetic Movement mainly include the image of sensual female. The essence of femininity is categorized by cultural value, poetic spirit. appetite for sex and self-expression. The ideal beauty of body pursued in this movement is the beauty of immatured body, which means rejection of maternity as well as appetite for sex in the form of metaphor of the power and enthusiasm of female. The features of Aesthetic Movement emphasize the image of sensual and characteristic woman. These features are expressed in the natural waist line and the vertical H silhouette of high waist, natural exposure of body by means of drapery, simplicity and decency by design without fixed forms and seemingly faded colors. Second, Rational Dress Movement attempted to evaluate the femininity in a different way and ultimately pursued masculinity. Therefore, morality, liberty, intelligence, spirituality, self-control, willingness, which had been believed to exclusively belong to male, are added to the categories of femininity. The ideal beauty of body is expressed in the form of Venus Coelestic which is refined and strong. This symbolizes woman's freeing from the fate of reproduction and subordinate relationship with male, morality, decision of one's own and willingness. The features of Rational Dress Movement represent the image of strong-willed and moral woman in its internal meaning. The features of its fashions represent the concealment of the body, emphasis on activeness in pants without decoration and simplicity in its external form. All these features resulted from the pursuit of masculinity.

• 혜화의학회지
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• 제20권2호
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• pp.67-78
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• 2012

Volatile odor substance originating from drying and making dry peel of tangerine from the fruit skin were collected through modern equipment. The anti-microbial activity of the substance against various skin-residing bacteria including acne, dandruff, athelete's foot, and gingivitis inducing microorganisms were tested. Anti-microbial activity was observed in purified oil, where 87 to 92% was D-limonene. Against P. acnes, 103$cfu/m{\ell}$ of P. acnes were suppressed at 0.1% Unshiu oil, and the MIC was measured to be 0.3%. Against P. ovale, a dandruff inducing bacteria, 104$cfu/m{\ell}$were suppressed at 0.1% Unshiu oil, and the MIC was measured to be 0.1%. Against T. rubrum and T. Mentagrophytes, both of which are athelete's foot inducing microorganisms, 83% of T. Mentagrophytes and 99.9% of T. rubrum were suppressed at 0.1% Unshiu oil, and the MIC were 0.3% and 0.05% respectively. Against S. aureus, a skin infection inducing bacteria, 103$cfu/m{\ell}$ of the bacteria were suppressed at 0.1% Unshiu Oil. Against B. subtilis, a non-pathogenic sporulating bacteria, 104$cfu/m{\ell}$ of the bacteria were suppressed at 0.1% Unshiu Oil. Against C. albicans, found in mucous membranes, 104$cfu/m{\ell}$ of the bacteria were suppressed at 0.1% Unshiu Oil. Against Aspergillus niger, an otomycosis inducing microorganism, 99.9% were suppressed at 0.1% Unshiu Oil. The results above indicate that low concentration of purified oil extracted from tangerine had strong antimicrobial activities against bacteria and fungi residing on the skin, and that it may be developed into skin disorder treating products in the future.

• 동의생리병리학회지
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• 제20권6호
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• pp.1763-1768
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• 2006

Cancer is one of the most serious health problem in modern society, and there are many studies to treat this disease. We have performed the study about analyzing papers related with anti-cancerous herbs that is used in clinical treatment recently. We found 257 papers in 'Pub med', the internet site, using the key words 'cancer' and the scientific name of anti-cancerous herbs. We also have compared the herbs' efficacy in oriental medicine with the experimental results in those papers, and thought the practical uses in clinical treatments. However, research studies that reported data on anti-cancerous herbs were wholly lacking. It is recommended that further studies be performed from the point of view of oriental medicine.

• 생약학회지
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• 제51권4호
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• pp.332-339
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• 2020

Lentinus edodes (LE) is the first medicinal macrofungus to enter the realm of modern biotechnology. Lentinus edodes is well-known to have anti-tumor, anti-inflammatory, and immunomodulatory effects. In this study, osteoporosis was induced by ovariectomy in female rats, and the prevention and treatment efficacy of the climacteric disease the postmenopausal type I pattern was examined using the experimental substance. Female rats were either sham-operated (sham; n = 5) or surgically ovariectomized (OVX; five animals per group) and then administered to OVX control, raloxifene hydrochloride 1 mg/kg/day, or LE (20 and 200 mg/kg/day) for 12 weeks. LE treatment suppressed the ovariectomy-induced reduction of bone mineral density in the entire tibia as well as its metaphysis with a decrease of serum osteocalcin and interleukin-6 levels. In addition, LE is suggested to elevate the serum levels of progesterone hormones and prevent bone loss in ovariectomized rats. In conclusion, LE 200 mg/kg/day may have inhibitory effects on osteoporosis in OVX rats.

• 산업경영시스템학회지
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• 제44권1호
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• pp.9-16
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• 2021

Modern combat has been extended to the concept of real-time response to a variety of threats simultaneously occurring in vast areas. In order to quick command determination and accurate engagement in these threats, the combat system has emerged in frigate. Frigates conduct anti-surface, anti-submarine, and anti-aircraft as the core forces of the fleet. In this study, the combat effectiveness measures naval frigates using AHP (analytic hierarchy process) method. A hierarchical structure for measuring the combat effectiveness was developed, and weights of criteria were calculated by expert surveys and pair-wise comparisons. In addition, the combat effectiveness of frigates was synthesized and compared. The weights for each attribute were calculated, and the weights for the three main attributes were in the order of act (0.594), evaluate (0.277), and see (0.129). As a result of calculating the weight, anti surface warfare (0.203) was the highest. The combat effectiveness of FFG Batch-III, which has advanced hardware and software and improved combat system capabilities, see (1.73 to 2.56 times), evaluate (1.68 to 2.08 times), and act (1.31 to 3.80 times) better than the comparative frigate. In summarizing the combat effects of the frigate, FFG Batch-III was 1.41~2.95 times superior to the comparative frigate. In particular, a group of experts evaluated the act importantly, resulting in better combat effectiveness.

• 한국패션뷰티학회지
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• 제6권2호
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• pp.119-128
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• 2008

The surrealism art form comes from the world of unconsciousness. Based on its expression of the world of imaginary, it boldly demonstrates the arrangement and the forms of contradicted objects and the development of collage, montage, and protage techniques in the works which had a big influence on the growth of the modern art. The ideology and the modeling characteristics shown in the surrealism had various expressive forms and meanings in the modern compound expression and it grew out of the former standarlized forms and brought diversity and individuality based on the sensibility of the new avant-garde art form and showed great potential as it presented harmony in the multiple forms of art. The purpose of the research was to analyze the influences that were put on the surrealistic fashion art works and the works of the representative designer, Jean Paul Gotie. The characteristics of Jean Paul Gotie's surrealistic fashion comes from destruction, sexual image, and the mixture of heterogeneous. It is evident that the surrealistic fashion went beyond certain groups of avant-gardists' salvation of the world and were put to practice use, reaching out to the ordinary consumers. This was resulted from the revolutionary movement called, "anti-mode van fashion" led by Gotie. The surrealistic style will be led by various techniques and trends and developed through new characteristics in multiculture merged with various fashion styles.

• 한국실내디자인학회논문집
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• 제13권3호
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• pp.43-51
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• 2004

1"his Study is to make research a Image and Symbol in the Gothic Architecture. Firstly, the concept of the symbol and the image effect are essentially based on the meaning that the activity of consciousness take on the constitution of the symbol. Therefore the image represent the deepest content of human nature has been imagination and reality. Secondly, the symbol concept showed in Gothic Architecture was associated with the passion of the order of middle ages. The world, the cosmos and the history had been revealed in Gothic architecture. In Gothic Image, Emile Male maintained the symbol of the Catholic Church as above mentioned. The Catholic Church was mirror of the natural, the institution, the moral and history, then this passion of the order was a christian order. Especially, E. Panofsky said that the scholastic method was shown in Gothic architecture. He assert that it was especially dialectic method used in theology. That is, he explained the transfiguration of Gothic Architecture with the process of thesis, anti-thesis, synthesis. These symbolize light, magnitude, clearness. Finally, symbolic image is important in Post-Modem architecture at present. Post-Modern architecture is associated with the public and the Pluralism. Post-Modern architecture attempt to communicate as symbolic language among the assumption for diverse aspect of culture.

• 복식
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• 제61권3호
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• pp.1-19
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• 2011

In the process of modernization from the traditional Korean Han-bok to today's modernized fashion. The Republic of Korea received the most influences form the United States among other western countries. The U. S. A. was the primary country who helped to release S. Korea from Japanese colonization in 1945, and provided the most economic and military aids after the Korean War in 1950. The purpose of this case study is to find out the traits of Americanization in modern Korean fashion through sociocultural evidences and reference pictures. The Americanization can be defined as the U. S. A. influencing cultures of other countries, and sometimes resulted in the substitution of a given culture with American culture. Americanization generally is a part of westernization. The analogous terms for Americanization, are Coca-colonization, McDonaldization, Starbuckslization, and Hollywoodization. The theories related to Americanization are theory of economic determination, global system theory, conspiracy theory, modernization theory, and theory of dependence. However, Americanization of Korea cannot be explained in one single theory, but only can be explained as a hybrid of two cultures. There also is a critical viewpoint of de-Americanization. Americanization of Korea were studied in three important chronicles, a period of modernization (1945-1950s), a period of industrialization & popularization(1960s-1970s), and a period of consumerization(1980s-present). The traits of Americanization in the process of modernizing Korean fashion, were found as simplicity, functionality, popularity(kitsch & mimicry), anti-traditional ethics(unchastity & skin revealing), and materialism(lavishness & trends).