• Journal of Periodontal and Implant Science
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• 제45권2호
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• pp.69-75
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• 2015

Purpose: Salivary fluid formation is primarily driven by Ca2+-activated, apical efflux of chloride into the lumen of the salivary acinus. The anoctamin1 protein is an anion channel with properties resembling the endogenous calcium-activated chloride channels. In order to better understand the role of anoctamin proteins in salivary exocrine secretion, the expression of the ten members of the anoctamin gene family in the mouse submandibular gland was studied. Methods: Total RNA extracted from mouse submandibular salivary glands was reverse transcribed using primer pairs to amplify the full-length coding regions of each anoctamin gene and was subcloned into plasmid vectors for DNA sequencing. Alternative splice variants were also screened by polymerase chain reaction using primer pairs that amplified six overlapping regions of the complementary DNA of each anoctamin gene, spanning multiple exons. Results: Multiple anoctamin transcripts were found in the mouse submandibular salivary gland, including full-length transcripts of anoctamin1, anoctamin3, anoctamin4, anoctamin5, anoctamin6, anoctamin9, and anoctamin10. Exon-skipping splicing in the N-terminal exons of the anoctamins1, anoctamin5, and anoctamin6 genes resulted in multiple alternative splice variants. No expression of anoctamin2, anoctamin7, or anoctamin8 was found. Conclusions: The predominant anoctamin transcript expressed in the mouse submandibular gland is anoctamin1ac. The chloride channel protein produced by anoctamin1ac is likely responsible for the $Ca^{2+}$-activated chloride efflux, which is the rate-limiting step in salivary exocrine secretion.

• 한국과학교육학회지
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• 제24권3호
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• pp.583-595
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• 2004

본 연구의 목적은 초등학생들의 힘에 대한 개념이 연모 실험을 설계하는 과정에 영향을 끼치고 있는 가를 탐색적으로 분석하는 것이다. 초등학교 6학년 학생 40명을 대상으로 힘에 대한 개념을 4개의 선다형 문항을 실시하여 응답 유형을 구분하였다. 힘 개념을 조사하는 문항과 짝을 이루도록 개발된 연모 실험의 4가지 과제를 동일한 학생들에게 해결하도록 하여 실험 설계 능력 중 가설 설정, 변인 통제 및 실험 방법의 요인으로 구분하여 조사하였다. 연구의 분석 결과 초등학생들을 힘에 대한 개념을 과학적 개념과 대안적 개념 집단으로 구별될 수 있었으며, 그 개념에 따라서 실험 설계 능력 중 가설 설정과 변인 통제 및 실험 방법에서 어떤 유형으로 구별되는 가를 분석하였는데, 과학적인 힘 개념을 가진 학생들이 연모 실험의 가설 설정과 변인 통제 및 실험 방법에서 차이를 보이지 못하였다. 이런 결과는 초등학생들의 힘 개념이 연모 실험을 설계하는데 아무런 영향을 주지 못하며, 결국 과학 개념이 실험을 설계하는데 긍정적인 역할을 하도록 한다는 가정이 유지되기 어렵다는 점을 시사받을 수 있었다.

• 한국환경과학회지
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• 제32권10호
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• pp.741-744
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• 2023

This study focused on high school laboratory research and the main purpose was to develop alternative additives for livestock waste and ammonia volatilization methods with high school students as participants and to provide information to business owners based on the results. Compared to the control groups, The bentonite and illite treatment groups had similar ammonia volatilization, pH, EC, and total nitrogen content. In particular, the alum and aluminum chloride mixed treatment group showed low pH and ammonia volatilization, and high EC and total nitrogen content for poultry litter. As a result, when focusing on high school laboratory research, the alum and aluminum chloride mixed agent treatment fulfilled its role as an alternative additive for ammonia reduction. In addition, this approach can be suggested as a method to solve difficulties in adapting to the field through a practical cooperative relationship with livestock farms.

• 한국콘텐츠학회논문지
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• 제21권7호
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• pp.477-487
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• 2021

한국의 대안교육은 1990년대 이후 교육운동으로 성장해왔다. 최근에는 혁신학교, 자유학기제, 고교학점제 등 공교육 체제에 영향을 미치고 있으며 성장해왔다. 2021년에는 교육 기관으로 인정받고 지원받기 위해 제도적 기반도 만들어졌다. 20년간 대안교육운동을 성찰한 결과 후반 10년은 정체된 잃어버린 시간으로 이해하고 있다. 새로운 '대안'에 대한 고민으로 교육철학의 빈곤함도 쟁점으로 부각되었지만 특별한 논의가 진행되지 않았다. 이에 이 연구는 그간 진행해온 대안교육의 이념들을 담을 수 있는 교육철학을 제안하고자 논의하였다. 비판교육학은 의식적인 해방을 통해 주체적이고, 자율적이며, 능동적이고, 자주적인 인간 양성이 목표이다. 최근에는 생태환경과 페미니즘에도 관심을 가지고 논의해왔다. 프레이리, 일리치 같은 학자들의 교육철학은 대안교육운동 초기 기초가 되기도 하였다. 이와 같은 점을 미루어 볼 때 한국의 대안교육운동은 비판교육학을 통해 이해할 수 있으며, 미래 새로운 대안을 위한 교육철학으로 타당함에 대한 가능성을 이 연구는 논의하고 있다.

• 한국환경교육학회지:환경교육
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• 제16권2호
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• pp.29-38
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• 2003

The main purpose of this study is to search a new perspective of environmental education through investigating of alternative education. Environmental education is introduced by needs of society for an effective way of solving environmental problems. But it also has a meaningfulness which is internal need of education for proposing and fostering ecological human corresponds with crisis of modernism. In spite of excessive rhetoric, vision of formal environmental education is very negative. Formal environmental education is restricted to optional course. So, its potential isn't fulfil. Education is both part of the problem and the solution. Education is proclaimed at high level as the key to a more sustainable society and yet it daily plays a part in reproducing an unsustainable society. If environmental education is to fulfil its potential as an agent of environmental problem solution, it becomes both part of the ideal and the practice of education. In this point, alternative education is a model of what environmental education ought to be. Environmental education and alternative education have a common ground in end of education and critical position to the modern education system.

• 한국수소및신에너지학회논문집
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• 제27권4호
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• pp.462-469
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• 2016

This paper presents the results of thermodynamic cycle analysis and performance tests of alternative mixtures in low temperature applications. Two near-azeotropic binary mixtures R-152a/R-1270 (35:65 by wt.%) and R-290/E170 (35:65 by wt.%) are considered in this study. They have zero ODP (Ozone Depletion Potential) and much lower GWP (Global Warming Potential) than R-404A which is an alternative of R-502. Refrigeration cycle characteristics such as cooling capacity, coefficient of performance, suction and discharge pressures and temperatures are compared to those for the baseline refrigerants (R-502 and R-404A) cycles. The performance tests are conducted at the evaporation and condensation temperatures of $5^{\circ}C$ and $45^{\circ}C$, subcooling and superheating temperatures of $5^{\circ}C$, respectively. Performance comparisons between baseline and alternative refrigerants are conducted on the same cooling capacity. The system performance of newly proposed refrigerant mixtures show promising results.

• 대한산업공학회지
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• 제36권1호
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• pp.42-51
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• 2010

The semiconductor industry is highly capital and technology intensive. Technology advancement on circuit design and process improvement requires chip makers continuously to invest a new fabrication facility that costs more than 3 billion US dollars. Especially major semiconductor companies recently started to discuss 450mm fabrication substituting existing 300mm fabrication of which facilities were initiated to build in 1998. If the plan is consolidated, the yield of 450mm facility would be more than doubled compared to existing 300mm facility. In steps of this important investment, facility layout has been acknowledged as one of the most important factors to be competitive in the market. This research proposes a new concept of semiconductor facility layout using hexagonal floor plan and its compatible material flow pattern. The main objective of this proposal is to improve the productivity of the unified layout that has been popularly used to build existing facilities. In this research, practical characteristics of the semiconductor fabrication are taken into account to develop a new layout alternative based on the analysis of Chung and Tanchoco (2009). The performance of the proposed layout alternative is analyzed using computer simulation and the results show that the new layout alternative outperforms the existing layout alternative, unified layout. However, a few questions on space efficiency to the new alternative were raised in communication with industry practitioners. These questions are left for a future study.

• 유기물자원화
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• 제19권1호
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• pp.57-63
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• 2011

화석연료가 고갈되어 감에 따라 사람들은 이를 대처할 수 있는 대체에너지를 찾기 시작했다. 이 대체 에너지는 환경 친화적이며 재생 가능해야 된다는 단서가 붙는데 그 중 가장 많은 주목을 받은 것이 수소이다. 현재 수소는 다양한 방법으로 생산되고 있는데 생물학적으로 수소를 생산하는 방법이 가장 환경 친화적인 방법으로 인식되고 있다. 그러나 아직 생물학적으로 수소를 생산하는 방법은 아직 상업화하기엔 경쟁력이 많이 부족하기 때문에 많은 연구자들이 바이오 수소 생산 방법과 그 생산성 및 생산수율을 높이기 위하여 노력하고 있다. 본 고에서는 생물학적 수소생산의 다양한 개발 접근방법들의 진행 추이를 정리하였다.

• 대한한의학회지
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• 제39권4호
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• pp.177-182
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• 2018

Background: Breast cancer is a treatable disease, but some women reject conventional treatment in favor of unproven "alternative therapies," which may have serious implications for their survival. Therefore, a process is needed to lead them to more appropriate treatment choices. Case presentation: Here, we present the case of a 51-year-old Korean female diagnosed with early-stage breast cancer (stage IIB, T2N1M0) in Nov. 2015. She refused a standard surgical resection together with chemotherapy and opted instead for moxibustion by nonmedical personnel. Consequently, her preference for alternative therapy without conventional treatment exacerbated her disease. Just a little over a year later, integrative cancer treatment, including chemotherapy based on histological founding, and complementary treatment, comprised of acupuncture, moxibustion, and herbal medicine, were administered for 5 months. Finally, she successfully underwent modified radical mastectomy showing a pathological complete response. She received only adjuvant chemotherapy without any alternative medicine afterwards, and she maintained a good status without recurrence. Conclusion: In the case of breast cancer patients who are resistant to surgery and chemotherapy, integrative therapy considering adverse effects from conventional treatment should be preferred to bitter opposition to alternative medicine.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.671-672
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• 2020