• Geomechanics and Engineering
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• v.11 no.4
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• pp.457-469
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• 2016

Steep rock slope with water-filled tension crack will happen to overturn around the toe of the slope under seismic loading. This failure type is completely different from the common toppling failure occurring in anti-dipping layered rock mass slopes with steeply dipping discontinuities. This paper presents an analytical approach to determine the seismic factor of safety against overturning for an intact rock mass slope with water-filled tension crack considering horizontal and vertical seismic coefficients. This solution is a generalized explicit expression and is derived using the moment equilibrium approach. A numerical program based on discontinuous deformation analysis (DDA) is adopted to validate the analytical results. The parametric study is carried out to adequately investigate the effect of horizontal and vertical seismic coefficients on the overall stability against overturning for a saturated rock slope under two water pressure modes. The analytical results show that vertically upward seismic inertia force or/and second water pressure distribution mode will remarkably decrease the slope stability against overturning. Finally, several representative design charts of slopes also are presented for the practical application.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.305-309
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• 2016

PTEN protein is an important tumour suppressor factor detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression focusing on length of survival in breast cancer patients. This descriptive-analytical study was conducted on 100 breast cancer cases referred to Sabzevar hospitals in the north east of Iran between 2010 and 2011, followed up to 2015. The PTEN gene expression of tumour tissue samples was determined using specific monoclonal antibodies. The data were analyzed using Chi-square test and Fisher's exact test. Patient length of survival was analyzed after 4 years of follow-up using the Cox regression model. The PTEN gene was expressed in 70 of 100 samples, while being found at a high level in all noncancerous samples. There was an inverse significant relationship between expression of PTEN and tumour stage and grade (p<0.001). In addition, expression of PTEN in invasive ductal tumours was less than in non-invasive tumours. There was also an inverse significant relationship between the likelihood of death and PTEN gene expression (p<0.01). These findings indicate that lack of PTEN gene expression can be sign for a worse prognosis and poor survival in breast cancer.

• Journal of the Korean Society of Costume
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• v.61 no.4
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• pp.38-51
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• 2011

The purpose of this study is to offer data that designers can utilize substantially, by developing creative materials in knit fashion through the analysis relevant to expression characteristics on the mixture in high low class culture, which were shown in knit fashion of contemporary women, as one of methods of pursuing a plan for being able to be appeared creative and unique knit wear. As for a method of this research, studied concept and characteristics on the mixture in high low class culture by preceding researches. And women's knit fashion was selected that is seen to be 3~18 gauge among the world's 4 collections from 2000~2008. The analysis was made with the analytical frame in mixture pattern, and the analytical frame in design element, and item. The results are as follows. The mixture of kidult element and high fashion was shown with characteristic of expressing humor and fun with graffiti, expression like character and cartoon, and fairy-tale fantasy through the exaggerated trifling article. The mixture of grungy element and high fashion was shown with the expression characteristic in the mixture of heterogenous pattern, and in tear, slit without the end treatment due to fraying the end strand in the knit fashion with basic stitch, patch work, fringing and tone-down gray, use of khaki and blue color, and match in opposite color. The mixture of underwear and high fashion was shown the expression characteristic with the emphasis on underwear line like volume up, or with the mixture of details such as pants in diverse lengths, mini skirt, underwear lace, and ribbon.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.493-503
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• 2022

Forkhead transcription factor 3a (Foxo3a) is believed to be a tumor suppressor as its inactivation leads to cell transformation and tumor development. However, further investigation is required regarding the involvement of the activating transcription factor 3 (ATF3)-mediated Tat-interactive protein 60 (Tip60)/Foxo3a pathway in cancer cell apoptosis. This study demonstrated that Chelidonium majus upregulated the expression of ATF3 and Tip60 and promoted Foxo3a nuclear translocation, ultimately increasing the level of Bcl-2-associated X protein (Bax) protein. ATF3 overexpression stimulated Tip60 expression, while ATF3 inhibition by siRNA repressed Tip60 expression. Furthermore, siRNA-mediated Tip60 inhibition significantly promoted Foxo3a phosphorylation, leading to blockade of Foxo3a translocation into the nucleus. Thus, we were able to deduce that ATF3 mediates the regulation of Foxo3a by Tip60. Moreover, siRNA-mediated Foxo3a inhibition suppressed the expression of Bax and subsequent apoptosis. Taken together, our data demonstrate that Chelidonium majus induces SKOV-3 cell death by increasing ATF3 levels and its downstream proteins Tip60 and Foxo3a. This suggests a potential therapeutic role of Chelidonium majus against ovarian cancer.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.49 no.5
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• pp.299-301
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• 2000

Analytical expression for the breakdown voltage of the gated diodes were derived as f function of doping concentration and gate voltage, and verified by numerical simulations using ATLAS. The analytical results are in good agreement with simulation results within 5% error when the gate voltage changes from -50V to 130V in case of ND = $1\times1015 cm^{-3}$ and within 10% error when the doping concentration is changed from $5\times1014 cm^{-3}\; to\; 2\times1015 cm6{-3}$, respectively.

• Proceedings of the KIPE Conference
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• 2004.07b
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• pp.940-943
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• 2004

This Paper analysis variable characteristics of inductance profiles and basic magnetic fields for Switched Reluctance Motors(SRM). The varying Inductance and flux linkage on operating control condition are very important for developing control algorithm and SRM accurate drive system. Therefore, we have analytical model for varying inductance and flux linkage with simulation and experimental method, and to find an analytical expression for the SRM coenergy. There are shown some good results that comparison of simulated and analytical inductance, flux linkage and current waves.

• Proceedings of the KIEE Conference
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• 1996.07c
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• pp.1612-1614
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• 1996

Analytical expression for the breakdown voltage of the Schottky diode with double epitaxial layer has been obtained. Analytical results agree reasonably with the numerical simulations using MEDICI. It is expected that our results can be used for the optimum design of power MOSFET as well as the Schottky diodes with double epitaxial layer.

• Proceedings of the KIEE Conference
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• 2001.04a
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• pp.156-159
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• 2001

This Paper analysis variable characteristics of inductance profiles and basic magnetic fields for Switched Reluctance Motors(SRM). The varying Inductance and flux linkage on operating control condition are very important for developing control algorithm and SRM accurate drive system. Therefore, we have analytical model for varying inductance and flux linkage with simulation and experimental mothed, and to find an analytical expression for the SRM coenergy. There are shown some good results that comparison of simulated and analytical inductance, flux linkage and current waves.

• JSTS:Journal of Semiconductor Technology and Science
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• v.8 no.3
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• pp.221-226
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• 2008

A new two dimensional (2-D) analytical model for the Threshold Voltage on dual material surrounding gate (DMSG) MOSFETs is presented in this paper. The parabolic approximation technique is used to solve the 2-D Poisson equation with suitable boundary conditions. The simple and accurate analytical expression for the threshold voltage and sub-threshold swing is derived. It is seen that short channel effects (SCEs) in this structure is suppressed because of the perceivable step in the surface potential which screens the drain potential. We demonstrate that the proposed model exhibits significantly reduced SCEs, thus make it a more reliable device configuration for high speed wireless communication than the conventional single material surrounding gate (SMSG) MOSFETs.

• Nuclear Engineering and Technology
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• v.39 no.1
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• pp.75-84
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• 2007

This paper presents a closed-form model for evaluating the restraint effect of pressure induced bending on the opening of a circumferential through-wall crack, which is considered plastic deformation behavior. Three-dimensional finite element analyses with different crack lengths, restraint conditions, pipe geometries, magnitudes of internal pressure, and tensile properties were used to investigate the influence of each parameter on the pressure-induced bending restraint on the crack opening displacement. From these investigations, an analytical model based on elastic-perfectly plastic material was developed in terms of the crack length, symmetric restraint length, mean radius to thickness ratio, axial stress corresponding to the internal pressure, and normalized crack opening displacement evaluated from a linear-elastic crack opening condition. Finite element analyses results demonstrate that the proposed analytical model reliably estimated the restraint effect of pressure-induced bending on the plastic crack opening of a circumferential through-wall crack and properly reflected the dependence on each parameter within the range over which the analytical expression was derived.