• Natural Product Sciences
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• 제13권1호
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• pp.23-26
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• 2007

Hepatoprotective activity of different extracts of Citrullus colocynthis L. sch. (roots) (cucurbitaceae) was investigated in albino rats by inducing hepatotoxicity with carbon tetrachloride. The alcoholic extract of Citrullus colocynthis sch. 100 mg/kg b.w. has been shown to posses significant hepatoprotective effect by lowering the serum level of transaminases (GPT & GOT), alkaline phosphate (ALP) and bilirubin (P < 0.05 to P < 0.001).

• Plant Resources
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• 제3권2호
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• pp.118-122
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• 2000

Many ascomycetes were collected at Mt.Unjang, Pyonsan penisula national park, Mt.Moak Chonbuk provincial park, Daea-ri hebarium and Mt.Whaam from August 1996 to October 1999. They were identified. According to the resulting, Lanzia echinophila, Discina parma, Hypomyces auranticus, Helotium versicolor, Cordyceps militaris f. albino, Isaria sinclairii are newly to Korea. They were designed Korean common names by author.

• 대한수의학회지
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• 제9권2호
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• pp.31-35
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• 1969

Nineteen cases of Albino rat having naturally occurred renal lesions were observed during the routine examination of a total of 240 cases. The lesions observed were focal suppurative nephritis (6 cases), acute nonsuppurative nephritis (3 cases), chronic interstitial nephritis (4 cases), nematode infection in pelvic epithelium (5 cases, in which one case was coincident with focal suppurative nephritis) and unilateral hydronephrosis (2 cases). Gross and microscopic findings for the lesions were described and discussed.

• 펄프종이기술
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• 제37권3호
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• pp.66-73
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• 2005

This study was performed to understand the changes in wood extractives, mainly acetone extracts, in pine woods (Pinus densiflora and Pinus rigida) treated by three blue stain fungi (BSF) such as native BSF in Korea, Leptographium sp., screened Albino strain(BSFcs-1) and commercial Cartapip and fungicide, Wood guard. In addition their pulping and bleaching properties were investigated. BSF treatment has significantly reduced acetone extracts, $25.1{\sim}30.4%$ decreasing in red pine and $22.9{\sim}28.1%$ in pitch pine. Three week aging treatment showed about 20% decreasing in red pine and 19.3% in pitch pine. There were not so significant differences in extracts reduction among native BSF and Albino-type strains (Albino strain, BSFcs-1, and commercial Cartapip). But fungicide, Wood guard, treated wood showed relatively lower decreasing rates of extractives, 14% in red pine and 10.1% in pitch pine. Therefore it is understandable that the fungicide could protect the wood from blue stain fungi attack, but has no effect on its extractive reduction. Concerned to pulping properties of BSF and fungicide treated woods, red pine and pitch pine, optimum pulping condition was 20% active alkali, wood to liquor ratio 1 to 6, $170^{\circ}C$, and 2.5 hr. In the case of BSF woods, optimum pulping condition was same as the sound wood, $43.5{\sim}45%$ of pulp yields and $1.3{\sim}1.45%$ of rejects. Screened pulp yield of fungicide treated wood was lower than those of BSF treated woods. Rejects in pulps were higher in fungicide-treated wood than BSF treated woods. Bleaching pulp yields were ranged of 92 to 93.5%. BSF, Cartapip and fungicide treated woods resulted in lower brightness of $55{\sim}58%$, but Albino-type strain(BSFcs-1) $61.3{\sim}62.3%$, very similar to untreated one. Therefore bleaching chemicals could be saved in the processing of chemical pulping.

• Advances in Traditional Medicine
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• 제8권2호
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• pp.111-124
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• 2008

In the present study, an attempt has been made to assess whether the effect of benzene extract of Ocimum sanctum leaves on the ultrastructural changes in the epithelial cells of the cauda epididymis, its subsequent recovery in the seminiferous epithelium and fertility of male albino rats. Wistar strain male albino rats were orally administered benzene extract of 250 mg/kg body weight of O. sanctum leaves followed by subsequent recovery maintaining suitable controls for 48 days. Results indicate decrease in the weights of testis, epididymis and seminal vesicles. Other accessory organs were not affected. Total count, cell and nuclei diameters of germ cells and Leydig cells were reduced. Cauda epididymis exhibited significant reduction in epithelial height and nuclei diameter of epithelial cells. Cells showed vacuolization with exhibit of signs of degeneration. Ultra study revealed that, in general, the cauda epididymis was affected and in particular, the principal, clear and basal cells were highly disturbed. Further, there was decrease in the size of lipid droplets, mitochondria, Golgi complex, endoplasmic reticulum and accumulation of lysosomal bodies. Fertility performance test showed no implantation in female rats mated with O. sanctum treated rats. Moreover, their recovery after withdrawal of treatment was observed suggesting that the effect of the treatment is transient and reversible. A recovery period resulted in normal spermatogenesis and fertility, suggesting reversible antispermatogenic and antifertility effects of the plant.

• Journal of Nutrition and Health
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• 제8권3호
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• pp.31-37
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• 1975

The effect of dietary restriction was obserbed in Albino rats. Dietary restriction was at 2 levels: 10%, 20%, 30 males and same number of females of Albino rats, aged $30{\sim}40$ days were devided into following 6 groups, 5 rats each. 1 group; rice standard group 2 group; 10% restriction of rice standard 3 group; 20% restriction of rice standard 4 group; 65% rice+35% chinese cabbage group 5 group; 10% restriction of 65% rice+35% chinese cabbage 6 group; 20% restriction of 65% rice+35% chinese cabbage The rats were kept in individual cage and given 6 different diet for 7 weeks. The results of this study were elucidated as follow. 1. Final body weight was not obserbed any significant differences between non-restriction group and 10% restriction group, but 20% restriction group revealed the decrease of body weight. 2. According to dietary restriction, final organ weight was almost decreased in the restriction group of rice+chinese cabbage, and in rice standard group, there were no significants differences between none-restriction group and 10% restriction group, but organ weight was sharply decreased such as Liver, Heart, Kidney, Adrenal, Spleen in 20% restriction group. Sex organ weight of female was increased but weight of male was decreased in 20% restriction group of rice standard group. 3. The result of biochemical analysis such as nitrogen retention, serum cholesterol, glucose of urine, feces, and serum, and lipid of feces and liver, was not revealed any significant diffences, but in 20% restriction group, urinary glucose and serum glucose levels were somewhat decreased, and liver nitrogen level was increased. 4. Therefore there is no effect on albino rats by 10% restricted diet. It can be concluded that it is possible to restrict the diet within 10%.

• Parasites, Hosts and Diseases
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• 제27권3호
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• pp.197-202
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• 1989

이 연구는 흰쥐, 개 및 고양이 숙주에 대한 이락촌폐흡충(Paragonimus iloktsuenensis)의 감염력 및 충체 성장 발육을 비교함으로써 개 및 고양이의 숙주 적합성을 알아보고 나아가 이 흡충 의 인체 감염 가능성을 추정해 보고자 실시하였다. 섬진강 하구산 말똥게(Sesarma dehaani)로부터 분리, 수집한 이락촌폐흡충의 피낭유충을 흰쥐, 개 및 고양이에 경구 감염시킨 후 42일을 기준으로 충체를 회수하였으며, 감염 후 42일에 회수한 충체를 유대로 하여 성장 발육을 비교하였다. 감염 후 42일에 흰쥐, 개 및 고양이에서 충체 회수율은 각각 평균 53.4%, 21.9% 및 12.7%이었으나 회수된 충체의 크기가 각각 평균 6.3×3.2mm, 6.3×3.0mm 및 6.2×3.5mm로 차이가 없었고 충체 발육 상에 있어서도 차이가 없었다. 이 연구의 결과는 이탁촌폐흡충의 종숙주로서 개 및 고양이가 충분히 가능함을 나타내었다.

• Applied Microscopy
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• 제13권1호
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• pp.13-30
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• 1983

[ $1-{\beta}-D-Arabinofuranosylcytosine$ ](ara-C), which is a pyrimidine nucleoside analog is cytotonic to mammalian cells in culture and is active in vitro and in vivo against a variety of DNA viruses. The precise mechanism of action of ara-C has not been determined, although ara-C is thought to act as an antimetabolite, interfering with the synthesis of deoxyribonucleic acid(DNA). Cytosine arabinoside originally seemed to act principally by inhibiting the conversion of cytidine to deoxytidine, thus inhibiting DNA synthesis. But recent data suggest that effects upon DNA polymerase and effects via incorporation into DNA and RNA may well be of equal importance. The author have demonstrated the effect of cytosine arabinoside on the hepatocytes of albino mice treated with ara-C, observing changes in the cytoplasmic organelles of the hepatocytes. A total of 120 healthy male albino mice were divided into the control and ara-C treated groups. The animals of the ara-C group were given 10mg. per kg of body weight of mouse ara-C in physiological saline solution and the animals of control group were given physiological saline solution, intraperitoneally. After an administration of ara-C or physiological saline solution, the animal were killed at. interval of 6, 12, and 24 hours. The specimens, which were obtained from the left anterier lobe of the liver, were stained with uranyl acetate and lead citrate and observed with JEM 100B electron microscope. The results were obtained as follow: A pronounced dilatation, sacculation and fragmentation of the cisterane of rough endoplasmic reticulum with dissociation of membrane bound-ribosomes, disaggregation of free ribosomes in the cytoplasm, proliferation of the smooth endoplasmic reticulum associated with depletion of glycogen paracles, atrophies of Golgi complex, production of numerous lipid droplets, and formation of antophagic vacuoles, multivesicular bodies and residual bodies are recognized in the hepatocytes of ara-C treated mice. Consequently it is suggested that cytosine arabinoside would induce a changes of the cytoplasmic organelles of the hepatocytes in albino mice.

• Journal of Ginseng Research
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• 제30권3호
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• pp.100-105
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• 2006

Liver and kidney are specific organs which play an active role in biotransformation and detoxification mechanisms. Ant adverse effect of chemicals or heavy metal can cause the delay or fade in these mechanisms. Present study was designed to find out the protective effect of Panax ginseng extract on renal functions altered by mercuric chloride (heavy metal) in albino rat. Fifty albino rats were divided into 10 groups. Five groups for acute study and five groups for sud-acute study viz. control group (Tween 20 and distilled water), mercuric chloride treated group (0.926 mg/kg body wt. for acute and 0.044 mg/kg body wt. for sub-acute group after calculated $LD_{50}$ (9.26 mg/kg body wt.) by probit analysis (Finney, 1971), Panax ginseng extract treated group (10 mg/kg body wt. for acute and sub-acute sets), mercuric chloride treated followed by Panax ginseng extract and Panax ginseng extract followed by mercuric chloride group. All doses were given orally by gavage tube. The result revealed that the serum urea and creatinine significantly increased in mercuric chloride treated group, while significantly decreased (p<0.01) in Panax ginseng extract group after acute and sub-acute treatment. The biochemical estimation is also confirmed by nephropathological aspect. However, the Panax ginseng extract treated followed by mercuric chloride group is more prominent than the mercuric chloride treated followed by Panax ginseng extract group. It can be concluded that Panax ginseng extract had a protective nature on renal functions against mercuric chloride toxicity in albino rats.

• 한국수산과학회지
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• 제40권4호
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• pp.234-242
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• 2007

We examined the cause of albinism in a hatchery population of flounder in terms of environmental and nutritional factors, including the effects of light intensity (130-12,300 lux), photoperiod (12L/12D or 24L/0D), tank substrate (concrete or fiber-reinforced polymer), tank color (white or dark green) and supplement with enriched live food, and also compared the growth of normal and albino fry under both 12L/12D and 24L/0D. Further to, normalization of the skin pigmentation pattern on the ocular side has been juvestigated after rearing the albino fry for 2 years after their identification and classification and found that, light intensity did not play a critical role in the development of normal pigmentation or albinism in the flounder. By contrast, the photoperiod was a weak inducer of albinism in the flounder. Tank substrate and color also affected the hypomelanosis on the ocular side of the flounder fry. The choice and supplementation of enriched live foods could drastically reduce the incidence of albinos in hatcheries. On comparing the growth of normal and albino fry, while there was no difference between the groups under 24L/0D, the growth of the albino flounder was slower under 12L/12D. Although coloration resulting from xanthophore and melanophore, but not iridophores, occurred on the ocular side, evidence of albinism remained on the ocular side of flounders.