• IMMUNE NETWORK
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• 제16권4호
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• pp.211-218
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• 2016

Due to the increasing prevalence and number of life-threatening cases, food allergy has emerged as a major health concern. The classic immune response seen during food allergy is allergen-specific IgE sensitization and hypersensitivity reactions to foods occur in the effector phase with often severe and deleterious outcomes. Recent research has advanced understanding of the immunological mechanisms occurring during the effector phase of allergic reactions to ingested food. Therefore, this review will not only cover the mucosal immune system of the gastrointestinal tract and the immunological mechanisms underlying IgE-mediated food allergy, but will also introduce cells recently identified to have a role in the hypersensitivity reaction to food allergens. These include IL-9 producing mucosal mast cells (MMC9s) and type 2 innate lymphoid cells (ILC2s). The involvement of these cell types in potentiating the type 2 immune response and developing the anaphylactic response to food allergens will be discussed. In addition, it has become apparent that there is a collaboration between these cells that contributes to an individual's susceptibility to IgE-mediated food allergy.

• Clinical and Experimental Pediatrics
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• 제60권4호
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• pp.99-105
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• 2017

Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending on the countries: peanuts in the United States and Switzerland, wheat in Germany and Japan, tree nuts in Spain, sesame in Israel, and walnuts in Korea. These common food allergens are different and difficult to identify because of differing study methodologies, population, geography, age, and dietary exposure patterns. The current management of FA relies on the strict avoidance of culprit allergens, the prompt treatment of allergic reactions, including epinephrine use for food-induced anaphylaxis, monitoring, and education to prevent further reactions. Newer approaches for tolerance induction to FA and FA immunotherapy have been under investigation but are not yet ready for real-world application. Thus, consistent and systematic education of patients, caregivers, and food-handling people is of primary importance for the management and prevention of FA reactions. This review assesses and compares IgE-mediated FA in children in Korea and other countries, with a focus on summarizing the prevalence, common triggers, and management of FA.

• Nutritional Sciences
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• 제2권2호
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• pp.119-124
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• 1999

Food allergies play an important role in Atopic Dermatitis (AD). Dietary manipulation is essential in the management of AD. However, there has been a paucity of data reporting the prevalence of food allergies in AD patients in Korea. In this study, the Food Open Challenge Tests (FOCT) were conducted to investigate food allergies in AD patients. The skin-prick test and the detection of specific IgE, as well as allergy history of patient were used to detect food allergies in all AD patients. Elimination diet was conducted for two weeks prior to FOCTs. The prevalence of food allergies by FOCT is as follows: milk (67.3%); chicken (64.2%); pork (62.8%); eggs (61.0%); beef(55.4%) ; wheat (52.0%) and soybean (45.2%). Allergenic food items in Korean AD patients were different from people in other foreign countries. The seven major foods those tested positively by FOCTs were completely eliminated from the replaced diets for two weeks, and were subsequently reintroduced one at a time. Results from FOCTs were not comparable with allergy history or skin-prick tests or specific IgE detection. The sensitivity and specificity of skin-prick tests and specific IgE detection were lower than FOCTs. Allergy history, skin-prick tests, and specific IgE detection are useful for the identification of food allergen but its clinical significance differed according to food items. Therefore, we conclude that even though a 10-day delay was necessary after food challenge, FOCT is a useful and valid method to confirm food allergies and may be essential for the effective control of food allergies for treatment of AD.

• 한국식품영양과학회지
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• 제26권1호
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• pp.1-9
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• 1997

한국인의 식품 알레르기 빈도와 그 원인 식품을 조 사하기 위하여 1,469명을 대상으로 실시한 식품 알레르기 에 대한 설문 조사 및 설문 조사 결과 식품 알레르기가 있다고 응답한 167명 중 헙조가 가능한 84명을 대상으로 실시한 알레르기특이 항체 검사(MAST검사) 결과는 다음과 같다. 총 응답자 1,469명 중 남자는 708 명, 여자는 761명이었으며, 연령대에 대체로 균등한 분포를 보였다 경제적 수준은 100~199만원이 726명 (49.4%)으로 가장 많았고 알레르기 가족력이 있다는 응답자는 684명 (46.6%)으로 조사대상자의 약 반수 정도가 가족력이 있는 것으로 나타났다. 병력상 식품 알레르기의 유병율은 11.4%(1,469명 중 167명)였고, 남자에서는 9.7%, 여자에서는 12.9%였다 식품 알레르기의 유병율은 고소득층에서 높은 경향을 보였으며, 알레르기 가족력을 가진 군에서의 식품 알레르기 유병율이 가족력이 없는 군에 비해 약 2배 이상 높았다. 식품 알레르기의 증상은 남녀 모두 피부 알레르기가 가장 많았다. 그 다음으로는 남자에서는 코 알레르기 , 여자에서는 눈 알레르기였다. 원인 식품 알레르겐의 수는 응답자의 약 반수가 1개의 식품에 알레르기를 가진 것으로 나타났다 원인 식품 섭취 후의 증상 발현시간은 30분 이내가 가장 많았고 조사대상자의 약 2/3가 2시간 이내에 알레르기 증상이 나타났다고 하였다. 병력에서 나타난 원인 식품 알레르기는 고등어가 가장 많았고 다음으로는 복숭아, 돼지고기, 닭고기, 우유, 계란의 순 이었다. MAST검사에서 나타난 식품 알레르기의 추정 유병율은 4.1%였으며, 원인 식품항원은 복숭아 및 돼지고기가 가장 많았고 다음으로는 우유 및 새우(각각 20.0%), 땅콩 및 콩(각각 16.7%) 등의 순이었다. 연령 대별로는 10대 이하에서는 우유, 20대~30대에서는 복숭아, 40대 이상에서는 돼지고기가 많이 나타났다.

• Journal of Yeungnam Medical Science
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• 제32권2호
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• pp.106-110
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• 2015

The prevalence of pneumothorax cases among Intensive Care Unit patients who require mechanical ventilation ranges from 4%-15%. A pneumothorax remains one of the most serious complications of positive pressure ventilation. It can be diagnosed in a critically ill patient through a physical examination or radiographic studies that include chest radiographs, ultrasonography, or computed tomography scanning. However, in a critically ill patient, the diagnosis of a pneumothorax is often complicated by other diseases and by difficulties in imaging sick and unconscious patients. Although electrocardiogram changes associated with a pneumothorax have been described for many years, there has been no report of such among patients who require mechanical ventilation. In this paper, we report 2 cases of a spontaneous pneumothorax with paroxysmal supraventricular tachycardia in patients who required invasive mechanical ventilation due to acute respiratory failure.

• 한국식품과학회지
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• 제33권4호
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• pp.501-505
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• 2001

대두 단백 제조유는 우유에 대해 알레르기를 일으키는 소아들에게 우유 알레르기를 치료하며 아토피의 예방을 위해 대체식품으로 1929년이래 사용되어 왔다. 그러나 대두 단백 제조유는 알레르기 반응을 유발시킬 수 있어서 이의 효용성에 대해서는 아직도 많은 논란이 지속되고 있다. 우리나라 식품 알레르기 환아에 대한 상황파악은 유럽이나 미국과 비교해 볼 때 아직도 잘 이루어지고 있지 않다. 본 연구의 목적은 국내 소아들의 우유 알레르기와 상관하여 대두 알레르기 발생 빈도 조사에 있다. 본 연구에서 임상적 증상을 나타내는 153명의 환아들 중에서 대두 또는 우유 단백질에 알레르기를 일으키는 환자가 각각 21% 또는 51.6%로 나타났다. 그리고 22명(14%)의 환아들은 우유와 대두 두가지 단백질에 모두 알레르기 증상을 나타내었다. 우유알레르기 환자의 경우는 27.8%의 소수 환아가 대두단백질에 알레르기 반응을 보여 주었으나, 대두 알레르기 환자는 대부분(68.8%)이 우유에 대한 알레르기 반응을 나타내는 것으로 확인되었다.

• Tuberculosis and Respiratory Diseases
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• 제80권3호
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• pp.226-229
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• 2017

Chronic obstructive pulmonary disease (COPD) had been considered the only major disease that is continuing to increase in prevalence. There were a few studies about the change of the prevalence of COPD, which showed the prevalence of COPD did not increase. In this review, we report on the trends in the prevalence of COPD in Korea using the data from Korea National Health and Nutrition Examination Survey (KNHANES). The prevalence of COPD in 2015 was 13.4% (male, 21.6%; female, 5.8%). The prevalence of COPD did not change much, which ranged from 13.1% to 14.6% during the period from 2010 to 2015. Among the subjects found to have COPD by spirometry, only 2.8% had been diagnosed as COPD by physicians during the period from 2011 and 2015. In conclusion, the prevalence of COPD did not change significantly during the period from 2010 to 2015. And most COPD patients still had not been diagnosed by physicians and consequently had not been treated appropriately.

• 한국생활과학회지
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• 제22권5호
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• pp.491-506
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• 2013

The allergenic food labeling system for 12 foods has been operated in Korean school food service since 2012. This study was conducted to evaluate the food allergy status of Korean elementary school children's and their parents' perceptions of allergenic food labeling system. The parents of school aged(6-9yr olds) children in Gyeongbuk area were recruited to assist in this survey. Surveys were conducted by 404 parents. The prevalence of food allergy was 18.1%(73 students) and about one-half of the food allergic children had a family history of allergies, in particular, maternal family history. The major symptoms were related to skin and the major allergenic foods were mackerel, eggs, milk, wheat, crab and tomatoes. The parents eliminated the allergenic food from diet of 43.8% of the children with food allergy. Participants had an average knowledge score of 68% correct. The average knowledge score was higher for parents with food allergic children than for parents with intact children(p<.05). Over 61% of the respondents were not satisfied with allergenic food labeling system operated in school food service. The requirements for the allergenic food labeling system were the front-of-package labeling, conspicuous description and insert of warning sign. The parents estimated that the most important effect of the allergenic food labeling system was the improvement of psychological and physical health in children with food allergy. Because the only prevention method for food allergy is the restriction of allergenic food, the institutional device to expand the food labeling to unpackaged food as well as packaged food and to make people trust the food labeling should be prepared.

• 대한지역사회영양학회지
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• 제22권4호
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• pp.298-306
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• 2017

Objectives: The purpose of this study was to investigate the awareness and nutritional management of food allergy (FA) by preschooler's faculty members in child care centers. Methods: A questionnaire survey was conducted among faculty members of child care centers in Seoul. The questionnaire was designed to identify the prevalence of food allergies, requirements of food allergy support and differences in food management depending on the presence of allergic diseases. After excluding incomplete responses, the data of 171 faculties in 137 child care centers (95.0%) were used for statistical analysis. Results: According to the 137 collected questionnaires, 96 child care centers asked parents about their children's allergic disease and 151 children from 66 child care centers had food allergies. A reported 89 children from 43 child care centers had food restrictions. However, 9 child care centers (21.0%) were not aware of food restriction for children with food allergies. Only 6 child care centers (14.0%) supplied substitute foods with the same amount and type of nutrients. Forty eight faculties (28.1%) received training about food allergies. Although there were some differences according to institution type, most of the faculty members wanted food allergy-related support. Conclusions: This study identified a lack of food allergy training for faculty members in child care centers. For proper management, it is necessary for faculty members of child care centers to be educated on overall food allergies. Food allergy-related support such as menus without allergenic ingredients, guidelines on emergency care for food allergies and anaphylaxis should be provided for faculty members in child care centers.

• Clinical and Experimental Pediatrics
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• 제56권12호
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• pp.505-513
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• 2013

Because the prevalence of allergic diseases has significantly increased in recent years, understanding the causes and mechanisms of these disorders is of high importance, and intense investigations are ongoing. Current knowledge pinpoints immune tolerance mechanisms as indispensable for healthy immune response to allergens in daily life. It is evident that development and maintenance of allergen-specific T cell tolerance is of vital importance for a healthy immune response to allergens. Such tolerance can be gained spontaneously by dose-dependent exposures to allergens in nature or by allergen-specific immunotherapy. Allergen-specific immunotherapy induces regulatory T cells with the capacity to secrete interleukin-10 and transforming growth factor-${\beta}$, limits activation of effector cells of allergic inflammation (such as mast cells and basophils), and switches antibody isotype from IgE to the noninflammatory type IgG4. Although allergen-specific immunotherapy is the only method of tolerance induction in allergic individuals, several factors, such as long duration of treatment, compliance problems, and life-threatening side effects, have limited widespread applicability of this immunomodulatory treatment. To overcome these limitations, current research focuses on the introduction of allergens in more efficient and safer ways. Defining the endotypes and phenotypes of allergic diseases might provide the ability to select ideal patients, and novel biomarkers might ensure new custom-tailored therapy modalities.