• Title/Summary/Keyword: alcoholics

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The Dopamine $D_2$ Receptor Locus as a Modifying Gene in Korean Schizophrenia, Alcoholism and Drug Addiction (정신분열증, 알코올중독, 약물중독에서 도파민 $D_2$ 수용체 유전자의 조절유전자(modifying gene)로서의 역할 - 충동적.강박적.탐닉적 행동을 나타내는 정신질환들에서 도파민 $D_2$ 수용체의 조절유전자로서의 역할 -)

  • Jung, Hyun-Mo;Lee, Hong-Seock;Chang, Dong-Won;Lee, Min-Soo
    • Korean Journal of Biological Psychiatry
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    • v.4 no.2
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    • pp.225-233
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    • 1997
  • The authors attempted to examine the allelic association between the A1 allele of Dopamine $D_2$ receptor and schizophrenia, alcoholism, drug addiction in Koreans. Schizophrenic patients(n=31), alcoholism(n=65), drug addiction(n=18) and controls(n=52) were examined by case-control study for distribution of the TaqI polymorphism of the dopamine $D_2$ receptor gene in Korean population to minimize the effect of racial differencies in gene frequencies. In schizophrenics, the numbers of schizophrenics with A1A1, A1A2, A2A2 were 9(29.0%), 15(48.4%) and 7(22.6%) respectively and in alcoholics with A1A1, A1A2, A2A2 were 14(21.5%), 36(55.4%) and 15(23.1%) respectively and in drug addiction with A1A1, A1A2, A2A2 were 2(11.1%), 10(55.6%) and 6(33.3%) respectively and in controls with A1A1, A1A2, A2A2 were 4(7.6%), 24(46.2%) and 24(46.2%) respectively. The prevalence of the A1 allele in schizophrenics, alcoholics, drug addiction and controls were 77%, 76.9%, 67% and 53.8% respectively. And the frequency of the A1 allele in schizophrenics, alcoholics, drug addiction and controls were 0.53, 0.49 0.39 and 0.31 respectively. There was significant difference in the frequency of the A1 allele between schizophrenics, alcoholics and controls. We also classified our alcoholic population. For classification by severity, we used the median MAST score 30 in our samples. There was also significant difference in the frequency of the A1 allele between less severe group(0.42) and more severe group(0.57). This data suggest that the A1 allele is associated with schizophrenia and alcoholism in Koreans. Furthermore the prevalence of the A1 allele increassed in more severely affected alcoholics. The authors conclude that our data support an allelic association between the A1 allele at dopamine $D_2$ receptor and schizophrenia, alcoholism. These results suggest the A1 allele of the $DRD_2$ gene is associated with a number of behavior disorders in which it may act as a modifying gene rather than as the primary etiological agent.

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Validity Verification of a Korean Version of Recovery Scale(Client Assessment Summary) for Alcoholics (알코올중독자의 회복척도 CAS(Client Assessment Summary) 한국어판의 타당도 검증)

  • Rhee, Young-Sun;Kim, Soo-Youn
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.11
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    • pp.386-394
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    • 2016
  • This study investigates the validity of a Korean version of the Client Assessment Summary (CAS), which is a tool used to assess the recovery of alcoholics. We investigated the Korean CAS's suitability for use in assessing the scale of recovery scale of general alcoholics in Korea. In this study, we analyzed the data of 205 abstaining alcoholics in order to determine the validity of the Korean CAS. We undertook relationship analyses of CAS contents, reliability, and composition validity through factor analysis. In addition, we assessed ARS, abstinence period, abstinence self-efficacy, illness insight, and motivation change variables. The factor analysis results, performed after verification of content suitability by assessing 12 questions and 4 factors, confirmed the tool's composition validity, with the results showing relatively high values (R2 = 76.26%, communality ${\geq}0.6$, and KMO = 0.92). Moreover, internal consistency was acceptable (Cronbach's alpha = 0.92), and the correlations among ARS, abstinence self-efficacy, illness insight, and motivation change variables confirmed the validity of the Korean CAS. The proposed Korean CAS is expected to be useful when academically and clinically assessing the recovery of alcoholics; thereby, eventually contributing to successful recoveries from alcoholism.

The Study on Effect of Alcoholics Anonymous for Anxiety and Depression (익명의 알코올 중독자 모임의 불안, 우울에 대한 효과 연구)

  • Kim, Hoi-Young;Son, Hyun-Soo;Kang, Ji-Hong;Shim, So-Ra;Park, Bo-Ra;Kim, Ji-Hwon;Kim, Tae-Heon
    • Journal of Oriental Neuropsychiatry
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    • v.20 no.2
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    • pp.71-84
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    • 2009
  • Objectives : This study was performed to assess the benefits of Alcoholics anonymous program for anxiety and depression of alcoholics. And we investigate Sasang constitution in Alcoholics Anonymous(A.A.) members to study relation between alcoholic and constitution. Methods : 21 members of A.A. groups in korea who agreed to the purpose of this study were selected. We evaluated anxiety by BAl, depression by BDI-II and sasang constitution by QSCCII+. Results : The research result is as follows. 1. Eighteens of 21 A.A. members are men and the rest are women. First alcohol drinking age(mean) is 15. Getting alcohol drunk age(mean) is 20.9. 2. The duration of alcohol drinking before A.A. participation(mean) is 20.2 years. The duration of giving up drinking after A.A. participation(mean) is 26.5 months. 3. A.A. program significantly reduced anxiety of A.A. members from 10.43${\pm}$1.37(mean${\pm}$S.E.)(light anxiety) to 6.86${\pm}$1.24(normal). 4. A.A. program significantly reduced depression of A.A. members from 4.14${\pm}$1.14(mean${\pm}$S.E)(normal) to 2.33${\pm}$0.75(normal) in the statistics, but it does not have the meaning clinically. 5. Sasang constitution classification result was Taeum group 10 people(47.6%), Soyang group 9 people(42.9%), Soeum group 2peopleC9.5%), Taeyang group 0 people(0%), Taeum group and Soyang group were relatively more than Soeum group. Conclusions : Participation in the A.A. program reduce anxiety and depression of A.A. members. This research provide data on positive effect of A.A. program and may prove that the self-help program(A.A.) can help to maintain long term sobriety and improve the quality of life of its members.

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Children's COA & Psychological-social Character by Parent's Problem Drinking (문제음주부모를 둔 청소년의 성인아이성향과 심리사회적 특성)

  • Yang, Hye-Jin
    • Journal of Families and Better Life
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    • v.25 no.2 s.86
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    • pp.1-12
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    • 2007
  • This is an investigative study to consider children's COA by parent's problem drinking and their psychological-social character by the COA. According to the results of this study, almost half of the children's COA, among those who have problem drinking parents, demonstrated high dangerous lever in the lower factors, such as emotional character, personnel relative character, and co-dependent character. Results of the inspection into the differences between the psyrhological-social characters, according to the danger lever of the children's COA, suggested the children's danger lever is higher, the self-efficiency and adaptable flexibility, which are the psychological-social characters, are lower, and there are no special differences in the social-support.

Structural Relationship between Psychosocial Factors Affecting Motivation for Change in Alcoholics

  • Baik, Ok Mi
    • International Journal of Advanced Culture Technology
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    • v.7 no.3
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    • pp.103-110
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    • 2019
  • The purpose of this study was to investigate the relationship between psychosocial factors, such as self-esteem, stress coping, and social support, and motivation for change in alcohol dependent inpatients. This study included 179 inpatients in the 7clinics for alcoholic in Chonbuk. For the analysis of the study questions, this study utilized the structural equation modeling. The results show that self-esteem was related to motivation for change with mediating role of problem-focused stress coping strategy in alcohol dependent inpatients. The study also reveal that self-esteem and social support was directly associated with the motivation for change. Based on the findings, the importance of programs to promote self-esteem and the involvement of family and acquaintances in the treatment process has been suggested.

Biochemical Evaluation of Nutritional Status of Protein and Lipid in Patinets with Alcoholic Liver Disease (생화학적 지표로 본 알코올성 간질환 환자의 단백질 및 지질 영양상태)

  • 구보경;정준모;이혜성
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.27 no.6
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    • pp.1236-1243
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    • 1998
  • The purpose of this study is to evaluate the nutritional status of protein and lipids in the patients with alcoholic liver disease, to find an effective way of dietary management for patients with alcoholic liver disease and to obtain the materials for nutritional education for alcoholics. The subjects consist of 80 patients with alcoholic liver cirrhosis(ALC) and 12 patients with alcoholic fatty liver(AFL). The control group included 57 alcoholics without liver disease(A), 32 patients with viral liver cir rhosis(VLC) and 194 normal(NL). Biochemical evaluation of nutritional status was performed by ana lyzing the profiles of protein and lipids in blood samples. The results are summarized as follows: 1) The frequency of subjects below the normal range of serum total protein was 26.3% in ALC, 16.7% in AFL and 3.5% in A. Serum albumin was lower in 41.3% of ALC. 2) The alcoholics without liver disease showed significantly higher level of serum triglycerides, total cholesterol and LDL cholesterol than the other groups. The alcoholic subjects had lower HDL cholesterol than normal subjects. Overall, the protein and lipids status of the alcoholic subjects in this study was evaluated to be very poor on the basis of biochemical assessments. The results suggest that alcohol abuse and poor dietary intake could cause malnutrition. An extensive nutritional education should be emphasized for the alcohol consuming population. High quality of protein and other dietary intakes from early stage of the disease may be effective in nutritional therapy for the patient with alcoholic liver disease.

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