• Journal of Power System Engineering
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• v.7 no.2
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• pp.66-72
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• 2003

Recently, the steel parts used at the aerospace and automobile industries are required to be used light weight parts. Therefore, used material, steel have to be a high stress, which is an indispensable condition in this field. At the consideration of parts design, high hardness of the lightweight parts have an benefit of saving fuel and material. A high stress of metal has a point of difference according to the shape of design, external cyclic load and condition of vibration. A crack generates on the surface of metal or under yield stress by defect of inner metal defect or surface defect and slowly, this crack grow stable growth. Finally, rapidity failure phenomena is happen. Fatigue failure_phenomena, which happen in metal, bring on danger in human life and property therefor, anti-fatigue failure technology take an important part of current industries Currently, the shot peening is used for removing the defect from the surface of steel and improving the fatigue strength on surface. Therefore, this paper investigated the effect on frcature toughness using shot peening which is improve the resistance of crack growth and crack expansion rate by fatigue that make a compressive residual stress on surface.

• Journal of Ginseng Research
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• v.46 no.4
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• pp.543-549
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• 2022

Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue.

• Journal of Ginseng Research
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• v.47 no.5
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• pp.605-614
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• 2023

Ginsenosides are bioactive components of Panax ginseng with many functions such as anti-aging, anti-oxidation, anti-inflammatory, anti-fatigue, and anti-tumor. Ginsenosides are categorized into dammarane, oleanene, and ocotillol type tricyclic triterpenoids based on the aglycon structure. Based on the sugar moiety linked to C-3, C-20, and C-6, C-20, dammarane type was divided into protopanaxadiol (PPD) and protopanaxatriol (PPT). The effects of ginsenosides on skin disorders are noteworthy. They play antiaging roles by enhancing immune function, resisting melanin formation, inhibiting oxidation, and elevating the concentration of collagen and hyaluronic acid. Thus, ginsenosides have previously been widely used to resist skin diseases and aging. This review details the role of ginsenosides in the anti-skin aging process from mechanisms and experimental research.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.2
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• pp.151-158
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• 2015

Recently, Cynanchi wilfordii Radix has gained wide use in Asian countries as a functional food effective for relieving fatigue, osteoporosis, and constipation, particularly in menopausal disorders. However, its anti-inflammatory and anti-microbial activities have not been explored in detail to date. The anti-inflammatory, antioxidant, and anti-bacterial properties of the Cynanchi wilfordii Radix extracts obtained with water, methanol, ethanol, and acetone were compared. All 4 polyphenol-containing extracts exhibited anti-inflammatory and antioxidant effects. The ethanol extract was found to elicit the most potent reduction of nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and cytokine (IL-$1{\beta}$, IL-6, IL-10, and TNF-${\alpha}$) levels, as well as inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a concentration-dependent manner. The evaluation of antioxidant activity also revealed the ethanol extract to have the highest free radical scavenging activity, measured as $85.3{\pm}0.4%$, which is equivalent to 99.9% of the activity of ${\alpha}$ -tocopherol. In the assessment of anti-bacterial activity, only ethanol extract was found to inhibit the growth of the Bacillus species Bacillus cereus and Bacillus anthracis. These results show that polyphenols of Cynanchi wilfordii Radix have anti-inflammatory, antioxidant, and anti-bacterial properties that can be exploited and further improved for use as a supplementary functional food, in cosmetics, and for pharmaceutical purposes.

• The Korea Journal of Herbology
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• v.23 no.4
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• pp.9-19
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• 2008

Objectives: In this study the authors investigated effects of the ethanolic extract of Rhodjola Rosea(HKC) on fatigue and hypothalamic IEG expression in rat forced swimming(FS) model. Methods: Sprague-Dawley rats were administered HKC extract(25 mg/100g, p.o.) for 3 days prior to FS, some rats underwent 10 min FS and others exhaustive forced swimming(EFS). In addition, other rats were administered extract at different times after EFS over 3 consecutive days. Results: When HKC administered before 10 mins of FS, serum actate dehydrogenase(LDH) and creatine phosphokinase(CPK) activities were significantly lower than control group. When HKC administered prior to EFS, blood lactate was significantly lower versus control group. When HKC was administered after EFS, blood lactate(at 6 and 24 hours after EFS) were significantly lower and serum LDH, CPK activities(at 24 hours after EFS) were significantly lower versus control group. When HKC was administered after EFS, c-Fos positive neurons in hypothalamic periventricular area(PVA), medial part(mPVN) and anterior hypothalamic nucleus caudal part(AHC) were significantly lower at 24 hours after EFS than in control group. HSP-72 positive neuron numbers in hypothalamus were significantly lower at 24 hours after EFS than in control group. Finally, when HKC was administered prior to 10 mins FS, HIF-$1{\alpha}$ expression in the gastrocnemius muscle was significantly increased. Conclusions: These results suggest that HKC extract has an anti-fatigue effect, and it reduces neuronal cell stress responses induced by physical stress by having a beneficial effect on lactate metabolism.

• Journal of Ginseng Research
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• v.45 no.3
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• pp.380-389
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• 2021

Metabolic syndrome (MS) refers to a clustering of at least three of the following medical conditions: high blood pressure, abdominal obesity, hyperglycemia, low high-density lipoprotein level, and high serum triglycerides. MS is related to a wide range of diseases which includes obesity, diabetes, insulin resistance, cardiovascular disease, dyslipidemia, or non-alcoholic fatty liver disease. There remains an ongoing need for improved treatment strategies for MS. The most important risk factors are dietary pattern, genetics, old age, lack of exercise, disrupted biology, medication usage, and excessive alcohol consumption, but pathophysiology of MS has not been completely identified. Korean Red Ginseng (KRG) refers to steamed/dried ginseng, traditionally associated with beneficial effects such as anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. KRG has been often used in traditional medicine to treat multiple metabolic conditions. This paper summarizes the effects of KRG in MS and related diseases such as obesity, cardiovascular disease, insulin resistance, diabetes, dyslipidemia, or non-alcoholic fatty liver disease based on experimental research and clinical studies.

• Journal of Ocean Engineering and Technology
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• v.3 no.2
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• pp.138-144
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• 1989

It has been very important in various industry fields to improve the fatigue strength characteristics of bearings such as bearing life, fatigue limit, etc., because such poor properties could result in shortening the machinery life as well as in decreasing the accuracy. However, no successful heat treatment criterion seems to be available at present. In this study, the effect of the $170^{\circ}C\times120min$ tempering cycles repeated after $380^{\circ}C\times80min$ oil quenching for $800^{\circ}C$ spheroidizing-annealed bearing steel (STB2) as base metal on the $120^{\circ}C$ high temperature rotary bending fatigue strength characteristics were investigated, including the effects on hardness, Charpy impact value and micro-structure, in order to seek for the best heat treatment condition finally. The important results obtained are as follows : 1) The optimal cycle of tempering so that the fatigue strength .sigma. could become the highest was the 4th cycle. And it is confirmed that this $\sigma_{F}$ is about 6 times more increased than that of base metal, and about 1.3 times more increased than the case of the 1 cycle tempered. 2) As a result of the investigation for the effects of tempering cycles on hardness, the hardness at the tempering number of 2 thru 5 cyles was not decreased severely ; only about 10% decrease from those of the quenched and 1 cycle tempered case. Such hardness is equivalent to $H_{R}$/C61-62 with no bad effect on anti-abrasion of bearing steel. 3) In the case of 2 thru 5 cycle tempering as well as 1 cycle tempering, the impact value was not so improved comparing with the case of quenching, but an increase of 5 to 10% could be expected at least. 4) It was experimentally confirmed that the control of the mechanical properties improvement such as fatigue strength and fatigue life for bearing steels could be possible by the number of tempering cycles.

• Journal of Ocean Engineering and Technology
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• v.3 no.2
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• pp.638-638
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• 1989

It has been very important in various industry fields to improve the fatigue strength characteristics of bearings such as bearing life, fatigue limit, etc., because such poor properties could result in shortening the machinery life as well as in decreasing the accuracy. However, no successful heat treatment criterion seems to be available at present. In this study, the effect of the $170^{\circ}C\times120min$ tempering cycles repeated after $380^{\circ}C\times80min$ oil quenching for $800^{\circ}C$ spheroidizing-annealed bearing steel (STB2) as base metal on the $120^{\circ}C$ high temperature rotary bending fatigue strength characteristics were investigated, including the effects on hardness, Charpy impact value and micro-structure, in order to seek for the best heat treatment condition finally. The important results obtained are as follows : 1) The optimal cycle of tempering so that the fatigue strength .sigma. could become the highest was the 4th cycle. And it is confirmed that this $\sigma_{F}$ is about 6 times more increased than that of base metal, and about 1.3 times more increased than the case of the 1 cycle tempered. 2) As a result of the investigation for the effects of tempering cycles on hardness, the hardness at the tempering number of 2 thru 5 cyles was not decreased severely ; only about 10% decrease from those of the quenched and 1 cycle tempered case. Such hardness is equivalent to $H_{R}$/C61-62 with no bad effect on anti-abrasion of bearing steel. 3) In the case of 2 thru 5 cycle tempering as well as 1 cycle tempering, the impact value was not so improved comparing with the case of quenching, but an increase of 5 to 10% could be expected at least. 4) It was experimentally confirmed that the control of the mechanical properties improvement such as fatigue strength and fatigue life for bearing steels could be possible by the number of tempering cycles.

• Proceedings of the EASDL Conference
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• 2003.09a
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• pp.79-79
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• 2003

• The Journal of the Convergence on Culture Technology
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• v.10 no.1
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• pp.363-368
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• 2024

Steel structures used in marine environments, such as ships, offshore structures or sub-structures in wind power generation facilities are prone to corrosion. In this study, the corrosion fatigue crack propagation characteristics due to the environmental load are examined by experiment at -1050 mV vs. SCE, which is equivalent to the anti-corrosion potential of zinc anodes that are widely used as sacrificial anodes. In this study, for this purpose, an experimental study is conducted on the effect of cathodic protection on the propagation of fatigue cracks in the seawater environment under the condition of -1050 mV vs. SCE, considering the wave period in synthetic seawater. Cathodic protection prevents corrosion; however, excessive protection generates hydrogen through chemical reactions as well as calcareous deposits. The fatigue crack propagation rate appeared to be faster than the rate in a seawater corrosion environment at the early stages of the experiment. As the crack length and stress intensity factor K increased, the crack propagation rate became slower than the fatigue crack propagation rate in seawater. However, the crack growth rate was faster than that in the atmosphere.