• Imaging Science in Dentistry
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• 제35권2호
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• pp.77-82
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• 2005

Purpose : To reveal what is the distinct differential diagnostic differences between unicystic ameloblastoma and solid or multicystic ameloblastoma. Materials and Methods : 56 cases of ameloblastoma were retrospectively reviewed and evaluated among the patients who had taken CT scans at the department of Oral & Maxillofacial Radiology in Yonsei University Dental Hospital from January 1996 to December 2003. Results : In 56 cases, 21 cases $(37.5\%)$ were unicystic ameloblastoma, 35 cases $(62.5\%)$ were solid or multicystic ameloblastoma. Only 1 case $(4.8\%)$ of unicystic ameloblastoma and 4 cases $(11.4\%)$ of solid or multicystic ameloblastoma were occurred in maxilla. 13 cases $(61.9\%)$ of unicystic ameloblastoma were observed as unilocular, and 8 cases $(38.1\%)$ as lobulated. 5 cases $(14.3\%)$ of solid or multicystic ameloblastoma were observed as unilocular, 13 cases $(37.1\%)$ as lobulated, and 17 cases $(48.6\%)$ as multilocular. Tn the results from the measurements after correction of the buccolingual widths and heights to the mesiodistal lengths, there is a statistically significant difference between unicystic ameloblastoma and solid or multicystic ameloblastoma in ANCOVA test (p<0.05). Hounsfield units in the lesion were $24.9{\pm}8.8\;HU$ in unicystic ameloblastoma, $31.2{\pm}11.5\;HU$ in solid or multicystic ameloblastoma. There is no statistically significant difference (p>0.05). Conclusion : Characteristic differences between unicystic ameloblastoma and solid or multicystic ameloblastoma is that there is higher prevalence of solid or multicystic ameloblastoma that have lobulated or multilocular patterns. To measure the Hounsfield units in the lesion is helpful, but it is not a differential diagnostic point between unicystic ameloblastoma and solid or multicystic ameloblastoma.

• 치과방사선
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• 제25권1호
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• pp.17-25
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• 1995

The purpose of this study was to obtain some informations for the radiographic differential diagnosis between odontogenic keratocyst and unicystic ameloblastoma in the mandible. The author compared and analysed the clinico-radiographic features of 48 cases of odontogenic keratocyst and 32 cases of unicystic ameloblastoma. The obtained results were as follows : 1. Odontogenic keratocyst and unicystic ameloblastoma occurred the most frequently in the 2nd and 3rd decades, and both lesions occurred with slight predilection in males. The most frequent lesional site was molar area in odontogenic keratocyst(50.0％) and mandibular angle and ramus area in unicystic amelobla-stoma(71.9％). 2. Cortical thinning and expansion were observed with similar occurrences in odontogenic keratocyst(77.l％) and in unicystic ameloblastoma(72.9％). 3. Typical undulating lesional border was observed more frequently in odontogenic keratocyst(79.2％) than in unicystic ameloblastoma(46.9％). 4. Well-defined lesional outline occurred more frequently in odontogenic keratocyst(97.9％) than in unicystic ameloblastoma(53.1％). 5. Root resorption of adjacent teeth occurred more frequently in unicystic ameloblastoma(65.2％) than in odontogenic keratocyst(18.8％) respectively, but loss of lamina dura was frequently observed in odontogenic keratocyst(79.2％). And tooth displacement occurred more frequently in odontogenic keratocyst(50.0％) than in unicystic ameloblastoma(17.4％). 6. Displacement of mandibular canal occurred more frequently in odontogenic keratocyst(75.0％) than in unicystic ameloblastoma(61.5％). 7. Inhomogeneous lesional radiolucency occurred more frequently in unicystic ameloblastoma(53.l％) than in odontogenic keratocyst(39.6％).

• Maxillofacial Plastic and Reconstructive Surgery
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• 제27권6호
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• pp.501-509
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• 2005

Ameloblastoma is a common odontogenic benign tumor of the jaw bone. However, it might be albe to infiltrate into the adjacent tissue, causing bony destruction and high recurrent rate. The aim of the study is to understand the biologic behavior of recurred ameloblastoma through immunohistochemical study. The PCNA, Ki-67, p53 and cytokeratin 17, cytokeratin 18 antibody staining were used. There was significant difference of positive reaction between non-recurred ameloblastoma and recurred ameloblastoma in PCNA and cytokeratin 17. There were no significant difference of positive reaction between non-recurred ameloblastoma and recurred ameloblastoma in p53, Ki-67 and cytokeratin 18. From the above results, it is suggested that the recurrence of ameloblastoma is related to positive reactions of PCNA and cytokeratin 17 and the progonsis of the recurrence of ameloblastoma is able to be predicted by using PCNA and cytokeratin 17.

• Journal of Korean Dental Science
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• 제15권2호
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• pp.121-131
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• 2022

Ameloblastoma is the most representative epithelial odontogenic tumor in the craniofacial region. Through several studies on Ameloblastoma that have been conducted so far, we have been able to get closer to the reality of Ameloblastoma. However, groundbreaking insight into the pathophysiology of Ameloblastoma has not yet been provided. This review assessed three aspects of five recently published papers on Ameloblastoma: cancer stem cells, calcium signaling, and tumor microenvironment, and compared them with previous studies on tumor physiology, including cancer. In addition, the characteristics of Ameloblastoma revealed by the experimental methods presented in the currently published five papers provide the possibility of Ameloblastoma as a study model in general tumor or cancer studies. Furthermore, the mechanisms of action of the chemicals identified in the studies support their potential as candidates for the second-line treatment of Ameloblastoma.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제13권2호
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• pp.160-166
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• 1991

치성낭종과 법랑아세포종과의 조직학적 기준이 모호한 경우에 과거에는 병리학자들이 진단하는데 어려움이 많았으나 1970년 Robinson & Martinez가 조직학적 기준을 제시하면서 unicystic ameloblastoma라 명명하였다. Unicystic ameloblastoma는 conventional ameloblastoma 보다 젊은 연령인 10대, 20대에서, 하악 제3대구치부에서 호발하며 방사선학적으로 단방성 혹은 다방성의 비교적 경계가 뚜렷한 방사선 투과성 병소를 보인다. 이 병소는 적출술만으로 치료하였을 때 solid or multicystic ameloblastoma보다 현저히 낮은 재발율을 보인다. 임상적, 방사선학적으로 unicystic ameloblastoma가 의심되면 병소를 완전히 적출하여 정확한 병리조직학적 진단을 하여 solid or multicystic ameloblastoma일 때는 2차적으로 광범위한 수술 등을 고려하는 것이 타당할 것으로 사료되어 문헌고찰과 함께 3증례의 치료 경험을 보고하는 바이다.

• 치과방사선
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• 제22권2호
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• pp.339-348
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• 1992

The purpose of this study was to evaluate the correlationship between histopathologic types of ameloblastoma and their radiographic appearances. The materials for this study consisted of 106 patients diagnosed as ameloblastoma both radiographically and histologically. The obtained results were as follows: 1. The incidence of ameloblastoma in male(60cases, 56.6%) was slightly higher than that in female (46 cases, 43.4%). The average age was estimated as 30.7 years with a range from 6 to 76 years. The second decade revealed the highest rate. 2. 106 ameloblstomas were histopathologically classified as 36 unicystic, 28 plexiform, 20 follicular, 14 acanthomatous, 7 granular cell, and 1 basal cell ameloblastoma. 3. Unilocular, soap-bubble appearance and scalloped margin were the radiographic appearances frequently seen in unicystic ameloblastoma. The predominant radiographic appearance of plexiform ameloblastoma showed unilocular radiolucency with scalloped margin. 4. 19.8%, 21 cases of ameloblastoma in this study showed containing tooth in their tumor mass by radiography. 5. Root resorption occured in 37 cases(34.9%) and tooth displacement in 7 cases(6.6%). Root resorption and tooth displacement occured in same patient were 24 cases(22.6%). 6. Recurrence occured in 21.7% and average year between initial treatment and recurrence were 2 years.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제16권3호
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• pp.303-308
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• 1994

The ameloblastoma is considered to be a slowly growing locally invasive tumor with a high rate of recurrence if not removed adequately. Ameloblastoma generally dose not metastasize to distant places. In very rar case, ameloblastoma changed its histologic appearance to carcinoma or showed distant metastasie, these generally called malignant ameloblastoma. Inadequate surgical procedures, radiation therapy, and a long duration of this tumor seem to have significant relation to the development of metastasis. Therefore, adequate surgical treatment of the primary lesion plays an important role in the prevention of metastasis postoperatively. This report described an instance of malignant ameloblastoma and review of literature.

• 치과방사선
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• 제12권1호
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• pp.27-33
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• 1982

The purpose of this study is to obtain some informations for the differential diagnosis of ameloblastoma from dentigerous cyst by analysis of the radiographic findings of these lesions. The author studied age and sex distribution, the site of the lesion, tooth behavior and several radiographic features of ameloblastoma and dentigerous cyst. The material consisted of 65 patients of ameloblastoma and 37 patients of dentigerous cyst. The results were obtained as followings. 1) The incidence was highest in 2nd decade (29.2%) and total 65 cases consists of 35 males (53.8%) and 30 females (46.2%) in ameloblastoma. 62 cases were found in lower jaw (95.4%) and the highest site of occurence of ameloblastoma was mandibular molar. region 27 cases. (41.5%) 2) In 65 cases of amelobl!!stoma, 18 cases were seen in association with tooth and 15 cases (83.2%) out of those were associated with mandibular molar teeth. Mandibular molar were most frequently involved in dentigerous cyst (11/31 cases, 29.7%). 3) (a) 23 cases (35.3%) of tooth resorption were found in ameloblastoma and 11 cases (29.7%) of tooth resorption were found in dentigerous cyst. (b) 15 cases (23.1%) of tooth migration were found in ameloblastoma and 10 cases (27.0%) of tooth migration were found in dentigerous cyst. 4) Several radiographic features. (a) Monolocular type ameloblastoma were seen in 23 cases (35.4) and multilocular type of ameloblastoma were seen in 42 cases (64.6%). Monolocular type of dentigerous cyst were seen in 33 cases (89.2%) and multilocular type was seen in 4 cases. (b) Monolocular type ameloblastoma showed 20 cases (87.0%) of scalloped border but 32 cases (97.0%) of dentigerous cyst showed smooth border. (c) 34 cases (81.0%) of ameloblastoma showed honey-comb appearance, soap-bubble appearance or mixed appearance. but all 4 cases of dentigerous cyst showed multicystic appearance. (d) 12 cases (52.2%) of monolocular type ameloblastoma showed slightly increased radiopacity in surrounding bone, and 22 cases (66.7%) of monolocular type dentigerous cyst showed sharp osteosclerotic border. 27 cases (64.3%) of multilocular type ameloblastoma and 3 cases (75.0%) of multilocular type dentigerous cyst showed no changes in surrounding bone.

• Imaging Science in Dentistry
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• 제41권2호
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• pp.89-93
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• 2011

Intraosseous ameloblastoma is the most common and simple type of ameloblastoma prevalent among odontogenic tumors. Clinico-radiographically intraosseous ameloblastoma presents as slow, painless swelling or expansion of the jaws and described as multilocular expansile radiolucency that occurs most frequently in mandibular molar/ramus area. This article describes a case of follicular ameloblastoma involving 45 year old male which is different from the usual presentation, which includes-exophytic growth, different location and without expansion of the cortex.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권6호
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• pp.553-555
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• 2010

Ameloblastoma is a common odontogenic tumor originating from the dental lamina, reduced dental epithelium and rests of Malassez, and represents 10% of all odontogenic tumors of the jaw. Unicystic ameloblastoma is normally encountered in young patients, and often occurs in the mandible, and is particularly associated with an impacted tooth. We encountered an unicystic ameloblastoma arising from a dentigerous cyst after the treatment of a radiolucent lesion on the mandible.