• 영어영문학
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• 제57권1호
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• pp.129-146
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• 2011

Despite the ubiquity of love in the work of Sarah Kane, the theme has been overshadowed by the violence that characterizes her early plays. This essay differentiates Kane from her contemporary "in-yer-face" playwrights, arguing that violence in Kane operates as a means of securing love. Antonin Artaud's concept of cruelty, often (mis)understood in a physical sense alone, provides a clue to the nature of Kane's violence and its relation to love. The essay focuses on Cleansed and Crave, both written in 1998, one about love's redemptive possibility, the other about its pure impossibility. What makes Cleansed hopeful is its violence that works as love's obstacle, creating the illusion that once it is removed love would be possible. The absence of violence in Crave on the contrary lays the illusion of love bare, making it Kane's most despairing play. Kane's oeuvre draws a trajectory of love from hope to despair; as a whole it stages the impossibility of love. To love the other requires the relinquishing of the self, making love logically impossible by depriving the verb of its subject. Love, if possible, would offer the bliss of unity, tearing out the constraint of the Symbolic Order. Kane's only alternative is death, as is expressed in Crave and 4.48 Psychosis.

• IMMUNE NETWORK
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• 제20권1호
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• pp.8.1-8.15
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• 2020

Immune checkpoint blockade targeting PD-1 and PD-L1 has resulted in unprecedented clinical benefit for cancer patients. Anti-PD-1/PD-L1 therapy has become the standard treatment for diverse cancer types as monotherapy or in combination with other anticancer therapies, and its indications are expanding. However, many patients do not benefit from anti-PD-1/PD-L1 therapy due to primary and/or acquired resistance, which is a major obstacle to broadening the clinical applicability of anti-PD-1/PD-L1 therapy. In addition, hyperprogressive disease, an acceleration of tumor growth following anti-PD-1/PD-L1 therapy, has been proposed as a new response pattern associated with deleterious prognosis. Anti-PD-1/PD-L1 therapy can also cause a unique pattern of adverse events termed immune-related adverse events, sometimes leading to treatment discontinuation and fatal outcomes. Investigations have been carried out to predict and monitor treatment outcomes using peripheral blood as an alternative to tissue biopsy. This review summarizes recent studies utilizing peripheral blood immune cells to predict various outcomes in cancer patients treated with anti-PD-1/PD-L1 therapy.

• 인터넷정보학회논문지
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• 제16권4호
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• pp.13-23
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• 2015

날로 증가하는 공공의료비 지출을 줄이고, 의료 취약계층에 효과적인 의료 서비스를 제공하기 위해 의사와 환자 간 원격 의료도입이 하나의 대안으로 제시되고 있으나, 의료계에서는 유효성과 안전성 등을 이유로 이에 반대하고 있다. 정부는 지난 10여년간 꾸준히 원격의료의 도입을 위해 다양한 시범사업을 진행하고 있으나, 아직 이를 실제화 시키지 못하고 있다. 이러한 상황에서 본 연구팀에서는 국내에 비해 비교적 원격의료에 대한 거부감이 덜한 캄보디아에서 원격의료 시범사업을 1년 간 진행하였다. 사업진행 후 이러한 새로운 진료방식이 앞으로 확산될 수 있을 것인지를 파악해 보고자 로저스 확산 이론에 근거한 설문을 진행하였다. 설문 분석결과, 의사와 환자 모두 원격진료의 상대적 이점에 대하여 긍정적으로 생각하고 있는 것으로 나타났다. 그러나 원격의료에 사용되는 기기의 복잡도와 가격은 보완 되어야 할 필요가 있는 것으로 나타났다. 또한 캄보디아와 같이 상대적으로 열악한 환경에서도 원격의료 서비스의 제공이 의미가 있는 것으로 분석되었다.

• Journal of Chest Surgery
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• 제43권6호
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• pp.747-752
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• 2010

흉복부대동맥류 질환에서 고전적인 수술은 고위험군 환자에서 아직까지 높은 합병증 발생과 사망률을 나타낸다. 최근에는 스텐트 그라프트를 이용한 혈관내 시술(endovascular repair)이 시행되고 있으나 내장동맥의 보존이 시술의 걸림돌이 되고 있다. 저자들은 2명의 고위험군 흉복부대동맥류 환자에서 내장동맥 우회술과 흉복부대동맥에 스벤트 그라프트를 삽입하는 하이브리드 술식을 이용하여 성공적으로 치료하였다.

• International Journal of Advanced Culture Technology
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• 제6권2호
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• pp.107-116
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• 2018

In the past, design has been recognized as a means to determine colors, shapes, and functions Recently, however, it has been accepted in a wider sense, namely designing the entire service, including product and user experience design. In this way, in addition to creativity and expressive power that designers have as their main competence, according to the expansion of this design object, designers are required to have comprehensive abilities in related fields and accompanying technical professional abilities. If designing as a technology application as a direction toward this situation, design education can be carried out by approaching technology as a method of expression or design subject. It can also be an effective alternative towards improving the understanding of technology. Meanwhile, many small microcontroller board products with advanced functions and multi-functional specialized programming integrated development environments (IDEs) are becoming widespread due to their open source, low cost, and scalable features. However, students in the design department who lack the basic knowledge of science and engineering have difficulties learning, which requires considerable time and is required for practical use. From this point of view, we have made advancements in the technical understanding of design education by conducting fundamental research to the effectiveness of microcontroller-based prototyping tools as means of expression. We also conducted basic education of microcontroller boards for a certain period of time on students who majored in design in conjunction with the basic survey and investigated the obstacle factors using a questionnaire. Through these surveys, we have confirmed the necessity of designing microcontroller boards of low difficulty, which simplify the coding process that can act as a barrier in difficulty for design students to apply smoothly in design education. In addition, we intend to carry out a basic study on the guideline of microcontroller design for design education and composition of education programs.

• Journal of Advanced Marine Engineering and Technology
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• 제37권4호
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• pp.425-430
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• 2013

수중통신은 지상통신에 비하여 통신채널의 강건성과 고속데이터 전송 측면에서 상당한 제약 요인을 가지고 있다. 공기 중에서 RF 통신은 장거리 전송에도 높은 데이터 전송률을 보이지만, 수중에서는 매질의 전도특성으로 인하여 전파에너지의 심각한 감쇠현상이 발생하여 통신이 어려운 실정이다. 현재 수중에서 수 십 킬로미터 이상의 장거리 통신이 가능한 음향파 통신 모뎀이 개발되어 사용되고 있지만 낮은 전송율과 높은 전력 소모, 느린 전송속도가 문제로 거론되고 있다. 이 문제를 보완할 수 있는 방안으로 빛을 이용한 근거리 수중무선통신이 대안으로 연구되고 있다. 본 논문에서는 가시광 파장영역에서 수중통신 채널 특성을 분석하였다. 자유공간 광무선 통신과 비교하여 수중 가시광 통신기술의 가능성을 제시하고, LED 기반 트랜시버와 CMOS 센서를 통신시스템에 장착하여 수중이미지 전송을 위한 광무선 통신 시스템을 시연하였다.

• 한국측량학회지
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• 제33권6호
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• pp.557-567
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• 2015

With the increasing demands of 3D spatial information in urban environment, the importance of point clouds generation techniques have been increased. In particular, for as-built BIM, the point clouds with the high accuracy and density is required to describe the detail information of building components. Since the terrestrial LiDAR has high performance in terms of accuracy and point density, it has been widely used for as-built 3D modelling. However, the high cost of devices is obstacle for general uses, and the image-based 3D reconstruction technique is being a new attraction as an alternative solution. This paper compares the image-based 3D reconstruction technique and the terrestrial LiDAR in point of establishing the as-built BIM of outdoor structures. The point clouds generated from the image-based 3D reconstruction technique could roughly present the 3D shape of a building, but could not precisely express detail information, such as windows, doors and a roof of building. There were 13.2~28.9 cm of RMSE between the terrestrial LiDAR scanning data and the point clouds, which generated from smartphone and DSLR camera images. In conclusion, the results demonstrate that the image-based 3D reconstruction can be used in drawing building footprint and wireframe, and the terrestrial LiDAR is suitable for detail 3D outdoor modeling.

• 상하수도학회지
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• 제34권3호
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• pp.183-190
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• 2020

Although membrane bio-reactor (MBR) has been widely applied for wastewater treatment plants, the membrane fouling problems are still considered as an obstacle to overcome. Thus, many studies and commercial developments on mitigating membrane fouling in MBR have been carried out. Recently, high voltage impulse (HVI) has gained attention for a possible alternative technique for desalting, non-thermal sterilization, bromate-free disinfection and mitigation of membrane fouling. In this study, it was verified if the HVI could be used for mitigation of membrane fouling, particularly the internal pore fouling in MBR. The HVI was applied to the fouled membrane under different conditions of electric fields (E) and contact time (t) of HVI in order to investigate how much of internal pore fouling was reduced. The internal pore fouling resistance (R_f) after HVI induction was reduced as both E and t increased. For example, R_f decreased by 19% when the applied E was 5 kV/cm and t was 80 min. However, the R_f decreased by 71% as the E increased to 15 kV/cm under the same contact time. The correlation between E and t that needed for 20% of R_f reduction was modeled based on kinetics. The model equation, E^1.54t = 1.2 × 10³ was obtained by the membrane filtration data that were obtained with and without HVI induction. The equation states the products of En and t is always constant, which means that the required contact time can be reduced in accordance with the increase of E.

• 한국정보과학회논문지:데이타베이스
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• 제31권2호
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• pp.140-149
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• 2004

수많은 이동 클라이언트가 있는 이동 사용자 환경에서 데이타 방송 기법은 매우 효과적인 데이타 전달 방식으로 주목을 받고 있다. 이 방식에서 데이타베이스 서버는 데이타를 무선채널을 통해 주기적으로 배포하며 클라이언트는 필요한 데이타를 선택적으로 액세스하는 읽기 전용 트랜잭션을 수행한다. 한편, 서버에서는 데이타 방송과 병행해서 데이타베이스 갱신도 수행하므로 플라이언트가 일관성 있는 데이타를 액세스할 수 있으려면 동시성제어 문제가 해결되어야 한다. 본 연구에서는 이러한 동시성제어 문제를 효율적으로 해결하는 알고리즘인 SCDSC(Serialization Checking with DirtySet on Commit) 기법을 제안한다. SCDSC는 이동 클라이언트에서 다중 데이타를 요구하는 읽기 트랜잭션을 커미트할 때 일반 데이타와 함께 방송된 DirtySet을 점검하여 일관성을 유지하는 일종의 낙관적 동시성 제어기법이다. DirtySet은 일정 방송주기 동안 변경된 데이타 집합으로 방송주기가 바뀔 때마다 슬라이딩 윈도우 방식으로 서버에서 갱신되어 배포된다. 또한, 제안하는 알고리즘의 성능을 데이타 일관성(data consistency) 및 현재성(data currency) 관점에서 분석하고 시뮬레이션을 통해 알아본다.

• 한국응용과학기술학회지
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• 제27권4호
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• pp.407-414
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• 2010

New biological treatments were being developed at a record place, but their potential could be compromised by a significant obstacle: the delivery of these drugs into a body. Pharmaceutical delivery is now nearly as important as product. New systems are being developed, and Drug Delivery Markets Series cover these new systems. Transdermal Delivery System(TDS) is often used as a method of drug dosage into the epidermic skin. An approach used to delivery drugs through the skin for therapeutic use as an alternative to oral, intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other methods of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stopped if the drug dosage lead to side effect. Polysaccharides, such as karaya gum and glucomannan, were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers, drug contents. Among these polysaccharide, the permeation rate of karaya gum matrix was fastest in fibric acid(ciprofibrate) such as lipophilic drug in vitro. We used glycerin, PEG400 and PEG800 as enhancers. Since dermis has more water content(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when PEG400 was more effective for lipophilic drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. Especially, this result suggests a possible use of polysaccharide gel ointment matrix as a transdermal delivery system of anti-hyperlipoproteinemic agent.