• Journal of English Language & Literature
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• v.57 no.1
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• pp.129-146
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• 2011

Despite the ubiquity of love in the work of Sarah Kane, the theme has been overshadowed by the violence that characterizes her early plays. This essay differentiates Kane from her contemporary "in-yer-face" playwrights, arguing that violence in Kane operates as a means of securing love. Antonin Artaud's concept of cruelty, often (mis)understood in a physical sense alone, provides a clue to the nature of Kane's violence and its relation to love. The essay focuses on Cleansed and Crave, both written in 1998, one about love's redemptive possibility, the other about its pure impossibility. What makes Cleansed hopeful is its violence that works as love's obstacle, creating the illusion that once it is removed love would be possible. The absence of violence in Crave on the contrary lays the illusion of love bare, making it Kane's most despairing play. Kane's oeuvre draws a trajectory of love from hope to despair; as a whole it stages the impossibility of love. To love the other requires the relinquishing of the self, making love logically impossible by depriving the verb of its subject. Love, if possible, would offer the bliss of unity, tearing out the constraint of the Symbolic Order. Kane's only alternative is death, as is expressed in Crave and 4.48 Psychosis.

• IMMUNE NETWORK
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• v.20 no.1
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• pp.8.1-8.15
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• 2020

Immune checkpoint blockade targeting PD-1 and PD-L1 has resulted in unprecedented clinical benefit for cancer patients. Anti-PD-1/PD-L1 therapy has become the standard treatment for diverse cancer types as monotherapy or in combination with other anticancer therapies, and its indications are expanding. However, many patients do not benefit from anti-PD-1/PD-L1 therapy due to primary and/or acquired resistance, which is a major obstacle to broadening the clinical applicability of anti-PD-1/PD-L1 therapy. In addition, hyperprogressive disease, an acceleration of tumor growth following anti-PD-1/PD-L1 therapy, has been proposed as a new response pattern associated with deleterious prognosis. Anti-PD-1/PD-L1 therapy can also cause a unique pattern of adverse events termed immune-related adverse events, sometimes leading to treatment discontinuation and fatal outcomes. Investigations have been carried out to predict and monitor treatment outcomes using peripheral blood as an alternative to tissue biopsy. This review summarizes recent studies utilizing peripheral blood immune cells to predict various outcomes in cancer patients treated with anti-PD-1/PD-L1 therapy.

• Journal of Internet Computing and Services
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• v.16 no.4
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• pp.13-23
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• 2015

In order to reduce public medical expenses as well as to provide effective medical services, telemedicine between doctors and patients is considered as an alternative to the conventional hospital visit. But the medical community has been protesting the introduction of telemedicine for the efficacy and safety reasons. Korean government has been conducting a number of pilot projects to demonstrate the efficacy and safety of telemedicine for more than 10 years. However, still the system is not yet legalized. In this study, we have conducted a telemedicine pilot project in Cambodia for one year, where telemedicine can be more freely exercised. After the project, we conducted a survey based on the 'Rogers diffusion' theory. Survey results show that both physicians and patients are positive about the relative advantage of the telemedicine. However, the complexity and high cost of the equipment used in telemedicine has been found to be a possible obstacle. In addition, we found that there is no problem for providing telemedicine services under challenged environment, such as in Cambodia.

• Journal of Chest Surgery
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• v.43 no.6
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• pp.747-752
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• 2010

Surgical repair of thoracoabdominal aortic aneurysm (TAAA) remains a formidable challenge associated with significant rates of mortality and morbidity, especially in patients with high risk. Use of endovascular stent graff in aortic aneurysm disease is now accepted as an alternative treatment to surgery. But the saving of visceral arteries is the chief obstacle to endovascular repair of TAAA. We successfully treated two patients of TAAA with high risk by hybrid procedure including open visceral debranching and concomitant endovascular aneurysm exclusion.

• International Journal of Advanced Culture Technology
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• v.6 no.2
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• pp.107-116
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• 2018

In the past, design has been recognized as a means to determine colors, shapes, and functions Recently, however, it has been accepted in a wider sense, namely designing the entire service, including product and user experience design. In this way, in addition to creativity and expressive power that designers have as their main competence, according to the expansion of this design object, designers are required to have comprehensive abilities in related fields and accompanying technical professional abilities. If designing as a technology application as a direction toward this situation, design education can be carried out by approaching technology as a method of expression or design subject. It can also be an effective alternative towards improving the understanding of technology. Meanwhile, many small microcontroller board products with advanced functions and multi-functional specialized programming integrated development environments (IDEs) are becoming widespread due to their open source, low cost, and scalable features. However, students in the design department who lack the basic knowledge of science and engineering have difficulties learning, which requires considerable time and is required for practical use. From this point of view, we have made advancements in the technical understanding of design education by conducting fundamental research to the effectiveness of microcontroller-based prototyping tools as means of expression. We also conducted basic education of microcontroller boards for a certain period of time on students who majored in design in conjunction with the basic survey and investigated the obstacle factors using a questionnaire. Through these surveys, we have confirmed the necessity of designing microcontroller boards of low difficulty, which simplify the coding process that can act as a barrier in difficulty for design students to apply smoothly in design education. In addition, we intend to carry out a basic study on the guideline of microcontroller design for design education and composition of education programs.

• Journal of Advanced Marine Engineering and Technology
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• v.37 no.4
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• pp.425-430
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• 2013

Robust and high speed underwater communication is severely limited when compared to communications in terrestial. In free space, RF communication operates over long distances at high data rates. However, the obstacle in seawater is the severe attenuation due to the conducting nature. Acoustic modems are capable of long range communication up to several tens of kilometers, but it has low data-rate, high power consumption and low propagation speed. An alternative means of underwater communication is based on optics, wherein high data rates are possible. In this paper, the characteristics of underwater channel in the range of visible wavelength is investigated. And the possibility of optical wireless communication in underwater is also described. The LED-based transceiver and CMOS sensor module are integrated in the system, and the performance of image transmission was demonstrated.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.33 no.6
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• pp.557-567
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• 2015

With the increasing demands of 3D spatial information in urban environment, the importance of point clouds generation techniques have been increased. In particular, for as-built BIM, the point clouds with the high accuracy and density is required to describe the detail information of building components. Since the terrestrial LiDAR has high performance in terms of accuracy and point density, it has been widely used for as-built 3D modelling. However, the high cost of devices is obstacle for general uses, and the image-based 3D reconstruction technique is being a new attraction as an alternative solution. This paper compares the image-based 3D reconstruction technique and the terrestrial LiDAR in point of establishing the as-built BIM of outdoor structures. The point clouds generated from the image-based 3D reconstruction technique could roughly present the 3D shape of a building, but could not precisely express detail information, such as windows, doors and a roof of building. There were 13.2~28.9 cm of RMSE between the terrestrial LiDAR scanning data and the point clouds, which generated from smartphone and DSLR camera images. In conclusion, the results demonstrate that the image-based 3D reconstruction can be used in drawing building footprint and wireframe, and the terrestrial LiDAR is suitable for detail 3D outdoor modeling.

• Journal of Korean Society of Water and Wastewater
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• v.34 no.3
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• pp.183-190
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• 2020

Although membrane bio-reactor (MBR) has been widely applied for wastewater treatment plants, the membrane fouling problems are still considered as an obstacle to overcome. Thus, many studies and commercial developments on mitigating membrane fouling in MBR have been carried out. Recently, high voltage impulse (HVI) has gained attention for a possible alternative technique for desalting, non-thermal sterilization, bromate-free disinfection and mitigation of membrane fouling. In this study, it was verified if the HVI could be used for mitigation of membrane fouling, particularly the internal pore fouling in MBR. The HVI was applied to the fouled membrane under different conditions of electric fields (E) and contact time (t) of HVI in order to investigate how much of internal pore fouling was reduced. The internal pore fouling resistance (R_f) after HVI induction was reduced as both E and t increased. For example, R_f decreased by 19% when the applied E was 5 kV/cm and t was 80 min. However, the R_f decreased by 71% as the E increased to 15 kV/cm under the same contact time. The correlation between E and t that needed for 20% of R_f reduction was modeled based on kinetics. The model equation, E^1.54t = 1.2 × 10³ was obtained by the membrane filtration data that were obtained with and without HVI induction. The equation states the products of En and t is always constant, which means that the required contact time can be reduced in accordance with the increase of E.

• Journal of KIISE:Databases
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• v.31 no.2
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• pp.140-149
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• 2004

Data broadcast has received much attention as a very efficient method for disseminating data items in mobile environment with large number of mobile clients. In this approach, a database server periodically and continuously broadcasts data items through wireless channels and clients perform read-only transactions by accessing necessary data items from the air. While broadcasting, the server must also process update transactions on the database, which raises an obstacle for client's accessing consistent data. In this research, we propose a new algorithm SCDSC(Serialization Checking with DirtySet on Commit) which is an alternative for solving the concurrency control problem efficiently. The SCDSC is a kind of optimistic concurrency control in that a client checks the consistency of data using a DirtySet as a part of data broadcast when it commits its transaction. In each broadcast cycle, the server updates and disseminates the DirtySet with newly changed data items for last few cycles in the sliding window approach. We perform an analysis and a simulation study to evaluate the performance of our SCDSC algorithm in terms of data consistency and data currency.

• Journal of the Korean Applied Science and Technology
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• v.27 no.4
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• pp.407-414
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• 2010

New biological treatments were being developed at a record place, but their potential could be compromised by a significant obstacle: the delivery of these drugs into a body. Pharmaceutical delivery is now nearly as important as product. New systems are being developed, and Drug Delivery Markets Series cover these new systems. Transdermal Delivery System(TDS) is often used as a method of drug dosage into the epidermic skin. An approach used to delivery drugs through the skin for therapeutic use as an alternative to oral, intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other methods of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stopped if the drug dosage lead to side effect. Polysaccharides, such as karaya gum and glucomannan, were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers, drug contents. Among these polysaccharide, the permeation rate of karaya gum matrix was fastest in fibric acid(ciprofibrate) such as lipophilic drug in vitro. We used glycerin, PEG400 and PEG800 as enhancers. Since dermis has more water content(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when PEG400 was more effective for lipophilic drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. Especially, this result suggests a possible use of polysaccharide gel ointment matrix as a transdermal delivery system of anti-hyperlipoproteinemic agent.