• 한국산학기술학회논문지
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• 제13권7호
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• pp.3048-3056
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• 2012

본 연구의 목적은 교사 및 성악가에 대한 음성장애지수(VHI), 음성관련 삶의 질 평가(V-RQOL), 음향음성학적 평가에 대한 특성을 연구하였다. 본 연구는 56명(성대결절이 있는 교사 20명 및 성악가, 그리고 정상화자 16명)을 대상으로 하였다. 모든 대상자에게 VHI, V-RQOL를 평가하였고, 음향학적 평가는 CSL 4500(Kay Pantax, USA)으로 측정하였다. 21명의 대상자에게 VHI, VRQOL, CSL을 이용한 음향적 평가에 대한 검사-재검사를 위해 두 번 실시하였다. 본 연구의 자료처리는 SPSS 18.0(SPSS Inc, Chicago, IL)을 사용하였다. 본 실험 결과, VHI 및 V-RQOL 결과, 교사 및 성악가 집단의 신체적, 기능적, 정서적 점수가 정상집단에 비해 유의하게 높았다(p<0.05). 음향학적 특성은 기본주파수 관련 변수, 기본주파수 변이 관련 변수, 음성강도 변이 관련 변수, 잡음 관련 변수, 진전 관련 변수) 범주에서 실험집단이 정상집단에 비해 유의하게 높았다(p<0.05). 결론적으로 교사 및 성악가들은 신체-기능영역에서 자신의 음성문제를 심각하게 인식하는 것 같다.

• 한국인터넷방송통신학회논문지
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• 제14권1호
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• pp.259-264
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• 2014

IEEE 802.15.4는 다양한 모니터링과 제어 응용을 위한 보편적인 대안으로 대두되고 있다. 본 논문에서는 IEEE 802.15.4를 이용하여 직류배전선로를 실시간으로 감시하고, 신속한 장애감지와 장애발생 선로를 차단하기 위한 직류배전선로 장애관리시스템을 설계하였다. 각 노드에 번호를 할당하였고, IEEE 802.15.4의 Unslotted CSMA-CA 방식을 사용하였으며, 시뮬레이션을 통해 성능분석을 하였다. 이를 위해 전류 16비트, 진폭 16비트, 기타 상태정보 28비트로 총 60비트의 제어정보를 보냈고, 직류배전선로 장애관리시스템의 패킷전달율과 전송 지연시간을 측정하고 분석하였다. 트래픽 부하가 초당 330 패킷 이하일 때, 0.02초보다 짧은 평균 지연이 나타났으며, 트래픽 부하가 초당 260 패킷 이하일 때, 99.99% 이상의 패킷 전달률을 보여준다. 따라서 트래픽 부하가 초당 260 패킷 이하일 때, 미국 DOE(Department of Energy)의 엄격한 조건을 만족함을 확인할 수 있었다. 본 논문의 연구결과는 IEEE 802.15.4를 이용한 직류배전선로 장애관리시스템 구축을 위한 기본 자료로서 활용이 가능할 것이다.

• Progress in Superconductivity
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• 제13권1호
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• pp.58-63
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• 2011

Recently, superconductor flywheel energy storage systems (SFESs) have been developed for application to a regenerative power of train, a power quality improvement, the storage of distributed power sources such as solar and wind power, and a load leveling. As the high temperature superconductor (HTS) bearings offer dynamic stability without the use of active control, accurate analysis of the HTS bearing is very important for application to SFESs. Mechanical property of a HTS bearing is the main index for evaluating the capacity of an HTS bearing and is determined by the interaction between the HTS bulks and the permanent magnet (PM) rotor. HTS bearing rotor consists of PM and iron collector and the proper dimension design of them is very important to determine a supporting characteristics. In this study, we have optimized a rotor magnet array, which depends on the limited bulk size and performed various dimension layouts for thickness of the pole pitch and iron collector. HTS bearing rotor was installed into a single axis universal test machine for a stiffness test. A hydraulic pump was used to control the amplitude and frequency of the rotor vibration. As a result, the stiffness result showed a large difference more than 30 % according to the thickness of permanent magnet and iron collector. This is closely related to the bulk stiffness controlled by flux pining area, which is limited by the total bulk dimension. Finally, the optimized HTS bearing rotor was installed into a flywheel system for a dynamic stability test. We discussed the dynamic properties of the superconductor bearing rotor and these results can be used for the optimal design of HTS bearings of the 10kWh SFESs.

• 대한후두음성언어의학회지
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• 제20권1호
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• pp.57-62
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• 2009

Background and Objectives : There are few studies reported that specifically examine the laryngeal function in patients with profound hearing loss or deafness, This study was designed to examine videostroboscopic findings and phonetic characteristics in adult patients with prelingually deaf. Materials and Method: Sixteen patients (seven males, nine females) diagnosed as prelingually deaf aged from 19 to 54 years, and were compared with a 20 normal control group with no laryngeal pathology and normal hearing group, Videostroboscopic evaluations were rated by experienced judges on various parameters describing the structure and function of the laryngeal mechanism during comfortable pitch and loudness phonations. Acoustic analysis test were done, and a nasalance test performed to measure rabbit, baby, and mother passage. CSL were measured to determine the first and two formant frequencies of vowels /a/, /i/, /u/, Statistical analysis was done using Mann-Whitney U or Wilcoxon signed ranks test. Results: Videostroboscopic findings showed phase symmetry but significantly more occurrences decrement in the amplitude of vibration, mucosal wave, irregularity of the vibration and increased glottal gap size during the closed phase of phonation, In addition, group of prelingually deaf patients were observed to have significantly more occurrences of abnormal supraglottic activities during phonation. The percentage of shimmer in the group of prelingually deaf patients were higher than in the control group. Characteristics of vowels were lower of the second formant of the vowel /i/. Nasalance in prelingually deaf patients showed normal nasality for all passages, Conclusion: Prelingually deaf patients show stroboscopic abnormal findings without any mucosal lesion, suggesting that they have considerable functional voice disorder. We suggest that prelingually deaf adults should perform vocal training for normalized laryngeal function after cochlear implantation.

• 한국항해항만학회지
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• 제27권2호
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• pp.209-215
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• 2003

본 논문은 IMT-2000 기지국용 15 Watt Feedforward 선형전력증폭기(Linear Power Amplifier; LPA)의 구현을 위한 에러증폭기를 설계 및 제작하여, 그 성능을 평가하였다. 에러증폭기는 상호 변조 왜곡 신호(Intermodulation Distortion: IMD)만을 검출하기 위한 빼기회로, RF 신호의 세기 및 위상을 제어하기 위한 가변 감쇠기, 가변 위상변환기, 그리고 신호의 증폭을 위한 저전력증폭기, 대전력증폭기로 구성되었다. 이들 구성요소는 RO4350 기판 위에 구현되어, 틴 도금한 알루미늄 기구물 안에 바이어스 회로와 함께 집적하였다. 제작시 RF 회로부의 바이어스 회로에 전원을 공급하기 위하여 내벽에 관통형 커패시터를 삽입하여 DC 전원에 의한 스퓨리어스 성분이 제거되도록 하였다. 제작된 에러증폭기는 45 dB 이상의 이득, $\pm$ 0.66 dB의 이득평탄도, -15 dB 이하의 입력반사 손실 특성을 나타내었다. 또한 성능을 평가하기 위해 Feedforward 방식의 LPA에 적용한 결과 주증폭기의 IM3 성분이 34 dBc에서 61 dBc,개선되었다. 이때 오차루프의 상쇄지수는 약 27 dB, 최종 출력 전력은 15 W로 나타났다.

• 대한약침학회지
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• 제3권1호
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• pp.35-51
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• 2000

The purpose of this study is to prove the analgesic effects of apitoxin and its mechanism via jaw-opening reflex(JOR) and measuring expression of mRNA in Phospholipase and Tryptophan hydroxylase(TPH) using RT-PCR. The experiments were carried out on Sprague-Dawley rats(300-400g) and mastocytoma(P-185 HTR) for JOR and RT-PCR, respectively. Rats anesthetized with thiopental sodium (80mg/kg) were used in the Tooth Pulp stimulation induced JOR. The amplitude of a digastric electromyogram (dEMG) was recorded during the stimulation at an intensity of 1.5 times the threshold for JOR. Apitoxin used in this experiment was diluted with normal saline by 1:1000. Apitoxin was injected intravenously into the test group while normal saline to the control group. However, it was injected directly into the cell of mastocytoma. We referred to base sequence registered in Genbank in designing primers for RT-PCR. The results were as follows; (1)Compared with control group, analgesic effect started to show right after Sprague-Dawely rats were treated with apitoxin($71.50{\pm}8.08$) and lasted for 50 minutes. (2)As a result of the experiment of RT-PCR, we witnessed significant changes in the degree of expression of phospholipase or rate-limiting enzyme of biosynthesis of prostaglandins with $10{\mu}g/ml$ apitoxin.($31.74{\pm}18.98%$, P<0.05) (3)As a result of the experiment of RT-PCR, we witnessed significant changes in the degree of expression of TPH or rate-limiting enzyme in biosynthesis of serotonin with $10{\mu}g/ml$ apitoxin.($131.37{\pm}16.87%$, P<0.05). These results suggest that $10{\mu}g/ml$ apitoxin have the most analgesic effects. This study showed that apitoxin has analgesic effects and held good for 50 minutes. The injection of apitoxin has brought out changes in the degree of expression of phospholipase and TPH. These results strongly suggest that analgesic mechanism by apitoxin is closely related to prostaglandins and serotonin.

• Reproductive and Developmental Biology
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• 제33권3호
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• pp.163-169
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• 2009

Many biological systems are regulated by an intricate set of feedback loops that oscillate with a circadian rhythm of roughly 24 h. This circadian clock mediates an increase in body temperature, heart rate, blood pressure, and cortisol secretion early in the day. Recent studies have shown changes in the amplitude of the circadian clock in the hearts and livers of streptozotocin (STZ)-treated rats. It is therefore important to examine the relationships between circadian clock genes and growth factors and their effects on diabetic phenomena in animal models as well as in human patients. In this study, we sought to determine whether diurnal variation in organ development and the regulation of metabolism, including growth and development during the juvenile period in rats, exists as a mechanism for anticipating and responding to the environment. Also, we examined the relationship between changes in growth factor expression in the liver and clock-controlled protein synthesis and turnover, which are important in cellular growth. Specifically, we assessed the expression patterns of several clock genes, including Per1, Per2, Clock, Bmal1, Cry1 and Cry2 and growth factors such as insulin-like growth factor (IGF)-1 and -2 and transforming growth factor (TGF)-${\beta}1$ in rats with STZ-induced diabetes. Growth factor and clock gene expression in the liver at 1 week post-induction was clearly increased compared to the level in control rats. In contrast, the expression patterns of the genes were similar to those observed after 5 weeks in the STZ-treated rats. The increase in gene expression is likely a compensatory change in response to the obstruction of insulin function during the initial phase of induction. However, as the period of induction was extended, the expression of the compensatory genes decreased to the control level. This is likely the result of decreased insulin secretion due to the destruction of beta cells in the pancreas by STZ.

• The Korean Journal of Physiology and Pharmacology
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• 제2권3호
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• pp.297-305
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• 1998

This study used in vivo intracellular recording in rat hippocampus to evaluate the effect of lidocaine and MK-801 on the membrane properties and the synaptic responses of individual neurons to electrical stimulation of the commissural pathway. Cells in control group typically fired in a tonic discharge mode with an average firing frequency of $2.4{\pm}0.9$ Hz. Neuron in MK-801 treated group (0.2 mg/kg, i.p.) had an average input resistance of $3.28{\pm}5.7\;M{\Omega}$ and a membrane time constant of $7.4{\pm}1.8$ ms. These neurons exhibited $2.4{\pm}0.2$ ms spike durations, which were similar to the average spike duration recorded in the neurons of the control group. Slightly less than half of these neurons were firing spontaneously with an average discharge rate of $2.4{\pm}1.1$ Hz. The average peak amplitude of the AHP following the spikes in these groups was $7.4{\pm}0.6$ mV with respect to the resting membrane potential. Cells in MK-801 and lidocaine treated group (5 mg/kg, i.c.v.) had an average input resistance of $3.45{\pm}6.0\;M{\Omega}$ and an average time constant of $8.0{\pm}1.4$ ms. The cells were firing spontaneously at an average discharge rate of $0.6{\pm}0.4$ Hz. Upon depolarization of the membrane by 0.8 nA for 400 ms, all of the tested cells exhibited accommodation of spike discharge. The most common synaptic response contained an EPSP followed by early-IPSP and late-IPSP. Analysis of the voltage dependence revealed that the early-IPSP and late-IPSP were putative $Cl^--and\;K^+-dependent$, respectively. Systemic injection of the NMDA receptor blocker, MK-801, did not block synaptic responses to the stimulation of the commissural pathway. No significant modifications of EPSP, early-IPSP, or late-IPSP components were detected in the MK-801 and/or lidocaine treated group. These results suggest that MK-801 and lidocaine manifest their CNS effects through firing pattern of hippocampal pyramidal cells and neural network pattern by changing the synaptic efficacy and cellular membrane properties.

• 대한약리학회지
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• 제20권2호
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• pp.35-47
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• 1984

실험적으로 L:D, 12:12또는 D:D, 12:12에 적응시킨 흰쥐의 간뇌에서 beta-endorphin함량의 일중변동과 이에 대한 수종 중추성 약물의 효과를 검토하고 beta-endorphin함량의 생리 및 약리학적 의의를 추구코저 $^3H-morphine$ binding을 측정하여 다음과 같은 성적을 얻었다. 1) L:D, 12:12 cycle에 적응시킨 대조군에서 뇌내 beta-endorphin함량은 06 : 00시 에 최고에 달하고 18 : 00시에 최저인 대단히 유의한 일중변동을 일으켰고 24시간 평균 beta-endorphin함량은 $46.7{\pm}3.6$ fmole/mg protein 이었다. 2) D:D, 12:12에 적응시친 표본에서 beta-endorphin 함량은 대조군에서와는 달리 14 : 00시에 최고에 이르고 02 : 00시에 최저에 이르는 일중변동을 보였으며 24시간 평균 beta-endorphin함량도 대조군에 비하여 현저히 감소되었다. 3) 뇌내 beta-endorphin함량 일중별동은 reserpine. pargyline, imipramine, amphetamine. 또는 chlorpromazine처리로써 변동되었다. 4) 대조군에서 $^3H-morphine$ binding은 22 : 00시에 최고에 달하는 일중변동을 보였으며, 지속적인 암적응군에서의 binding은 02 : 00최고, 그리고 14 : 00시에 최하에 이르는 일중변동을 보였다. 5) 대조군과 지속적인 암적응군에서 함량과 maximum $^3H-morphine$ binding간에는 유의한 역상관관계가 있었다. 이상의 실험성적으로 흰쥐 뇌내 beta-endorphin함량과 수용체는 유의란 일중변동을 일으키고 opiate receptor binding의 일중변동은 beta-·endorphin함량변동에 따른 receptor regulation에 의함을 시사하며 또한 지속적인 암적응을 포함하여 수종 중추에 작용하는 약물들이 endorphin함량 일중변동을 변동시킬 수 있음을 보여 준다.

• 한국자동차공학회논문집
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• 제13권4호
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• pp.74-80
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• 2005

This paper presents a misfire monitoring method by using the weight factor. According to OBD II(On-Board Diagnostics) regulations of the CARB (California Air Resources Board), an ECU (Electronic Control Unit) should detect misfires which occur in the internal combustion engine. A misfire is 1311owe4 by post-oscillations for short duration. Sometimes, the amplitude of oscillations may be as high as misfire and can be falsely detected as another misfire. To prevent this, the software designers do not attempt to detect another misfire for this short duration, during which the post oscillations exist. Because of this, ECU does not detect all the misfires and hence, the unstable state of automobile cannot be detected. If this happens for a long time, automobile may get damaged. To solve these problems, this paper suggests a new algorithm to detect misfire by using weighting factor Weighting factor is a concept to distinguish the misfire with the post oscillation and to improve the detection rate. This value of weighting factor is used for counting the misfire. This paper also shows the result of experiment done on a automobile using this software. The software is implemented using ASCET-SD which is preferred in the design of engine control. This paper's result show the possibility of improving the misfire detection by implementing this algorithm.