• Natural Product Sciences
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• 제27권4호
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• pp.264-273
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• 2021

Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatography (HPLC) analysis is still a challenge due to the complexity in various parameters to be considered and co-existing multi-components. As a case study, a reliable HPLC method for simultaneous quantification of paeoniflorin from Paeoniae Radix and decursin from Angelicae Gigantis Radix in various commercial herbal medicine was developed based on analytical quality by design (AQbD) strategy. As a first step, risk assessment was performed to select the critical method parameters (CMPs) which were decided as organic mobile phase ratio and column oven temperature. In order to evaluate the effect of the CMPs on critical method attributes (CMAs) of peak resolution and tailing, central composite design (CCD) was employed. The final chromatographic conditions were optimized as follows: column- C₁₈, 4.6 × 250 mm, 5 ㎛ particle size; mobile phase- A: acetonitrile, B: 0.1% acetic acid water; detection wavelength- 235 nm for paeoniflorin, 325 nm for decursin; column oven temperature- 25℃; flow rate- 1.0 mL/min; gradient mobile phase system as Time (min) : % A, 0:14, 25:14, 30:50, 60:50, 61:100, 65:100, 66:14, 75:14. The method was successfully validated according to the International Conference on Harmonization (ICH) guidelines and piloted for ten commercial herbal medicines.

• Computers and Concrete
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• 제29권 5호
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• pp.303-321
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• 2022

The current design equations for predicting the torsional capacity of RC members underestimate the torsional strength of under-reinforced members and overestimate the torsional strength of over-reinforced members. This is because the design equations consider only the yield strength of torsional reinforcement and the cross-sectional properties of members in determining the torsional capacity. This paper presents an analytical model to predict the thickness of shear flow path in RC beams subjected to pure torsion. The analytical model assumes that torsional reinforcement resists torsional moment with a sufficient deformation capacity until concrete fails by crushing. The ACI 318 code is modified by applying analytical results from the proposed model such as the average stress of torsional reinforcement and the effective gross area enclosed by the shear flow path. Comparison of the calculated and observed torsional strengths of existing 129 test beams showed good agreement. Two design variables related to the compressive strength of concrete in the proposed model are approximated for design application. The accuracy of the ACI 318 code for the over-reinforced test beams improved somewhat with the use of the approximations for the average stresses of reinforcements and the effective gross area enclosed by the shear flow path.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2002년도 가을 학술발표회 논문집
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• pp.149-154
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• 2002

An analytical fracture mechanics approach was used to investigate the fracture behavior of reinforced concrete beams. By use of this approach based on fracture mechanics concepts, the crack width and length as well as the strength and cracking stability of reinforced concrete beams were investigated. The results obtained from the analytical studies were also discussed in terms of the minimum reinforcement ratio and crack width specified in design code provisions. The analytical approach based on fracture mechanics concepts are very useful to predict the fracture behavior of reinforced concrete beams.

• 한국시뮬레이션학회논문지
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• 제9권3호
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• pp.65-75
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• 2000

In recent years, significant advances in computers and communication technologies have made multimedia services feasible. As a result, various queuing models and cost models on architecture and data placement for multimedia server have been proposed. However, these analytical techniques use only probabilistic models to represent the behavior of a system, and then they have several limitations like accuracy. Simulation is a viable alternative to analytical model. It avoids many of the limitations associated with analytical techniques, allowing for more precise representation of system attributes like workload in program code. In this paper, we propose a simulation test bed that can evaluate performance of real-time multimedia server by using simulation model.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1998년도 가을 학술발표대회 논문집(III)
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• pp.821-826
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• 1998

The design methods for the steel plate strengthened RC structures are not well established yet because the structural behavior of plated RC beams is more complex than that of regular unplated ones. The main purpose of this paper is to present the premature failure mechanism of steel plate strengthened RC beams. The analytical models of interfacial stress and normal are also proposed in this paper. The comparisons between the analytical results using the proposed theory and experimental ones relatively satisfied.

• 한국공간구조학회:학술대회논문집
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• 한국공간구조학회 2006년도 춘계 학술발표회 논문집 제3권1호(통권3호)
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• pp.81-87
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• 2006

This study has been conducted to predict the ultimate moment capacities of double angle connections with various angle thicknesses and bolt gage distances. Considering the results of experimental tests conducted previously, a simplified analytical model is suggested in this research. In addition, some basic data are also provided for structural engineers to design a double angle connection preliminary.

• Structural Engineering and Mechanics
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• 제11권6호
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• pp.651-662
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• 2001

In order to investigate the seismic behavior and seismic design methods in the transverse direction of a shield tunnel, a series of model shaking table tests and a two-dimensional finite element dynamic analysis on the tests are carried out. Two kinds of static analytical methods based on ground-tunnel composite finite element model and beam-spring element model are proposed, and the validity of the static analyses is verified by model shaking table tests. The investigation concerns the dynamic response behavior of a tunnel and the ground, the interaction between the tunnel and ground, and an evaluation of different seismic design methods. Results of the investigation indicate that the shield tunnel follows the surrounding ground in displacement and dynamic characteristics in the transverse direction; also, the static analytical methods proposed by the authors can be used directly as the seismic design methods in the transverse direction of a shield tunnel.

• Earthquakes and Structures
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• 제10권4호
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• pp.735-755
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• 2016

This article presents a proposed analytical methodology to determine seismic force-resisting system R-values for steel diagrid framed systems. As current model building codes do not explicitly address the seismic design performance factors for this new and emerging structural system, the purpose of this study is to provide a sound and reliable basis for defining such seismic design parameters. An approach and methodology for the reliable determination of seismic performance factors for use in the design of steel diagrid framed structural systems is proposed. The recommended methodology is based on current state-of-the-art and state-of-the practice methods including structural nonlinear dynamic analysis techniques, testing data requirements, building code design procedures and earthquake ground motion characterization. In determining appropriate seismic performance factors (R, ${\Omega}_O$, $C_d$) for new archetypical building structural systems, the methodology defines acceptably low values of probability against collapse under maximum considered earthquake ground shaking.

• Journal of Positioning, Navigation, and Timing
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• 제9권3호
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• pp.191-205
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• 2020

Designing a new signal is essential in the development of a new Radio Navigation Satellite Service (RNSS) system. This paper introduces the signal design parameters and the figures of merit (FoMs) to be considered in designing a new RNSS signal, and then reviews their relationship in details. In addition, we show examples of the trade-off analysis between FoMs according to the signal design scenarios using an analytical simulation tool based on the relationship between the signal design parameters and the FoMs.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1986년도 한국자동제어학술회의논문집; 한국과학기술대학, 충남; 17-18 Oct. 1986
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• pp.431-436
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• 1986

The design and manufacture of injection molded polymeic parts with desired mechanical properties is a costly process dominated by empiricism, including the modification of actual tooling. This paper presents an interactive computer-based design system for injection molded plastic parts. This knowledge-based synthesis system provides a rational design strategy for injection molding and molded parts. It synergistically combines a rule-based expert system for hurestic knowledge with analytical process simulation programs. The theremomechanical properties of a molded part such as the effect of molecular orientation and weldline strength are predicted by the analysis programs; while the expert system interprets the analytical results from the process simulation, evaluates the design, and generates recommendations for optimal design alternatives. The heuristic knowledge of injection molding is formalized as production rules of the expert consultation system.