• 셀메드
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• 제12권3호
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• pp.10.1-10.12
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• 2022

Objective: The objective of the study was to evaluate the effect of Sharbat Afsantin in Polycystic Ovarian Disease. Methods: An open observational study was carried out in the Department of Ilmul Qabalat wa Amraze Niswan. Diagnosed cases(n=30) of PCOD were included in the study. Patients with thyroid dysfunction, systemic diseases, on hormonal treatment in last three months, pregnancy and lactation were excluded. Research drug (Sharbat Afsantin) was administered orally in a dose of 25ml twice daily for 15 days/cycle for three consecutive cycles. Outcome measures were, changes in subjective parameters (duration of cycle, duration and amount of flow and weight reduction) and objective parameters {pictorial blood loss assessment chart (PBAC) score, basal metabolic index (BMI), modified Ferriman Gallwey (mFG) score, acanthosis nigricans scale and pelvic ultrasonography}. Data were analyzed using paired Student 't' test. Results: Changes in duration of cycle, duration and amount of flow were achieved in 83.3%, 50% and 40% patients respectively and weight reduction in 30% patients. Changes in PBAC score and BMI were achieved in 50% and 30% patients respectively and 30% patients showed normal findings on pelvic ultrasonography. Conclusion: Sharbat Afsantin can be used as an alternate remedy in PCOD patients, as it has significant effect to regularize menstruation by reduction in BMI and probably by improving insulin resistance in PCOD. No adverse effect of Sharbat Afsantin was noted during the trial.

• 한국동물위생학회지
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• 제46권3호
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• pp.219-225
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• 2023

Canine atopic dermatitis (CAD) has a genetic basis and is primarily a skin disorder characterized by allergic features. It is caused by an excessive immune response, associated with immunoglobulin E(IgE), to allergens and shows clinical signs of itching and inflammation. The present study evaluated the allergen-specific and total IgE concentration in dogs with allergic disorders. Allergen-specific IgE analysis was performed using a Multiple Allergen Simultaneous Test (MAST) assay, and total IgE analysis was conducted using an ELISA in 82 dogs with CAD. The subjects were divided into two groups: dogs aged ≤3 years and dogs aged >3 years, enabling a comparison of total IgE concentrations between the two age groups. The results showed that the major affecting environmental allergen was Alternaria alternate, and the major affecting dietary allergen was raw chestnut. The results revealed that dogs aged ≤3 years had higher total IgE concentrations than dogs aged >3 years with significant difference. The results of this study can contribute to the diagnosis and treatment of CAD in South Korea.

• Nutrition Research and Practice
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• 제8권2호
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• pp.220-226
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• 2014

BACKGROUND/OBJECTIVES: Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found in vegetal dietary sources that has antioxidant and chemopreventive properties, in arsenic trioxide ($As_2O_3$)-induced Male Wistar rats. MATERIALS/METHODS: Adult rats received 3 mg/kg $As_2O_3$ (intravenous injection, iv.) on alternate days for 4 days. Resveratrol (8 mg/kg) was administered (iv.) 1 h before $As_2O_3$ treatment. The plasma and homogenization enzymes associated with oxidative stress of rat kidneys were measured, the kidneys were examined histologically and trace element contents were assessed. RESULTS: Rats treated with $As_2O_3$ had significantly higher oxidative stress and kidney arsenic accumulation; however, pretreatment with resveratrol reversed these changes. In addition, prior to treatment with resveratrol resulted in lower blood urea nitrogen, creatinine and insignificant renal tubular epithelial cell necrosis. Furthermore, the presence of resveratrol preserved the selenium content ($0.805{\pm}0.059{\mu}g/g$) of kidneys in rats treated with $As_2O_3$. However, resveratrol had no effect on zinc level in the kidney relative to $As_2O_3$-treated groups. CONCLUSIONS: Our data show that supplementation with resveratrol alleviated nephrotoxicity by improving antioxidant capacity and arsenic efflux. These findings suggest that resveratrol has the potential to protect against kidney damage in populations exposed to arsenic.

• Corrosion Science and Technology
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• 제17권3호
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• pp.101-108
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• 2018

AA7010 is an Al-Zn-Mg-Cu alloy containing Zr, developed as an alternate to traditional AA7075 alloy owing to their high strength combined with better fracture toughness. It is necessary to improve the corrosion resistance and surface properties of the alloy by incorporating plasma electrolytic oxidation (PEO) method. AA7010-T7452 aluminum alloy has been processed through the forging route with multi-stage working operations, and was coated with $10{\mu}m$ thick $Al_2O_3$ ceramic aluminina coating using the plasma electrolytic oxidation (PEO) method. The corrosion, stress corrosion cracking (SCC) and nano-mechanical behaviours were examined by means of potentiodynamic polarization, slow strain rate test (SSRT) and nano-indentation tests. The results indicated that the additional thermomechanical treatment during the forging process caused a fully recrystallized microstructure, which lead to the poor environmental cracking resistance of the alloy in 3.5% NaCl solution, despite the overaging treatment. Although the fabricated PEO coating improved general corrosion resistance, the brittle nature of the coating did not provide any improvement in SCC resistance of the alloy. However, the hardness and elastic modulus of the coating were significantly higher than the base alloy.

• 한국응용곤충학회지
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• 제11권1호
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• pp.31-35
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• 1972

밀, 보리 붉은곰팡이병균의 분생포자 및 자낭각형성에 미치는 광선의 영향을 수량적으로 연구하고, 분생포자의 제1차 전염원으로서의 가능성을 증명하기 위해서 토양에서의 일동상태를 조사하였다. 1. 균주 진주 1은 연속광선조사구에서는 광암교호구 및 암처리구보다 분생포자 형성이 많았다. 균주 수원 3은 암처리에서도 진주 1의 광처리보다 분생포자 형성이 많았으며, 광암교호구에서는 배양일 8일후 현저히 증가하였다. 2. 두 균주 모두 자낭각 형성에는 광선이 필요했고, 수원 3은 연속광선처리에서도 미숙 자낭각만을, 진주 1은 암처리를 제외한 다른 처리에서 많은 성숙자낭각 및 미숙자낭각을 형성했다. 분생포자 형성과 자낭각형성은 균주간에 차이가 있었고, 진주 1은 분생포자 형성량은 적으나, 자낭각형성은 많았고, 수인 3은 그와 반대였다. 3. 분생포자는 각각 $10,\; 30,\; 50\%$의 토양습도에서 겨울동안 그 수가 현저하게 감소했으나, 이듬해 3월부터 토양습도에 관계없이 그 수가 증가했다 즉 밀, 보리 붉은곰팡이병균의 분생포자는 토양에서 월동할 수 있었으며, 1차 전염원의 가능성이 있다고 본다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6141-6147
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• 2015

Background: Cancer is a leading cause of death worldwide. A large proportion of cancer deaths are preventable through early detection but there are a range of social, emotional, cultural and financial dimensions that hinder the effectiveness of cancer prevention and treatment efforts. Cancer stigma is one such barrier and is increasingly recognized as an important factor influencing health awareness and promotion, and hence, disease prevention and control. The impact and extent of stigma on the cancer early detection and care continuum is poorly understood in India. Objectives: To evaluate cancer awareness and stigma from multiple stakeholder perspectives in North India, including men and women from the general population, health care professionals and educators, and cancer survivors. Materials and Methods: A qualitative study was conducted with in-depth interviews (IDIs) and focus group discussions (FGDs) among 39 individuals over a period of 3 months in 2014. Three groups of participants were chosen purposively - 1) men and women who attended cancer screening camps held by the Indian Cancer Society, Delhi; 2) health care providers and 3) cancer survivors. Results: Most participants were unaware of what cancers are in general, their causes and ways of prevention. Attitudes of families towards cancer patients were observed to be positive and caring. Nevertheless, stigma and its impact emerged as a cross cutting theme across all groups. Cost of treatment, lack of awarenes and beliefs in alternate medicines were identified as some of the major barriers to seeking care. Conclusions: This study suggests a need for spreading awareness, knowledge about cancers and assessing associated impact among the people. Also Future research is recommended to help eradicate stigma from the society and reduce cancer-related stigma in the Indian context.

• 상하수도학회지
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• 제30권5호
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• pp.561-569
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• 2016

In this paper a concept of the paradigm shift in the operations of Water and Wastewater systems regarding the production and usage of water was introduced. Based on this concept the interrelationships between the water quality in the upper basin of NakDong River relative to Busan and the degree of satisfaction of the customers on the water supply service in Busan were modeled using the System Dynamics modeling methodology. SamRangJin basin area was determined as the upper basin of Busan after analyzing the relationships between the water quality of MoolGeum water intake point and water quality data of various mid- and upper water intake points along NakDong River. The amount of contaminants generated in SamRangJin basin was modeled using the Gross Regional Domestic Product in the area and the treated amount was calculated using the efficiency of wastewater treatment and the degree of improvement of environmental condition per investment. The water quality at MoolGeum water intake point was modeled to take the effects of the remaining amount of contaminants after treatment and the non-point source contaminants in SamRangJin basin. Using the developed System Dynamics model the effects of the investment for the improvement of environmental condition in SamRangJin basin were compared to the case of alternate water source development for Busan in terms of the degree of satisfaction of the customers on the water supply service in Busan.

• 대한영상의학회지
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• 제83권3호
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• pp.712-718
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• 2022

판사이 동정맥루(diploic arteriovenous fistula) 혹은 골내 동정맥루(intraosseous arteriovenous fistulas)는 동정맥 단락의 한 형태로 드물게 발생한다. 판사이 동정맥루에서 누공은 뇌막동맥(meningeal artery)과 골내 판사이 정맥(intraosseous diploic vein) 혹은 이끌정맥(emissary vein) 사이에 형성되고, 누공의 핵은 골내에만 위치한다. 현재, 경막 동정맥루에 대한 대표적 치료 방법은 혈관내 색전술로 대부분이 대퇴동맥/대퇴정맥을 통하여 접근한다. 하지만 혈관내 색전술 시 접근 가능한 통로가 없는 경우에는 대체할 수 있는 다른 접근법을 고려해야 한다. 우리는 이번 증례에서 두개골내 판사이정맥을 직접 천자하여 혈관내 색전술로 치료된 판사이 동정맥루 증례를 보고하고자 한다.

• 대한의생명과학회지
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• 제20권4호
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• pp.250-255
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• 2014

Mycobacterium tuberculosis (MTB) resides and replicates inside macrophages. In our previous report, we reported that CD8+ T cell-mediated immune responses specific for the peptide derived from MTB RNA polymerase beta-subunit ($RpoB_{127-135}$) could be induced in TB patients expressing HLA-$A^*0201$ subtype. In order to examine whether $RpoB_{127-135}$ specific CD8+ T cells can recognize MTB infected macrophages in vitro, CD8+ T cell lines specific for $RpoB_{127-135}$ peptide were generated from peripheral blood mononuclear cells (PBMCs) of healthy HLA-$A^*0201$ subjects by in vitro immunization technique. In this study, we observed $RpoB_{127-135}$ specific CD8+ T cells could recognize and destroy macrophages infected with MTB for 2 to 4 days. $RpoB_{127-135}$ specific CD8+ T cell immune response was inducible from PBMC of healthy subjects expressing HLA-$A^*0206$ subtype, one of HLA-A2 supertype members. Next, we investigated the HLA-I processing mechanism of $RpoB_{127-135}$ peptide in MTB infected macrophages. As a result, the presentation of the MTB derived epitope peptide, $RpoB_{127-135}$, to CD8+ T cells was not inhibited by the treatment with brefeldin-A (ER-Golgi transport inhibitor) or lactacystin (proteasome inhibitor), which blocks the classical HLA-I processing pathway. However, $RpoB_{127-135}$ specific CD8+ T cell activity was blocked either by the blocking agent for the endocytosis (cytochalasin D) or by the blocking antibody (W6/32) for HLA-I molecules. Therefore, the $RpoB_{127-135}$ peptide may be processed by accessing the alternate HLA-I processing pathway. Understanding the processing and presentation mechanisms of the MTB derived proteins will help to improve the efficacy of vaccines and the efficiency of therapeutic agents for TB.

• 농업생명과학연구
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• 제43권5호
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• pp.9-15
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• 2009

본 연구에서는 국내 주요 고추 12품종의 종자 처리시 적정 SMP carrier 선발을 하고자 하였다. SMP carrier 중 탄산칼슘은 carrier와 수분의 배율이 증가할수록 낮은 발아율을 보이거나, 처리 중 유근이 돌출되어 실용성이 낮은 carrier로 판단되었다. Micro-cel E는 수분의 배율이 증가할수록 $T_{50}$이 단축되는 경향을 보였으나, 왕 품종의 경우 처리 중 유근이 돌출되어 차후 대량의 종자처리방법으로 적합하지 못한 결과를 나타냈다. 규조토의 처리는 수분의 배율을 1.5배 처리한 조양과 향촌품종이 처리 중 유근이 돌출되는 현상이 발생되기도 하였으나, 수분의 배율이 증가할수록 $T_{50}$과 MDG가 단축되었다. 왕 품종의 경우 규조토로 1.0, 1.5배 처리는 $T_{50}$이 0.99일과 0.89일로, Micro-cel E의 5.0, 7.0배의 1.59, 0.94일 보다 0.60일, 0.05일 단축되는 경향이었다. 따라서 고추 품종에 적용 가능한 carrier는 Micro-cel E와 대등한 성능을 갖는 규조토로 판단되며, 수분 배율은 1.0배 처리가 적절할 것으로 사료된다.